The adaptative mechanisms of Trypanosoma brucei for sterol homeostasis in its different life-cycle environments

Annual Review of Microbiology

Volumn 54, Issue , 2000, Pages 129-156

  Coppens, I ^a   Courtoy, P J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Invariant surface antigens; LDL receptor; Lipid supply; Trypanosome

Indexed keywords

CHOLESTEROL ESTER; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE ANTIGEN; PHOSPHOLIPID; STEROL;

ADAPTATION; ENDOCYTOSIS; HOMEOSTASIS; INTERNALIZATION; LIFE CYCLE; LIPID TRANSPORT; LIPOPROTEIN METABOLISM; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN METABOLISM; REGULATORY MECHANISM; REVIEW; STEROL SYNTHESIS; TRYPANOSOMA BRUCEI;

ADAPTATION, BIOLOGICAL; ANIMALS; BIOLOGICAL TRANSPORT; ENDOCYTOSIS; HOMEOSTASIS; LIPOPROTEINS, LDL; RECEPTORS, LDL; STEROLS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0033758773     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.micro.54.1.129     Document Type: Review

References (140)

1. Trypanosomiasis and trypanotolerance in cattle: A role for congopain
2. The pellicle and the membrane of the flagellum, flagellar adhesion zone, and flagellar pocket: Functionally discrete surface domains of the bloodstream form of African trypanosomes
3. Isolation and characterization of human Lp-B lipoprotein containing apoprotein B as the sole apolipo protein
4. Cell-mediated extracellular acidification and bone resorption: Evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclasts ruffled border
5. L-trans-epoxysuccinyl-leucylamido(4-guanidino)-butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L
6. Etude du recepteur LDL du trypanosome en vue d'un vaccin contre la maladie du sommeil
7. Identification of a specific epitope on the extracellular domain of the LDL-receptor of Trypanosoma brucei brucei
8. A Mr 145,000 low-density lipoprotein (LDL)-binding protein is conserved through the Kinetoplastida order
9. Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
10. Serum lipoproteins are required for multiplication of Trypanosoma brucei brucei under axenic culture conditions
11. Discontinuous transcription and antigenic variation in trypanosomes
12. Transferrin receptor, antigenic variation and the prospect of a trypanosome vaccine
13. Surface receptors and transporters of Trypanosoma brucei
14. Trypanosoma brucei brucei and T. b. gambiense: Stumpy bloodstream forms express more CB1 epitope in endosomes and lysosomes than slender forms
15. Low temperature reversibly inhibits transport from tubular endosomes to a perinuclear, acidic compartment in African trypanosomes
16. Regulation of the activity of the low density lipoprotein receptor in human fibroblasts
17. Evolution of the LDL receptor concept - From cultured cells to intact animals
18. Rapid lateral diffusion of the variant surface glycoprotein in the coat of Trypanosoma brucei
19. Lipid composition of bloodstream forms of Trypanosoma brucei brucei
20. Animal lipopoteins: Chemistry, structure and comparative aspects
21. Trypanosomiasis: An approach to chemotherapy by the inhibition of carbohydrate catabolism
22. Protein trafficking in kinetoplastid protozoa
23. Metabolic compartmentation in African trypanosomes
24. α-Helical coiled-coil structures of Trypanosoma brucei variable surface glycoproteins
25. Receptor-mediated endocytosis in Trypanosoma brucei brucei
26. A rapid method purifies a glycoprotein of Mr 145,000 as the LDL receptor of Trypanosoma brucei brucei
27. 3-Hydroxy-3-methylglutaryl coenzyme A reductase in Trypanosoma brucei: Activity, pharmacological inhibition and biological regulation
28. Trypanosoma brucei brucei: Antigenic stability of its LDL receptor and immunological crossreactivity with the LDL receptor of the mammalian host
29. Receptors for the host density lipoproteins on the hemoflagellate Trypanosoma brucei: Purification and involvement in the growth of the parasite
30. Role of acidic compartments in Trypanosoma brucei, with special reference to low-density lipoprotein processing
31. Exogenous and endogenous sources of sterols in the culture-adapted procyclic trypomastigotes of Trypanosoma brucei
32. The mevalonate pathway in parasitic protozoa and helminths
33. Host plasma low-density lipoproteins particles as an essential source of lipids for the bloodstream forms of Trypanosoma brucei
34. Receptor-mediated endocytosis in the bloodstream form of Trypanosoma brucei
35. Cellular and genetic aspects of antigenic variation in trypanosomes
36. Lysosomes revisited
37. Lysosomotropic agents
38. Inhibition of bone resorption in culture by inhibitors of thiol proteinases
39. The lipid metabolism of blood and culture forms of Trypanosoma lewisi and Trypanosoma rhodesiense
