Adenoviral delivery of an antisense RNA complementary to the 3′ coding sequence of transforming growth factor-β1 inhibits fibrogenic activities of hepatic stellate cells

Cell Growth and Differentiation

Volumn 13, Issue 6, 2002, Pages 265-273

  Arias, Monica ^a   Lahme, Birgit ^a   Van de Leur, Eddy ^a   Gressner, Axel M ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; RNA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; ACTIVIN RECEPTOR 1; CARRIER PROTEIN; COMPLEMENTARY RNA; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN; SIGNAL PEPTIDE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, RAT; TGFB3 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROGENESIS; IMMUNOPRECIPITATION; LIVER CELL; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; STELLATE CELL; TRANSGENE; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECT; GENETICS; LIVER; LIVER CIRRHOSIS; METABOLISM; NORTHERN BLOTTING; OPEN READING FRAME; SOUTHERN BLOTTING; SPRAGUE DAWLEY RAT;

ACTIVIN RECEPTORS, TYPE I; ADENOVIRIDAE; ANIMAL; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; ENZYME-LINKED IMMUNOSORBENT ASSAY; LIVER; LIVER CIRRHOSIS; MALE; OPEN READING FRAMES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, ANTISENSE; RNA, COMPLEMENTARY; SUPPORT, NON-U.S. GOV'T; TRANSFORMING GROWTH FACTOR BETA; ANIMALS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LATENT TGF-BETA BINDING PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

EID: 0035989936     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Specificity, diversity, and regulation in TGF-β superfamily signaling
2. Transcriptional control by the TGF-β/Smad signaling system
3. Kopp fibrosis
4. TGF-β1 in liver fibrosis: An inducible transgenic mouse model to study liver fibrogenesis
5. Inhibition of rat hepatocyte proliferation by transforming growth factor β and glucagon is associated with inhibition of ERK2 and p70 S6 kinase
6. Regulation of cell cycle-related genes in rat hepatocytes by transforming growth factor β1
7. Negative regulation of cell growth by TGF β
8. Transforming growth factor-β1 modulates myofibroblastic phenotype of rat palatal fibroblasts in vitro
9. Transforming growth factor β1 induces the expression of a α1(I) procollagen mRNA by a hydrogen peroxide-C/EBP β-dependent mechanism in rat hepatic stellate cells
10. Roles of TGF-β in hepatic fibrosis
11. Modulation of α-smooth muscle actin expression in fibroblasts by transforming growth factor-β isoforms: An in vivo and in vitro study
12. Immunohistochemical detection of transforming growth factor-β1 in fibrotic liver diseases
13. Glutathione levels discriminate between oxidative stress and transforming growth factor-β signaling in activated rat hepatic stellate cells
14. A pilot study of the effects of d-α-tocopherol on hepatic stellate cell activation in chronic hepatitis C
15. Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells
16. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-β
17. Angiotensin-II type I receptor interaction is a major regulator for liver fibrosis development in rats
18. Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats
19. Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats
20. 2-Macroglobulin reduces paracrine- and autocrine-stimulated matrix synthesis of cultured rat hepatic stellate cells
21. Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease
22. Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats
23. Effects of TGF-β(1) antisense S-oligonucleotide on synthesis and accumulation of matrix proteoglycans in balloon catheter-injury neointima of rabbit carotid arteries
24. Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
25. A soluble transforming growth factor β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats
26. Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats
27. Bissell In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis
28. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
29. Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts
30. Gressner Biglycan and decorin gene expression in normal and fibrotic rat liver: Cellular localization and regulatory factors
31. Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis
32. Antisense RNA complementary to 3′ coding and noncoding sequences of creatine kinase is a potent inhibitor of translation in vivo. RNA block of translation
33. Characterization and regulation of insulin-like growth factor binding proteins in human hepatic stellate cells
34. Growth inhibition by insulin-like growth factor-binding protein-3 in T47D breast cancer cells requires transforming growth factor-β (TGF-β) and the type II TGF-β receptor
35. Signaling through the Smad pathway by insulin-like growth factor binding protein-3 in breast cancer cells: Relationship to transforming growth factor-β1 signaling
36. Preparation of isolated rat liver cells
37. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1
38. The synthesis of proteoglycans in fat-storing cells of rat liver
39. Kupffer cell-mediated induction of synthesis and secretion of proteoglycans by rat liver fat-storing cells in culture
40. Proliferation of fat-storing cells is stimulated by secretions of Kupffer cells from normal and injured liver
41. Upregulated expression of the receptor for advanced glycation end products (RAGE) in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts
42. Expression of isoforms and spice variants of the latent transforming growth factor binding protein (LTBP) in cultured human liver myofibroblasts
43. The expression and antigenicity identification of recombinant rat TGF-β1 in bacteria
44. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
45. A simple technique for the rescue of early region 1 mutations into infectious human adenovirus type 5
46. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)
47. Expression and matrix deposition of latent transforming growth factor β binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture