Long-term consumption of Platycodi radix ameliorates obesity and insulin resistance via the activation of AMPK pathways

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Lee, Chae Eun ^a   Hur, Haeng Jeon ^a   Hwang, Jin Taek ^a   Sung, Mi Jeong ^a   Yang, Hye Jeong ^a   Kim, Hyun Jin ^a   Park, Jae Ho ^a   Kwon, Dae Young ^a   Kim, Myung Sunny ^a  

^a Korea Food Research Institute   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ADENOSINE PHOSPHATE; CHOLESTEROL; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PLANT EXTRACT; PLATYCODI RADIX EXTRACT; RESISTIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; ENZYME PHOSPHORYLATION; FLOWER; FOOD INTAKE; INSULIN RESISTANCE; LIPID DIET; MALE; MOUSE; MYOTUBE; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT GAIN; WHITE BALLOON FLOWER;

EID: 84864955018     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/759143     Document Type: Article

References (34)

1. Schenk S., Saberi M., Olefsky J. M., Insulin sensitivity: modulation by nutrients and inflammation The Journal of Clinical Investigation 2008 118 9 2992 3002
2. Stumvoll M., Goldstein B. J., van Haeften T. W., Type 2 diabetes: principles of pathogenesis and therapy The Lancet 2005 365 9467 1333 1346
3. Shoelson S. E., Lee J., Goldfine A. B., Inflammation and insulin resistance The Journal of Clinical Investigation 2006 116 7 1793 1801 (Pubitemid 44033299)
4. Li Y. H., Zheng F. J., Huang Y., Zhong X. G., Guo M. Z., Synergistic anti-inflammatory effect of Radix Platycodon in combination with herbs for cleaning-heat and detoxification and its mechanism. Chinese Journal of Integrative Medicine. In press
5. Kim K. S., Seo E. K., Lee Y. C., Lee T. K., Cho Y. W., Ezaki O., Kim C. H., Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats The Journal of Nutritional Biochemistry 2000 11 9 420 424
6. Han L. K., Xu B. J., Kimura Y., Zheng Y., Okuda H., Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity The Journal of Nutrition 2000 130 11 2760 2764
7. Noh J. R., Kim Y. H., Gang G. T., Yang K. J., Kim S. K., Ryu S. Y., Kim Y. S., Lee C. H., Lee H. S., Preventative effects of Platycodon grandiflorum treatment on hepatic steatosis in high fat diet-fed C57BL/6 mice Biological Pharmaceutical Bulletin 2010 33 3 450 454
8. Noh J. R., Kim Y. H., Gang G. T., Hwang J. H., Kim S. K., Ryu S. Y., Kim Y. S., Lee H. S., Lee C. H., Hepatoprotective effect of Platycodon grandiflorum against chronic ethanol-induced oxidative stress in C57BL/6 mice Annals of Nutrition Metabolism 2011 58 3 224 231
9. Khanal T., Choi J. H., Hwang Y. P., Chung Y. C., Jeong H. G., Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice Food and Chemical Toxicology 2009 47 3 530 535
10. Khanal T., Choi J. H., Hwang Y. P., Chung Y. C., Jeong H. G., Protective effects of saponins from the root of Platycodon grandiflorum against fatty liver in chronic ethanol feeding via the activation of AMP-dependent protein kinase Food and Chemical Toxicology 2009 47 11 2749 2754
11. Ruderman N. B., Saha A. K., Vavvas D., Witters L. A., Malonyl-CoA, fuel sensing, and insulin resistance The American Journal of Physiology 1999 276 1, part 1 E1 E18
12. Winder W. W., Hardie D. G., AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes The American Journal of Physiology 1999 277 1, part 1 E1 E10
13. Dean D., Daugaard J. R., Young M. E., Saha A., Vavvas D., Asp S., Kiens B., Kim K. H., Witters L., Richter E. A., Ruderman N., Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle Diabetes 2000 49 8 1295 1300 (Pubitemid 30624228)
14. Winder W. W., Hardie D. G., Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise The American Journal of Physiology 1996 270 2 part 1 E299 E304
15. Park H. S., Kim S. H., Kim Y. S., Ryu S. Y., Hwang J. T., Yang H. J., Kim G. H., Kwon D. Y., Kim M. S., Luteolin inhibits adipogenic differentiation by regulating PPARc activation Biofactors 2009 35 4 373 379
