Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation

Biochemical Pharmacology

Volumn 81, Issue 5, 2011, Pages 649-660

  Jump, Donald B ^a   Torres Gonzalez, Moises ^a   Olson, L Karl ^b  

^a OREGON STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Acetyl CoA carboxylase; De novo lipogenesis; Fatty acid desaturation; Fatty acid elongation; Fatty acid oxidation; Soraphen A

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ACETYL COENZYME A CARBOXYLASE 2; ANTIOBESITY AGENT; FATTY ACID; FATTY ACID DESATURASE FADS1; FATTY ACID DESATURASE FADS2; FATTY ACID ELONGASE; FATTY ACID ELONGASE ELOVL5; FATTY ACID ELONGASE ELOVL6; LINOLEIC ACID; MALONYL COENZYME A; MONOUNSATURATED FATTY ACID; PALMITIC ACID; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; SORAPHEN A; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; VERY LONG CHAIN FATTY ACID;

ARTICLE; CELL STRAIN HEPG2; CELL STRAIN LNCAP; CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; LIPOGENESIS; MICROSOME; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYL-COA CARBOXYLASE; ACETYLTRANSFERASES; CELL LINE, TUMOR; FATTY ACID DESATURASES; FATTY ACIDS; HUMANS; LINOLEIC ACID; LIPOGENESIS; MACROLIDES; OXIDATION-REDUCTION; PALMITIC ACID;

EID: 79551480612     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.12.014     Document Type: Article

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