Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation

Journal of Biological Chemistry

Volumn 288, Issue 10, 2013, Pages 7252-7262

  Jung, Hae Yun ^a   Wang, Xin ^a   Jun, Sohee ^a   Park, Jae Il ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELLS; CATALYTIC SUBUNITS; E3 LIGASE; REGULATORY MECHANISM; TELOMERASE; TELOMERASE ACTIVITY; TELOMERASE REVERSE TRANSCRIPTASE;

BIOCHEMISTRY; BIOLOGY;

STEM CELLS;

DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2; PHOSPHOTRANSFERASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CANCER; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL DISRUPTION; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2 GENE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SUBUNIT; MOUSE; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TUMOR GENE;

ANIMALS; CARRIER PROTEINS; CELL DIVISION; CELLS, CULTURED; DNA-BINDING PROTEINS; G2 PHASE; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; MCF-7 CELLS; MICE; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEOLYSIS; RNA INTERFERENCE; TELOMERASE; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84874883284     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.416792     Document Type: Article

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