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Volumn 22, Issue 4, 2013, Pages 499-515

Hepatocyte growth factor is an attractive target for the treatment of pulmonary fibrosis

Author keywords

Anti fibrotic agents; Apoptosis; Hepatocyte growth factor; Inflammation; Pulmonary fibrosis

Indexed keywords

ACETYLCYSTEINE; AMBRISENTAN; ANG 1170; ANTIFIBROTIC AGENT; ANTIOXIDANT; AZATHIOPRINE; BB 3; BEPERMINOGENE PERPLASMID; BOSENTAN; CHRONSEAL; COLCHICINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; ETANERCEPT; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MACITENTAN; PENICILLAMINE; PIRFENIDONE; PLACEBO; PREDNISONE; RECOMBINANT HUMAN HEPATOCYTE GROWTH FACTOR; RECOMBINANT SCATTER FACTOR; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 84875125485     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2013.778972     Document Type: Review
Times cited : (50)

References (123)
  • 1
    • 0033593572 scopus 로고    scopus 로고
    • Cell death in development
    • Vaux DL, Korsmeyer SJ. Cell death in development. Cell 1999;96:245-54
    • (1999) Cell , vol.96 , pp. 245-254
    • Vaux, D.L.1    Korsmeyer, S.J.2
  • 2
    • 34447528599 scopus 로고    scopus 로고
    • Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis
    • Antoniou KM, Pataka A, Bouros D, Siafakas NM. Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis. Pulm Pharmacol Ther 2007;20:453-61
    • (2007) Pulm Pharmacol Ther , vol.20 , pp. 453-461
    • Antoniou, K.M.1    Pataka, A.2    Bouros, D.3    Siafakas, N.M.4
  • 3
    • 78650184311 scopus 로고    scopus 로고
    • HGF-0205 Trial Investigators. Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: Results of the HGF-0205 trial
    • Powell RJ, Goodney P, Mendelsohn FO, et al. HGF-0205 Trial Investigators. Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: results of the HGF-0205 trial. J Vasc Surg 2010;52:1525-30
    • (2010) J Vasc Surg , vol.52 , pp. 1525-1530
    • Powell, R.J.1    Goodney, P.2    Mendelsohn, F.O.3
  • 4
    • 50949129278 scopus 로고    scopus 로고
    • Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia
    • Powell RJ, Simons M, Mendelsohn FO, et al. Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. Circulation 2008;118:58-65
    • (2008) Circulation , vol.118 , pp. 58-65
    • Powell, R.J.1    Simons, M.2    Mendelsohn, F.O.3
  • 6
    • 0021071294 scopus 로고
    • Response of the lower respiratory tract to injury. Mechanisms of repair of the parenchymal cells of the alveolar wall
    • Rennard SI, Bitterman PB, Crystal RG. Response of the lower respiratory tract to injury. Mechanisms of repair of the parenchymal cells of the alveolar wall. Chest 1983;84:735-9
    • (1983) Chest , vol.84 , pp. 735-739
    • Rennard, S.I.1    Bitterman, P.B.2    Crystal, R.G.3
  • 7
    • 33749444308 scopus 로고    scopus 로고
    • Incidence and prevalence of idiopathic pulmonary fibrosis
    • Raghu G, Weycker D, Edelsberg J, et al. Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174:810-16
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 810-816
    • Raghu, G.1    Weycker, D.2    Edelsberg, J.3
  • 8
    • 0031693463 scopus 로고    scopus 로고
    • Epithelial/mesenchymal interactions and branching morphogenesis of the lung
    • Hogan BL, Yingling JM. Epithelial/mesenchymal interactions and branching morphogenesis of the lung. Curr Opin Genet Dev 1998;8:481-6
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 481-486
    • Hogan, B.L.1    Yingling, J.M.2
  • 9
    • 15844370315 scopus 로고    scopus 로고
    • PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
    • Bostrom H, Willetts K, Pekny M, et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996;85:863-73
    • (1996) Cell , vol.85 , pp. 863-873
    • Bostrom, H.1    Willetts, K.2    Pekny, M.3
  • 10
  • 11
    • 0036277026 scopus 로고    scopus 로고
    • Myofibroblasts and mechano-regulation of connective tissue remodelling
    • Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002;3:349-63
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 349-363
    • Tomasek, J.J.1    Gabbiani, G.2    Hinz, B.3
  • 12
    • 0035895243 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    • Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001;134:136-51
    • (2001) Ann Intern Med , vol.134 , pp. 136-151
    • Selman, M.1    King, T.E.2    Pardo, A.3
  • 13
    • 0023854506 scopus 로고
    • Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis
    • Adamson IY, Young L, Bowden DH. Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 1988;130:377-83
    • (1988) Am J Pathol , vol.130 , pp. 377-383
    • Adamson, I.Y.1    Young, L.2    Bowden, D.H.3
  • 14
    • 0016442807 scopus 로고
    • Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2
    • Evans MJ, Cabral LJ, Stephens RJ, Freeman G. Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2. Exp Mol Pathol 1975;22(1):142-50
    • (1975) Exp Mol Pathol , vol.22 , Issue.1 , pp. 142-150
    • Evans, M.J.1    Cabral, L.J.2    Stephens, R.J.3    Freeman, G.4
  • 15
    • 48949119341 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: Association with altered surfactant protein processing and herpesvirus infection
    • Lawson WE, Crossno PF, Polosukhin VV, et al. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol 2008;294(6):L1119-26
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294 , Issue.6
    • Lawson, W.E.1    Crossno, P.F.2    Polosukhin, V.V.3
  • 16
    • 54049115076 scopus 로고    scopus 로고
    • Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
    • Korfei M, Ruppert C, Mahavadi P, et al. Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008;178(8):838-46
    • (2008) Am J Respir Crit Care Med , vol.178 , Issue.8 , pp. 838-846
    • Korfei, M.1    Ruppert, C.2    Mahavadi, P.3
  • 17
    • 0030215822 scopus 로고    scopus 로고
    • P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis
    • Kuwano K, Kunitake R, Kawasaki M, et al. P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1996;154(2 Pt 1):477-83
    • (1996) Am J Respir Crit Care Med , vol.154 , Issue.2 PART 1 , pp. 477-483
    • Kuwano, K.1    Kunitake, R.2    Kawasaki, M.3
  • 18
    • 13844314302 scopus 로고    scopus 로고
    • Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis
    • Plataki M, Koutsopoulos AV, Darivianaki K, et al. Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis. Chest 2005;127:266-74
    • (2005) Chest , vol.127 , pp. 266-274
    • Plataki, M.1    Koutsopoulos, A.V.2    Darivianaki, K.3
  • 19
    • 0030638505 scopus 로고    scopus 로고
    • Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice
    • Hagimoto N, Kuwano K, Nomoto Y, et al. Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol 1997;16:91-101
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 91-101
    • Hagimoto, N.1    Kuwano, K.2    Nomoto, Y.3
  • 20
    • 0036933503 scopus 로고    scopus 로고
    • Apoptosis in lung fibrosis and repair
    • Uhal BD. Apoptosis in lung fibrosis and repair. Chest 2002;122(6 Suppl):293S-8S
    • (2002) Chest , vol.122 , Issue.6 SUPPL.
