Hypoxia stimulates osteoclast formation from human peripheral blood

Cell Biochemistry and Function

Volumn 28, Issue 5, 2010, Pages 374-380

  Utting, Jennifer C ^a   Flanagan, Adrienne M ^a   Brandao Burch, Andrea ^a   Orriss, Isabel R ^a   Arnett, Timothy R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

HIF1; HIF2; Hypoxia; Osteoclast; Resorption

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INTERLEUKIN 6; VASCULOTROPIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, HUMAN; VASCULOTROPIN A;

ARTICLE; BLOOD; BONE DESTRUCTION; BONE MARROW; CELL CULTURE; CELL NUCLEUS; CELL STIMULATION; CONTROLLED STUDY; EXPOSURE; EXTRAVASATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HYPOXIA; INFLAMMATION; MICROENVIRONMENT; NORMAL HUMAN; OSTEOCLAST; OSTEOLYSIS; OXYGEN TENSION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; UPREGULATION; CELL HYPOXIA; CYTOLOGY; GENETICS; METABOLISM; MONONUCLEAR CELL; TIME;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE RESORPTION; CELL HYPOXIA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; OSTEOCLASTS; TIME FACTORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77956747911     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1660     Document Type: Article

References (38)

1. Bradley TR, Hodgson GS, Rosendaal M. The effect of oxygen tension on haemopoietic and fibroblast cell proliferation in vitro. J Cell Physiol 1978; 97: 517-522.
2. Broxmeyer HE, Cooper S, Lu L, Miller ME, Langefeld CD, Ralph P. Enhanced stimulation of human bone marrow macrophage colony formation in vitro by recombinant human macrophage colony-stimulating factor in agarose medium and at low oxygen tension. Blood 1990; 76: 323-329.
3. Ishikawa Y, Ito T. Kinetics of hemopoietic stem cells in a hypoxic culture. Eur J Haematol 1988; 40: 126-129.
4. Koller MR, Bender JG, Miller WM, Papoutsakis ET. Reduced oxygen tension increases hematopoiesis in long-term culture of human stem and progenitor cells from cord blood and bone marrow. Exp Hematol 1992; 20: 264-270.
5. Lewis JS, Lee JA, Underwood JC, Harris AL, Lewis CE. Macrophage responses to hypoxia: Relevance to disease mechanisms. J Leukoc Biol 1999; 66: 889-900.
6. Arnett TR,Gibbons DC, Utting JC, et al. Hypoxia is a major stimulator of osteoclast formation and bone resorption. J Cell Physiol 2003; 196. 2-8.
7. Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107: 43-54.
8. Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399: 271-275.
9. Semenza GL. Regulation of vascularization by hypoxia-inducible factor 1. Ann N Y Acad Sci 2009; 1177: 2-8.
10. Flanagan AM, Massey HM. Generating human osteoclasts in vitro from bone marrow and peripheral blood. Methods MolMed 2003; 80: 113-128.
11. Dempster DW, Hughes-Begos CE, Plavetic-Chee K, et al. Normal human osteoclasts formed from peripheral blood monocytes express PTH type 1 receptors and are stimulated by PTH in the absence of osteoblasts. J Cell Biochem 2005; 95: 139-148.
12. Hoebertz A, Arnett TR. Isolated osteoclast cultures. Methods Mol Med 2003; 80: 53-64.
13. Jevon M, Sabokbar A, Fujikawa Y, et al. Gender- and age-related differences in osteoclast formation from circulating precursors. J Endocrinol 2002; 172: 673-681.
14. Lader CS, Flanagan AM. Prostaglandin E2, interleukin 1alpha and tumor necrosis factor-alpha increase human osteoclast formation and bone resorption in vitro. Endocrinology 1998; 139: 3157-3164.
15. Semenza GL. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 2001; 107: 1-3.
