Expression profiles of BRCA1 splice variants in asynchronous and in G1/S synchronized tumor cell lines

Biochemical and Biophysical Research Communications

Volumn 280, Issue 1, 2001, Pages 32-38

  Orban, Tamas I ^a   Olah, Edith ^a  

^a NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

Author keywords

Alternative splicing; BRCA1; G1 S synchronization; Gene expression

Indexed keywords

MESSENGER RNA; RIBONUCLEASE;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0034816781     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4068     Document Type: Article

References (40)

1. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
2. Analysis of BRCA1 and BRCA2 mutations in Hungarian families with breast and breast-ovarian cancer
3. A breast/ovarian cancer patient with germline mutations in both BRCA1 and BRCA2
4. Strong founder effects in BRCA1 mutation carrier breast cancer patients from Latvia
5. Germline mutation analysis of BRCA1 and BRCA2 genes in Yugoslav breast/ovarian cancer families
6. Molecular cancer genetics in eastern and central Europe
7. Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast and/or ovarian cancer families from North-Eastern Poland
8. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours
9. Frequency of germline and somatic BRCA1 mutations in ovarian cancer
10. Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer
11. A sporadic breast tumor with a somatically acquired complex genomic rearrangement in BRCA1
12. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
13. Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region
14. Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells
15. The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells
16. BRCA1 is a 220-Da nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
17. Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells
18. BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells
19. An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA
20. Alternative splicing of mRNA as a mode of endocrine regulation
21. Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation
22. Frequent alternative splicing of human genes
23. Characterization of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumor-derived breast cells
24. Localization of BRCA1 and a splice variant identifies the nuclear localization signal
25. Mutations and alternative splicing of the BRCA1 gene in UK breast/ovarian cancer families
26. Real-time PCR quantification of full-length and exon 11 spliced BRCA1 transcripts in human breast cancer cell lines
27. Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b
28. Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells
29. Functional association between promoter structure and transcript alternative splicing
30. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
31. Expression of estrogen receptor α1, α2, and α5 messenger RNAs in human breast tissue
32. Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1
33. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases
34. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
35. Emerging roles of BRCA1 in transcriptional regulation and DNA repair
36. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene
37. Association of BRCA1 with Rad51 in mitotic and meiotic cells
38. Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks
39. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site