    • Uhal, B.D.1
  • 21
    • 14344283933 scopus 로고    scopus 로고
    • Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor
    • Kuwano K, Kunitake R, Maeyama T, et al. Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 2001;280:L316-25
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280
    • Kuwano, K.1    Kunitake, R.2    Maeyama, T.3
  • 22
    • 3543109115 scopus 로고    scopus 로고
    • Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis
    • Lee CG, Cho SJ, Kang MJ, et al. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 2004;200:377-89
    • (2004) J Exp Med , vol.200 , pp. 377-389
    • Lee, C.G.1    Cho, S.J.2    Kang, M.J.3
  • 23
    • 0032717522 scopus 로고    scopus 로고
    • Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis
    • Kuwano K, Hagimoto N, Kawasaki M, et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest 1999;104:13-19
    • (1999) J Clin Invest , vol.104 , pp. 13-19
    • Kuwano, K.1    Hagimoto, N.2    Kawasaki, M.3
  • 24
    • 0031230494 scopus 로고    scopus 로고
    • Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen
    • Hagimoto N, Kuwano K, Miyazaki H, et al. Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen. Am J Respir Cell Mol Biol 1997;17:272-8
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 272-278
    • Hagimoto, N.1    Kuwano, K.2    Miyazaki, H.3
  • 26
    • 18144371956 scopus 로고    scopus 로고
    • Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts
    • Waghray M, Cui Z, Horowitz JC, et al. Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts. FASEB J 2005;19:854-6
    • (2005) FASEB J , vol.19 , pp. 854-856
    • Waghray, M.1    Cui, Z.2    Horowitz, J.C.3
  • 28
    • 0033835930 scopus 로고    scopus 로고
    • Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis
    • Christensen PJ, Bailie MB, Goodman RE, et al. Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2000;279(3):L487-95
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279 , Issue.3
    • Christensen, P.J.1    Bailie, M.B.2    Goodman, R.E.3
  • 29
    • 0030054203 scopus 로고    scopus 로고
    • Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
    • Eitzman DT, McCoy RD, Zheng X, et al. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996;97(1):232-7
    • (1996) J Clin Invest , vol.97 , Issue.1 , pp. 232-237
    • Eitzman, D.T.1    McCoy, R.D.2    Zheng, X.3
  • 30
    • 0033588866 scopus 로고    scopus 로고
    • Treatment of bleomycin-induced pulmonary fibrosis by transfer of urokinase-type plasminogen activator genes
    • Sisson TH, Hattori N, Xu Y, et al. Treatment of bleomycin-induced pulmonary fibrosis by transfer of urokinase-type plasminogen activator genes. Hum Gene Ther 1999;10(14):2315-23
    • (1999) Hum Gene Ther , vol.10 , Issue.14 , pp. 2315-2323
    • Sisson, T.H.1    Hattori, N.2    Xu, Y.3
  • 31
    • 0035153146 scopus 로고    scopus 로고
    • Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice
    • Chan JCY, Duszczyszyn DA, Castellino FJ, et al. Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. Am J Pathol 2001;159:1681-8
    • (2001) Am J Pathol , vol.159 , pp. 1681-1688
    • Jcy, C.1    Duszczyszyn, D.A.2    Castellino, F.J.3
  • 32
    • 84863748841 scopus 로고    scopus 로고
    • Wound repair and regeneration
    • Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res 2012;49(1):35-43
    • (2012) Eur Surg Res , vol.49 , Issue.1 , pp. 35-43
    • Reinke, J.M.1    Sorg, H.2
  • 33
    • 0037899249 scopus 로고    scopus 로고
    • The myofibroblast in wound healing and fibrocontractive diseases
    • Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 2003;200:500-3
    • (2003) J Pathol , vol.200 , pp. 500-503
    • Gabbiani, G.1
  • 34
    • 0036933489 scopus 로고    scopus 로고
    • The myofibroblast in pulmonary fibrosis
    • Phan SH. The myofibroblast in pulmonary fibrosis. Chest 2002;122(Suppl 6):286S-9S
    • (2002) Chest , vol.122 , Issue.SUPPL. 6
    • Phan, S.H.1
  • 35
    • 4043055316 scopus 로고    scopus 로고
    • Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    • Phillips RJ, Burdick MD, Hong K, et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004;114:438-46
    • (2004) J Clin Invest , vol.114 , pp. 438-446
    • Phillips, R.J.1    Burdick, M.D.2    Hong, K.3
  • 36
    • 1342268310 scopus 로고    scopus 로고
    • Bone marrow-derived progenitor cells in pulmonary fibrosis
    • Hashimoto N, Jin H, Liu T, et al. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 2004;113:243-52
    • (2004) J Clin Invest , vol.113 , pp. 243-252
    • Hashimoto, N.1    Jin, H.2    Liu, T.3
  • 37
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: Potential role in idiopathic pulmonary fibrosis
    • Willis BC, Liebler JM, Luby-Phelps K, et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 2005;166:1321-32
