메뉴 건너뛰기




Volumn 18, Issue 2, 2013, Pages 1704-1719

Chemical genetics of acetyl-CoA carboxylases

Author keywords

ACC chemical genetics; ACC inhibitors; Acetyl CoA carboxylase; Cancer therapy; Fatty acid biosynthesis

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ENZYME INHIBITOR;

EID: 84874609819     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18021704     Document Type: Review
Times cited : (39)

References (113)
  • 1
    • 18144396604 scopus 로고    scopus 로고
    • Treating the meytabolic syndrome: Acetyl-CoA carboxylase inhibition
    • DOI 10.1517/14728222.9.2.267
    • Harwood, H.J., Jr. Treating the metabolic syndrome: Acetyl-CoA carboxylase inhibition. Expert Opin. Ther. Targets 2005, 9, 267-281. (Pubitemid 40613868)
    • (2005) Expert Opinion on Therapeutic Targets , vol.9 , Issue.2 , pp. 267-281
    • Harwood Jr., H.J.1
  • 3
    • 22144496594 scopus 로고    scopus 로고
    • Why Syndrome X? From Harold Himsworth to the insulin resistance syndrome
    • DOI 10.1016/j.cmet.2004.12.001, PII S1550413104000075
    • Reaven, G.M. Why Syndrome X? From Harold Himsworth to the insulin resistance syndrome. Cell Metab. 2005, 1, 9-14. (Pubitemid 43960585)
    • (2005) Cell Metabolism , vol.1 , Issue.1 , pp. 9-14
    • Reaven, G.M.1
  • 4
    • 0030795278 scopus 로고    scopus 로고
    • Regulation of mammalian acetyl-coenzyme A carboxylase
    • Kim, K.H. Regulation of mammalian acetyl-coenzyme A carboxylase. Annu. Rev. Nutr. 1997, 17, 77-99.
    • (1997) Annu. Rev. Nutr. , vol.17 , pp. 77-99
    • Kim, K.H.1
  • 5
    • 23944509003 scopus 로고    scopus 로고
    • Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery
    • DOI 10.1007/s00018-005-5121-4
    • Tong, L. Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery. Cell. Mol. Life Sci. 2005, 62, 1784-1803. (Pubitemid 41188519)
    • (2005) Cellular and Molecular Life Sciences , vol.62 , Issue.16 , pp. 1784-1803
    • Tong, L.1
  • 6
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • DOI 10.1074/jbc.R200008200
    • Hannun, Y.A.; Obeid, L.M. The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 2002, 277, 25847-25850. (Pubitemid 34967060)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.29 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 7
    • 33751579134 scopus 로고    scopus 로고
    • Acetyl-coenzyme A carboxylases: Versatile targets for drug discovery
    • DOI 10.1002/jcb.21077
    • Tong, L.; Harwood, H.J., Jr. Acetyl-coenzyme A carboxylases: Versatile targets for drug discovery. J. Cell Biochem. 2006, 99, 1476-1488. (Pubitemid 44845709)
    • (2006) Journal of Cellular Biochemistry , vol.99 , Issue.6 , pp. 1476-1488
    • Tong, L.1    Harwood Jr., H.J.2
  • 8
    • 0000449348 scopus 로고
    • Ribbon models of macromoleculars
    • Carson, M. Ribbon models of macromoleculars. J. Mol. Graph. 1987, 5, 103-106.
    • (1987) J. Mol. Graph. , vol.5 , pp. 103-106
    • Carson, M.1
  • 10
    • 0031467818 scopus 로고    scopus 로고
    • A diverse superfamily of enzymes with ATP-dependent carboxylate- amine/thiol ligase activity
    • Galperin, M.Y.; Koonin, E.V. A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. Protein Sci. 1997, 6, 2639-2643. (Pubitemid 28006703)
    • (1997) Protein Science , vol.6 , Issue.12 , pp. 2639-2643
    • Galperin, M.Y.1    Koonin, E.V.2
  • 11
    • 0034717247 scopus 로고    scopus 로고
    • Movement of the biotin carboxylase B-domain as a result of ATP binding
    • DOI 10.1074/jbc.275.21.16183
    • Thoden, J.B.; Blanchard, C.Z.; Holden, H.M.; Waldrop, G.L. Movement of the biotin carboxylase B-domain as a result of ATP binding. J. Biol. Chem. 2000, 275, 16183-16190. (Pubitemid 30366930)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.21 , pp. 16183-16190
    • Thoden, J.B.1    Blanchard, C.Z.2    Holden, H.M.3    Waldrop, G.L.4
  • 12
    • 0028085434 scopus 로고
    • Three-dimensional structure of the biotin carboxylase subunit of acetyl- CoA carboxylase
    • Waldrop, G.L.; Rayment, I.; Holden, H.M. Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase. Biochemistry 1994, 33, 10249-10256. (Pubitemid 24281789)
    • (1994) Biochemistry , vol.33 , Issue.34 , pp. 10249-10256
    • Waldrop, G.L.1    Rayment, I.2    Holden, H.M.3
  • 13
    • 0037470947 scopus 로고    scopus 로고
    • Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase
    • DOI 10.1126/science.1081366
    • Zhang, H.; Yang, Z.; Shen, Y.; Tong, L. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science 2003, 299, 2064-2067. (Pubitemid 36383732)
    • (2003) Science , vol.299 , Issue.5615 , pp. 2064-2067
    • Zhang, H.1    Yang, Z.2    Shen, Y.3    Tong, L.4
  • 14
    • 0015524195 scopus 로고
    • Acetyl coenzyme A carboxylase. Molecular forms and subunit composition of biotin carboxyl carrier protein
    • Fall, R.R.; Vagelos, P.R. Acetyl coenzyme A carboxylase. Molecular forms and subunit composition of biotin carboxyl carrier protein. J. Biol. Chem. 1972, 247, 8005-8015.
