Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness

Journal of Psychiatry and Neuroscience

Volumn 35, Issue 5, 2010, Pages 296-302

  Che, Yi ^a   Wang, Jun Feng ^b   Shao, Li ^b   Young, L Trevor ^b  

^a SOOCHOW UNIVERSITY   (Taiwan)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA;

ADULT; AGED; BIPOLAR DISORDER; CYTOPLASM; DENTATE GYRUS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENETIC DAMAGE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR DEPRESSION; MALE; OXIDATIVE STRESS; REVIEW; SCHIZOPHRENIA;

EID: 77956549615     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: 10.1503/jpn.090083     Document Type: Review

References (43)

1. Henchcliffe C, Beal MF. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol 2008;4:600-9.
2. Nunomura A, Moreira PI, Lee HG, et al. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol Disord Drug Targets 2007;6:411-23.
3. Kuloglu M, Ustundag B, Atmaca M, et al. Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder. Cell Biochem Funct 2002;20:171-5.
4. Ranjekar PK, Hinge A, Hegde MV, et al. Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry Res 2003;121:109-22.
5. Benes FM, Matzilevich D, Burke RE, et al. The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia. Mol Psychiatry 2006;11:241-51.
6. Yao JK, Leonard S, Reddy RD. Altered glutathione redox state in schizophrenia. Dis Markers 2006;22:83-93.
7. Yao JK, Leonard S, Reddy RD. Increased nitric oxide radicals in postmortem brain from patients with schizophrenia. Schizophr Bull 2004;30:923-34.
8. Shao L, Young LT, Wang JF. Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells. Biol Psychiatry 2005;58:879-84.
9. Cui J, Shao L, Young LT, et al. Role of glutathione in neuro - protective effects of mood stabilizing drugs lithium and valproate. Neuro science 2007;144:1447-53.
10. Wang JF, Shao L, Sun X, et al. Glutathione S-transferase is a novel target for mood stabilizing drugs in primary cultured neurons. J Neurochem 2004;88:1477-84.
11. Shao L, Cui J, Young LT, et al. The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Neuroscience 2008;151:518-24.
12. Wei Z, Bai O, Richardson JS, et al. Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide. J Neurosci Res 2003;73:364-8.
13. Wang H, Xu H, Dyck LE, et al. Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide(25-35)-induced oxidative stress and the ensuing apoptosis. J Neurosci Res 2005;81:572-80.
14. Frey BN, Valvassori SS, Reus GZ, et al. Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychiatry Neurosci 2006;31:326-32.
15. Frey BN, Andreazza AC, Kunz M, et al. Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:283-5.
16. Wang JF, Shao L, Sun X, et al. Increased oxidative stress in anterior cingulate cortex of subjects with bipolar disorder and schizophrenia. Bipolar Disord 2009;11:523-9.
17. Andreazza AC, Shao L, Wang JF, et al. Mitochondrial complex activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Arch Gen Psychiatry 2010;67:360-8.
18. Papez JW. A proposed mechanism of emotion. Arch Neurol Psychiatry 1937;38:725-43.
19. Beyer JL, Krishnan KR. Volumetric brain imaging findings in mood disorders. Bipolar Disord 2002;4:89-104.
20. Harrison PJ. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology (Berl) 2004;174:151-62.
21. Dowlatshahi D, MacQueen G, Wang JF, et al. G protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. J Neurochem 1999;73:1121-6.
22. Knable MB, Barci BM, Webster MJ, et al.; Stanley Neuropathology Consortium. Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 2004;9:609-20.
23. Brégeon D, Sarasin A. Hypothetical role of RNA damage avoidance in preventing human disease. Mutat Res 2005;577:293-302.
24. Li Z, Wu J, Deleo CJ. RNA damage and surveillance under oxidative stress. IUBMB Life 2006;58:581-8.
25. Nunomura A, Hofer T, Moreira PI, et al. RNA oxidation in Alzheimer disease and related neurodegenerative disorders. Acta Neuropathol 2009;118:151-66.
26. Shan X, Tashiro H, Lin CL. The identification and characterization of oxidized RNAs in Alzheimer's disease. J Neurosci 2003;23:4913-21.
27. Kong Q, Shan X, Chang Y, et al. RNA oxidation: a contributing factor or an epiphenomenon in the process of neurodegeneration. Free Radic Res 2008;42:773-7.
28. Beasley CL, Pennington K, Behan A, et al. Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes. Proteomics 2006;6:3414-25.
29. Pennington K, Beasley CL, Dicker P, et al. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry 2008;13:1102-17.
30. Prabakaran S, Swatton JE, Ryan MM, et al. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry 2004;9:684-97.
31. Martins-de-Souza D, Gattaz WF, Schmitt A, et al. Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. J Neural Transm 2009;116:275-89.
32. Kato T, Shioiri T, Murashita J, et al. Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded 31P-MRS. Psychol Med 1995;25:557-66.
33. Deicken RF, Fein G, Weiner MW. Abnormal frontal lobe phosphorous metabolism in bipolar disorder. Am J Psychiatry 1995;152:915-8.
34. Volz HP, Rzanny R, Riehemann S, et al. 31P magnetic resonance spectroscopy in the frontal lobe of major depressed patients. Eur Arch Psychiatry Clin Neurosci 1998;248:289-95.
35. Moore CM, Christensen JD, Lafer B, et al. Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study. Am J Psychiatry 1997;154:116-8.
36. Kung L, Roberts RC. Mitochondrial pathology in human schizophrenic striatum: a post-mortem ultrastructural study. Synapse 1999;31:67-75.
37. Gardner A, Johansson A, Wibom R, et al. Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients. J Affect Disord 2003;76:55-68.
38. Regenold WT, Phatak P, Marano CM, et al. Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis. Biol Psychiatry 2009;65:489-94.
39. Munakata K, Tanaka M, Mori K, et al. Mitochondrial DNA 3644T to C mutation associated with bipolar disorder. Genomics 2004;84:1041-50.
40. Sun X, Wang JF, Tseng M, et al. Down regulation in components of mitochondrial electron transport chain in post-mortem frontal cortex from subjects with bipolar disorder. J Psychiatry Neurosci 2006; 31:189-96.
41. Konradi C, Eaton M, MacDonald ML, et al. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry 2004;61:300-8.
42. Adam-Vizi V. Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and nonelectron transport chain sources. Antioxid Redox Signal 2005;7:1140-9.
43. Meyer JH, Ginovart N, Boovariwala A, et al. Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry 2006;63:1209-16.