Platycodon grandiflorum modifies adipokines and the glucose uptake in high-fat diet in mice and L6 muscle cells

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 5, 2012, Pages 697-704

  Ahn, Young Min ^a   Kim, Su Kang ^a   Kang, Ji Suck ^a   Lee, Byung Cheol ^a  

^a Kyung Hee University   (South Korea)

Author keywords

adipokines; glucose uptake; high fat diet; L6 muscle cells; Platycodon grandiflorum

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALCOHOL; FRUCTOSAMINE; GLUCOSE; INSULIN; LEPTIN; PLANT MEDICINAL PRODUCT; PLATYCODIN; PLATYCODON GRANDIFLORUM EXTRACT; RESISTIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WATER;

ADIPOCYTE; ADIPONECTIN BLOOD LEVEL; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL SIZE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG ISOLATION; EPIDIDYMIS FAT; EPIDIDYMIS FAT WEIGHT; FRUCTOSAMINE BLOOD LEVEL; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HORMONE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LEPTIN BLOOD LEVEL; LIPID DIET; MALE; MOUSE; MUSCLE CELL; NONHUMAN; PLATYCODON; PLATYCODON GRANDIFLORUM; PROTEIN BLOOD LEVEL; PROTEIN MODIFICATION; RESISTIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ADIPOCYTES; ADIPOKINES; ADIPONECTIN; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; ENERGY INTAKE; FRUCTOSAMINE; GENE EXPRESSION; GLUCOSE; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INSULIN; LEPTIN; MALE; MICE; MICE, INBRED ICR; MUSCLE CELLS; OBESITY; PHYTOTHERAPY; PLANT EXTRACTS; PLATYCODON; RESISTIN; SAPONINS; TRIGLYCERIDES; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862799799     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01455.x     Document Type: Article

References (33)

1. Must A, et al,. The disease burden associated with overweight and obesity. JAMA 1999; 16: 1523-1529.
2. Kadowaki T, et al,. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006; 7: 1784-1792.
3. Shoelson SE, et al,. Inflammation and insulin resistance. J Clin Invest 2006; 7: 1793-1801.
4. Steppan CM, Lazar MA,. The current biology of resistin. J Intern Med 2004; 4: 439-447.
5. Kim MJ, Kim HK,. Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet. Phytother Res 2009; 23: 1685-1690.
6. Konopko-Zubrzycka M, et al,. The effect of intragastric balloon on plasma ghrelin, leptin, and adiponectin levels in patients with morbid obesity. J Clin Endocrinol Metab 2009; 5: 1644-1649.
7. Nammi S, et al,. Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats. Basic Clin Pharmacol Toxicol 2009; 5: 366-373.
8. Yin J, et al,. Effect of Shilianhua extract and its fractions on body weight of obese mice. Metabolism 2008; 7 (Suppl 1): S47-S51.
9. Xie JT, et al,. American ginseng berry juice intake reduces blood glucose and body weight in ob/ob mice. J Food Sci 2007; 8: S590-S594.
10. Gum SI, et al,. The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[alpha]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs. J Ethnopharmacol 2007; 3: 568-576.
11. Banz WJ, et al,. Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat. Phytomedicine 2007; 10: 681-689.
12. Park YS, et al,. Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats. World J Gastroenterol 2007; 25: 3493-3499.
13. Zhao HL, et al,. Hypocholesterolemic and anti-obesity effects of saponins from Platycodon grandiflorum in hamsters fed atherogenic diets. J Food Sci 2008; 8: H195-H200.
14. Kim KS, et al,. Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats. J Nutr Biochem 2000; 9: 420-424.
15. Wie HJ, et al,. Enzymatic modification of saponins from Platycodon grandiflorum with Aspergillus niger. J Agric Food Chem 2007; 22: 8908-8913.
16. Ginter E, Simko V,. Adult obesity at the beginning of the 21st century: epidemiology, pathophysiology and health risk. Bratisl Lek Listy 2008; 5: 224-230.
17. Bray GA,. A concise review on the therapeutics of obesity. Nutrition 2000; 10: 953-960.
18. Stern MP, et al,. Hyperdynamic circulation and the insulin resistance syndrome ('syndrome X'). Hypertension 1992; 6: 802-808.
19. Choo HY, et al,. Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones. Bioorg Med Chem 2002; 3: 517-523.
20. Greenway FL, Smith SR,. The future of obesity research. Nutrition 2000; 10: 976-982.
21. Kretsinger K, et al,. Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel. MMWR Recomm Rep 2006; RR-17: 1-37.
22. Tada A, et al,. Studies on the saponins of the root of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D. Chem Pharm Bull (Tokyo) 1975; 11: 2965-2972.
23. Wozniak SE, et al,. Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci 2009; 9: 1847-1856.
24. Havel PJ,. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol 2002; 1: 51-59.
25. Matsuzawa Y,. Adiponectin: a key player in obesity related disorders. Curr Pharm Des 2010; 17: 1896-1901.
26. Margetic S, et al,. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002; 11: 1407-1433.
27. Fruebis J, et al,. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A 2001; 4: 2005-2010.
28. Nogueiras R, et al,. Resistin: regulation of food intake, glucose homeostasis and lipid metabolism. Endocr Dev 2010; 17: 175-184.
29. Diez JJ, Iglesias P,. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003; 3: 293-300.
30. Tzanavari T, et al,. TNF-alpha and obesity. Curr Dir Autoimmun 2010; 11: 145-156.
31. Hotamisligil GS, et al,. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A 1994; 11: 4854-4858.
32. Romanatto T, et al,. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient-effects on leptin and insulin signaling pathways. Peptides 2007; 5: 1050-1058.
33. Corica F, et al,. Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects. Int J Obes Relat Metab Disord 1999; 4: 355-360.