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Volumn 14, Issue 2, 2013, Pages 147-156

Role of the transforming-growth-factor-β1 gene in late-onset alzheimer's disease: Implications for the treatment

Author keywords

Alzheimer's disease; Depression; Drugs; Genetic polymorphism; Risk factor; Transforming growth factor 1

Indexed keywords

APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; N METHYL DEXTRO ASPARTIC ACID; PAROXETINE; SERTRALINE; TRANSFORMING GROWTH FACTOR BETA1; VENLAFAXINE;

EID: 84874835774     PISSN: 13892029     EISSN: 18755488     Source Type: Journal    
DOI: 10.2174/1389202911314020007     Document Type: Review
Times cited : (38)

References (120)
  • 1
    • 67651180986 scopus 로고    scopus 로고
    • The amyloid hypothesis for Alzheimer's disease: A critical reappraisal
    • Hardy, J. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J. Neurochem., 2009, 110(4), 1129-1134.
    • (2009) J. Neurochem , vol.110 , Issue.4 , pp. 1129-1134
    • Hardy, J.1
  • 2
    • 54249156942 scopus 로고    scopus 로고
    • Neuropsychiatric symptoms in dementia: Importance and treatment considerations
    • Ballard, C.; Day, S.; Sharp, S.; Wing, G.; Sorensen, S. Neuropsychiatric symptoms in dementia: importance and treatment considerations. Int. Rev. Psychiatry, 2008, 20(4), 396-404.
    • (2008) Int. Rev. Psychiatry , vol.20 , Issue.4 , pp. 396-404
    • Ballard, C.1    Day, S.2    Sharp, S.3    Wing, G.4    Sorensen, S.5
  • 3
    • 84860434364 scopus 로고    scopus 로고
    • Promoter polymorphisms of serpine1 are associated with the antidepressant response to depression in Alzheimer's disease
    • Fang, Y.; Zhang, L.; Zeng, Z.; Lian, Y.; Jia, Y.; Zhu, H.; Xu, Y. Promoter polymorphisms of serpine1 are associated with the antidepressant response to depression in Alzheimer's disease. Neurosci. Lett., 2012, 516(2), 217-220.
    • (2012) Neurosci. Lett , vol.516 , Issue.2 , pp. 217-220
    • Fang, Y.1    Zhang, L.2    Zeng, Z.3    Lian, Y.4    Jia, Y.5    Zhu, H.6    Xu, Y.7
  • 6
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: Back to the future
    • Bertram, L.; Lill, C.M.; Tanzi, R.E. The genetics of Alzheimer disease: back to the future. Neuron., 2010, 68(2), 270-281.
    • (2010) Neuron , vol.68 , Issue.2 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 7
    • 41549115893 scopus 로고    scopus 로고
    • Advances on the Understanding of the Origins of Synaptic Pathology in AD
    • Lacor, P.N. Advances on the Understanding of the Origins of Synaptic Pathology in AD. Curr. Genomics, 2007, 8(8), 486-508.
    • (2007) Curr. Genomics , vol.8 , Issue.8 , pp. 486-508
    • Lacor, P.N.1
  • 8
    • 0028981090 scopus 로고
    • Apolipoprotein E 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers
    • St Clair, D.; Rennie, M.; Slorach, E.; Norrman, J.; Yates, C.; Carothers, A. Apolipoprotein E 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers. J Med Genet., 1995, 32(8), 642-644.
    • (1995) J Med Genet , vol.32 , Issue.8 , pp. 642-644
    • St Clair, D.1    Rennie, M.2    Slorach, E.3    Norrman, J.4    Yates, C.5    Carothers, A.6
  • 11
    • 0028167193 scopus 로고
    • Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease
    • Brousseau, T.; Legrain, S.; Berr, C.; Gourlet, V.; Vidal, O.; Amouyel, P. Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease. Neurology, 1994, 44(2), 342-344.
    • (1994) Neurology , vol.44 , Issue.2 , pp. 342-344
    • Brousseau, T.1    Legrain, S.2    Berr, C.3    Gourlet, V.4    Vidal, O.5    Amouyel, P.6
  • 12
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder, E.H.; Saunders, A.M.; Strittmatter, W.J.; Schmechel, D.E.; Gaskell, P.C.; Small, G.W. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 1993, 261(5123), 921-923.
    • (1993) Science , vol.261 , Issue.5123 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 14
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in lateonset familial Alzheimer disease
    • Strittmatter WJ.; Saunders, AM.; Schmechel, D.; Pericak-Vance, M.; Enghild, J.; Salvesen, GS. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in lateonset familial Alzheimer disease. Proc. Natl. Acad Sci. U S A. 1993, 90(5), 1977-1981.
    • (1993) Proc. Natl. Acad Sci. U S A , vol.90 , Issue.5 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3    Pericak-Vance, M.4    Enghild, J.5    Salvesen, G.S.6
  • 16
    • 33750028579 scopus 로고    scopus 로고
    • Definition of Genes and Paths Involved in Alzheimer's Disease: Using Gene Expression Profiles and Chemical Genetics at the Mouse Brain Level
    • Wu, P.; Hu, Y. Definition of Genes and Paths Involved in Alzheimer's Disease: Using Gene Expression Profiles and Chemical Genetics at the Mouse Brain Level. Curr. Genomics, 2006, 7(5), 293-300.
    • (2006) Curr. Genomics , vol.7 , Issue.5 , pp. 293-300
    • Wu, P.1    Hu, Y.2
  • 17
    • 0036697305 scopus 로고    scopus 로고
    • Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease
    • Griffin, W.S.; Mrak, R.E. Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease. J. Leukoc. Biol., 2002, 72(2), 233-238.
