In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 18, 2004, Pages 4885-4893

  Aguirre, Gabriela ^a   Boiani, Lucía ^a   Cerecetto, Hugo ^a,d   Fernández, Marcelo ^a   González, Mercedes ^a,d   Denicola, Ana ^b   Otero, Lucía ^b   Gambino, Dinorah ^b   Rigol, Carolina ^c   Olea Azar, Claudio ^c   Faundez, Mario ^c  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c UNIVERSITY OF CHILE   (Chile)

^d Departamento de Quimica Organica   (Uruguay)

Author keywords

Anti chagasic compounds; Microsomes free radicals production; Nitrofuryl thiosemicarbazones

Indexed keywords

ANTIPROTOZOAL AGENT; NIFURTIMOX; THIOSEMICARBAZONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; EPIMASTIGOTE; EVALUATION; FEMALE; GROWTH INHIBITION; IN VITRO STUDY; INCUBATION TIME; LIVER MICROSOME METABOLISM; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHARMACOPHORE; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MICE; NITROFURANS; RATS; THIOSEMICARBAZONES; TRYPANOSOMA CRUZI;

MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 4444312101     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.003     Document Type: Article

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