    • (1972) J. Biol. Chem. , vol.247 , pp. 8005-8015
    • Fall, R.R.1    Vagelos, P.R.2
  • 15
    • 0029986466 scopus 로고    scopus 로고
    • Purification and characterization of intact and truncated forms of the Escherichia coli biotin carboxyl carrier subunit of acetyl-CoA carboxylase
    • DOI 10.1074/jbc.271.13.7559
    • Nenortas, E.; Beckett, D. Purification and characterization of intact and truncated forms of the Escherichia coli biotin carboxyl carrier subunit of acetyl-CoA carboxylase. J. Biol. Chem. 1996, 271, 7559-7567. (Pubitemid 26107032)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.13 , pp. 7559-7567
    • Nenortas, E.1    Beckett, D.2
  • 17
    • 0005906807 scopus 로고
    • Requirement for a malonyl CoA-CO2 exchange reaction in long chain but not short chain fatty acid synthesis in Clostridium Kluvveri
    • Goldman, P.; Alberts, A.W.; Vagelos, P.R. Requirement for a malonyl CoA-CO2 exchange reaction in long chain but not short chain fatty acid synthesis in Clostridium Kluvveri. Biochem. Biophys. Res. Commun. 1961, 5, 280-285.
    • (1961) Biochem. Biophys. Res. Commun. , vol.5 , pp. 280-285
    • Goldman, P.1    Alberts, A.W.2    Vagelos, P.R.3
  • 18
    • 0014422474 scopus 로고
    • On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA
    • Seubert, W.; Lamberts, I.; Kramer, R.; Ohly, B. On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA. Biochim. Biophys. Acta 1968, 164, 498-517.
    • (1968) Biochim. Biophys. Acta , vol.164 , pp. 498-517
    • Seubert, W.1    Lamberts, I.2    Kramer, R.3    Ohly, B.4
  • 19
    • 0030767942 scopus 로고    scopus 로고
    • Broad specificity of carnitine palmitoyltransferase II towards long-chain acyl-CoA β-oxidation intermediates and its practical approach to the synthesis of various long-chain acylcarnitines
    • DOI 10.1023/A:1005315003913
    • Ventura, F.V.; Costa, C.G.; Ijist, L.; Dorland, L.; Duran, M.; Jakobs, C.; Tavares de Almeida, I.; Wanders, R.J.A. Broad specificity of carnitine palmitoyltransferase II towards long-chain acyl-CoA beta-oxidation intermediates and its practical approach to the synthesis of various long-chain acylcarnitines. J. Inherit. Metab. Dis. 1997, 20, 423-426. (Pubitemid 27354632)
    • (1997) Journal of Inherited Metabolic Disease , vol.20 , Issue.3 , pp. 423-426
    • Ventura, F.V.1    Costa, C.G.2    Ijlst, L.3    Dorland, L.4    Duran, M.5    Jakobs, C.6    Tavares De Almeida, I.7    Wanders, R.J.A.8
  • 20
    • 0037163047 scopus 로고    scopus 로고
    • Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2)
    • DOI 10.1074/jbc.M203263200
    • Diacovich, L.; Peiru, S.; Kurth, D.; Rodriguez, E.; Podesta, F.; Khosla, C.; Gramajo, H. Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2). J. Biol. Chem. 2002, 277, 31228-31236. (Pubitemid 34970830)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.34 , pp. 31228-31236
    • Diacovich, L.1    Peiru, S.2    Kurth, D.3    Rodriguez, E.4    Podesta, F.5    Khosla, C.6    Gramajo, H.7
  • 21
    • 0035951861 scopus 로고    scopus 로고
    • Cloning of human acetyl-CoA carboxylase beta promoter and its regulation by muscle regulatory factors
    • Lee, J.J.; Moon, Y.A.; Ha, J.H.; Yoon, D.J.; Ahn, Y.H.; Kim, K.S. Cloning of human acetyl-CoA carboxylase beta promoter and its regulation by muscle regulatory factors. J. Biol. Chem. 2001, 276, 2576-2585.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2576-2585
    • Lee, J.J.1    Moon, Y.A.2    Ha, J.H.3    Yoon, D.J.4    Ahn, Y.H.5    Kim, K.S.6
  • 22
    • 0037119410 scopus 로고    scopus 로고
    • Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis
    • DOI 10.1074/jbc.M203813200
    • Atkinson, L.L.; Fischer, M.A.; Lopaschuk, G.D. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl- CoA axis. J. Biol. Chem. 2002, 277, 29424-29430. (Pubitemid 41079226)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.33 , pp. 29424-29430
    • Atkinson, L.L.1    Fischer, M.A.2    Lopaschuk, G.D.3
  • 23
    • 0036711553 scopus 로고    scopus 로고
    • New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: A role for the transcription factor sterol regulatory element binding protein-1c
    • DOI 10.1042/BJ20020430
    • Foufelle, F.; Ferre, P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: A role for the transcription factor sterol regulatory element binding protein-1c. Biochem. J. 2002, 366, 377-391. (Pubitemid 35001682)
    • (2002) Biochemical Journal , vol.366 , Issue.2 , pp. 377-391
    • Foufelle, F.1    Ferre, P.2
  • 24
    • 0043210499 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver
    • Oh, S.Y.; Park, S.K.; Kim, J.W.; Ahn, Y.H.; Park, S.W.; Kim, K.S. Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver. J. Biol. Chem. 2003, 278, 28410-28417.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28410-28417
    • Oh, S.Y.1    Park, S.K.2    Kim, J.W.3    Ahn, Y.H.4    Park, S.W.5    Kim, K.S.6