    • (2005) Am J Pathol , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3
  • 38
    • 0038823614 scopus 로고    scopus 로고
    • Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase
    • Thannickal VJ, Lee DY, White ES, et al. Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem 2003;278:12384-9
    • (2003) J Biol Chem , vol.278 , pp. 12384-12389
    • Thannickal, V.J.1    Lee, D.Y.2    White, E.S.3
  • 39
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT
    • Kasai H, Allen JT, Mason RM, et al. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 2005;6:56
    • (2005) Respir Res , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3
  • 40
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis
    • Daniels CE, Wilkes MC, Edens M, et al. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J Clin Invest 2004;114:1308-16
    • (2004) J Clin Invest , vol.114 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3
  • 41
    • 0028851160 scopus 로고
    • Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar
    • Desmouliere A, Redard M, Darby I, Gabbiani G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 1995;146:56-66
    • (1995) Am J Pathol , vol.146 , pp. 56-66
    • Desmouliere, A.1    Redard, M.2    Darby, I.3    Gabbiani, G.4
  • 42
    • 33744914050 scopus 로고    scopus 로고
    • Evolving concepts of apoptosis in idiopathic pulmonary fibrosis
    • Thannickal VJ, Horowitz JC. Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006;3(4):350-6
    • (2006) Proc Am Thorac Soc , vol.3 , Issue.4 , pp. 350-356
    • Thannickal, V.J.1    Horowitz, J.C.2
  • 43
    • 83555164807 scopus 로고    scopus 로고
    • Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis
    • Horowitz JC, Ajayi IO, Kulasekaran P, et al. Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis. Int J Biochem Cell Biol 2012;44(1):158-69
    • (2012) Int J Biochem Cell Biol , vol.44 , Issue.1 , pp. 158-169
    • Horowitz, J.C.1    Ajayi, I.O.2    Kulasekaran, P.3
  • 44
    • 0035989812 scopus 로고    scopus 로고
    • Resistance to Fas-mediated apoptosis in human lung fibroblast
    • Tanaka T, Yoshimi M, Maeyama T, et al. Resistance to Fas-mediated apoptosis in human lung fibroblast. Eur Respir J 2002;20:359-68
    • (2002) Eur Respir J , vol.20 , pp. 359-368
    • Tanaka, T.1    Yoshimi, M.2    Maeyama, T.3
  • 45
    • 0033258047 scopus 로고    scopus 로고
    • Inhibition of myofibroblast apoptosis by transforming growth factor beta
    • Zhang HY, Phan SH. Inhibition of myofibroblast apoptosis by transforming growth factor beta(1). Am J Respir Cell Mol Biol 1999;21:658-65
    • (1999) Am J Respir Cell Mol Biol , vol.1 , Issue.21 , pp. 658-665
    • Zhang, H.Y.1    Phan, S.H.2
  • 46
    • 33644649577 scopus 로고    scopus 로고
    • Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis
    • Matsuyama W, Watanabe M, Shirahama Y, et al. Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis. Am J Pathol 2006;168:866-77
    • (2006) Am J Pathol , vol.168 , pp. 866-877
    • Matsuyama, W.1    Watanabe, M.2    Shirahama, Y.3
  • 47
    • 0023884059 scopus 로고
    • Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue
    • Jordana M, Schulman J, McSharry C, et al. Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue. Am Rev Respir Dis 1988;137:579-84
    • (1988) Am Rev Respir Dis , vol.137 , pp. 579-584
    • Jordana, M.1    Schulman, J.2    McSharry, C.3
  • 48
    • 0023801369 scopus 로고
    • Differential proliferation of fibroblasts cultured from normal and fibrotic human lungs
    • Raghu G, Chen YY, Rusch V, Rabinovitch PS. Differential proliferation of fibroblasts cultured from normal and fibrotic human lungs. Am Rev Respir Dis 1988;138:703-8
    • (1988) Am Rev Respir Dis , vol.138 , pp. 703-708
    • Raghu, G.1    Chen, Y.Y.2    Rusch, V.3    Rabinovitch, P.S.4
  • 49
    • 77958475711 scopus 로고    scopus 로고
    • Current and future treatment options in idiopathic pulmonary fibrosis
    • Hauber HP, Blaukovitsch M. Current and future treatment options in idiopathic pulmonary fibrosis. Inflamm Allergy Drug Targets 2010;9(3):158-72
    • (2010) Inflamm Allergy Drug Targets , vol.9 , Issue.3 , pp. 158-172
    • Hauber, H.P.1    Blaukovitsch, M.2
  • 50
    • 0028955979 scopus 로고
    • Workshop summary: Approaches to the treatment of pulmonary fibrosis
    • Hunninghake GW, Kalica AR. Workshop summary: approaches to the treatment of pulmonary fibrosis. Am J Respir Crit Care Med 1995;151:915-18
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 915-918
    • Hunninghake, G.W.1    Kalica, A.R.2
  • 51
    • 0029995678 scopus 로고    scopus 로고
    • Corticosteroids and the treatment of idiopathic pulmonary fibrosis: Past, present, and future
    • Mapel DW, Samet JM, Coultas DB. Corticosteroids and the treatment of idiopathic pulmonary fibrosis: past, present, and future. Chest 1996;110:1058-67
