The BRCA1 alternative splicing variant δ14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells

Cellular Signalling

Volumn 24, Issue 5, 2012, Pages 1023-1030

  Sevcik, Jan ^a,b   Falk, Martin ^c   Kleiblova, Petra ^a   Lhota, Filip ^a   Stefancikova, Lenka ^c   Janatova, Marketa ^a   Weiterova, Lenka ^c   Lukasova, Emilie ^c   Kozubek, Stanislav ^c   Pohlreich, Petr ^a   Kleibl, Zdenek ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

Alternative splicing; BRCA1; BRCA1 serine containing domain (SCD); Breast cancer; DNA damage; Homologous recombination; Non homologous end joining

Indexed keywords

BRCA1 PROTEIN; SHORT HAIRPIN RNA;

ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME REGULATION; GAMMA RADIATION; GENE DELETION; GENE SEQUENCE; GENETIC VARIABILITY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA SPLICING;

AMINO ACID SEQUENCE; BASE SEQUENCE; BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; FEMALE; GAMMA RAYS; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; READING FRAMES; SEQUENCE DELETION;

EID: 84857122761     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.12.023     Document Type: Article

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