-
1
-
-
67649424560
-
The p21 in cancer: Intricate networks and multiple activities
-
Abbas T, Dutta A. The p21 in cancer: Intricate networks and multiple activities. Nat Rev Cancer 2009; 9: 400-14.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 400-414
-
-
Abbas, T.1
Dutta, A.2
-
2
-
-
66849095259
-
Perspectives for cancer prevention with natural compounds
-
Amin AR, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. J Clin Oncol. 2009; 27: 2712-25.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2712-2725
-
-
Amin, A.R.1
Kucuk, O.2
Khuri, F.R.3
Shin, D.M.4
-
3
-
-
0033987198
-
New sources and antifungal activity of sesquiterpene lactones
-
Barrero AF, Oltra JE, Alvarez M, Raslan DS, Saude DA, Akssira M. New sources and antifungal activity of sesquiterpene lactones. Fitoterapia 2000; 71: 60-64.
-
(2000)
Fitoterapia
, vol.71
, pp. 60-64
-
-
Barrero, A.F.1
Oltra, J.E.2
Alvarez, M.3
Raslan, D.S.4
Saude, D.A.5
Akssira, M.6
-
4
-
-
0346024017
-
A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells
-
Bocca C, Gabriel L, Bozzo F, Miglietta A. A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells. Chem Biol Interact. 2004; 147: 79-86.
-
(2004)
Chem Biol Interact
, vol.147
, pp. 79-86
-
-
Bocca, C.1
Gabriel, L.2
Bozzo, F.3
Miglietta, A.4
-
5
-
-
0033760941
-
Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens
-
Castro V, Murillo R, Klaas CA, Meunier C, Mora G, Pahl HL, Merfort I. Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens. Planta Med. 2000; 66: 591-95.
-
(2000)
Planta Med
, vol.66
, pp. 591-595
-
-
Castro, V.1
Murillo, R.2
Klaas, C.A.3
Meunier, C.4
Mora, G.5
Pahl, H.L.6
Merfort, I.7
-
6
-
-
33845738189
-
Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells
-
Chen CN, Huang HH, Wu CL, Lin CP, Hsu JT, Hsieh HP, Chuang SE, Lai GM. Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells. Cancer Lett. 2007; 246: 237-52.
-
(2007)
Cancer Lett
, vol.246
, pp. 237-252
-
-
Chen, C.N.1
Huang, H.H.2
Wu, C.L.3
Lin, C.P.4
Hsu, J.T.5
Hsieh, H.P.6
Chuang, S.E.7
Lai, G.M.8
-
7
-
-
0029073836
-
Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells
-
Chen HC, Chou CK, Lee SD, Wang JC, Yeh SF. Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. Antiviral Res. 1995; 27: 99-109.
-
(1995)
Antiviral Res
, vol.27
, pp. 99-109
-
-
Chen, H.C.1
Chou, C.K.2
Lee, S.D.3
Wang, J.C.4
Yeh, S.F.5
-
8
-
-
0036949216
-
Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols
-
Choi JH, Ha J, Park JH, Lee JY, Lee YS, Park HJ, Choi JW, Masuda Y, Nakaya K, Lee KT. Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols. Jpn J Cancer Res. 2002a; 93: 1327-33.
-
(2002)
Jpn J Cancer Res
, vol.93
, pp. 1327-1333
-
-
Choi, J.H.1
Ha, J.2
Park, J.H.3
Lee, J.Y.4
Lee, Y.S.5
Park, H.J.6
Choi, J.W.7
Masuda, Y.8
Nakaya, K.9
Lee, K.T.10
-
9
-
-
70349949009
-
Costunolide-induced apoptosis in human leukemia cells: Involvement of c-jun N-terminal kiase activation
-
Choi JH, Lee KT. Costunolide-induced apoptosis in human leukemia cells: Involvement of c-jun N-terminal kiase activation. Biol Pharm Bull. 2009; 32: 1803-08.
-
(2009)
Biol Pharm Bull
, vol.32
, pp. 1803-1808
-
-
Choi, J.H.1
Lee, K.T.2
-
10
-
-
0036692105
-
Costunolide induces differentiation of human leukemia HL-60 cells
-
Choi JH, Seo BR, Seo SH, Lee KT, Park JH, Park HJ, Choi JW, Itoh Y, Miyamoto K. Costunolide induces differentiation of human leukemia HL-60 cells. Arch Pharm Res. 2002b; 25: 480-84.