    • (2002) J. Leukoc. Biol , vol.72 , Issue.2 , pp. 233-238
    • Griffin, W.S.1    Mrak, R.E.2
  • 19
    • 37849186628 scopus 로고    scopus 로고
    • Apolipoprotein E, Methylenetetrahydrofolate Reductase (MTHFR) mutation and the risk of senile dementia - an epidemiological study using the polymerase chain reaction (PCR)
    • Nishiyama, M.; Kato, Y.; Hashimoto, M.; Yukawa, S.; Omori, K. Apolipoprotein E, Methylenetetrahydrofolate Reductase (MTHFR) mutation and the risk of senile dementia - an epidemiological study using the polymerase chain reaction (PCR). Method. Epidemiol., 2000, 10(3), 163-172
    • (2000) Method. Epidemiol , vol.10 , Issue.3 , pp. 163-172
    • Nishiyama, M.1    Kato, Y.2    Hashimoto, M.3    Yukawa, S.4    Omori, K.5
  • 20
    • 77953728422 scopus 로고    scopus 로고
    • One-Carbon Metabolism and Alzheimer's Disease: Focus on Epigenetics
    • Coppedè, F. One-Carbon Metabolism and Alzheimer's Disease: Focus on Epigenetics. Curr. Genomics, 2010,11(4), 246-260.
    • (2010) Curr. Genomics , vol.11 , Issue.4 , pp. 246-260
    • Coppedè, F.1
  • 21
    • 79957604912 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease: New evidences for an old hypothesis?
    • Lambert J.C.; Amouyel P. Genetics of Alzheimer's disease: new evidences for an old hypothesis? Curr. Opin. Genet. Dev., 2011, 21(3), 295-301.
    • (2011) Curr. Opin. Genet. Dev , vol.21 , Issue.3 , pp. 295-301
    • Lambert, J.C.1    Amouyel, P.2
  • 23
    • 79955484414 scopus 로고    scopus 로고
    • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    • Alzheimer's Disease Neuroimaging Initiative, CHARGE consortium, EADI1 consortium
    • Hollingworth, P.; Harold, D.; Sims, R.; Gerrish, A.; Lambert, J.C.; Carrasquillo, M.M.; Abraham, R.; Hamshere, M.L.; Pahwa, J.S.; Moskvina, V.; Dowzell, K.; Jones, N.; Stretton, A.; Thomas, C.; Richards, A.; Ivanov, D.; Widdowson, C.; Chapman, J.; Lovestone, S.; Powell, J.; Proitsi, P.; Lupton, M.K.; Brayne, C.; Rubinsztein, D.C.; Gill, M.; Lawlor, B.; Lynch, A.; Brown, K.S.; Passmore, P.A.; Craig, D.; McGuinness, B.; Todd, S.; Holmes, C.; Mann, D.; Smith, A.D.; Beaumont, H.; Warden, D.; Wilcock, G.; Love, S.; Kehoe, P.G.; Hooper, N.M.; Vardy, E.R.; Hardy, J.; Mead, S.; Fox, N.C.; Rossor, M.; Collinge, J.; Maier, W.; Jessen, F.; Rüther, E.; Schürmann, B.; Heun, R.; Kölsch, H.; van den Bussche, H.; Heuser, I.; Kornhuber, J.; Wiltfang, J.; Dichgans, M.; Frölich, L.; Hampel, H.; Gallacher, J.; Hüll, M.; Rujescu, D.; Giegling, I.; Goate, A.M.; Kauwe, J.S.; Cruchaga, C.; Nowotny, P.; Morris, J.C.; Mayo, K.; Sleegers, K.; Bettens, K.; Engelborghs, S.; De Deyn, P.P.; Van Broeckhoven, C.; Livingston, G.; Bass, N.J.; Gurling, H.; McQuillin, A.; Gwilliam, R.; Deloukas, P.; Al- Chalabi, A.; Shaw, C.E.; Tsolaki, M.; Singleton, A.B.; Guerreiro, R.; Mühleisen, T.W.; Nöthen, M.M.; Moebus, S.; Jöckel, K.H.; Klopp, N.; Wichmann, H.E.; Pankratz, V.S.; Sando, S.B.; Aasly, J.O.; Barcikowska, M.; Wszolek, Z.K.; Dickson, D.W.; Graff- Radford, N.R.; Petersen, R.C. Alzheimer's Disease Neuroimaging Initiative, van Duijn, C.M.; Breteler, M.M.; Ikram, M.A.; DeStefano, A.L.; Fitzpatrick, A.L.; Lopez, O.; Launer, L.J.; Seshadri, S. CHARGE consortium, Berr, C.; Campion, D.; Epelbaum, J.; Dartigues, J.F.; Tzourio, C.; Alpérovitch, A.; Lathrop, M. EADI1 consortium, Feulner, T.M.; Friedrich, P.; Riehle, C.; Krawczak, M.; Schreiber, S.; Mayhaus, M.; Nicolhaus, S.; Wagenpfeil, S.; Steinberg, S.; Stefansson, H.; Stefansson, K.; Snaedal, J.; Björnsson, S.; Jonsson, P.V.; Chouraki, V.; Genier-Boley, B.; Hiltunen, M.; Soininen, H.; Combarros, O.; Zelenika, D.; Delepine, M.; Bullido, M.J.; Pasquier, F.; Mateo, I.; Frank-Garcia, A.; Porcellini, E.; Hanon, O.; Coto, E.; Alvarez, V.; Bosco, P.; Siciliano, G.; Mancuso, M.; Panza, F.; Solfrizzi, V.; Nacmias, B.; Sorbi, S.; Bossù, P.; Piccardi, P.; Arosio, B.; Annoni, G.; Seripa, D.; Pilotto, A.; Scarpini, E.; Galimberti, D.; Brice, A.; Hannequin, D.; Licastro, F.; Jones, L.; Holmans, P.A.; Jonsson, T.; Riemenschneider, M.; Morgan, K.; Younkin, S.G.; Owen, M.J.; O'Donovan, M.; Amouyel, P.; Williams, J. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet., 2011, 43(5), 429-435.
