A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization

Clinical and Experimental Allergy

Volumn 41, Issue 12, 2011, Pages 1729-1739

  Abrahamsson, T R ^a   Sandberg Abelius, M ^a   Forsberg, A ^a   Bjorksten B ^b   Jenmalm, M C ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Chemokine; Day care; Eczema; Infant; Lactobacillus reuteri; Pregnancy; Probiotics; Sensitization; Skin prick test; Wheeze

Indexed keywords

CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE DERIVED CHEMOKINE; PLACEBO; PROBIOTIC AGENT; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ALLERGIC DISEASE; ARTICLE; BIRTH; CONTROLLED STUDY; DAY CARE; DOUBLE BLIND PROCEDURE; ECZEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES; FEMALE; HUMAN; IN VIVO STUDY; INFANCY; INFANT; LACTOBACILLUS REUTERI; MAJOR CLINICAL STUDY; MALE; NEWBORN; PREGNANCY; PRIORITY JOURNAL; SENSITIZATION; TH1 TH2 BALANCE; WHEEZING;

CHEMOKINES; CHILD, PRESCHOOL; ECZEMA; ENVIRONMENT; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; INFANT; INFANT, NEWBORN; KINETICS; MALE; NUTRITIONAL STATUS; PROBIOTICS; RESPIRATORY SOUNDS; TH1 CELLS; TH2 CELLS;

EID: 82155173521     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2011.03827.x     Document Type: Article

References (45)

