Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor

Biochemical Journal

Volumn 363, Issue 3, 2002, Pages 645-655

  Rouquette Jazdanian, Alexandre K ^a   Pelassy, Claudette ^a   Breittmayer, Jean Philippe ^a   Cousin, Jean Louis ^a   Aussel, Claude ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

Ca2; Cholesterol; Diacylglycerol; Fatty acid; Sphingomyelin

Indexed keywords

CELL MEMBRANES; CENTRIFUGATION; CHOLESTEROL; FATTY ACIDS; PHOSPHOLIPIDS;

SIGNAL TRANSDUCTION;

BIOCHEMISTRY;

CD3 ANTIGEN; CHOLESTEROL; DIACYLGLYCEROL; GLYCEROPHOSPHOLIPID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PROTEIN KINASE; PROTEIN P56; T LYMPHOCYTE RECEPTOR; TRITON X 100;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LABELING INDEX; LEUKEMIA CELL LINE; LIPID COMPOSITION; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SUCROSE DENSITY GRADIENT CENTRIFUGATION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD3; ARACHIDONIC ACID; BETA-CYCLODEXTRINS; CALCIUM; CELL MEMBRANE; CHOLESTEROL; CYCLODEXTRINS; DIGLYCERIDES; GLYCEROPHOSPHOLIPIDS; HUMANS; JURKAT CELLS; MEMBRANE LIPIDS; PALMITIC ACID; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

EID: 0036566552     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630645     Document Type: Article

References (48)

1. T cell antigen receptor activation pathways: The tyrosine kinase connection
2. Signal transduction by lymphocyte antigen receptors
3. The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium
4. Functional rafts in cell membranes
5. Structure and function of sphingolipid- and cholesterol-rich membrane rafts
6. Functions of lipid rafts in biological membranes
7. Structure and origin of ordered lipid domains in biological membranes
8. Looking at lipid rafts?
9. Cellular cholesterol efflux mediated by cyclodextrins. Demonstration of kinetic pools and mechanism of efflux
10. Effects of cholesterol depletion by cyclodextrin on the sphingotipid microdomains of the plasma membrane
11. Caveolins, liquid-ordered domains, and signal transduction
12. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical celt surface
13. Absence of lipid gel-phase domains in seven mammalian cell lines and in four primary cell types
14. Theoretical models of phospholipid phase transitions
15. On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: Physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes
16. Cholesterol and sphingolipid enhance the Triton X-1O0 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains
17. Digging into caveolae
18. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
19. A rapid method of total lipid extraction and purification
20. 2+ indicators with greatly improved fluorescence properties
21. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior
22. Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol
23. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: Accumulation of actin regulated by local tyrosine phosphorylation
24. The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1
25. Reversible palmitoylation of the protein-tyrosine kinase p56lck
26. Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation
27. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
28. Signals determining protein tyrosine kinase and glycosyl phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction
29. Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae
30. Identification of a distinct pool of sphingomyelin involved in the sphingomyetin cycle
31. Compartmentalized production of ceramide at the cell surface
32. Use of cyclodextrins for manipulating cellular cholesterol content
33. Intracellular trafficking of cholesterol monitored with a cyclodextrin
34. Inhibition of protein palmitoylation, raft localization, and T cell signalling by 2-bromopalmitate and polyunsaturated fatty acids
35. 1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored rotate receptor
36. Partioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers
37. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
38. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes
39. Membrane compartmentation is required for efficient T cell activation
40. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover
41. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains
42. Heterogeneity of protein kinase C expression and regulation in T lymphocytes
43. Expression of protein kinase C genes in hemopoietic cells is cell type and B cell differentiation stage specific
44. Stimulation of T lymphocyte proliferation by monoclonal antibodies against GD3 ganglioside
45. T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: Implications for innate immunity
46. Cell calcium signaling via GM1 cell surface gangliosides in the human Jurkat T cell line
47. Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway
48. The glycosylphosphatidylinositol-anchored CD59 protein stimulates both T cell receptor zeta/ZAP-70-dependent and -independent signaling pathways in T cells