    • (2011) Nat. Genet , vol.43 , Issue.5 , pp. 429-435
    • Hollingworth, P.1    Harold, D.2    Sims, R.3    Gerrish, A.4    Lambert, J.C.5    Carrasquillo, M.M.6    Abraham, R.7    Hamshere, M.L.8    Pahwa, J.S.9    Moskvina, V.10    Dowzell, K.11    Jones, N.12    Stretton, A.13    Thomas, C.14    Richards, A.15    Ivanov, D.16    Widdowson, C.17    Chapman, J.18    Lovestone, S.19    Powell, J.20    more..
  • 24
    • 26244466228 scopus 로고    scopus 로고
    • The role of neurotrophins in brain aging: A perspective in honor of Regino Perez-Polo
    • Cotman, C.W. The role of neurotrophins in brain aging: a perspective in honor of Regino Perez-Polo. Neurochem. Res., 2005, 30(6- 7), 877-881.
    • (2005) Neurochem. Res , vol.30 , Issue.6-7 , pp. 877-881
    • Cotman, C.W.1
  • 27
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signalling
    • Ten Dijke, P.; Hill CS. New insights into TGF-beta-Smad signalling. Trends Biochem. Sci., 2004, 29(5), 265-273.
    • (2004) Trends Biochem. Sci , vol.29 , Issue.5 , pp. 265-273
    • Ten Dijke, P.1    Hill, C.S.2
  • 31
    • 0031684855 scopus 로고    scopus 로고
    • Extracellular matrixaassociated transforming growth factor-beta: Role in cancer cell growth and invasion
    • Taipale, J.; Saharinen, J.; Keski-Oja, J. Extracellular matrixaassociated transforming growth factor-beta: role in cancer cell growth and invasion. Adv. Cancer Res.,1998, 75, 87-134.
    • (1998) Adv. Cancer Res , vol.75 , pp. 87-134
    • Taipale, J.1    Saharinen, J.2    Keski-Oja, J.3
  • 34
    • 0032573136 scopus 로고    scopus 로고
    • Genotypic variation in the transforming growth factor-beta1 gene: Association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation
    • Awad, M.R.; El-Gamel, A.; Hasleton, P.; Turner, D.M.; Sinnott, P.J.; Hutchinson I.V. Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation, 1998, 66(8), 1014-1020.
    • (1998) Transplantation , vol.66 , Issue.8 , pp. 1014-1020
    • Awad, M.R.1    El-Gamel, A.2    Hasleton, P.3    Turner, D.M.4    Sinnott, P.J.5    Hutchinson, I.V.6
  • 35
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck, R.; Zhang, Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature, 2203, 425(6958), 577-84.
    • (2203) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 36
    • 16844381310 scopus 로고    scopus 로고
    • TGF-{beta}1 activates two distinct type I receptors in neurons: Implications for neuronal NF-{kappa}B signaling
    • König, H.G.; Kögel, D.; Rami, A.; Prehn, J.H. TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J. Cell. Biol., 2005, 168(7), 1077-86.
    • (2005) J. Cell. Biol , vol.168 , Issue.7 , pp. 1077-1086
    • König, H.G.1    Kögel, D.2    Rami, A.3    Prehn, J.H.4
  • 37
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
    • Bakin, A.V.; Tomlinson, A.K.; Bhowmick, N.A.; Moses, H.L. & Arteaga C.L. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J. Biol. Chem., 2000, 275(47), 36803-36810.
    • (2000) J. Biol. Chem , vol.275 , Issue.47 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 39
    • 1642441435 scopus 로고    scopus 로고
    • Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways
    • Zhu, Y.; Culmsee, C.; Klumpp, S.; Krieglstein, J. Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways. Neuroscience, 2004, 123(4), 897-906.
    • (2004) Neuroscience , vol.123 , Issue.4 , pp. 897-906
    • Zhu, Y.1    Culmsee, C.2    Klumpp, S.3    Krieglstein, J.4
  • 40
    • 0024848815 scopus 로고
    • Activation of the second promoter of the transforming growth factor-beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences
    • Kim, S.J.; Denhez, F.; Kim, K.Y.; Holt, J.T.; Sporn, M.B.; Roberts, A.B. Activation of the second promoter of the transforming growth factor-beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences. J. Biol. Chem., 1989, 264(32), 19373-19378.
    • (1989) J. Biol. Chem , vol.264 , Issue.32 , pp. 19373-19378
    • Kim, S.J.1    Denhez, F.2    Kim, K.Y.3    Holt, J.T.4    Sporn, M.B.5    Roberts, A.B.6
  • 41
    • 0024496499 scopus 로고
    • Characterization of the promoter region of the human transforming growth factorbeta 1 gene
    • Kim, S.J.; Glick, A.; Sporn, M.B.; Roberts, A.B. Characterization of the promoter region of the human transforming growth factorbeta 1 gene. J. Biol. Chem., 1989, 264(1), 402-408.
    • (1989) J. Biol. Chem , vol.264 , Issue.1 , pp. 402-408
    • Kim, S.J.1    Glick, A.2    Sporn, M.B.3    Roberts, A.B.4
  • 42
    • 10344243008 scopus 로고    scopus 로고
    • Poirier, O. Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure. The Etude Cas- Témoin de l'Infarctus du Myocarde (ECTIM) Study
    • Cambien, F.; Ricard, S.; Troesch, A.; Mallet, C.; Générénaz, L.; Evans, A.; Arveiler, D.; Luc, G.; Ruidavets, J.B.; Poirier, O. Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure. The Etude Cas- Témoin de l'Infarctus du Myocarde (ECTIM) Study. Hypertension, 1996, 28(5), 881-887.