40. Trypanosome sterols and their metabolic origins
41. 2+ storage compartment in trypanosomatids and apicomplexan parasites
42. Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor
43. Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis
44. Endocytosis and intracellular transport of VSGs in trypanosomes
45. Ribonucleotide reductase: Regulation, regulation, regulation
46. Presence of dolichol and its derivatives in human blood
47. Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo
48. Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei
49. Complexity of trypanosomatid endocytosis pathways revealed by Rab4 and Rab5 isoforms in Trypanosoma brucei
50. Sterols of parasitic protozoa and helminths
51. Trypanosoma brucei brucei obtains cholesterol from plasma lipoproteins
52. Characteristics of the binding of human and bovine high-density lipoproteins by bloodstream forms of the African trypanosome, Trypanosoma brucei brucei
53. The lowdensity lipoprotein pathway and its relation to atherosclerosis
54. Regulation of the mevalonate pathway
55. Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia
56. The transferrin receptor in African trypanosomes: Identification, partial characterization and subcellular localization
57. Ammonium chloride causes reversible inhibition of low density lipoprotein receptor recycling and accelerates receptor degradation
58. Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by β-lactone inhibitors and binding of these inhibitors to the enzyme
59. Mechanism of resistance of African trypanosomes to cytotoxic human HDL
60. Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes
61. Topologic mapping of protective and nonprotective epitopes on the variant surface glycoprotein of the WRATat 1 clone of Trypanosoma brucei rhodesiense
62. The phospholipases of pathogenic and nonpathogenic Trypanosoma species
63. Immunoblotting and ligand blotting of the low-density lipoprotein receptor of human liver, HepG2 cells and HeLa cells
64. Structures and functions of multiligand lipoprotein receptors-macrophage scavenger receptors and LDL receptor-related protein (LRP)
65. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement
66. Coenzyme Q10, alpha-tocopherol and free cholesterol in HDL and LDL fractions
67. Scrutinizing sleeping sickness
68. Protein uptake and digestion in bloodstream and culture forms of T. brucei J
69. Concentration and time dependence of the effects of ketoconazole on growth and sterol synthesis by Trypanosoma (Schizotrypanum) cruzi
70. Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi
71. Characterization of a cDNA encoding a cystein-rich cell-surface protein located in the flagellar pocket of the protozoan Trypanosoma brucei
72. Displacement of apolipophorin III from the surface of low density lipophorin by human apoprotein A-I
73. Lysosomal and non-lysosomal peptidyl hydrolases of the bloodstream forms of Trypanosoma brucei brucei
74. Trypanosomatid cysteine protease activity may be enhanced by a kininogen-like moiety from host serum
75. The mevalonate pathway in the bloodstream form of Trypanosoma brucei
76. Specific uptake of tumor necrosis factorα is involved in growth control of Trypanosoma brucei
77. Murine TNF-α has a protective role during experimental infection mice with T. brucei brucei
78. Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei brucei. infections
79. Inhibition of the lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in B apoproteins
80. Topologic analysis of the epitopes of a variant surface glycoprotein of Trypanosoma brucei
81. Trypanosoma rhodesiense: Antigenicity and immunogenicity of flagellant pocket membrane components
82. The acquisition of lipids by African trypanosomes
83. Organization, structure and evolutionary aspects of genes in trypanosomes
84. How do African game animals control trypanosome infections?
85. Ironcontaining superoxide dismutase from Crithidia fasciculata. Purification, characterization and similarity to leismanial and trypanosomal enzymes
86. A flagellar pocket membrane fraction from Trypanosoma brucei rhodesiense: Immunogold localization and nonvariant immunoprotection
87. Biochemical peculiarities of trypanosomes, African and South American
88. Digestive enzymes, receptor-mediated endocytosis and their role in the nutrition of bloodstream-form Trypanosome
89. Localization of hydrolases in cultured procyclic trypomastigotes of Trypanosoma brucei
90. The phospholipases of Trypanosoma brucei. Bloodstream forms and cultured procyclics
91. Invariant surface proteins in bloodstream forms of Trypanosoma brucei
92. Endocytosis and secretion in trypanosomatid parasites - Tumultuous traffic in a pocket