1. Kondo N, Kobayashi Y, Shinoda Set al. Reduced interferon gamma production by antigen-stimulated cord blood mononuclear cells is a risk factor of allergic disorders 6-year follow-up study. Clin Exp Allergy 1998; 28:1340-4.
2. Böttcher MF, Björkstén B, Jenmalm MC.Immune response to birch in young children during their first 7 years of life. Clin Exp Allergy 2002; 32:1690-8.
3. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG.Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999; 353:196-200.
4. Yazdanbakhsh M, Kremsner PG, van Ree R.Allergy, parasites, and the hygiene hypothesis. Science 2002; 296:490-4.
5. Stene LC, Nafstad P.Relation between occurrence of type 1 diabetes and asthma. Lancet 2001; 357:607-8.
6. Sandberg M, Frykman A, Ernerudh Jet al. Cord blood cytokines and chemokines and development of allergic disease. Pediatr Allergy Immunol 2009; 20:519-27.
7. Pease JE, Williams TJ.Chemokines and their receptors in allergic disease. J Allergy Clin Immunol 2006; 118:305-18; quiz 319-320.
8. Fujisawa T, Fujisawa R, Kato Yet al. Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis. J Allergy Clin Immunol 2002; 110:139-46.
9. Jahnz-Rozyk K, Targowski T, Paluchowska E, Owczarek W, Kucharczyk A.Serum thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis. Allergy 2005; 60:685-8.
10. Kakinuma T, Nakamura K, Wakugawa Met al. Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis. Clin Exp Immunol 2002; 127:270-3.
11. Gunther C, Bello-Fernandez C, Kopp Tet al. CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. J Immunol 2005; 174:1723-8.
12. Hartl D, Griese M, Nicolai Tet al. Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough. J Allergy Clin Immunol 2005; 115:728-36.
13. de Nadai P, Charbonnier AS, Chenivesse Cet al. Involvement of CCL18 in allergic asthma. J Immunol 2006; 176:6286-93.
14. Pilette C, Francis JN, Till SJ, Durham SR.CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge. Eur Respir J 2004; 23:876-84.
15. Miotto D, Christodoulopoulos P, Olivenstein Ret al. Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases. J Allergy Clin Immunol 2001; 107:664-70.
16. Singh UP, Singh S, Iqbal N, Weaver CT, McGhee JR, Lillard JWJrIFN-gamma-inducible chemokines enhance adaptive immunity and colitis. J Interferon Cytokine Res 2003; 23:591-600.
17. Abrahamsson TR, Jakobsson T, Böttcher MFet al. Probiotics in prevention of IgE-associated eczema: a double blind randomised placebo-controlled trial. J Allergy Clin Immunol 2007; 119:1174-80.
18. Abrahamsson TR, Sinkiewicz G, Jakobsson T, Fredrikson M, Bjorksten B.Probiotic lactobacilli in breast milk and infant stool in relation to oral intake during the first year of life. J Pediatr Gastroenterol Nutr 2009; 49:349-54.
19. de Jager W, Prakken BJ, Bijlsma JW, Kuis W, Rijkers GT.Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies. J Immunol Methods 2005; 300:124-35.
20. Kakinuma T, Nakamura K, Wakugawa Met al. Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 2001; 107:535-41.
21. Bochner BS, Hudson SA, Xiao HQ, Liu MC.Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. J Allergy Clin Immunol 2003; 112:930-4.
22. Thomas MS, Kunkel SL, Lukacs NW.Differential role of IFN-gamma-inducible protein 10 kDa in a cockroach antigen-induced model of allergic airway hyperreactivity: systemic versus local effects. J Immunol 2002; 169:7045-53.
23. Tavernier G, Fletcher G, Gee Iet al. IPEADAM study: indoor endotoxin exposure, family status, and some housing characteristics in English children. J Allergy Clin Immunol 2006; 117:656-62.
24. Andrew DP, Chang MS, McNinch Jet al. STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13. J Immunol 1998; 161:5027-38.
25. Vulcano M, Struyf S, Scapini Pet al. Unique regulation of CCL18 production by maturing dendritic cells. J Immunol 2003; 170:3843-9.
26. Tiemessen MM, Jagger AL, Evans HG, van Herwijnen MJ, John S, Taams LSCD4+CD25+Foxp3+regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci U S A 2007; 104:19446-51.
27. Medoff BD, Seung E, Hong Set al. CD11b+myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J Immunol 2009; 182:623-35.
28. Meyer EH, Wurbel MA, Staton TLet al. iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. J Immunol 2007; 179:4661-7.
29. Mikhak Z, Fukui M, Farsidjani A, Medoff BD, Tager AM, Luster ADContribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation. J Allergy Clin Immunol 2009; 123:67-73.
30. Campbell JJ, Haraldsen G, Pan Jet al. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 1999; 400:776-80.
31. D'Ambrosio D, Albanesi C, Lang R, Girolomoni G, Sinigaglia F, Laudanna C.Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion. J Immunol 2002; 169:2303-12.
32. Penna G, Vulcano M, Roncari A, Facchetti F, Sozzani S, Adorini L.Cutting edge: differential chemokine production by myeloid and plasmacytoid dendritic cells. J Immunol 2002; 169:6673-6.
33. Megiovanni AM, Sanchez F, Gluckman JC, Rosenzwajg M.Double-stranded RNA stimulation or CD40 ligation of monocyte-derived dendritic cells as models to study their activation and maturation process. Eur Cytokine Netw 2004; 15:126-34.
34. Cole KE, Strick CA, Paradis TJet al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med 1998; 187:2009-21.
35. Polte T, Hennig C, Hansen G.Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma. J Allergy Clin Immunol 2008; 122:1022-30.
36. Mold JE, Michaelsson J, Burt TDet al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008; 322:1562-5.
37. Smits HH, Engering A, van der Kleij Det al. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 2005; 115:1260-7.
38. Karimi K, Inman MD, Bienenstock J, Forsythe P.Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice. Am J Respir Crit Care Med 2009; 179:186-93.
39. Saito S, Nakashima A, Shima T, Ito M.Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010; 63:601-10.
40. Prescott SL, Macaubas C, Holt BJet al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 1998; 160:4730-7.
41. PrabhuDas M, Adkins B, Gans Het al. Challenges in infant immunity: implications for responses to infection and vaccines. Nat Immunol 12:189-94.
42. Halonen M, Lohman IC, Stern DAet al. Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort. J Immunol 2009; 182:3285-93.
43. Romagnani S. Coming back to a missing immune deviation as the main explanatory mechanism for the hygiene hypothesis. J Allergy Clin Immunol 2007; 119:1511-3.
44. Krämer J, Heinrich J, Wjst M, Wichmann HE.Age of entry to day nursery and allergy in later childhood. The Lancet 1998; 353:450-2.
45. Dwinell MB, Lugering N, Eckmann L, Kagnoff MF.Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. Gastroenterology 2001; 120:49-59.