Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 279, Issue 1 23-1, 2000, Pages

  Wang, Rongqi ^a   Ibarra Sunga, Olivia ^a   Verlinski, Luba ^a   Pick, Ruth ^a   Uhal, Bruce D ^b  

^a MICHAEL REESE HOSPITAL   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Deoxyribonucleic acid fragmentation; Fibrogenesis; Interstitial pulmonary fibrosis; Programmed cell death; Type II pneumocytes

Indexed keywords

BLEOMYCIN; CAPTOPRIL; CASPASE INHIBITOR; COLLAGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; FIBROGENESIS; HISTOPATHOLOGY; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; TISSUE LEVEL;

EID: 0033862955     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2000.279.1.l143     Document Type: Article

References (32)

1. Adamson IYR and Bowden DH. Pulmonary injury and repair. Organ culture studies of murine lung after oxygen. Arch Pathol Lab Med 100: 640-643, 1976.
2. Adamson IYR, Young L, and Bowden DH. Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 130: 377-383, 1988.
3. Barile F, Ripley R, Siddiqi Z, and Bienkowski R. Effects of prostaglandin E1 on collagen production and degradation in human fetal lung fibroblasts. Arch Biochem Biophys 265: 441-446, 1988.
4. Chaucey JG, Peters GM, and Simon RH. Arachidonic acid metabolism by rat alveolar epithelial cells. Lab Invest 58: 133-140, 1988.
5. Hagimoto N, Kuwano K, Miyazaki H, Kunitake R, Fujita M, Kawasaki M, Kanika Y, and Hara N. Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of FAS antigen. Am J Respir Cell Mol Biol 17: 272-278, 1997.
6. Hagimoto N, Kuwano K, Nomoto Y, Kunitake R, and Hara N. Apoptosis and expression of FAS/FAS ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol 16: 91-101, 1997.
7. Hamilton RF, Li L, Felder T, and Holian A. Bleomycin induces apoptosis in human alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 269: L318-L325, 1995.
8. Haschek WM and Witschi HP. Pulmonary fibrosis: a possible mechanism. Toxicol Appl Pharmacol 51: 475-487, 1979.
9. Iyer R and Holian A. Involvement of the ICE family of proteases in silica-induced apoptosis of human alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 273: L760-L767, 1997.
10. Kuhn C III, Boldt J, King TE Jr, Crouch E, Vartio T, and McDonald JA. An immunohistochemical study of architectural remodeling and connective tissue synthesis in pulmonary fibrosis. Am Rev Respir Dis 140: 1693-1703, 1989.
11. Kunstle G, Leist M, Uhlig S, Revesz L, Feifel R, MacKenzie A, and Wendel A. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha. Immunol Lett 55: 5-10, 1997.
12. Molteni A, Ward W, Ts'ao C, Solliday N, and Dunne M. Monocrotaline-induced pulmonary fibrosis in rats: amelioration by captopril and penicillamine. Proc Soc Exp Biol Med 180: 112-120, 1985.
13. Mundle S, Iftikhar A, Shetty V, Alvi S, Dameron S, Gregory S, Marcus B, Khan S, and Raza A. In situ end labeling of DNA to detect apoptotic cell death in a variety of human tumors. Cell Death Differ 1: 117-122, 1994.
14. Paine R and Simon RA. Expanding the frontiers of lung biology through the creative use of alveolar epithelial cells in culture. Am J Physiol Lung Cell Mol Physiol 270: L484-L486, 1996.
15. Pick R, Jalil J, Janicki J, and Weber K. The fibrillar nature and structure of isoproterenol-induced myocardial fibrosis in the rat. Am J Pathol 134: 365-371, 1989.
16. Robbins M and Hopewell J. Physiological factors affecting renal radiation tolerance: a guide to the treatment of late effects. Br J Cancer 53: 265-267, 1986.
17. Rodriguez I, Matsuura K, Ody C, Nagata S, and Vassalli P. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J Exp Med 184: 2067-2072, 1996.
18. Simon RH. Alveolar epithelial cells in pulmonary fibrosis. In: Pulmonary Fibrosis, edited by Phan SH and Thrall RS. New York: Dekker, 1995, vol. 80, p. 511-540. (Lung Biol Health Dis Ser)
19. Simon RH, Gross TJ, Edwards JA, and Sitrin RG. Fibrin degradation by rat pulmonary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 262: L482-L488, 1992.
20. Thrall R, McCormick J, Jack R, McReynolds R, and Ward P. Bleomycin-induced pulmonary fibrosis in the rat. Am J Pathol 95: 117-130, 1979.
21. Uhal BD, Gidea C, Bargout R, Bifero A, Ibarra-Sunga O, Papp M, Flynn K, and Filippatos G. Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism. Am J Physiol Lung Cell Mol Physiol 275: L1013-L1017, 1998.
22. Uhal BD, Joshi I, Ramos C, Pardo A, and Selman M. Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced flbrotic human lung. Am J Physiol Lung Cell Mol Physiol 275: L1192-L1199, 1998.
23. Uhal BD, Joshi I, True A, Mundle S, Raza A, Pardo A, and Selman M. Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol 269: L819-L828, 1995.
24. Wang R, Ramos C, Joshi I, Zagariya A, Ibarra-Sunga O, Pardo A, Selman M, and Uhal BD. Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotensin peptides. Am J Physiol Lung Cell Mol Physiol 277: L1158-L1164, 1999.
25. Wang R, Zagariya A, Ang E, Ibarra-Sunga O, and Uhal BD. Fas-induced apoptosis of alveolar epithelial cells requires angiotensin II generation and receptor interaction. Am J Physiol Lung Cell Mol Physiol 277: L1245-L1250, 1999.
26. Wang R, Zagariya A, Ibarra-Sunga O, Gidea C, Ang E, Deshmukh S, Choudhary G, Baraboutis J, Filippatos G, and Uhal BD. Angiotensin II induces apoptosis in human and rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 276: L885-L889, 1999.
27. Ward W, Molteni A, Ts'ao C, and Hinz J. Captopril reduces collagen and mast cell accumulation in irradiated rat lung. Int J Radiat Oncol Biol Phys 19: 1405-1409, 1990.
28. Ward W, Molteni A, Ts'ao C, and Hinz J. The effect of captopril on benign and malignant reactions in irradiated rat skin. Br J Radiol 63: 349-354, 1990.
29. Woessner J. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem, Biophys 93: 440-447, 1961.
30. Yaoita H, Ogawa K, Maehara K, and Maruyama Y. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation 97: 276-281, 1998.
31. Young L and Adamson I. Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair. Environ Health Perspect 101: 56-61, 1993.
32. Zhang K, Rekhter MD, Gordon D, and Phan SH. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined histochemical and in situ hybridization study. Am J Pathol 145: 114-125, 1994.