93. Expression and function of surface proteins in Trypanosoma brucei
94. Control of antigen expression in African trypanosomes
95. The genes and transcripts of an antigen gene expression site from T. brucei
96. Incubation of endothelial cells in a superoxide-generating system impairs low-density lipoprotein receptor-mediated endocytosis
97. Possible localization of dolichol-dependent mannosyltransferase of Trypanosoma brucei to the rough endoplasmic reticulum
98. Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3methylglutaryl coenzyme A reductase: Implications for enzyme degradation in the endoplasmic reticulum
99. A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in Trypanosoma brucei
100. Characterization of the ligand-binding site of the transferrin receptor in Trypanosoma brucei demonstrates a structural relationship with the N-terminal domain of the variant surface glycoprotein
101. Coated vesicles from the protozoan parasite Trypanosoma brucei: Purification and characterization
102. Transferrin is a growth factor for the bloodstream form of Trypanosoma brucei
103. A transferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant glycoprotein gene expression site
104. A transferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant glycoprotein gene expression site
105. Purification of the low-density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight
106. Subpellicular and flagellar microtubules of Trypanosoma brucei are extensively glutamylated
107. γ-Tubulin in trypanosomes: Molecular characterization and localisation to multiple and diverse microtubule organising centres
108. The cell division cycle of Trypanosoma brucei brucei: Timing of event markers and cytoskeletal modulations
109. A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits
110. Subcellular fractionation of Trypanosoma brucei bloodstream forms with special reference to hydrolases
111. Bloodstream forms of Trypanosoma brucei require only small amounts of iron for growth
112. ESAG6 and 7 products of Trypanosoma brucei form a transferrin binding protein complex
113. The TFBPcomplex is the receptor for transferrin uptake in Trypanosoma brucei
114. Trypanosoma brucei brucei: Inhibition of glycosylation of the major variable surface coat glycoprotein by tunicamycin
115. Protein radical involvement in biological catalysis?
116. Antiproliferative synergism of the allylalime SF-86327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi
117. Antiproliferative effects and mechanisms of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: In vivo and in vitro studies
118. Cure of short-and long-term experimental Chagas' disease using D0870
119. An analysis of cosmid clones of nuclear DNA from Trypanosoma brucei shows that the genes for variant surface glycoproteins are clustered in the genome
120. Antiprotozoal activity of ergosterol biosynthesis inhibitors: Focus on Trypanosomatidae and Plasmodiidae
121. The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action
122. Influence of pH on the binding of suramin to human serum albumin
123. Lipid content of the slender and stumpy forms of Trypanosoma brucei rhodesiense: A comparative study
124. + exchange in acidic vacuoles of Trypanosoma brucei
125. On the surface coat and flagellar adhesion in trypanosomes
126. Binding of low-density lipoprotein and chylomicrons remnants to the hepatic low-density lipoprotein receptor of dogs, rats and rabbits demonstrated by ligand blotting
127. Plasmodium falciparum: Inhibition of dolichol kinase by mefloquine
128. Subcellular distribution of adenylate cyclase, cyclic AMP phosphodiesterase, protein kinases and phosphoprotein phosphatase in Trypanosoma brucei
129. Endocytosis by African trypanosomes. I. Three-dimensional struc ture of the endocytic organelles in Trypanosoma brucei and Trypanosoma congolense
130. Endocytosis by African trypanosomes. II. Occurrence in different life-cycle stages and intracellular sorting
131. Intracellular colocalization of variant surface glycoprotein and transferrin-gold in Trypanosoma brucei
132. Trypanosoma brucei: A membrane-associated protein in coated endocytotic vesicles
133. Role of the lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts
134. The chemical composition of trypanosomes. III. Antigenic constituents of brucei trypanosomes
135. Synthesis and activity of inhibitors highly specific for the glycolytic enzymes from Trypanosoma brucei
136. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E
137. Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics
138. Antigenic variation in Trypanosoma brucei a telomeric expression site for variant-specific surface glycoprotein genes with novel features