    • (1996) Hypertension , vol.28 , Issue.5 , pp. 881-887
    • Cambien, F.1    Ricard, S.2    Troesch, A.3    Mallet, C.4    Générénaz, L.5    Evans, A.6    Arveiler, D.7    Luc, G.8    Ruidavets, J.B.9
  • 44
    • 23944523676 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 (TGFB1) and peak bone mass: Association between intragenic polymorphisms and quantitative ultrasound of the heel
    • Tzakas, P.; Wong, B.Y.; Logan, A.G.; Rubin, L.A.; Cole, D.E.; Transforming growth factor beta-1 (TGFB1) and peak bone mass: association between intragenic polymorphisms and quantitative ultrasound of the heel. BMC Musculoskelet. Disord., 2005, 6,
    • (2005) BMC Musculoskelet. Disord , vol.6
    • Tzakas, P.1    Wong, B.Y.2    Logan, A.G.3    Rubin, L.A.4    Cole, D.E.5
  • 45
    • 0344132027 scopus 로고    scopus 로고
    • Restriction enzyme-based method for transforming growth factor-beta (1) genotyping: Nonisotopic detection of polymorphisms in codons 10 and 25 and the 5'-flanking region
    • Lario, S.; Iñigo, P.; Campistol, J.M.; Poch, E.; Rivera, F.; Oppenheimer, F. Restriction enzyme-based method for transforming growth factor-beta (1) genotyping: nonisotopic detection of polymorphisms in codons 10 and 25 and the 5'-flanking region. Clin. Chem., 1999, 45(8), 1290-1292.
    • (1999) Clin. Chem , vol.45 , Issue.8 , pp. 1290-1292
    • Lario, S.1    Iñigo, P.2    Campistol, J.M.3    Poch, E.4    Rivera, F.5    Oppenheimer, F.6
  • 48
    • 0034724167 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 hyperexpression in african-american hypertensives: A novel mediator of hypertension and/or target organ damage
    • Suthanthiran, M.; Li, B.; Song, J.O.; Ding, R.; Sharma, V.K.; Schwartz, J.E.; August, P. Transforming growth factor-beta 1 hyperexpression in african-american hypertensives: a novel mediator of hypertension and/or target organ damage. Proc. Natl. Acad. Sci. U S A, 2000, 97(7), 3479-3484.
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , Issue.7 , pp. 3479-3484
    • Suthanthiran, M.1    Li, B.2    Song, J.O.3    Ding, R.4    Sharma, V.K.5    Schwartz, J.E.6    August, P.7
  • 49
    • 0033950739 scopus 로고    scopus 로고
    • Identification of human TGF-beta1 signal (leader) sequence polymorphisms by PCR-RFLP
    • Wood, N.A.; Thomson, S.C.; Smith, R.M.; Bidwell, J.L. Identification of human TGF-beta1 signal (leader) sequence polymorphisms by PCR-RFLP. J. Immunol. Methods, 2000, 234(1-2), 117-122.
    • (2000) J. Immunol. Methods , vol.234 , Issue.1-2 , pp. 117-122
    • Wood, N.A.1    Thomson, S.C.2    Smith, R.M.3    Bidwell, J.L.4
  • 50
    • 0032440577 scopus 로고    scopus 로고
    • Molecular genetics of coronary artery disease: Measuring the phenotype
    • Samani, N.J. Molecular genetics of coronary artery disease: measuring the phenotype. Clin. Sci. (Lond)., 1998, 95(6), 645-646.
    • (1998) Clin. Sci. (Lond) , vol.95 , Issue.6 , pp. 645-646
    • Samani, N.J.1
  • 51
    • 0030963564 scopus 로고    scopus 로고
    • Molecular genetic analysis of TGF beta1 in breast cancer
    • Cardillo, MR.; Yap, E.; Castagna, G. Molecular genetic analysis of TGF beta1 in breast cancer. J. Exp. Clin. Cancer Res., 1997, 16(1), 57-63.
    • (1997) J. Exp. Clin. Cancer Res , vol.16 , Issue.1 , pp. 57-63
    • Cardillo, M.R.1    Yap, E.2    Castagna, G.3
  • 52
    • 0030609151 scopus 로고    scopus 로고
    • TGF-beta1 in colonic neoplasia: A genetic molecular and immunohistochemical study
    • Cardillo, M.R.; Yap, E. TGF-beta1 in colonic neoplasia: a genetic molecular and immunohistochemical study. J. Exp. Clin. Cancer Res., 1997, 16(3), 281-288.
    • (1997) J. Exp. Clin. Cancer Res. , vol.16 , Issue.3 , pp. 281-288
    • Cardillo, M.R.1    Yap, E.2
  • 53
    • 0030887437 scopus 로고    scopus 로고
    • Molecular genetic analysis of TGF-beta1 in ovarian neoplasia
    • Cardillo, M.R.; Yap, E.; Castagna, G. Molecular genetic analysis of TGF-beta1 in ovarian neoplasia. J. Exp. Clin. Cancer Res., 1997, 16(1), 49-56.
    • (1997) J. Exp. Clin. Cancer Res , vol.16 , Issue.1 , pp. 49-56
    • Cardillo, M.R.1    Yap, E.2    Castagna, G.3
  • 54
    • 63849191286 scopus 로고    scopus 로고
    • Modulation of TGF-beta signaling during progression of chronic liver diseases
    • Matsuzaki, K. Modulation of TGF-beta signaling during progression of chronic liver diseases. Front Biosci., 2009, 14, 2923-34.
    • (2009) Front Biosci , vol.14 , pp. 2923-2934
    • Matsuzaki, K.1
  • 55
    • 80052806419 scopus 로고    scopus 로고
    • Genetic polymorphism at codon 10 of the transforming growth factor-β1 gene in patients with alcoholic liver cirrhosis
    • Lee, J.J., Park, S.K., Kwon, O.S., Won, I.S., Kim, D.K., Jung, Y.K., Ku, Y.S., Kim, Y.S., Choi, D.J., Kim, J.H. Genetic polymorphism at codon 10 of the transforming growth factor-β1 gene in patients with alcoholic liver cirrhosis. Korean J Hepatol., 2011, 17(1), 37-43.