  • 25
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: Master regulators of lipid homeostasis
    • DOI 10.1016/j.biochi.2004.09.018, PII S0300908404001658, Recent Advances in Lipid Metabolism and Related Disorders
    • Eberle, D.; Hegarty, B.; Bossard, P.; Ferre, P.; Foufelle, F. SREBP transcription factors: Master regulators of lipid homeostasis. Biochimie 2004, 86, 839-848. (Pubitemid 39602764)
    • (2004) Biochimie , vol.86 , Issue.11 , pp. 839-848
    • Eberle, D.1    Hegarty, B.2    Bossard, P.3    Ferre, P.4    Foufelle, F.5
  • 27
    • 70349904455 scopus 로고    scopus 로고
    • Dietary supplementation with alpha-amylase inhibitor wheat albumin to high-fat diet-induced insulinresistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose tissue
    • Murayama, Y.; Mochizuki, K.; Shimada, M.; Fujimoto, S.; Nukui, K.; Shibata, K. Dietary supplementation with alpha-amylase inhibitor wheat albumin to high-fat diet-induced insulinresistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose tissue. J. Agric. Food Chem. 2009, 57, 9332-9338.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 9332-9338
    • Murayama, Y.1    Mochizuki, K.2    Shimada, M.3    Fujimoto, S.4    Nukui, K.5    Shibata, K.6
  • 28
    • 34548814981 scopus 로고    scopus 로고
    • Up-regulation of acetyl-CoA carboxylase α and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    • DOI 10.1074/jbc.M702854200
    • Yoon, S.; Lee, M.Y.; Park, S.W.; Moon, J.S.; Koh, Y.K.; Ahn, Y.H.; Park, B.W.; Kim, K.S. Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J. Biol. Chem. 2007, 282, 26122-26131. (Pubitemid 47443806)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.36 , pp. 26122-26131
    • Yoon, S.1    Lee, M.-Y.2    Park, S.W.3    Moon, J.-S.4    Koh, Y.-K.5    Ahn, Y.-H.6    Park, B.-W.7    Kim, K.-S.8
  • 30
    • 15444372255 scopus 로고    scopus 로고
    • Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase
    • DOI 10.1152/japplphysiol.00621.2004
    • Rubink, D.S.; Winder, W.W. Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase. J. Appl. Physiol. 2005, 98, 1221-1227. (Pubitemid 40396493)
    • (2005) Journal of Applied Physiology , vol.98 , Issue.4 , pp. 1221-1227
    • Rubink, D.S.1    Winder, W.W.2
  • 31
    • 0026604926 scopus 로고
    • Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase
    • Hardie, D.G. Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase. Biochim. Biophys. Acta 1992, 1123, 231-238.
    • (1992) Biochim. Biophys. Acta , vol.1123 , pp. 231-238
    • Hardie, D.G.1
  • 32
    • 0036863086 scopus 로고    scopus 로고
    • Regulation of mammalian acetyl-CoA carboxylase
    • DOI 10.1042/BST0301059
    • Munday, M.R. Regulation of mammalian acetyl-CoA carboxylase. Biochem. Soc. Trans. 2002, 30, 1059-1064. (Pubitemid 36002406)
    • (2002) Biochemical Society Transactions , vol.30 , Issue.6 , pp. 1059-1064
    • Munday, M.R.1
  • 34
    • 0037015671 scopus 로고    scopus 로고
    • BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains
    • DOI 10.1038/sj.onc.1205915
    • Magnard, C.; Bachelier, R.; Vincent, A.; Jaquinod, M.; Kieffer, S.; Lenoir, G.M.; Venezia, N.D. BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. Oncogene 2002, 21, 6729-6739. (Pubitemid 35221915)
    • (2002) Oncogene , vol.21 , Issue.44 , pp. 6729-6739
    • Magnard, C.1    Bachelier, R.2    Vincent, A.3    Jaquinod, M.4    Kieffer, S.5    Lenoir, G.M.6    Dalla Venezia, N.7
  • 35
    • 44349121896 scopus 로고    scopus 로고
    • Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1
    • DOI 10.1021/bi800314m
    • Shen, Y.; Tong, L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry 2008, 47, 5767-5773. (Pubitemid 351747055)
    • (2008) Biochemistry , vol.47 , Issue.21 , pp. 5767-5773
    • Shen, Y.1    Tong, L.2
  • 36
    • 0037027299 scopus 로고    scopus 로고
    • Preclinical developments in type 2 diabetes
    • DOI 10.1016/S0169-409X(02)00092-3, PII S0169409X02000923
    • Lenhard, J.M.; Gottschalk, W.K. Preclinical developments in type 2 diabetes. Adv. Drug. Deliv. Rev. 2002, 54, 1199-1212. (Pubitemid 35230001)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.9 , pp. 1199-1212
    • Lenhard, J.M.1    Gottschalk, W.K.2
  • 37
    • 3042619469 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome
    • Harwood, H.J., Jr. Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome. Curr. Opin. Investig. Drugs. 2004, 5, 283-289.
    • (2004) Curr. Opin. Investig. Drugs. , vol.5 , pp. 283-289
    • Harwood Jr., H.J.1
  • 40
    • 0029016886 scopus 로고
    • Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta, beta'- tetramethylhexadecanedioic acid (MEDICA 16)
    • Russell, J.C.; Amy, R.M.; Graham, S.E.; Dolphin, P.J.; Wood, G.O.; Bar-Tana, J. Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta, beta'- tetramethylhexadecanedioic acid (MEDICA 16). Arterioscler Thromb. Vasc. Biol. 1995, 15, 918-923.