    • (1996) Chest , vol.110 , pp. 1058-1067
    • Mapel, D.W.1    Samet, J.M.2    Coultas, D.B.3
  • 52
    • 55549147184 scopus 로고    scopus 로고
    • Treatment of idiopathic pulmonary fibrosis with etanercept: An exploratory, placebo-controlled trial
    • Raghu G, Brown KK, Costabel U, et al. Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial. Am J Respir Crit Care Med 2008;178(9):948-55
    • (2008) Am J Respir Crit Care Med , vol.178 , Issue.9 , pp. 948-955
    • Raghu, G.1    Brown, K.K.2    Costabel, U.3
  • 53
    • 4243592637 scopus 로고
    • Treatment of idiopathic pulmonary fibrosis
    • Fulmer J, Elson N, Von Gal E, et al. Treatment of idiopathic pulmonary fibrosis. Clin Res 1978;26:538A
    • (1978) Clin Res , vol.26
    • Fulmer, J.1    Elson, N.2    Von Gal, E.3
  • 54
    • 17944391083 scopus 로고    scopus 로고
    • Colchicine versus prednisone in the treatment of idiopathic pulmonary fibrosis: A randomized prospective study. Members of the Lung Study Group
    • Douglas WW, Ryu JH, Swensen SJ, et al. Colchicine versus prednisone in the treatment of idiopathic pulmonary fibrosis: a randomized prospective study. Members of the Lung Study Group. Am J Respir Crit Care Med 1998;158:220-5
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 220-225
    • Douglas, W.W.1    Ryu, J.H.2    Swensen, S.J.3
  • 56
    • 0032056141 scopus 로고    scopus 로고
    • Effect of endothelin receptor antagonists (BQ-485, Ro 47-0203) on collagen deposition during the development of bleomycin-induced pulmonary fibrosis in rats
    • Mutsaers SE, Marshall RP, Goldsack NR, et al. Effect of endothelin receptor antagonists (BQ-485, Ro 47-0203) on collagen deposition during the development of bleomycin-induced pulmonary fibrosis in rats. Pulm pharmacol Ther 1998;11(2-3):221-5
    • (1998) Pulm Pharmacol Ther , vol.11 , Issue.2-3 , pp. 221-225
    • Mutsaers, S.E.1    Marshall, R.P.2    Goldsack, N.R.3
  • 57
    • 77953261195 scopus 로고    scopus 로고
    • Pirfenidone: Antifibrotic agent for idiopathic pulmonary fibrosis
    • Azuma A. Pirfenidone: antifibrotic agent for idiopathic pulmonary fibrosis. Expert Rev Resp Med 2010;4:301-10
    • (2010) Expert Rev Resp Med , vol.4 , pp. 301-310
    • Azuma, A.1
  • 58
    • 77951160564 scopus 로고    scopus 로고
    • Pirfenidone in idiopathic pulmonary fibrosis: A phase III clinical trial in Japan
    • Pirfenidone Clinical Study Group in Japan
    • Taniguchi H, Ebina M, Kondoh Y, et al. Pirfenidone Clinical Study Group in Japan. Pirfenidone in Idiopathic Pulmonary Fibrosis: A phase III clinical trial in Japan. Eur Respir J 2010;35:821-821
    • (2010) Eur Respir J , vol.35 , pp. 821-821
    • Taniguchi, H.1    Ebina, M.2    Kondoh, Y.3
  • 59
    • 81255146512 scopus 로고    scopus 로고
    • Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment
    • Pirfenidone Clinical Study Group in Japan
    • Azuma A, Taguchi Y, Ogura T, et al. Pirfenidone Clinical Study Group in Japan. Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment. Respir Res 2011;12:143
    • (2011) Respir Res , vol.12 , pp. 143
    • Azuma, A.1    Taguchi, Y.2    Ogura, T.3
  • 60
    • 0031449645 scopus 로고    scopus 로고
    • Antioxidative and clinical effects of high-dose n-acetylcysteine in fibrosing alveolitis: Adjunctive therapy to maintenance immunosuppression
    • Behr J, Maier K, Degenkolb B, et al. Antioxidative and clinical effects of high-dose n-acetylcysteine in fibrosing alveolitis: adjunctive therapy to maintenance immunosuppression. Am J Respir Crit Care Med 1997;156:1897-901
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1897-1901
    • Behr, J.1    Maier, K.2    Degenkolb, B.3
  • 61
    • 84861394764 scopus 로고    scopus 로고
    • Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis
    • Idiopathic Pulmonary Fibrosis Clinical Research Network
    • Idiopathic Pulmonary Fibrosis Clinical Research Network. Raghu G, Anstrom KJ, King TE Jr, et al. Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N Engl J Med 2012;366:1968-77
    • (2012) N Engl J Med , vol.366 , pp. 1968-1977
    • Raghu, G.1    Anstrom, K.J.2    King Jr., T.E.3
  • 62
    • 0042856654 scopus 로고    scopus 로고
    • Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis
    • Thabut G, Mal H, Castier Y, et al. Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis. J Thorac Cardiovasc Surg 2003;126:469-75
    • (2003) J Thorac Cardiovasc Surg , vol.126 , pp. 469-475
    • Thabut, G.1    Mal, H.2    Castier, Y.3
  • 63
    • 0021285134 scopus 로고
    • Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats
    • Nakamura T, Nawa K, Ichihara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun 1984;122:1450-9
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 1450-1459
    • Nakamura, T.1    Nawa, K.2    Ichihara, A.3
  • 64