    • (2011) Korean J Hepatol. , vol.17 , Issue.1 , pp. 37-43
    • Lee, J.J.1    Park, S.K.2    Kwon, O.S.3    Won, I.S.4    Kim, D.K.5    Jung, Y.K.6    Ku, Y.S.7    Kim, Y.S.8    Choi, D.J.9    Kim, J.H.10
  • 56
    • 0035989936 scopus 로고    scopus 로고
    • Adenoviral delivery of an antisense RNA complementary to the 3' coding sequence of transforming growth factor- beta1 inhibits fibrogenic activities of hepatic stellate cells
    • Arias, M., Lahme, B., Van de Leur, E., Gressner, A.M., Weiskirchen, R. Adenoviral delivery of an antisense RNA complementary to the 3' coding sequence of transforming growth factor- beta1 inhibits fibrogenic activities of hepatic stellate cells. Cell Growth Differ., 2002, 13(6), 265-73.
    • (2002) Cell Growth Differ , vol.13 , Issue.6 , pp. 265-273
    • Arias, M.1    Lahme, B.2    van de Leur, E.3    Gressner, A.M.4    Weiskirchen, R.5
  • 58
    • 0031593542 scopus 로고    scopus 로고
    • TGF-beta1 gene mutations in insulindependent diabetes mellitus and diabetic nephropathy
    • Pociot, F.; Hansen, P.M.; Karlsen, A.E.; Langdahl, B.L.; Johannesen, J.; Nerup, J. TGF-beta1 gene mutations in insulindependent diabetes mellitus and diabetic nephropathy. J. Am. Soc. Nephrol., 1998, 9(12), 2302-2307.
    • (1998) J. Am. Soc. Nephrol , vol.9 , Issue.12 , pp. 2302-2307
    • Pociot, F.1    Hansen, P.M.2    Karlsen, A.E.3    Langdahl, B.L.4    Johannesen, J.5    Nerup, J.6
  • 59
    • 0032445196 scopus 로고    scopus 로고
    • Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma
    • Hobbs, K.; Negri, J.; Klinnert, M.; Rosenwasser, L.J.; Borish, L. Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am. J. Respir. Crit. Care Med., 1998, 158(6), 1958-1962.
    • (1998) Am. J. Respir. Crit. Care Med , vol.158 , Issue.6 , pp. 1958-1962
    • Hobbs, K.1    Negri, J.2    Klinnert, M.3    Rosenwasser, L.J.4    Borish, L.5
  • 60
    • 0032100761 scopus 로고    scopus 로고
    • Linkage and association analysis of genes encoding cytokines and myelin proteins in multiple sclerosis
    • He, B.; Xu, C.; Landtblom, A.M.; Fredrikson, S.; Hillert, J. Linkage and association analysis of genes encoding cytokines and myelin proteins in multiple sclerosis. J. Neuroimmunol., 1998, 86(1), 13-19.
    • (1998) J. Neuroimmunol , vol.86 , Issue.1 , pp. 13-19
    • He, B.1    Xu, C.2    Landtblom, A.M.3    Fredrikson, S.4    Hillert, J.5
  • 62
    • 0031667368 scopus 로고    scopus 로고
    • Asso ciation of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women
    • Yamada, Y.; Miyauchi, A.; Goto, J.; Takagi, Y.; Okuizumi, H.; Kanematsu, M.; Hase, M.; Takai, H.; Harada, A.; Ikeda, K. Asso ciation of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J. Bone Miner. Res., 1998, 13(10), 1569-1576.
    • (1998) J. Bone Miner. Res , vol.13 , Issue.10 , pp. 1569-1576
    • Yamada, Y.1    Miyauchi, A.2    Goto, J.3    Takagi, Y.4    Okuizumi, H.5    Kanematsu, M.6    Hase, M.7    Takai, H.8    Harada, A.9    Ikeda, K.10
  • 63
    • 0030999773 scopus 로고    scopus 로고
    • A sequence variation: 713-8delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women
    • Langdahl, B.L.; Knudsen, J.Y.; Jensen, H.K.; Gregersen, N.; Eriksen, E.F. A sequence variation: 713-8delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women. Bone, 1997, 20(3), 289-294.
    • (1997) Bone , vol.20 , Issue.3 , pp. 289-294
    • Langdahl, B.L.1    Knudsen, J.Y.2    Jensen, H.K.3    Gregersen, N.4    Eriksen, E.F.5
  • 65
    • 74149090655 scopus 로고    scopus 로고
    • Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
    • Salvioli, S.; Capri, M.; Bucci, L. Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53. Cancer Immunol. Immunother., 2009, 58(12), 1909-1917.
    • (2009) Cancer Immunol. Immunother , vol.58 , Issue.12 , pp. 1909-1917
    • Salvioli, S.1    Capri, M.2    Bucci, L.3
  • 66
    • 13844280837 scopus 로고    scopus 로고
    • The G/C 915 polymorphism of transforming growth factor beta1 is associated with human longevity: A study in Italian centenarians
    • Carrieri, G.; Marzi, E.; Olivieri, F. The G/C 915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell., 2004, 3(6), 443-448.
    • (2004) Aging Cell , vol.3 , Issue.6 , pp. 443-448
    • Carrieri, G.1    Marzi, E.2    Olivieri, F.3
  • 67
    • 0037396220 scopus 로고    scopus 로고
    • Plasma cytokine profiles in elderly humans
    • Forsey, R.J.; Thompson, J.M.; Ernerudh, J. Plasma cytokine profiles in elderly humans. Mech. Ageing Dev., 2003, 124(4), 487-493.
    • (2003) Mech. Ageing Dev , vol.124 , Issue.4 , pp. 487-493
    • Forsey, R.J.1    Thompson, J.M.2    Ernerudh, J.3
  • 69
  • 72
    • 33745603438 scopus 로고    scopus 로고
    • Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's
    • Wyss-Coray, T. Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's. Curr. Alzh. Res., 2006, 3(3), 191-195.