-
(2002)
Arch Pharm Res
, vol.25
, pp. 480-484
-
-
Choi, J.H.1
Seo, B.R.2
Seo, S.H.3
Lee, K.T.4
Park, J.H.5
Park, H.J.6
Choi, J.W.7
Itoh, Y.8
Miyamoto, K.9
-
11
-
-
46249113516
-
Melanogenesis inhibitory compounds from Saussureae Radix
-
Choi JY, Choi EH, Jung HW, Oh JS, Lee WH, Lee JG, Son JK, Kim Y, Lee SH. Melanogenesis inhibitory compounds from Saussureae Radix. Arch Pharm Res. 2008; 31: 294-99.
-
(2008)
Arch Pharm Res
, vol.31
, pp. 294-299
-
-
Choi, J.Y.1
Choi, E.H.2
Jung, H.W.3
Oh, J.S.4
Lee, W.H.5
Lee, J.G.6
Son, J.K.7
Kim, Y.8
Lee, S.H.9
-
12
-
-
23844486024
-
Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells
-
Choi SH, Im E, Kang HK, Lee JH, Kwak HS, Bae YT, Park HJ, Kim ND. Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 2005; 227: 153-62.
-
(2005)
Cancer Lett
, vol.227
, pp. 153-162
-
-
Choi, S.H.1
Im, E.2
Kang, H.K.3
Lee, J.H.4
Kwak, H.S.5
Bae, Y.T.6
Park, H.J.7
Kim, N.D.8
-
13
-
-
84857909839
-
Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231
-
Choi YK, Seo HS, Choi HS, Kim SR, Shin YC, Ko SG. Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231. Mol Cell Biochem. 2011; 363: 119-28.
-
(2011)
Mol Cell Biochem
, vol.363
, pp. 119-128
-
-
Choi, Y.K.1
Seo, H.S.2
Choi, H.S.3
Kim, S.R.4
Shin, Y.C.5
Ko, S.G.6
-
14
-
-
27644529751
-
The (1)H, (13)C NMR and X-ray crystallographic studies of highly polyhalogenated derivatives of costunolide lactone
-
Corona D, Diaz E, Nava JL, Guzman A, Barrios H, Fuentes A, Hernandez-Plata SA, Allard J, Jankowski CK. (1)H, (13)C NMR and X-ray crystallographic studies of highly polyhalogenated derivatives of costunolide lactone. Spectrochim Acta A Mol Biomol Spectrosc. 2005; 62: 604-13.
-
(2005)
Spectrochim Acta a Mol Biomol Spectrosc
, vol.62
, pp. 604-613
-
-
Corona, D.1
Diaz, E.2
Nava, J.L.3
Guzman, A.4
Barrios, H.5
Fuentes, A.6
Hernandez-Plata, S.A.7
Allard, J.8
Jankowski, C.K.9
-
15
-
-
23044490704
-
Plants as a source of anti-cancer agents
-
Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol. 2005; 100: 72-79.
-
(2005)
J Ethnopharmacol
, vol.100
, pp. 72-79
-
-
Cragg, G.M.1
Newman, D.J.2
-
16
-
-
24944527887
-
New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production
-
De Marino S, Borbone N, Zollo F, Ianaro A, Di Meglio P, Iorizzi M. New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production. Planta Med. 2005; 71: 706-10.
-
(2005)
Planta Med
, vol.71
, pp. 706-710
-
-
de Marino, S.1
Borbone, N.2
Zollo, F.3
Ianaro, A.4
Di Meglio, P.5
Iorizzi, M.6
-
17
-
-
0018183376
-
Isolation and characterization of the sesquiterpene lactones costunolide, parthenolide, costunolide diepoxide, santamarine, and reynosin from Magnolia grandiflora L
-
el-Feraly FS, Chan YM. Isolation and characterization of the sesquiterpene lactones costunolide, parthenolide, costunolide diepoxide, santamarine, and reynosin from Magnolia grandiflora L. J Pharm Sci. 1978; 67: 347-50.
-
(1978)
J Pharm Sci
, vol.67
, pp. 347-350
-
-
El-Feraly, F.S.1
Chan, Y.M.2
-
18
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-2917.
-
(2010)
Int J Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
19
-
-
17344366120
-
Direct identification and quantitative determination of costunolide and dehydrocostuslactone in the fixed oil of Laurus novocanariensis by 13C-NMR spectroscopy
-
Ferrari B, Castilho P, Tomi F, Rodrigues AI, do Ceu Costa M, Casanova J. Direct identification and quantitative determination of costunolide and dehydrocostuslactone in the fixed oil of Laurus novocanariensis by 13C-NMR spectroscopy. Phytochem Anal. 2005; 16: 104-07.
-
(2005)
Phytochem Anal
, vol.16
, pp. 104-107
-
-
Ferrari, B.1
Castilho, P.2
Tomi, F.3
Rodrigues, A.I.4
do Ceu, C.M.5
Casanova, J.6
-
20
-
-
0032575870
-
Antimycobacterial evaluation of germacranolides
-
Fischer NH, Lu T, Cantrell CL, Castaneda-Acosta J, Quijano L, Franzblau SG (1998). Antimycobacterial evaluation of germacranolides. Phytochemistry 1998; 49: 559-64.
-
(1998)
Phytochemistry
, vol.49
, pp. 559-564
-
-
Fischer, N.H.1
Lu, T.2
Cantrell, C.L.3
Castaneda-Acosta, J.4
Quijano, L.5
Franzblau, S.G.6
-
21
-
-
0035836074
-
Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1
-
Fukuda K, Akao S, Ohno Y, Yamashita K, Fujiwara H. Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1. Cancer Lett. 2001; 164: 7-13.
-
(2001)
Cancer Lett
, vol.164
, pp. 7-13
-
-
Fukuda, K.1
Akao, S.2
Ohno, Y.3
Yamashita, K.4
Fujiwara, H.5
-
22
-
-
0028143317
-
The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin
-
Furuya Y, Lundmo P, Short AD, Gill DL, Isaacs JT. The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin. Cancer Res. 1994; 54: 6167-75.
-
(1994)
Cancer Res
, vol.54
, pp. 6167-6175
-
-
Furuya, Y.1
Lundmo, P.2
Short, A.D.3
Gill, D.L.4
Isaacs, J.T.5
-
23
-
-
0034090097
-
Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
-
Griffioen AW, Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev. 2000; 52: 237-68.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 237-268
-
-
Griffioen, A.W.1
Molema, G.2
-
24
-
-
52049109838
-
Natural products in drug discovery
-
Harvey AL. Natural products in drug discovery. Drug Discov Today 2008; 13: 894-901.
-
(2008)
Drug Discov Today
, vol.13
, pp. 894-901
-
-
Harvey, A.L.1
-
25
-
-
0141907374
-
Sesquiterpenes (costunolide and zaluzanin D) isolated from laurel (Laurus nobilis L.) induce (13)triene-12,6alpha-olide] isolated from laurel (Laurus cell death and morphological change indicative of apoptotic nobilis L.) induce cell death and morphological change chromatin condensation in leukemia HL-60 cells
-
Hibasami H, Yamada Y, Moteki H, Katsuzaki H, Imai K, Yoshioka K, Komiya T. Sesquiterpenes (costunolide and zaluzanin D) isolated from laurel (Laurus nobilis L.) induce (13)triene-12,6alpha-olide] isolated from laurel (Laurus cell death and morphological change indicative of apoptotic nobilis L.) induce cell death and morphological change chromatin condensation in leukemia HL-60 cells. Int J Mol indicative of apoptotic chromatin condensation in leukemia Med. 2003; 12: 147-51.
-
(2003)
Int J Mol Indicative of Apoptotic Chromatin Condensation In Leukemia Med
, vol.12
, pp. 147-151
-
-
Hibasami, H.1
Yamada, Y.2
Moteki, H.3
Katsuzaki, H.4
Imai, K.5
Yoshioka, K.6
Komiya, T.7
-
26
-
-
10644279947
-
Vascular endothelial growth factor and angiogenesis
-
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev. 2004; 56: 549-80.