16. Kim M. S., Kim J. K., Kim H. J., Moon S. R., Shin B. C., Park K. W., Yang H. O., Kim S. M., Park R., Hibiscus extract inhibits the lipid droplet accumulation and adipogenic transcription factors expression of 3T3-L1 preadipocytes The Journal of Alternative and Complementary Medicine 2003 9 4 499 504 (Pubitemid 37048000)
17. Osuga T., Mitamura K., Mashige F., Imai D., Evaluation of fluorimetrically estimated serum bile acid in liver disease Clinica Chimica Acta 1977 75 1 81 90 (Pubitemid 8030860)
18. Tada A., Kaneiwa Y., Shoji J., Shibata S., Studies on the saponins of the root of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D Chemical and Pharmaceutical Bulletin 1975 23 11 2965 2972
19. Kim J. Y., Moon K. D., Seo K. I., Park K. W., Choi M. S., Do G. M., Jeong Y. K., Cho Y. S., Lee M. K., Supplementation of sk1 from platycodi radix ameliorates obesity and glucose intolerance in mice fed a high-fat diet Journal of Medicinal Food 2009 12 3 629 636
20. Kim J. Y., Hwang Y. P., Kim D. H., Han E. H., Chung Y. C., Roh S. H., Jeong H. G., Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation Bioscience, Biotechnology and Biochemistry 2006 70 4 858 864
21. Zhao H. L., Sim J. S., Shim S. H., Ha Y. W., Kang S. S., Kim Y. S., Antiobese and hypolipidemic effects of platycodin saponins in diet-induced obese rats: evidences for lipase inhibition and calorie intake restriction International Journal of Obesity 2005 29 8 983 990 (Pubitemid 41076239)
22. Han L. K., Zheng Y. N., Xu B. J., Okuda H., Kimura Y., Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice The Journal of Nutrition 2002 132 8 2241 2245 (Pubitemid 34851657)
23. Park Y. S., Yoon Y., Ahn H. S., Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats World Journal of Gastroenterology 2007 13 25 3493 3499 (Pubitemid 47162023)
24. Ahn K. S., Hahn B. S., Kwack K., Lee E. B., Kim Y. S., Platycodin D-induced apoptosis through nuclear factor- B activation in immortalized keratinocytes European Journal of Pharmacology 2006 537 13 1 11
25. Kim M. O., Moon D. O., Choi Y. H., Shin D. Y., Kang H. S., Choi B. T., Lee J. D., Li W., Kim G. Y., Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells Cancer Letters 2008 261 1 98 107
26. Han S. B., Park S. H., Lee K. H., Lee C. W., Lee S. H., Kim H. C., Kim Y. S., Lee H. S., Kim H. M., Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells International Immunopharmacology 2001 1 11 1969 1978 (Pubitemid 32835127)
27. Ahn K. S., Noh E. J., Zhao H. L., Jung S. H., Kang S. S., Kim Y. S., Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor- B activation in RAW 264.7 cells Life Sciences 2005 76 20 2315 2328 (Pubitemid 40313419)
28. Kim J. Y., Kim D. H., Kim H. G., Song G. Y., Chung Y. C., Roh S. H., Jeong H. G., Inhibition of tumor necrosis factor- -induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum Toxicology and Applied Pharmacology 2006 210 1-2 150 156 (Pubitemid 41790563)
29. Choi J. H., Hwang Y. P., Lee H. S., Jeong H. G., Inhibitory effect of Platycodi Radix on ovalbumin-induced airway inflammation in a murine model of asthma Food and Chemical Toxicology 2009 47 6 1272 1279
30. Lee H., Kang R., Kim Y. S., Chung S. I., Yoon Y., Platycodin D inhibits adipogenesis of 3T3-L1 cells by modulating kruppel-like factor 2 and peroxisome proliferator-activated receptor Phytotherapy Research 2010 24 supplement 2 S161 S167
31. Lee H., Bae S., Kim Y. S., Yoon Y., WNT/ -catenin pathway mediates the anti-adipogenic effect of platycodin D, a natural compound found in Platycodon grandiflorum Life Sciences 2011 89 11-12 388 394
32. Corbett J. W., Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008 Expert Opinion on Therapeutic Patents 2009 19 7 943 956
33. Song G. Y., Gao Y., Wang C., Hu S. G., Wang J., Qu D. M., Ma H. J., Rosiglitazone reduces fatty acid translocase and increases AMPK in skeletal muscle in aged rats: a possible mechanism to prevent high-fat-induced insulin resistance Chinese Medical Journal 2010 123 17 2384 2391
34. Reaven G. M., Banting lecture 1988. Role of insulin resistance in human disease Diabetes 1988 37 12 1595 1607 (Pubitemid 19004941)