    • (1995) Arterioscler Thromb. Vasc. Biol. , vol.15 , pp. 918-923
    • Russell, J.C.1    Amy, R.M.2    Graham, S.E.3    Dolphin, P.J.4    Wood, G.O.5    Bar-Tana, J.6
  • 41
    • 0024205501 scopus 로고
    • Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of β,β'-methyl-substituted hexadecanedioic acid in sand rats
    • Tzur, R.; Rose-Kahn, G.; Adler, J.H.; Bar-Tana, J. Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of beta,beta'-methyl- substituted hexadecanedioic acid in sand rats. Diabetes 1988, 37, 1618-1624. (Pubitemid 19004943)
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1618-1624
    • Tzur, R.1    Rose-Kahn, G.2    Adler, J.H.3    Bar-Tana, J.4
  • 43
    • 0034970149 scopus 로고    scopus 로고
    • The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: Metabolism and metabolic effects
    • DOI 10.1016/S0163-7827(01)00004-2, PII S0163782701000042
    • Bremer, J. The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: Metabolism and metabolic effects. Prog. Lipid. Res. 2001, 40, 231-268. (Pubitemid 32544958)
    • (2001) Progress in Lipid Research , vol.40 , Issue.4 , pp. 231-268
    • Bremer, J.1
  • 44
    • 0035970805 scopus 로고    scopus 로고
    • Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-coa carboxylase 2
    • DOI 10.1126/science.1056843
    • Abu-Elheiga, L.; Matzuk, M.M.; Abo-Hashema, K.A.; Wakil, S.J. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 2001, 291, 2613-2616. (Pubitemid 32249687)
    • (2001) Science , vol.291 , Issue.5513 , pp. 2613-2616
    • Abu-Elheiga, L.1    Matzuk, M.M.2    Abo-Hashema, K.A.H.3    Wakil, S.J.4
  • 46
    • 0019332410 scopus 로고
    • Interaction of the fluorescent analogue stearoyl-(1,N6)-etheno coenzyme A with chicken liver acetyl coenzyme A carboxylase
    • Sreekrishna, K.; Gunsberg, S; Wakil, S.J.; Joshi, V.C. Interaction of the fluorescent analogue stearoyl-(1,N6)-etheno coenzyme A with chicken liver acetyl coenzyme A carboxylase. J. Biol. Chem. 1980, 255, 3348-3351.
    • (1980) J. Biol. Chem. , vol.255 , pp. 3348-3351
    • Sreekrishna, K.1    Gunsberg, S.2    Wakil, S.J.3    Joshi, V.C.4
  • 48
    • 0017879460 scopus 로고
    • Inhibition of rat-liver acetyl-coenzyme-a carboxylase by palmitoyl-coenzyme A. Formation of equimolar enzyme-inhibitor complex
    • Ogiwara, H.; Tanabe, T.; Nikawa, J.; Numa, S. Inhibition of rat-liver acetyl-coenzyme-A carboxylase by palmitoyl-coenzyme A. Formation of equimolar enzyme-inhibitor complex. Eur. J. Biochem. 1978, 89, 33-41. (Pubitemid 8402075)
    • (1978) European Journal of Biochemistry , vol.89 , Issue.1 , pp. 33-41
    • Ogiwara, H.1    Tanabe, T.2    Nikawa, J.3    Numa, S.4
  • 50
    • 0018791593 scopus 로고
    • Inhibitory effects of long-chain acyl coenzyme A analogues on rat liver acetyl coenzyme A carboxylase
    • Nikawa, J.; Tanabe, T.; Ogiwara, H.; Shiba, T.; Numa, S. Inhibitory effects of long-chain acyl coenzyme A analogues on rat liver acetyl coenzyme A carboxylase. FEBS Lett. 1979, 102, 223-226.
    • (1979) FEBS Lett. , vol.102 , pp. 223-226
    • Nikawa, J.1    Tanabe, T.2    Ogiwara, H.3    Shiba, T.4    Numa, S.5
  • 52
    • 2642679232 scopus 로고    scopus 로고
    • Identification and characterization of a novel human aldose reductase- like gene
    • DOI 10.1074/jbc.273.19.11429
    • Cao, D.; Fan, S.T.; Chung, S.S. Identification and characterization of a novel human aldose reductase-like gene. J. Biol. Chem. 1998, 273, 11429-11435. (Pubitemid 28272034)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.19 , pp. 11429-11435
    • Cao, D.1    Fan, S.T.2    Chung, S.S.M.3
  • 53
    • 34447573861 scopus 로고    scopus 로고
    • Reduced 293T cell susceptibility to acrolein due to aldose reductase-like-1 protein expression
    • DOI 10.1093/toxsci/kfm033
    • Zu, X; Yan, R.; Robbins, S.; Krishack, P.A.; Liao, D.F.; Cao, D. Reduced 293T cell susceptibility to acrolein due to aldose reductase-like-1 protein expression. Toxicol. Sci. 2007, 97, 562-568. (Pubitemid 47073870)
    • (2007) Toxicological Sciences , vol.97 , Issue.2 , pp. 562-568
    • Zu, X.1    Yan, R.2    Robbins, S.3    Krishack, P.A.4    Liao, D.-F.5    Cao, D.6
  • 54
    • 35348887886 scopus 로고    scopus 로고
    • Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention
    • DOI 10.1002/ijc.22933
    • Yan, R.; Zu, X.; Ma, J.; Liu, Z; Adeyanju, M.; Cao, D. Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. Int. J. Cancer 2007, 121, 2301-2306. (Pubitemid 47585613)
    • (2007) International Journal of Cancer , vol.121 , Issue.10 , pp. 2301-2306
    • Yan, R.1    Zu, X.2    Ma, J.3    Liu, Z.4    Adeyanju, M.5    Cao, D.6
  • 55
    • 84864151893 scopus 로고    scopus 로고
    • AKR1B10 overexpression in breast cancer: Association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker
    • Ma, J.; Luo, D.X.; Huang, C.; Shen, Y.; Bu, Y.; Markwell, S.; Gao, J.; Liu, J.; Zu, X.; Cao, Z.; et al. AKR1B10 overexpression in breast cancer: association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker. Int. J. Cancer 2012, 131, E862-E871.
    • (2012) Int. J. Cancer , vol.131
    • Ma, J.1    Luo, D.X.2    Huang, C.3    Shen, Y.4    Bu, Y.5    Markwell, S.6    Gao, J.7    Liu, J.8    Zu, X.9    Cao, Z.10
  • 56
    • 70350371727 scopus 로고    scopus 로고
    • Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls
    • Wang, C.; Yan, R.; Luo, D.; Watabe, K.; Liao, D.F.; Cao, D. Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls. J. Biol. Chem. 2009, 284, 26742-26748.