-
(2004)
Pharmacol Rev
, vol.56
, pp. 549-580
-
-
Hoeben, A.1
Landuyt, B.2
Highley, M.S.3
Wildiers, H.4
van Oosterom, A.T.5
de Bruijn, E.A.6
-
27
-
-
79953799722
-
Costunolide induces apoptosis through nuclear calcium2+overload and DNA damage response in human prostate cancer
-
Hsu JL, Pan SL, Ho YF, Hwang TL, Kung FL, Guh JH. Costunolide induces apoptosis through nuclear calcium2+overload and DNA damage response in human prostate cancer. J Urol. 2011; 185: 1967-74.
-
(2011)
J Urol
, vol.185
, pp. 1967-1974
-
-
Hsu, J.L.1
Pan, S.L.2
Ho, Y.F.3
Hwang, T.L.4
Kung, F.L.5
Guh, J.H.6
-
28
-
-
0037058636
-
Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway
-
Jeong SJ, Itokawa T, Shibuya M, Kuwano M, Ono M, Higuchi R, Miyamoto T. Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 2002; 187: 129-33.
-
(2002)
Cancer Lett
, vol.187
, pp. 129-133
-
-
Jeong, S.J.1
Itokawa, T.2
Shibuya, M.3
Kuwano, M.4
Ono, M.5
Higuchi, R.6
Miyamoto, T.7
-
29
-
-
0348111400
-
Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells
-
Kang JS, Yoon YD, Lee KH, Park SK, Kim HM. Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. Biochem Biophys Res Commun. 2004; 313: 171-77.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 171-177
-
-
Kang, J.S.1
Yoon, Y.D.2
Lee, K.H.3
Park, S.K.4
Kim, H.M.5
-
30
-
-
44349171180
-
Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells
-
Kanno S, Kitajima Y, Kakuta M, Osanai Y, Kurauchi K, Ujibe M, Ishikawa M. Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells. Biol Pharm Bull. 2008; 31: 1024-28.
-
(2008)
Biol Pharm Bull
, vol.31
, pp. 1024-1028
-
-
Kanno, S.1
Kitajima, Y.2
Kakuta, M.3
Osanai, Y.4
Kurauchi, K.5
Ujibe, M.6
Ishikawa, M.7
-
31
-
-
67650671664
-
Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)
-
Kassuya CA, Cremoneze A, Barros LF, Simas AS, Lapa Fda R, Mello-Silva R, Stefanello ME, Zampronio AR. Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). J Ethnopharmacol. 2009; 124: 369-76.
-
(2009)
J Ethnopharmacol
, vol.124
, pp. 369-376
-
-
Kassuya, C.A.1
Cremoneze, A.2
Barros, L.F.3
Simas, A.S.4
Lapa, F.R.5
Mello-Silva, R.6
Stefanello, M.E.7
Zampronio, A.R.8
-
32
-
-
0028931506
-
Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats
-
Kawamori T, Tanaka T, Hara A, Yamahara J, Mori H. Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. Cancer Res. 1995; 55: 1277-82.
-
(1995)
Cancer Res
, vol.55
, pp. 1277-1282
-
-
Kawamori, T.1
Tanaka, T.2
Hara, A.3
Yamahara, J.4
Mori, H.5
-
33
-
-
79953768967
-
Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway
-
Kim JH, Yang YI, Lee KT, Park HJ, Choi JH. Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway. Biol Pharm Bull. 2011a; 34: 580-85.
-
(2011)
Biol Pharm Bull
, vol.34
, pp. 580-585
-
-
Kim, J.H.1
Yang, Y.I.2
Lee, K.T.3
Park, H.J.4
Choi, J.H.5
-
34
-
-
57349129039
-
Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds
-
Kim SH, Danilenko M, Kim TS. Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds. Br J Pharmacol. 2008; 155: 814-25.
