Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design

European Journal of Medicinal Chemistry

Volumn 39, Issue 5, 2004, Pages 421-431

  Aguirre, Gabriela ^a   Cabrera, Eliana ^a   Cerecetto, Hugo ^a   Di Maio, Rossanna ^a   González, Mercedes ^a   Seoane, Gustavo ^a   Duffaut, Adelina ^b   Denicola, Ana ^c   Gil, María J ^d   Martínez Merino, Victor ^d  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b Consejo de Ensenanza Secundaria ^*  (Uruguay)

^c FACULTAD DE CIENCIAS   (Uruguay)

^d PUBLIC UNIVERSITY OF NAVARRE   (Spain)

Author keywords

5 Nitrofuryl derivatives; Anti trypanosomal compounds; Structure activity relationship

Indexed keywords

ANTITRYPANOSOMAL AGENT; HEXYL 4 (5 NITROFURFURYLIDENE)CARBAZATE; N HEXYL 3 (5 NITROFURYL)PROPENAMIDE; NIFURTIMOX; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG ACTIVITY; DRUG BINDING SITE; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; EVALUATION; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GLUTATHIONE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NADH, NADPH OXIDOREDUCTASES; NITROFURANS; PARASITIC SENSITIVITY TESTS; SPERMIDINE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 11144355789     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.02.007     Document Type: Article

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