Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced HepG2 cells

Food Chemistry

Volumn 140, Issue 1-2, 2013, Pages 115-123

  Hwang, Yong Pil ^a,b   Choi, Jae Ho ^a   Kim, Hyung Gyun ^a   Lee, Hyun Sun ^c   Chung, Young Chul ^b   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b International University of Korea   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

AMPK; High glucose; Lipogenesis; Platycodon grandiflorum; Saponins

Indexed keywords

AMPK; HIGH GLUCOSE; LIPOGENESIS; PLATYCODON GRANDIFLORUM; SAPONINS;

CELLS; ENZYMES; GLUCOSE; METABOLITES;

CYTOLOGY;

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NICOTINAMIDE; SAPONIN DERIVATIVE; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CYTOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; NONHUMAN; PLATYCODON; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AMP-ACTIVATED PROTEIN KINASES; ANTIGENS, CD95; DOWN-REGULATION; ENZYME ACTIVATION; GLUCOSE; HEP G2 CELLS; HUMANS; LIPID METABOLISM; LIPOGENESIS; LIVER; PHOSPHORYLATION; PLANT EXTRACTS; PLATYCODON; SAPONINS; SIRTUIN 1;

PLATYCODON GRANDIFLORUM;

EID: 84874944882     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.02.041     Document Type: Article

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