    • (2006) Curr. Alzh. Res , vol.3 , Issue.3 , pp. 191-195
    • Wyss-Coray, T.1
  • 73
    • 15044353664 scopus 로고    scopus 로고
    • Role of the APP promoter in Alzheimer's disease: Cell type-specific expression of the beta-amyloid precursor protein
    • Lahiri, D.K.; Ge, Y.W.; Role of the APP promoter in Alzheimer's disease: cell type-specific expression of the beta-amyloid precursor protein. Ann. N. Y. Acad Sci., 2004, 1030, 310-316.
    • (2004) Ann. N. Y. Acad Sci , vol.1030 , pp. 310-316
    • Lahiri, D.K.1    Ge, Y.W.2
  • 74
    • 0034045634 scopus 로고    scopus 로고
    • Analysis of genetic polymorphisms in the transforming growth factor-beta1 gene and the risk of Alzheimer's disease
    • Luedecking, E.K.; DeKosky, S.T.; Mehdi, H.; Ganguli, M.; Kamboh, M.I. Analysis of genetic polymorphisms in the transforming growth factor-beta1 gene and the risk of Alzheimer's disease. Hum. Genet., 2000, 106(5), 565-569.
    • (2000) Hum. Genet , vol.106 , Issue.5 , pp. 565-569
    • Luedecking, E.K.1    Dekosky, S.T.2    Mehdi, H.3    Ganguli, M.4    Kamboh, M.I.5
  • 75
    • 0036311159 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF complex and Smads
    • Burton, T.; Liang, B.; Dibrov, A.; Amara, F. Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF complex and Smads. Biochem. Biophys. Res. Commun., 2002, 295(3), 713-723.
    • (2002) Biochem. Biophys. Res. Commun , vol.295 , Issue.3 , pp. 713-723
    • Burton, T.1    Liang, B.2    Dibrov, A.3    Amara, F.4
  • 76
    • 0038719725 scopus 로고    scopus 로고
    • Transforming growth factorbeta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice
    • Lesne, S.; Docagne, F.; Gabriel, C. Transforming growth factorbeta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. J. Biol. Chem., 2003, 278(20), 18408-18418.
    • (2003) J. Biol. Chem , vol.278 , Issue.20 , pp. 18408-18418
    • Lesne, S.1    Docagne, F.2    Gabriel, C.3
  • 77
    • 3042693940 scopus 로고    scopus 로고
    • Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease
    • Hynd, M.R.; Scott, H.L.; Dodd. P.R. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem. Int., 2004, 45(5), 583-595.
    • (2004) Neurochem. Int , vol.45 , Issue.5 , pp. 583-595
    • Hynd, M.R.1    Scott, H.L.2    Dodd, P.R.3
  • 79
    • 7044237034 scopus 로고    scopus 로고
    • Divide and die: Cell cycle events as triggers of nerve cell death
    • Herrup, K.; Neve, R.; Ackerman, S.L.; Copani, A. Divide and die: cell cycle events as triggers of nerve cell death. J. Neurosci., 2004, 24(42), 9232-9239.
    • (2004) J. Neurosci , vol.24 , Issue.42 , pp. 9232-9239
    • Herrup, K.1    Neve, R.2    Ackerman, S.L.3    Copani, A.4
  • 80
    • 36549083642 scopus 로고    scopus 로고
    • Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of Alzheimer's disease
    • Rojo, L.E.; Fernández, J.A.; Maccioni, A.A.; Jimenez, J.M.; Maccioni, R.B. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch. Med. Res., 2008, 39(1), 1-16.
    • (2008) Arch. Med. Res , vol.39 , Issue.1 , pp. 1-16
    • Rojo, L.E.1    Fernández, J.A.2    Maccioni, A.A.3    Jimenez, J.M.4    Maccioni, R.B.5
  • 81
    • 77951617994 scopus 로고    scopus 로고
    • TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5
    • doi: 10.1186/1742-2094-7-28
    • Huang, W.C.; Yen, F.C.; Shie, F.S.; Pan, C.M.; Shiao, Y.J.; Yang, C.N.; Huang, F.L.; Sung, Y.J.; Tsay, H.J. TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5. J Neuroinflammation, 2010, 7(28), doi: 10.1186/1742-2094-7-28.
    • (2010) J Neuroinflammation , vol.7 , Issue.28
    • Huang, W.C.1    Yen, F.C.2    Shie, F.S.3    Pan, C.M.4    Shiao, Y.J.5    Yang, C.N.6    Huang, F.L.7    Sung, Y.J.8    Tsay, H.J.9
  • 82
  • 83
    • 33747228489 scopus 로고    scopus 로고
    • Polymorphisms in the interleukin 6 and transforming growth factor beta1 gene and risk of dementia. The Rotterdam Study
    • van Oijen, M.; Arp, P.P.; de Jong, F.J.; Hofman, A.; Koudstaal, P.J.; Uitterlinden, A.G.; Breteler, M.M. Polymorphisms in the interleukin 6 and transforming growth factor beta1 gene and risk of dementia. The Rotterdam Study. Neurosci. Lett., 2006, 402(1-2), 113-117.
    • (2006) Neurosci. Lett , vol.402 , Issue.1-2 , pp. 113-117
    • van Oijen, M.1    Arp, P.P.2    de Jong, F.J.3    Hofman, A.4    Koudstaal, P.J.5    Uitterlinden, A.G.6    Breteler, M.M.7
  • 84
    • 78149234564 scopus 로고    scopus 로고
    • No association between cytokine gene polymorphism and risk of Alzheimeŕs disease in Slovaks
    • Shawkatová, I.; Javor, J.; Párnická, Z.; Vražda, L.; Novák, M.; Buc, M. No association between cytokine gene polymorphism and risk of Alzheimeŕs disease in Slovaks. Acta Neurobiol. Exp., 2010, 70(3), 303-307.