    • (2009) J. Biol. Chem. , vol.284 , pp. 26742-26748
    • Wang, C.1    Yan, R.2    Luo, D.3    Watabe, K.4    Liao, D.F.5    Cao, D.6
  • 57
    • 41249090769 scopus 로고    scopus 로고
    • Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells
    • Ma, J.; Yan, R.; Zu, X.; Cheng, J.M.; Rao, K.; Liao, DF.; Cao, D. Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. J. Biol. Chem. 2008, 283, 3418-3423.
    • (2008) J. Biol. Chem. , vol.283 , pp. 3418-3423
    • Ma, J.1    Yan, R.2    Zu, X.3    Cheng, J.M.4    Rao, K.5    Liao, D.F.6    Cao, D.7
  • 58
    • 0028154083 scopus 로고
    • The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (Myxobacteria): I - Soraphen A(1α): Fermentation, isolation, biological properties
    • Gerth, K.; Bedorf, N.; Irschik, H.; Hofle, G.; Reichenbach, H. The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (Myxobacteria). I. Soraphen A1 alpha: fermentation, isolation, biological properties. J. Antibiot. (Tokyo) 1994, 47, 23-31. (Pubitemid 24045521)
    • (1994) Journal of Antibiotics , vol.47 , Issue.1 , pp. 23-31
    • Gerth, K.1    Bedorf, N.2    Irschik, H.3    Hofle, G.4    Reichenbach, H.5
  • 59
    • 0142164488 scopus 로고    scopus 로고
    • Myxobacteria: Proficient producers of novel natural products with various biological activities - Past and future biotechnological aspects with the focus on the genus Sorangium
    • DOI 10.1016/j.jbiotec.2003.07.015
    • Gerth, K.; Pradella, S.; Perlova, O.; Beyer, S.; Muller, R. Myxobacteria: Proficient producers of novel natural products with various biological activities - Past and future biotechnological aspects with the focus on the genus Sorangium. J. Biotechnol. 2003, 106, 233-253. (Pubitemid 37494861)
    • (2003) Journal of Biotechnology , vol.106 , Issue.2-3 , pp. 233-253
    • Gerth, K.1    Pradella, S.2    Perlova, O.3    Beyer, S.4    Muller, R.5
  • 61
    • 79551480612 scopus 로고    scopus 로고
    • Soraphen A an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation
    • Jump, D.B.; Torres-Gonzalez, M.; Olson, L.K. Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem. Pharmacol. 2011, 81, 649-660.
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 649-660
    • Jump, D.B.1    Torres-Gonzalez, M.2    Olson, L.K.3
  • 62
    • 70349774650 scopus 로고    scopus 로고
    • Soraphen an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet
    • Schreurs, M.; van Dijk, T.H.; Gerding, A; Havinga, R.; Reijngoud, D.J.; Kuipers. F. Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet. Diabetes Obes. Metable. 2009, 11, 987-991.
    • (2009) Diabetes Obes. Metable. , vol.11 , pp. 987-991
    • Schreurs, M.1    Van Dijk, T.H.2    Gerding, A.3    Havinga, R.4    Reijngoud, D.J.5    Kuipers, F.6
  • 63
    • 10944226843 scopus 로고    scopus 로고
    • A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product
    • DOI 10.1016/j.molcel.2004.11.034, PII S1097276504007257
    • Shen, Y.; Volrath, S.L.; Weatherly, S.C.; Elich, T.D.; Tong, L. A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. Mol. Cell. 2004, 16, 881-891. (Pubitemid 40018399)
    • (2004) Molecular Cell , vol.16 , Issue.6 , pp. 881-891
    • Shen, Y.1    Volrath, S.L.2    Weatherly, S.C.3    Elich, T.D.4    Tong, L.5
  • 64
    • 1542375212 scopus 로고    scopus 로고
    • A new dominant selection marker for transformation of Pichia pastoris to soraphen A resistance
    • DOI 10.1016/j.mimet.2003.11.013, PII S0167701203003269
    • Wan, H.; Sjolinder, M; Schairer, H.U; Leclerque, A. A new dominant selection marker for transformation of Pichia pastoris to soraphen A resistance. J. Microbiol. Methods 2004, 57, 33-39. (Pubitemid 38299349)
    • (2004) Journal of Microbiological Methods , vol.57 , Issue.1 , pp. 33-39
    • Wan, H.1    Sjolinder, M.2    Schairer, H.U.3    Leclerque, A.4
  • 65
    • 2642540877 scopus 로고    scopus 로고
    • Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain
    • DOI 10.1042/BJ20031960
    • Weatherly, S.C; Volrath, S.L.; Elich, T.D. Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain. Biochem. J. 2004, 380, 105-110. (Pubitemid 38725734)
    • (2004) Biochemical Journal , vol.380 , Issue.1 , pp. 105-110
    • Weatherly, S.C.1    Volrath, S.L.2    Elich, T.D.3
  • 68
    • 0018605657 scopus 로고
    • Mechanism responsible for 5-(tetradecyloxy)-2-furoic acid inhibition of hepatic lipogenesis
    • McCune, S.A.; Harris, R.A. Mechanism responsible for 5-(tetradecyloxy)-2- furoic acid inhibition of hepatic lipogenesis. J. Biol. Chem. 1979, 254, 10095-10101. (Pubitemid 10162030)
    • (1979) Journal of Biological Chemistry , vol.254 , Issue.20 , pp. 10095-10101
    • McCune, S.A.1    Harris, R.A.2
  • 69
    • 0017736575 scopus 로고
    • 5 (Tetradecyloxy) 2 furancarboxylic acid and related hypolipidemic fatty acid like alkyloxyarylcarboxylic acids
    • Parker, R.A.; Kariya, T.; Grisar, J.M. Petrow V. 5-(Tetradecyloxy)-2- furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids. J. Med. Chem. 1977, 20, 781-791. (Pubitemid 8096806)
    • (1977) Journal of Medicinal Chemistry , vol.20 , Issue.6 , pp. 781-791
    • Parker, R.A.1    Kariya, T.2    Grisar, J.M.3    Petrow, V.4
  • 70
    • 0026753102 scopus 로고
    • Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster
    • Arbeeny, C.M.; Meyers, D.S.; Bergquist, K.E.; Gregg, R.E. Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster. J. Lipid. Res. 1992, 33, 843-851.
    • (1992) J. Lipid. Res. , vol.33 , pp. 843-851
    • Arbeeny, C.M.1    Meyers, D.S.2    Bergquist, K.E.3    Gregg, R.E.4
  • 71
    • 0021170046 scopus 로고
    • Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver
    • Fukuda, N.; Ontko, J.A. Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver. J. Lipid. Res. 1984, 25, 831-842. (Pubitemid 14032393)
    • (1984) Journal of Lipid Research , vol.25 , Issue.8 , pp. 831-842
    • Fukuda, N.1    Ontko, J.A.2
  • 72
    • 0029165856 scopus 로고
    • Secretion of apolipoproteins A-I and B by HepG2 cells: Regulation by substrates and metabolic inhibitors
    • Kempen, H.J.; Imbach, A.P.; Giller, T.; Neumann, W.J.; Hennes, U.; Nakada, N. Secretion of apolipoproteins A-I and B by HepG2 cells: regulation by substrates and metabolic inhibitors. J. Lipid. Res. 1995, 36, 1796-1806.
    • (1995) J. Lipid. Res. , vol.36 , pp. 1796-1806
    • Kempen, H.J.1    Imbach, A.P.2    Giller, T.3    Neumann, W.J.4    Hennes, U.5    Nakada, N.6
  • 73
    • 0021604077 scopus 로고
    • Anti-obesity activity of a novel lipid synthesis inhibitor
    • Triscari, J.; Sullivan, A.C. Anti-obesity activity of a novel lipid synthesis inhibitor. Int. J. Obes. 1984, 8, 227-239. (Pubitemid 15019744)
    • (1984) International Journal of Obesity , vol.8 , Issue.SUPPL. 1 , pp. 227-239
    • Triscari, J.1    Sullivan, A.C.2
  • 74
    • 0021715781 scopus 로고
    • Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid
    • DOI 10.1007/BF02534514
    • Halvorson, D.L.; McCune, S.A. Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid. Lipids 1984, 19, 851-856. (Pubitemid 15188497)
    • (1984) Lipids , vol.19 , Issue.11 , pp. 851-856
    • Halvorson, D.L.1    McCune, S.A.2
  • 76
    • 67349227746 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis
    • Wang, C.; Xu, C.; Sun, M.; Luo, D.; Liao, D.F.; Cao, D. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem. Biophys. Res. Commun. 2009, 385, 302-306.
    • (2009) Biochem. Biophys. Res. Commun. , vol.385 , pp. 302-306
    • Wang, C.1    Xu, C.2    Sun, M.3    Luo, D.4    Liao, D.F.5    Cao, D.6
  • 77
    • 77956210076 scopus 로고    scopus 로고
    • Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells
    • Hess, D.; Chisholm, J.W.; Igal, R.A. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One 2010, 5, e11394.
    • (2010) PLoS One , vol.5
    • Hess, D.1    Chisholm, J.W.2    Igal, R.A.3
  • 78
    • 34548580317 scopus 로고    scopus 로고
    • Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
    • DOI 10.1158/0008-5472.CAN-07-0389
    • Beckers, A.; Organe, S.; Timmermans, L.; Scheys, K.; Peeters, A.; Brusselmans, K.; Verhoeven, G.; Swinnen, J.V. Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res. 2007, 67, 8180-8187. (Pubitemid 47395154)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 8180-8187
    • Beckers, A.1    Organe, S.2    Timmermans, L.3    Scheys, K.4    Peeters, A.5    Brusselmans, K.6    Verhoeven, G.7    Swinnen, J.V.8
  • 79
    • 36049029132 scopus 로고    scopus 로고
    • A novel acetyl-CoA carboxylase inhibitor reduces de novo fatty acid synthesis in HepG2 cells and rat primary hepatocytes
    • DOI 10.1016/j.abb.2007.09.012, PII S0003986107004705
    • Sugimoto, Y.; Naniwa, Y.; Nakamura, T.; Kato, H.; Yamamoto, M.; Tanabe, H.; Inoue, K.; Imaizumi, A. A novel acetyl-CoA carboxylase inhibitor reduces de novo fatty acid synthesis in HepG2 cells and rat primary hepatocytes. Arch. Biochem. Biophys. 2007, 468, 44-48. (Pubitemid 350087850)
    • (2007) Archives of Biochemistry and Biophysics , vol.468 , Issue.1 , pp. 44-48
    • Sugimoto, Y.1    Naniwa, Y.2    Nakamura, T.3    Kato, H.4    Yamamoto, M.5    Tanabe, H.6    Inoue, K.7    Imaizumi, A.8
  • 80
    • 0028218398 scopus 로고
    • The effect of β,β'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: Role of apolipoprotein C-III
    • Frenkel, B.; Bishara-Shieban, J.; Bar-Tana, J. The effect of beta,beta'- tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III. Biochem. J. 1994, 298, 409-414. (Pubitemid 24072485)
    • (1994) Biochemical Journal , vol.298 , Issue.2 , pp. 409-414
    • Frenkel, B.1    Bishara-Shieban, J.2    Bar-Tana, J.3
  • 81
    • 0022256692 scopus 로고
    • 22, α,ω-dicarboxylic acids in the rat in vivo
    • Bar-Tana, J.; Rose-Kahn, G; Srebnik, M. Inhibition of lipid synthesis by beta beta'-tetramethylsubstituted, C14-C22, alpha, omega-dicarboxylic acids in the rat in vivo. J. Biol. Chem. 1985, 260, 8404-8410. (Pubitemid 15249849)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.14 , pp. 8404-8410
    • Bar-Tana, J.1    Rose-Kahn, G.2    Srebnik, M.3
  • 82
