Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

Journal of Pathology

Volumn 229, Issue 5, 2013, Pages 755-764

  Morten, Karl J ^a   Badder, Luned ^a   Knowles, Helen J ^b  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

ATP; hypoxia; hypoxia inducible factor; metabolism; osteoclast

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALAMAR BLUE; CD14 ANTIGEN; DYE; GLUCOSE; GLUTAMINE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; LACTIC ACID; METFORMIN; OXYGEN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL HYPOXIA; CELL RESPIRATION; CELL SURVIVAL; CONTROLLED STUDY; ELECTRON TRANSPORT; GENE TARGETING; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LONG TERM SURVIVAL; MEDIATOR; MITOCHONDRIAL RESPIRATION; MONOCYTE; OSTEOBLAST; OSTEOCLAST; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ADAPTATION, PHYSIOLOGICAL; ADENOSINE TRIPHOSPHATE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE RESORPTION; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ENERGY METABOLISM; GLUCOSE; GLUTAMINE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTIC ACID; MITOCHONDRIA; OSTEOCLASTS; OXYGEN CONSUMPTION; PYRUVATE DEHYDROGENASE COMPLEX; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84875043252     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4159     Document Type: Article

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