    • 0024427178 scopus 로고
    • Molecular cloning and expression of human hepatocyte growth factor
    • Nakamura T, Nishizawa T, Hagiya M, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989;342:440-3
    • (1989) Nature , vol.342 , pp. 440-443
    • Nakamura, T.1    Nishizawa, T.2    Hagiya, M.3
  • 65
    • 0031590435 scopus 로고    scopus 로고
    • Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration
    • Matsumoto K, Nakamura T. Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochem Biophys Res Commun 1997;239:639-44
    • (1997) Biochem Biophys Res Commun , vol.239 , pp. 639-644
    • Matsumoto, K.1    Nakamura, T.2
  • 66
    • 0025805633 scopus 로고
    • A Identification of the hepatocyte growth factor receptor as the c-met protooncogene product
    • Bottaro DP, Rubin JS, Faletto DL, et al. A Identification of the hepatocyte growth factor receptor as the c-met protooncogene product. Science 1991;251:802-4
    • (1991) Science , vol.251 , pp. 802-804
    • Bottaro, D.P.1    Rubin, J.S.2    Faletto, D.L.3
  • 67
    • 3142595278 scopus 로고    scopus 로고
    • Crystal structure of the HGF b-chain in complex with the sema domain of the Met receptor
    • Stamos J, Lazarus RA, Yao XY, et al. Crystal structure of the HGF b-chain in complex with the sema domain of the Met receptor. EMBO J 2004;23:2325-35
    • (2004) EMBO J , vol.23 , pp. 2325-2335
    • Stamos, J.1    Lazarus, R.A.2    Yao, X.Y.3
  • 68
    • 0038026134 scopus 로고    scopus 로고
    • Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor
    • Kataoka H, Miyata S, Uchinokura S, Itoh H. Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor. Cancer Metastasis Rev 2003;22(2-3):223-36
    • (2003) Cancer Metastasis Rev , vol.22 , Issue.2-3 , pp. 223-236
    • Kataoka, H.1    Miyata, S.2    Uchinokura, S.3    Itoh, H.4
  • 69
    • 77951719025 scopus 로고    scopus 로고
    • Hepatocyte growth factor activator (HGFA): Pathophysiological functions in vivo
    • Kataoka H, Kawaguchi M. Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo. FEBS J 2010;277:2230-7
    • (2010) FEBS J , vol.277 , pp. 2230-2237
    • Kataoka, H.1    Kawaguchi, M.2
  • 70
    • 0027318311 scopus 로고
    • A novel putative receptor protein tyrosine kinase of the met family
    • Ronsin C, Muscatelli F, Mattei MG, Breathnach R. A novel putative receptor protein tyrosine kinase of the met family. Oncogene 1993;8:1195-202
    • (1993) Oncogene , vol.8 , pp. 1195-1202
    • Ronsin, C.1    Muscatelli, F.2    Mattei, M.G.3    Breathnach, R.4
  • 71
    • 0025771101 scopus 로고
    • Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor
    • Naldini L, Weidner KM, Vigna E, et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J 1991;10:2867-78
    • (1991) EMBO J , vol.10 , pp. 2867-2878
    • Naldini, L.1    Weidner, K.M.2    Vigna, E.3
  • 72
    • 0028084984 scopus 로고
    • Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase
    • Gandino L, Longati P, Medico E, et al. Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J Biol Chem 1994;269:1815-20
    • (1994) J Biol Chem , vol.269 , pp. 1815-1820
    • Gandino, L.1    Longati, P.2    Medico, E.3
  • 73
    • 3142761786 scopus 로고    scopus 로고
    • A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation
    • Peschard P, Ishiyama N, Lin T, et al. A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation. J BiolChem 2004;279:29565-71
    • (2004) J BiolChem , vol.279 , pp. 29565-29571
    • Peschard, P.1    Ishiyama, N.2    Lin, T.3
  • 74
    • 0028181118 scopus 로고
    • Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor)
    • Longati P, Bardelli A, Ponzetto C, et al. Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene 1994;9:49-57
    • (1994) Oncogene , vol.9 , pp. 49-57
    • Longati, P.1    Bardelli, A.2    Ponzetto, C.3
  • 75
    • 0040269807 scopus 로고
    • Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene
    • Vigna E, Naldini L, Tamagnone L, et al. Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cell Mol Biol (Noisy-le-grand) 1994;40(5):597-604
    • (1994) Cell Mol Biol (Noisy-le-grand) , vol.40 , Issue.5 , pp. 597-604
    • Vigna, E.1    Naldini, L.2    Tamagnone, L.3
  • 76
    • 0030927326 scopus 로고    scopus 로고
    • Activation of the JNK pathway is essential for transformation by the Met oncogene
    • Rodrigues GA, Park M, Schlessinger J. Activation of the JNK pathway is essential for transformation by the Met oncogene. EMBO J 1997;16:2634-45
    • (1997) EMBO J , vol.16 , pp. 2634-2645
    • Rodrigues, G.A.1    Park, M.2    Schlessinger, J.3
  • 77
    • 84997941720 scopus 로고    scopus 로고
    • An overview of the c-MET signaling pathway
    • Organ SL, Tsao MS. An overview of the c-MET signaling pathway. Ther Adv Med Oncol 2011;3(1 Suppl):S7-S19
    • (2011) Ther Adv Med Oncol , vol.3 , Issue.1 SUPPL.
