A novel model of continuous depletion of glutathione in mice treated with L-Buthionine (S,R)-sulfoximine

Journal of Toxicological Sciences

Volumn 28, Issue 5, 2003, Pages 455-469

  Watanabe, Toshiyuki ^a   Sagisaka, Hideki ^a   Arakawa, Shingo ^a   Shibaya, Yukari ^a   Watanabe, Mayumi ^a   Igarashi, Isao ^a   Tanaka, Kohji ^a   Totsuka, Shigeo ^a   Takasaki, Wataru ^a   Manabe, Sunao ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Acetaminophen; Glutathione depletion; Idiosyncrasy; L Buthionine (S,R) sulfoximine; Liver; Reactive intermediate

Indexed keywords

BUTHIONINE SULFOXIMINE; CYTOCHROME P450; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PARACETAMOL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER TOXICITY; MODEL; MOUSE; NONHUMAN; TOXICOKINETICS;

ANIMALIA;

EID: 1642472658     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.28.455     Document Type: Article

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