16. Arnett TR. Extracellular pH regulates bone cell function. J Nutr 2008; 138: 415S-418.S.
17. Knowles HJ, Athanasou NA. Acute hypoxia and osteoclast activity: A balance between enhanced resorption and increased apoptosis. J Pathol 2009; 218: 256-264.
18. Murrills RJ, Stein LS, Dempster DW. Stimulation of bone resorption and osteoclast clear zone formation by low pH: A time-course study. J Cell Physiol 1993; 154: 511-518.
19. Cramer T, Yamanishi Y, Clausen BE, et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003; 112: 645-657.
20. Roiniotis J, Dinh H, Masendycz P, et al. Hypoxia prolongs monocyte/ macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions. J Immunol 2009; 182: 7974-7981.
21. Fukuoka H, Aoyama M, Miyazawa K, Asai K, Goto S. Hypoxic stress enhances osteoclast differentiation via increasing IGF2 production by nonosteoclastic cells. Biochem Biophys Res Commun 2005; 328: 885-894.
22. Eghbali-Fatourechi GZ, Lamsam J, Fraser D, Nagel D, Riggs BL, Khosla S. Circulating osteoblast-lineage cells in humans. N Engl J Med 2005; 352: 1959-1966.
23. Knowles HJ, Athanasou NA. Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF. J Pathol 2008; 215: 56-66.
24. Bozec A, Bakiri L, Hoebertz A, et al. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 2008; 454: 221-225.
25. Aldridge SE, Lennard TW, Williams JR, Birch MA. Vascular endothelial growth factor receptors in osteoclast differentiation and function. Biochem Biophys Res Commun 2005; 335: 793-798.
26. Nakagawa M, Kaneda T, Arakawa T, et al. Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett 2000; 473: 161-164.
27. Kudo O, Sabokbar A, Pocock A, Itonaga I, Fujikawa Y, Athanasou NA. Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone 2003; 32: 1-7.
28. Naldini A, Carraro F, Silvestri S, Bocci V. Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells. J Cell Physiol 1997; 173: 335-342.
29. Kovacevic-Filipovic M, PetakovM, Hermitte F, et al. Interleukin-6 (IL- 6) and low O(2) concentration (1%) synergize to improve the maintenance of hematopoietic stem cells (pre-CFC). J Cell Physiol 2007; 212: 68-75.
30. Harrison JS, Rameshwar P, Chang V, Bandari P. Oxygen saturation in the bone marrow of healthy volunteers. Blood 2002; 99: 394.
31. Wan C, Gilbert SR, Wang Y, et al. Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci USA 2008; 105: 686-691.
32. Dunn LK, Mohammad KS, Fournier PG, et al. Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS ONE 2009; 4: E6896.
33. Miller RG, Segal JB, Ashar BH, et al. High prevalence and correlates of low bone mineral density in young adults with sickle cell disease. Am J Hematol 2006; 81: 236-241.
34. Zheng LW, Ma L, Cheung LK. Changes in blood perfusion and bone healing induced by nicotine during distraction osteogenesis. Bone 2008; 43: 355-361.
35. Dinenno FA, Seals DR, DeSouza CA, Tanaka H. Age-related decreases in basal limb blood flow in humans : Time course, determinants and habitual exercise effects. J Physiol 2001; 531: 573-579.
36. Griffith JF, Yeung DK, Tsang PH, et al. Compromised bone marrow perfusion in osteoporosis. J Bone Miner Res 2008; 23: 1068-1075.
37. Wang YX, Griffith JF, Kwok AW, et al. Reduced bone perfusion in proximal femur of subjects with decreased bone mineral density preferentially affects the femoral neck. Bone 2009; 45: 711-715.
38. Utting JC, Robins SP, Brandao-Burch A, Orriss IR, Behar J, Arnett TR. Hypoxia inhibits the growth, differentiation and bone-forming capacity of rat osteoblasts. Exp Cell Res 2006; 312: 1693-1702.