    • Organ, S.L.1    Tsao, M.S.2
  • 78
    • 0037686249 scopus 로고    scopus 로고
    • Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer
    • Maulik G, Madhiwala P, Brooks S, et al. Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer. J Cell Mol Med 2002;6:539-53
    • (2002) J Cell Mol Med , vol.6 , pp. 539-553
    • Maulik, G.1    Madhiwala, P.2    Brooks, S.3
  • 79
    • 0027322529 scopus 로고
    • Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger
    • Graziani A, Gramaglia D, dalla Zonca P, et al. Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. J Biol Chem 1993;268:9165-8
    • (1993) J Biol Chem , vol.268 , pp. 9165-9168
    • Graziani, A.1    Gramaglia, D.2    Dalla Zonca, P.3
  • 80
    • 0037018260 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway
    • Paumelle R, Tulasne D, Kherrouche Z, et al. Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway. Oncogene 2002;21:2309-19
    • (2002) Oncogene , vol.21 , pp. 2309-2319
    • Paumelle, R.1    Tulasne, D.2    Kherrouche, Z.3
  • 81
    • 17544371922 scopus 로고    scopus 로고
    • Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein
    • Fixman ED, Fournier TM, Kamikura DM, et al. Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein. J Biol Chem 1996;271:13116-22
    • (1996) J Biol Chem , vol.271 , pp. 13116-13122
    • Fixman, E.D.1    Fournier, T.M.2    Kamikura, D.M.3
  • 82
    • 0035793091 scopus 로고    scopus 로고
    • Antiapoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen activated protein kinase pathways
    • Xiao GH, Jeffers M, Bellacosa A, et al. Antiapoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen activated protein kinase pathways. Proc Natl Acad Sci USA 2001;98:247-52
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 247-252
    • Xiao, G.H.1    Jeffers, M.2    Bellacosa, A.3
  • 83
    • 0033576621 scopus 로고    scopus 로고
    • Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1-Crk signaling complex formation
    • Garcia-Guzman M, Dolfi F, Zeh K, Vuori K. Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1-Crk signaling complex formation. Oncogene 1999;18:7775-86
    • (1999) Oncogene , vol.18 , pp. 7775-7786
    • Garcia-Guzman, M.1    Dolfi, F.2    Zeh, K.3    Vuori, K.4
  • 84
    • 0028301299 scopus 로고
    • Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase
    • Rodrigues GA, Park M. Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase. Oncogene 1994;9:2019-27
    • (1994) Oncogene , vol.9 , pp. 2019-2027
    • Rodrigues, G.A.1    Park, M.2
  • 85
    • 0032518375 scopus 로고    scopus 로고
    • Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
    • Boccaccio C, Ando M, Tamagnone L, et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 1998;391:285-8
    • (1998) Nature , vol.391 , pp. 285-288
    • Boccaccio, C.1    Ando, M.2    Tamagnone, L.3
  • 86
    • 79956055536 scopus 로고    scopus 로고
    • HGF/c-met/Stat3 signaling during skin tumor cell invasion: Indications for a positive feedback loop
    • Syed ZA, Yin W, Hughes K, et al. HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop. BMC Cancer 2011;11:180
    • (2011) BMC Cancer , vol.11 , pp. 180
    • Syed, Z.A.1    Yin, W.2    Hughes, K.3
  • 87
    • 0037050212 scopus 로고    scopus 로고
    • Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis
    • Zhang YW, Wang LM, Jove R, Vande Woude GF. Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene 2002;21:217-26
    • (2002) Oncogene , vol.21 , pp. 217-226
    • Zhang, Y.W.1    Wang, L.M.2    Jove, R.3    Vande Woude, G.F.4
  • 88
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994;77:261-71
    • (1994) Cell , vol.77 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3
  • 89
    • 0032509402 scopus 로고    scopus 로고
    • C-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells
    • Rahimi N, Hung W, Tremblay E, et al. c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells. J Biol Chem 1998;273:33714-21
    • (1998) J Biol Chem , vol.273 , pp. 33714-33721
    • Rahimi, N.1    Hung, W.2    Tremblay, E.3
  • 90
    • 0031922793 scopus 로고    scopus 로고
    • Hepatocyte growth factor (HGF) acts as a mesenchyme-derived morphogenic factor during fetal lung development
    • Ohmichi H, Koshimizu U, Matsumoto K, Nakamura T. Hepatocyte growth factor (HGF) acts as a mesenchyme-derived morphogenic factor during fetal lung development. Development 1998;125:1315-24
    • (1998) Development , vol.125 , pp. 1315-1324
    • Ohmichi, H.1    Koshimizu, U.2    Matsumoto, K.3    Nakamura, T.4
  • 91
    • 0027380637 scopus 로고    scopus 로고
    • Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury
    • Yanagita K, Matsumoto K, Sekiguchi K, et al. Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury. J Biol Chem 1997;268:21212-17
    • (1997) J Biol Chem , vol.268 , pp. 21212-21217
    • Yanagita, K.1    Matsumoto, K.2    Sekiguchi, K.3
  • 92
    • 77249091823 scopus 로고    scopus 로고
    • Imbalance in the prohepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice
    • Phin S, Marchand-Adam S, Fabre A, et al. Imbalance in the prohepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice. Am J Respir Cell Mol Biol 2010;42:286-93
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 286-293
    • Phin, S.1    Marchand-Adam, S.2    Fabre, A.3
  • 93
    • 0242636991 scopus 로고    scopus 로고
    • Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis
    • Marchand-Adam S, Marchal J, Cohen M, et al. Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2003;168:1156-61
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1156-1161
    • Marchand-Adam, S.1    Marchal, J.2    Cohen, M.3
  • 94
    • 33745472563 scopus 로고    scopus 로고