    • (2010) Acta Neurobiol. Exp , vol.70 , Issue.3 , pp. 303-307
    • Shawkatová, I.1    Javor, J.2    Párnická, Z.3    Vražda, L.4    Novák, M.5    Buc, M.6
  • 87
    • 77955883396 scopus 로고    scopus 로고
    • Cytokine polymorphisms and Alzheimer disease: Possible associations
    • Ribizzi, G.; Fiordoro, S.; Barocci, S.; Ferrari, E.; Megna, M. Cytokine polymorphisms and Alzheimer disease: possible associations. Neurol. Sci., 2010, 31(3), 321-325.
    • (2010) Neurol. Sci , vol.31 , Issue.3 , pp. 321-325
    • Ribizzi, G.1    Fiordoro, S.2    Barocci, S.3    Ferrari, E.4    Megna, M.5
  • 88
    • 34848849014 scopus 로고    scopus 로고
    • +10 T/C polymorphisms in the gene of transforming growth factorbeta1 are associated with neurodegeneration and its clinical evolution
    • Arosio, B.; Bergamaschini, L.; Galimberti, L.; La Porta, C.; Zanetti, M.; Calabresi, C.; Scarpini, E.; Annoni, G.; Vergani, C. +10 T/C polymorphisms in the gene of transforming growth factorbeta1 are associated with neurodegeneration and its clinical evolution. Mech. Ageing Dev., 2007, 128(10), 553-557.
    • (2007) Mech. Ageing Dev , vol.128 , Issue.10 , pp. 553-557
    • Arosio, B.1    Bergamaschini, L.2    Galimberti, L.3    la Porta, C.4    Zanetti, M.5    Calabresi, C.6    Scarpini, E.7    Annoni, G.8    Vergani, C.9
  • 91
    • 70849130339 scopus 로고    scopus 로고
    • Depression and Alzheimer's disease: Neurobiological links and common pharmacological targets
    • Caraci, F.; Copani, A.; Nicoletti, F.; Drago, F. Depression and Alzheimer's disease: neurobiological links and common pharmacological targets. Eur. J. Pharmacol., 2010, 626(1), 64-71.
    • (2010) Eur. J. Pharmacol , vol.626 , Issue.1 , pp. 64-71
    • Caraci, F.1    Copani, A.2    Nicoletti, F.3    Drago, F.4
  • 92
    • 27744584602 scopus 로고    scopus 로고
    • The construct of minor and major depression in Alzheimer's disease
    • Starkstein, S.E.; Jorge, R.; Mizrahi, R.; Robinson, R.G. The construct of minor and major depression in Alzheimer's disease. Am. J. Psych., 2005, 162(11), 2086-2093.
    • (2005) Am. J. Psych , vol.162 , Issue.11 , pp. 2086-2093
    • Starkstein, S.E.1    Jorge, R.2    Mizrahi, R.3    Robinson, R.G.4
  • 93
    • 33747194140 scopus 로고    scopus 로고
    • Depression as prognostic factor: 6 months follow-up in a geriatric institution
    • Shim, Y.S.; Yang, D.W. Depression as prognostic factor: 6 months follow-up in a geriatric institution. Arch. Gerontol. Geriatr., 2006, 43(2), 277-283.
    • (2006) Arch. Gerontol. Geriatr , vol.43 , Issue.2 , pp. 277-283
    • Shim, Y.S.1    Yang, D.W.2
  • 94
    • 33646923143 scopus 로고    scopus 로고
    • Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis
    • Ownby, R.L.; Crocco, E.; Acevedo, A.; John, V.; Loewenstein, D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch. Gen. Psychiatry, 2006, 63(5), 530-538.
    • (2006) Arch. Gen. Psychiatry , vol.63 , Issue.5 , pp. 530-538
    • Ownby, R.L.1    Crocco, E.2    Acevedo, A.3    John, V.4    Loewenstein, D.5
  • 95
    • 4043179916 scopus 로고    scopus 로고
    • Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: A prospective cohort study
    • Modrego, P.J.; Ferrández, J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. Arch. Neurol., 2004, 61(3), 1290-1293.
    • (2004) Arch. Neurol , vol.61 , Issue.3 , pp. 1290-1293
    • Modrego, P.J.1    Ferrández, J.2
  • 96
    • 77955635771 scopus 로고    scopus 로고
    • Effect of brainderived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment
    • Forlenza, O.V.; Diniz, B.S.; Teixeira, A.L.; Ojopi, E.B.; Talib, L.L.; Mendonça, V.A.; Izzo, G.; Gattaz, W.F. Effect of brainderived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment. World J. Biol. Psychiatry, 2010, 11(6), 774-780.
    • (2010) World J Biol. Psychiatry , vol.11 , Issue.6 , pp. 774-780
    • Forlenza, O.V.1    Diniz, B.S.2    Teixeira, A.L.3    Ojopi, E.B.4    Talib, L.L.5    Mendonça, V.A.6    Izzo, G.7    Gattaz, W.F.8
  • 100
    • 79956125839 scopus 로고    scopus 로고
    • Biomarkers in Alzheimer's disease drug development
    • Cummings, J.L. Biomarkers in Alzheimer's disease drug development. Alzheimers Dement., 2011, 7(3), e13-44.
    • (2011) Alzheimers Dement , vol.7 , Issue.3
    • Cummings, J.L.1
  • 102
    • 80053463292 scopus 로고    scopus 로고
    • Central insulin and insulin-like growth factor-1 signaling: Implications for diabetes associated dementia
    • Zemva, J.; Schubert, M. Central insulin and insulin-like growth factor-1 signaling: implications for diabetes associated dementia. Curr. Diabetes Rev., 2011, 7(5), 356-366.
    • (2011) Curr. Diabetes Rev , vol.7 , Issue.5 , pp. 356-366
    • Zemva, J.1    Schubert, M.2
  • 103
    • 80052024330 scopus 로고    scopus 로고
    • Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither
    • Zhuo, J.M.; Wang, H.; Praticò, D. Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol. Sci., 2011, 32(9), 562-571.