    • 0031894623 scopus 로고    scopus 로고
    • Development of insulin resistance in the JCR:LA-cp rat: Role of triacylglycerols and effects of MEDICA 16
    • DOI 10.2337/diabetes.47.5.770
    • Russell, J.C.; Shillabeer, G.; Bar-Tana, J.; Lau, D.C.; Richardson, M.; Wenzel, L.M.; Graham, S.E.; Dolphin, P.J. Development of insulin resistance in the JCR:LA-cp rat: Role of triacylglycerols and effects of MEDICA 16. Diabetes 1998, 47, 770-778. (Pubitemid 28201807)
    • (1998) Diabetes , vol.47 , Issue.5 , pp. 770-778
    • Russell, J.C.1    Shillabeer, G.2    Bar-Tana, J.3    Lau, D.C.W.4    Richardson, M.5    Wenzel, L.M.6    Graham, S.E.7    Dolphin, P.J.8
  • 83
    • 0030773514 scopus 로고    scopus 로고
    • Sensitization to insulin induced by β,β'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo
    • Mayorek, N.; Kalderon, B.; Itach, E.; Bar-Tana, J. Sensitization to insulin induced by beta,beta'- methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo. Diabetes 1997, 46, 1958-1964. (Pubitemid 27512080)
    • (1997) Diabetes , vol.46 , Issue.12 , pp. 1958-1964
    • Mayorek, N.1    Kalderon, B.2    Itach, E.3    Bar-Tana, J.4
  • 84
    • 0032512651 scopus 로고    scopus 로고
    • Mitochondria uncoupling by a long chain fatty acyl analogue
    • Hermesh, O.; Kalderon, B; Bar-Tana, J. Mitochondria uncoupling by a long chain fatty acyl analogue. J. Biol. Chem. 1998, 273, 3937-3942.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3937-3942
    • Hermesh, O.1    Kalderon, B.2    Bar-Tana, J.3
  • 85
    • 0037053285 scopus 로고    scopus 로고
    • A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis
    • DOI 10.1074/jbc.C200113200
    • Levert, K.L.; Waldrop, G.L.; Stephens, J.M. A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis. J. Biol. Chem. 2002, 277, 16347-16350. (Pubitemid 34967642)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.19 , pp. 16347-16350
    • Levert, K.L.1    Waldrop, G.L.2    Stephens, J.M.3
  • 86
    • 0033453314 scopus 로고    scopus 로고
    • Synthesis of the optical isomers of 4-[1-(4-tert-butylphenyl)-2- oxopyrrolidine-4-yl]methyloxybenzoic acid (S-2) and their biological evaluation as antilipidemic agent
    • Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.; Yamamoto, A.; Kobayashi, K.; Ogawa, K. Synthesis of the optical isomers of 4-[1-(4-tert-butylphenyl)-2- oxo- pyrrolidine-4- yl]methyloxybenzoic acid (S-2) and their biological evaluation as antilipidemic agent. Chem. Pharm. Bull. (Tokyo). 1999, 47, 1549-1554. (Pubitemid 30002087)
    • (1999) Chemical and Pharmaceutical Bulletin , vol.47 , Issue.11 , pp. 1549-1554
    • Ohno, T.1    Yano, S.-G.2    Yamada, H.3    Shirasaka, T.4    Yamamoto, A.5    Kobayashi, K.6    Ogawa, K.7
  • 87
  • 88
    • 2342531091 scopus 로고    scopus 로고
    • Effects of a Novel Antihyperlipidemic Agent, S-2E, on the Blood Lipid Abnormalities in Homozygous WHHL Rabbits
    • DOI 10.1016/j.metabol.2003.11.024
    • Ohmori, K.; Yamada, H.; Yasuda, A.; Yamamoto, A.; Matsuura, N.; Kiniwa, M. Effects of a novel antihyperlipidemic agent, S-2E, on the blood lipid abnormalities in homozygous WHHL rabbits. Metabolism 2004, 53, 680-685. (Pubitemid 38596545)
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.5 , pp. 680-685
    • Ohmori, K.1    Yamada, H.2    Yasuda, A.3    Yamamoto, A.4    Matsuura, N.5    Kiniwa, M.6
  • 92
    • 0036566552 scopus 로고    scopus 로고
    • Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor
    • DOI 10.1042/0264-6021:3630645
    • Rouquette-Jazdanian, A.K.; Pelassy, C.; Breittmayer, J.P; Cousin, J.L; Aussel, C. Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor. Biochem. J. 2002, 363, 645-655. (Pubitemid 34526385)
    • (2002) Biochemical Journal , vol.363 , Issue.3 , pp. 645-655
    • Rouquette-Jazdanian, A.K.1    Pelassy, C.2    Breittmayer, J.-P.3    Cousin, J.-L.4    Aussel, C.5
  • 94
    • 0038527555 scopus 로고    scopus 로고
    • Membrane raft microdomains mediate front-rear polarity in migrating cells
    • DOI 10.1093/emboj/18.22.6211
    • Manes, S.; Mira, E.; Gomez-Mouton, C.; Lacalle, R.A.; Keller, P.; Labrador, J.P.; Martinez-A, C. Membrane raft microdomains mediate front-rear polarity in migrating cells. EMBO J. 1999, 18, 6211-6220. (Pubitemid 29533225)
    • (1999) EMBO Journal , vol.18 , Issue.22 , pp. 6211-6220
    • Manes, S.1    Mira, E.2    Gomez-Mouton, C.3    Lacalle, R.A.4    Keller, P.5    Labrador, J.P.6    Martinez-A, C.7
  • 95
    • 0012249041 scopus 로고
    • Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
    • Medes, G.; Thomas, A.; Weinhouse, S. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 1953, 13, 27-29.