    • Defect of prohepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis
    • Marchand-Adam S, Fabre A, Mailleux AA, et al. Defect of prohepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174:58-66
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 58-66
    • Marchand-Adam, S.1    Fabre, A.2    Mailleux, A.A.3
  • 95
    • 0034524385 scopus 로고    scopus 로고
    • Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis
    • Dohi M, Hasegawa T, Yamamoto K, Marshall BC. Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 2000;162(6):2302-7
    • (2000) Am J Respir Crit Care Med , vol.162 , Issue.6 , pp. 2302-2307
    • Dohi, M.1    Hasegawa, T.2    Yamamoto, K.3    Marshall, B.C.4
  • 96
    • 20844447573 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis
    • Watanabe M, Ebina M, Orson FM, et al. Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis. Mol Ther 2005;12(1):58-67
    • (2005) Mol Ther , vol.12 , Issue.1 , pp. 58-67
    • Watanabe, M.1    Ebina, M.2    Orson, F.M.3
  • 97
    • 3042589911 scopus 로고    scopus 로고
    • Skeletal muscle targeting in vivo electroporation-mediated HGF gene therapy of bleomycin-induced pulmonary fibrosis in mice
    • Umeda Y, Marui T, Matsuno Y, et al. Skeletal muscle targeting in vivo electroporation-mediated HGF gene therapy of bleomycin-induced pulmonary fibrosis in mice. Lab Invest 2004;84(7):836-44
    • (2004) Lab Invest , vol.84 , Issue.7 , pp. 836-844
    • Umeda, Y.1    Marui, T.2    Matsuno, Y.3
  • 98
    • 84865739760 scopus 로고    scopus 로고
    • Cell-specific expression of human HGF by alveolar type II cells induces remodeling of septal wall tissue in the lung: A morphometric study
    • Leuenberger A, Gazdhar A, Herrmann G, et al. Cell-specific expression of human HGF by alveolar type II cells induces remodeling of septal wall tissue in the lung: a morphometric study. J Appl Physiol 2012;113(5):799-807
    • (2012) J Appl Physiol , vol.113 , Issue.5 , pp. 799-807
    • Leuenberger, A.1    Gazdhar, A.2    Herrmann, G.3
  • 99
    • 14444271598 scopus 로고    scopus 로고
    • Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study
    • Yaekashiwa M, Nakayama S, Ohnuma K, et al. Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. Am J Respir Crit Care Med 1997;156:1937-44
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1937-1944
    • Yaekashiwa, M.1    Nakayama, S.2    Ohnuma, K.3
  • 100
    • 84872782921 scopus 로고    scopus 로고
    • Targeted gene transfer of hepatocyte growth factor to alveolar type II epithelial cells reduces lung fibrosis in rats
    • Gazdhar A, Temuri A, Knudsen L, et al. Targeted gene transfer of hepatocyte growth factor to alveolar type II epithelial cells reduces lung fibrosis in rats. Hum Gene Ther 2013;24:105-16
    • Hum Gene Ther , vol.2013 , Issue.24 , pp. 105-116
    • Gazdhar, A.1    Temuri, A.2    Knudsen, L.3
  • 101
    • 0026722243 scopus 로고
    • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
    • Bussolino F, Di Renzo MF, Ziche M, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 1992;119:629-41
    • (1992) J Cell Biol , vol.119 , pp. 629-641
    • Bussolino, F.1    Di Renzo, M.F.2    Ziche, M.3
  • 102
    • 0035092841 scopus 로고    scopus 로고
    • Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK STAT3, and AKT in endothelial cells
    • Nakagami H, Morishita R, Yamamoto K, et al. Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells. Hypertension 2001;37(2 Pt 2):581-6
    • (2001) Hypertension , vol.37 , Issue.2 PART 2 , pp. 581-586
    • Nakagami, H.1    Morishita, R.2    Yamamoto, K.3
  • 103
    • 1242272097 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells
    • Wang X, Zhou Y, Kim HP, et al. Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells. J Biol Chem 2004;279(7):5237-43
    • (2004) J Biol Chem , vol.279 , Issue.7 , pp. 5237-5243
    • Wang, X.1    Zhou, Y.2    Kim, H.P.3
  • 104
    • 0029813095 scopus 로고    scopus 로고
    • Hepatocyte growth factor is a mitogen for alveolar type II cells in rat lavage fluid
    • Mason RJ, McCormick-Shannon K, Rubin JS, et al. Hepatocyte growth factor is a mitogen for alveolar type II cells in rat lavage fluid. Am J Physiol 1996;271(1 Pt 1):L46-53
    • (1996) Am J Physiol , vol.271 , Issue.1 PART 1
    • Mason, R.J.1    McCormick-Shannon, K.2    Rubin, J.S.3
  • 105
    • 0029858258 scopus 로고    scopus 로고
    • HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death
    • Bardelli A, Longati P, Albero D, et al. HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J 1996;15:6205-12
    • (1996) EMBO J , vol.15 , pp. 6205-6212
    • Bardelli, A.1    Longati, P.2    Albero, D.3
  • 106
    • 0032793098 scopus 로고    scopus 로고
    • Hepatocyte growth factor stimulates migration of type II alveolar epithelial cells on the provisional matrix proteins fibronectin and fibrinogen
    • Kim HJ, Sammak PJ, Ingbar DH. Hepatocyte growth factor stimulates migration of type II alveolar epithelial cells on the provisional matrix proteins fibronectin and fibrinogen. Chest 1999;116:94S-5S
    • (1999) Chest , vol.116
    • Kim, H.J.1    Sammak, P.J.2    Ingbar, D.H.3
  • 107
    • 0029243555 scopus 로고
    • Hepatocyte growth factor stimulates DNA synthesis in alveolar epithelial type II cells in vitro
    • Shiratori M, Michalopoulos G, Shinozuka H, et al. Hepatocyte growth factor stimulates DNA synthesis in alveolar epithelial type II cells in vitro. Am J Respir Cell Mol Biol 1995;12(2):171-80
    • (1995) Am J Respir Cell Mol Biol , vol.12 , Issue.2 , pp. 171-180
    • Shiratori, M.1    Michalopoulos, G.2    Shinozuka, H.3
  • 108
    • 4344683986 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects small airway epithelial cells from apoptosis induced by tumor necrosis factor-alpha or oxidative stress