    • (2011) Trends Pharmacol. Sci , vol.32 , Issue.9 , pp. 562-571
    • Zhuo, J.M.1    Wang, H.2    Praticò, D.3
  • 106
    • 29144471908 scopus 로고    scopus 로고
    • Lithium: Potential therapeutics against acute brain injuries and chronic neurodegenerative diseases
    • Wada, A.; Yokoo, H.; Yanagita, T.; Kobayashi, H. Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases. J. Pharmacol. Sci., 2005, 99(4), 307-321.
    • (2005) J. Pharmacol. Sci , vol.99 , Issue.4 , pp. 307-321
    • Wada, A.1    Yokoo, H.2    Yanagita, T.3    Kobayashi, H.4
  • 108
    • 34147210411 scopus 로고    scopus 로고
    • Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder
    • Nunes, P.V.; Forlenza, O.V.; Gattaz, W.F. Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder. Br. J. Psychiatry, 2008, 190, 359-360.
    • (2008) Br. J. Psychiatry , vol.190 , pp. 359-360
    • Nunes, P.V.1    Forlenza, O.V.2    Gattaz, W.F.3
  • 109
    • 53949105460 scopus 로고    scopus 로고
    • Lithium may be useful in the prevention of Alzheimer's disease in individuals at risk of presenile familial Alzheimer's disease
    • Yeh, H.L.; Tsai, S.J. Lithium may be useful in the prevention of Alzheimer's disease in individuals at risk of presenile familial Alzheimer's disease. Med. Hypotheses, 2008, 71(6), 948-951.
    • (2008) Med. Hypotheses , vol.71 , Issue.6 , pp. 948-951
    • Yeh, H.L.1    Tsai, S.J.2
  • 110
    • 79955546563 scopus 로고    scopus 로고
    • Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: Randomised controlled trial
    • Forlenza, O.V.; Diniz, B.S.; Radanovic, M.; Santos, F.S.; Talib, L.L.; Gattaz, W.F. Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br. J. Psychiatry, 2011, 198(5), 351-356.
    • (2011) Br. J. Psychiatry , vol.198 , Issue.5 , pp. 351-356
    • Forlenza, O.V.1    Diniz, B.S.2    Radanovic, M.3    Santos, F.S.4    Talib, L.L.5    Gattaz, W.F.6
  • 111
    • 79951975389 scopus 로고    scopus 로고
    • Targeting group-II metabotropic glutamate receptors for the treatment of psychosis associated with Alzheimer's disease: Selective activation of mGlu2 receptors amplifies {beta}-amyloid toxicity in cultured neurons whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective
    • Caraci, F.; Molinaro, G.; Battaglia, G.; Giuffrida, M.L.; Riozzi, B.; Traficante, A.; Bruno, V.; Cannella, M.; Merlo, S.; Wang, X.; Heinz, B.A.; Nisenbaum, E.S.; Britton, T.C.; Drago, F.; Sortino, M.A.; Copani, A.; Nicoletti, F. Targeting group-II metabotropic glutamate receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies {beta}-amyloid toxicity in cultured neurons whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. Mol. Pharmacol., 2011, 79(3), 618-626.
    • (2011) Mol. Pharmacol , vol.79 , Issue.3 , pp. 618-626
    • Caraci, F.1    Molinaro, G.2    Battaglia, G.3    Giuffrida, M.L.4    Riozzi, B.5    Traficante, A.6    Bruno, V.7    Cannella, M.8    Merlo, S.9    Wang, X.10    Heinz, B.A.11    Nisenbaum, E.S.12    Britton, T.C.13    Drago, F.14    Sortino, M.A.15    Copani, A.16    Nicoletti, F.17
  • 113
    • 79955594301 scopus 로고    scopus 로고
    • A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia
    • and the HBBI Study Group
    • Kinon, B.J.; Zhang, L.; Millen, B.A.; Osuntokun, O.O.; Williams, J.E.; Kollack-Walker, S.; Jackson, K.; Kryzhanovskaya, L.; Jarkova, N.; and the HBBI Study Group. A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia. J. Clin. Psychopharmacol., 2011, 31(3), 349-355.
    • (2011) J. Clin. Psychopharmacol , vol.31 , Issue.3 , pp. 349-355
    • Kinon, B.J.1    Zhang, L.2    Millen, B.A.3    Osuntokun, O.O.4    Williams, J.E.5    Kollack-Walker, S.6    Jackson, K.7    Kryzhanovskaya, L.8    Jarkova, N.9
  • 116
    • 24644433745 scopus 로고    scopus 로고
    • Th1, Th2, and Th3 cytokine alterations in major depression
    • Myint, A.M.; Leonard, B.E.; Steinbusch, H.W.; Kim, Y.K. Th1, Th2, and Th3 cytokine alterations in major depression. J. Affect. Disord., 2005, 88(2), 167-173.
    • (2005) J. Affect. Disord , vol.88 , Issue.2 , pp. 167-173
    • Myint, A.M.1    Leonard, B.E.2    Steinbusch, H.W.3    Kim, Y.K.4
  • 117
    • 33745162262 scopus 로고    scopus 로고
    • The role of IL-12 and TGF-beta1 in the pathophysiology of major depressive Disorder
    • Lee, K.M.; Kim, Y.K. The role of IL-12 and TGF-beta1 in the pathophysiology of major depressive Disorder. Int. Immunopharmacol., 2006, 6(8), 1298-1304.
    • (2006) Int. Immunopharmacol , vol.6 , Issue.8 , pp. 1298-1304
    • Lee, K.M.1    Kim, Y.K.2
  • 119
    • 80053383804 scopus 로고    scopus 로고
    • Depression in dementia: Epidemiology, mechanisms, and treatment
    • Enache, D.; Winblad, B.; Aarsland, D. Depression in dementia: epidemiology, mechanisms, and treatment. Curr. Opin. Psychiatry, 2011, 24(6), 461-472.
    • (2011) Curr. Opin. Psychiatry , vol.24 , Issue.6 , pp. 461-472
    • Enache, D.1    Winblad, B.2    Aarsland, D.3


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