Expression of human BRCA1δ17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response

Cellular Signalling

Volumn 25, Issue 5, 2013, Pages 1186-1193

  Sevcik, Jan ^a,d   Falk, Martin ^b   Macurek, Libor ^c   Kleiblova, Petra ^a   Lhota, Filip ^a   Hojny, Jan ^a   Stefancikova, Lenka ^b   Janatova, Marketa ^a   Bartek, Jiri ^c,e,f   Stribrna, Jana ^a   Hodny, Zdenek ^c   Jezkova, Lucie ^b,g   Pohlreich, Petr ^a   Kleibl, Zdenek ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e PALACKÝ UNIVERSITY   (Czech Republic)

^f DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^g INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

Author keywords

Abraxas; Alternative splicing; BARD1; BRCA1; BRCA1 C terminal (BRCT) domain; BRCA1 containing complexes; Breast cancer; CtIP; DNA damage; Homologous recombination (HR); Ionizing radiation induced foci (IRIF); Non homologous end joining (NHEJ)

Indexed keywords

BRCA1 PROTEIN; C TERMINAL INTERACTION PROTEIN; MITOMYCIN; PROTEIN; PROTEIN ABRAXAS; UNCLASSIFIED DRUG;

ABERRANT DNA DAMAGE RESPONSE; ARTICLE; BRCA1 17 19 ALTERNATIVE SPLICING VARIANT; BRCA1 ASSOCIATED RING DOMAIN 1; BRCA1 C TERMINAL DOMAIN; BREAST CANCER; CANCER GROWTH; CELL PROLIFERATION; CELL PROTECTION; CELL STRAIN MCF 7; CHEMOSENSITIZATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA END JOINING REPAIR; DNA FLANKING REGION; DNA REPAIR COMPLEX; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; GENE DELETION; GENE OVEREXPRESSION; GENETIC VARIABILITY; GENOMIC INSTABILITY; HIGH RISK PATIENT; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION INDUCED FOCUS; MOLECULAR DYNAMICS; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECOMBINATION REPAIR; TUMOR SUPPRESSOR GENE; WILD TYPE;

ALTERNATIVE SPLICING; BRCA1 PROTEIN; CARRIER PROTEINS; DNA DAMAGE; DNA REPAIR; HUMANS; MCF-7 CELLS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; RADIATION, IONIZING;

EID: 84875097557     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.02.008     Document Type: Article

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