    • (1953) Cancer Res. , vol.13 , pp. 27-29
    • Medes, G.1    Thomas, A.2    Weinhouse, S.3
  • 97
    • 0014076991 scopus 로고
    • Control of lipid metabolism in hepatomas: Insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control
    • Sabine, J.R.; Abraham, S.; Chaikoff, I.L. Control of lipid metabolism in hepatomas: Insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control. Cancer Res. 1967, 27, 793-799.
    • (1967) Cancer Res. , vol.27 , pp. 793-799
    • Sabine, J.R.1    Abraham, S.2    Chaikoff, I.L.3
  • 99
    • 0030706079 scopus 로고    scopus 로고
    • Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
    • Milgraum, L.Z.; Witters, L.A.; Pasternack, G.R.; Kuhajda, F.P. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin. Cancer Res. 1997, 3, 2115-2120. (Pubitemid 27505140)
    • (1997) Clinical Cancer Research , vol.3 , Issue.11 , pp. 2115-2120
    • Milgraum, L.Z.1    Witters, L.A.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 101
    • 0032499787 scopus 로고    scopus 로고
    • The "spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: Implications for control of tumor metabolism
    • Moncur, J.T.; Park, J.P.; Memoli, V.A.; Mohandas, T.K.; Kinlaw, W.B. The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: Implications for control of tumor metabolism. Proc. Natl. Acad. Sci. USA 1998, 95, 6989-6994.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6989-6994
    • Moncur, J.T.1    Park, J.P.2    Memoli, V.A.3    Mohandas, T.K.4    Kinlaw, W.B.5
  • 103
    • 0346888598 scopus 로고    scopus 로고
    • The risk of a contralateral breast cancer among women diagnosed with ductal and lobular breast carcinoma in situ: Data from the Connecticut Tumor Registry
    • DOI 10.1016/S0960-9776(03)00152-8
    • Claus, E.B.; Stowe, M.; Carter, D.; Holford, T. The risk of a contralateral breast cancer among women diagnosed with ductal and lobular breast carcinoma in situ: Data from the Connecticut Tumor Registry. Breast 2003, 12, 451-456. (Pubitemid 38008659)
    • (2003) Breast , vol.12 , Issue.6 , pp. 451-456
    • Claus, E.B.1    Stowe, M.2    Carter, D.3    Holford, T.4
  • 104
    • 0035341888 scopus 로고    scopus 로고
    • Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression
    • DOI 10.1002/pros.1052
    • Pizer, E.S.; Pflug, B.R.; Bova, G.S.; Han, W.F.; Udan, M.S.; Nelson, J.B. Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression. Prostate 2001, 47, 102-110. (Pubitemid 32336579)
    • (2001) Prostate , vol.47 , Issue.2 , pp. 102-110
    • Pizer, E.S.1    Pflug, B.R.2    Steven Bova, G.3    Han, W.F.4    Udan, M.S.5    Nelson, J.B.6
  • 106
    • 33744808464 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase α is essential to breast cancer cell survival
    • DOI 10.1158/0008-5472.CAN-05-1489
    • Chajes, V.; Cambot, M.; Moreau, K.; Lenoir, G.M.; Joulin, V. Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Cancer Res. 2006, 66, 5287-5294. (Pubitemid 43844953)
    • (2006) Cancer Research , vol.66 , Issue.10 , pp. 5287-5294
    • Chajes, V.1    Cambot, M.2    Moreau, K.3    Lenoir, G.M.4    Joulin, V.5
  • 107
    • 23044482013 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the acetyl-Coa-carboxylase-α gene induces growth inhibition and apoptosis of prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-05-0571
    • Brusselmans, K.; De Schrijver, E.; Verhoeven, G.; Swinnen, J.V. RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res. 2005, 65, 6719-6725. (Pubitemid 41060709)
    • (2005) Cancer Research , vol.65 , Issue.15 , pp. 6719-6725
    • Brusselmans, K.1    De Schrijver, E.2    Verhoeven, G.3    Swinnen, J.V.4
  • 110
    • 14844315920 scopus 로고    scopus 로고
    • Inhibition of β-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARγ agonists
    • DOI 10.1016/j.febslet.2005.01.082
    • Andela, V.B.; Altuwaijri, S.; Wood, J.; Rosier, R.N. Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists. FEBS Lett. 2005, 579, 1765-1769. (Pubitemid 40341555)
    • (2005) FEBS Letters , vol.579 , Issue.7 , pp. 1765-1769
    • Andela, V.B.1    Altuwaijri, S.2    Wood, J.3    Rosier, R.N.4
  • 111
    • 69249202281 scopus 로고    scopus 로고
    • Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells
    • Zhou, W.; Tu, Y.; Simpson, P.J.; Kuhajda, F.P. Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells. Oncogene 2009, 28, 2979-2987.
    • (2009) Oncogene , vol.28 , pp. 2979-2987
    • Zhou, W.1    Tu, Y.2    Simpson, P.J.3    Kuhajda, F.P.4
  • 112
    • 3843061592 scopus 로고    scopus 로고
    • AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome
    • Ruderman, N.; Prentki, M. AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome. Nat. Rev. Drug Discov. 2004, 3, 340-351. (Pubitemid 38499761)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.4 , pp. 340-351
    • Ruderman, N.1    Prentki, M.2
  • 113
    • 0242600806 scopus 로고    scopus 로고
    • 5-Amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes
    • DOI 10.2337/diabetes.52.5.1066
    • Koistinen, H.A.; Galuska, D.; Chibalin, A.V.; Yang, J.; Zierath JR, Holman, G.D.; Wallberg-Henriksson, H. 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 2003, 52, 1066-1072. (Pubitemid 36523338)
    • (2003) Diabetes , vol.52 , Issue.5 , pp. 1066-1072
    • Koistinen, H.A.1    Galuska, D.2    Chibalin, A.V.3    Yang, J.4    Zierath, J.R.5    Holman, G.D.6    Wallberg-Henriksson, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.