    • Okada M, Sugita K, Inukai T, et al. Hepatocyte growth factor protects small airway epithelial cells from apoptosis induced by tumor necrosis factor-alpha or oxidative stress. Pediatr Res 2004;56(3):336-44
    • (2004) Pediatr Res , vol.56 , Issue.3 , pp. 336-344
    • Okada, M.1    Sugita, K.2    Inukai, T.3
  • 109
    • 33847040423 scopus 로고    scopus 로고
    • Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis
    • Gazdhar A, Fachinger P, van Leer C, et al. Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2007;292(2):L529-36
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , Issue.2
    • Gazdhar, A.1    Fachinger, P.2    Van Leer, C.3
  • 110
    • 0032750817 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms
    • Liu Y. Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms. Am J Physiol 1999;277(4 Pt 2):F624-33
    • (1999) Am J Physiol , vol.277 , Issue.4 PART 2
    • Liu, Y.1
  • 111
    • 78149410562 scopus 로고    scopus 로고
    • Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells
    • Togo S, Sugiura H, Nelson A, et al. Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells. Exp Cell Res 2010;316(20):3501-11
    • (2010) Exp Cell Res , vol.316 , Issue.20 , pp. 3501-3511
    • Togo, S.1    Sugiura, H.2    Nelson, A.3
  • 112
    • 0033795370 scopus 로고    scopus 로고
    • Apoptosis of lung epithelial cells in response to TNF-alpha requires angiotensin II generation de novo
    • Wang R, Alam G, Zagariya A, et al. Apoptosis of lung epithelial cells in response to TNF-alpha requires angiotensin II generation de novo. J Cell Physiol 2000;185:253-9
    • (2000) J Cell Physiol , vol.185 , pp. 253-259
    • Wang, R.1    Alam, G.2    Zagariya, A.3
  • 113
    • 0033372935 scopus 로고    scopus 로고
    • Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction
    • Wang R, Zagariya A, Ang E, et al. Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction. Am J Physiol 1999;277:L1245-50
    • (1999) Am J Physiol , vol.277
    • Wang, R.1    Zagariya, A.2    Ang, E.3
  • 114
    • 0033862955 scopus 로고    scopus 로고
    • Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor
    • Wang R, Ibarra-Sunga O, Verlinski L, et al. Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 2000;279:L143-51
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279
    • Wang, R.1    Ibarra-Sunga, O.2    Verlinski, L.3
  • 115
    • 1542365323 scopus 로고    scopus 로고
    • Hepatocyte growth factor regulates angiotensin converting enzyme expression
    • Day RM, Thiel G, Lum J, et al. Hepatocyte growth factor regulates angiotensin converting enzyme expression. J Biol Chem 2004;279:8792-801
    • (2004) J Biol Chem , vol.279 , pp. 8792-8801
    • Day, R.M.1    Thiel, G.2    Lum, J.3
  • 116
    • 66349113736 scopus 로고    scopus 로고
    • Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7
    • Shukla MN, Rose JL, Ray R, et al. Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. Am J Respir Cell Mol Biol 2009;40:643-53
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 643-653
    • Shukla, M.N.1    Rose, J.L.2    Ray, R.3
  • 117
    • 0042827955 scopus 로고    scopus 로고
    • Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca(2+)-and phosphoinositide 3-kinase/Aktdependent phosphorylation in aortic endothelial cells
    • Makondo K, Kimura K, Kitamura N, et al. Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca(2+)-and phosphoinositide 3-kinase/Aktdependent phosphorylation in aortic endothelial cells. Biochem J 2003;374:63-9
    • (2003) Biochem J , vol.374 , pp. 63-69
    • Makondo, K.1    Kimura, K.2    Kitamura, N.3
  • 119
    • 70349987103 scopus 로고    scopus 로고
    • HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells
    • Moore AE, Greenhough A, Roberts HR, et al. HGF/Met signalling promotes PGE (2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. Carcinogenesis 2009;30:1796-804
    • (2009) Carcinogenesis , vol.30 , pp. 1796-1804
    • Moore, A.E.1    Greenhough, A.2    Roberts, H.R.3
  • 120
    • 42049114845 scopus 로고    scopus 로고
    • Hepatocyte growth factor regulates cyclooxygenase-2 expression via beta-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells
    • Lee YH, Suzuki YJ, Griffin AJ, Day RM. Hepatocyte growth factor regulates cyclooxygenase-2 expression via beta-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008;294:L778-86
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Lee, Y.H.1    Suzuki, Y.J.2    Griffin, A.J.3    Day, R.M.4
  • 121
    • 34547647436 scopus 로고    scopus 로고
    • PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling
    • Thomas PE, Peters-Golden M, White ES, et al. PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling. Am J Physiol Lung Cell Mol Physiol 2007;293:L417-28
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Thomas, P.E.1    Peters-Golden, M.2    White, E.S.3
  • 122
    • 16344367737 scopus 로고    scopus 로고
    • HGF reduces advancing lung fibrosis in mice: A potential role for MMP-dependent myofibroblast apoptosis
    • Mizuno S, Matsumoto K, Li MY, Nakamura T. HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis. FASEB J 2005;19:580-2
    • (2005) FASEB J , vol.19 , pp. 580-582
    • Mizuno, S.1    Matsumoto, K.2    Li, M.Y.3    Nakamura, T.4
  • 123
    • 0026894529 scopus 로고
    • Lung cancer in patients with idiopathic pulmonary fibrosis
    • Nagai A, Chiyotani A, Nakadate T, Konno K. Lung cancer in patients with idiopathic pulmonary fibrosis. Tohoku J Exp Med 1992;167:231-7
    • (1992) Tohoku J Exp Med , vol.167 , pp. 231-237
    • Nagai, A.1    Chiyotani, A.2    Nakadate, T.3    Konno, K.4


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