-
(2008)
Br J Pharmacol
, vol.155
, pp. 814-825
-
-
Kim, S.H.1
Danilenko, M.2
Kim, T.S.3
-
35
-
-
0037107596
-
Potentiation of 1,25-dihydroxyvitamin D(3)-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone
-
Kim SH, Kang SN, Kim HJ, Kim TS. Potentiation of 1,25-dihydroxyvitamin D(3)-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone. Biochem Pharmacol. 2002; 64: 1233-42.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1233-1242
-
-
Kim, S.H.1
Kang, S.N.2
Kim, H.J.3
Kim, T.S.4
-
36
-
-
80052278228
-
Inhibitory Effects of costunolide Isolated from Laurus nobilis on IgE-induced degranulation of mast cell-like RBL- 2H3 cells and the growth of Y16 pro-B Cells
-
Kim TJ, Nam KW, Kim B, Lee SJ, Oh KB, Kim KH, Mar W, Shin J. Inhibitory Effects of costunolide Isolated from Laurus nobilis on IgE-induced degranulation of mast cell-like RBL- 2H3 cells and the growth of Y16 pro-B Cells. Phytother Res. 2011b; 25: 1392-97.
-
(2011)
Phytother Res
, vol.25
, pp. 1392-1397
-
-
Kim, T.J.1
Nam, K.W.2
Kim, B.3
Lee, S.J.4
Oh, K.B.5
Kim, K.H.6
Mar, W.7
Shin, J.8
-
37
-
-
14644399795
-
Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells
-
Ko SG, Kim HP, Jin DH, Bae HS, Kim SH, Park CH, Lee JW. Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells. Cancer Lett. 2005; 220: 11-19.
-
(2005)
Cancer Lett
, vol.220
, pp. 11-19
-
-
Ko, S.G.1
Kim, H.P.2
Jin, D.H.3
Bae, H.S.4
Kim, S.H.5
Park, C.H.6
Lee, J.W.7
-
38
-
-
3543126648
-
Hot water soluble sesquiterpenes [anhydroperoxy-costunolide and 3-oxoeudesma-1,4(15),11(13)triene-12,6alpha-olide] isolated from laurel (Laurus nobilis L.) induce cell death and morphological change indicative of apoptotic chromatin condensation in leukemia cells
-
Komiya T, Yamada Y, Moteki H, Katsuzaki H, Imai K, Hibasami H. Hot water soluble sesquiterpenes [anhydroperoxy-costunolide and 3-oxoeudesma-1,4(15),11(13)triene-12,6alpha-olide] isolated from laurel (Laurus nobilis L.) induce cell death and morphological change indicative of apoptotic chromatin condensation in leukemia cells. Oncol Rep. 2004; 11: 85-88
-
(2004)
Oncol Rep
, vol.11
, pp. 85-88
-
-
Komiya, T.1
Yamada, Y.2
Moteki, H.3
Katsuzaki, H.4
Imai, K.5
Hibasami, H.6
-
39
-
-
0035084149
-
A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation
-
Koo TH, Lee JH, Park YJ, Hong YS, Kim HS, Kim KW, Lee JJ. A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation. Planta Med. 2001; 67: 103-07.
-
(2001)
Planta Med
, vol.67
, pp. 103-107
-
-
Koo, T.H.1
Lee, J.H.2
Park, Y.J.3
Hong, Y.S.4
Kim, H.S.5
Kim, K.W.6
Lee, J.J.7
-
40
-
-
0028847003
-
The biochemistry of programmed cell death
-
Kroemer G, Petit P, Zamzami N, Vayssiere JL, Mignotte B. The biochemistry of programmed cell death. FASEB J. 1995; 9: 1277-87.
-
(1995)
FASEB J
, vol.9
, pp. 1277-1287
-
-
Kroemer, G.1
Petit, P.2
Zamzami, N.3
Vayssiere, J.L.4
Mignotte, B.5
-
41
-
-
0035080282
-
Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release
-
Lee MG, Lee KT, Chi SG, Park JH. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. Biol Pharm Bull. 2001; 24: 303-06.
-
(2001)
Biol Pharm Bull
, vol.24
, pp. 303-306
-
-
Lee, M.G.1
Lee, K.T.2
Chi, S.G.3
Park, J.H.4
-
42
-
-
19444384973
-
Preparative isolation and purification of costunolide and dehydrocostuslactone from Aucklandia lappa Decne by high-speed counter-current chromatography
-
Li A, Sun A, Liu R. Preparative isolation and purification of costunolide and dehydrocostuslactone from Aucklandia lappa Decne by high-speed counter-current chromatography. J Chromatogr A. 2005; 1076: 193-97.
-
(2005)
J Chromatogr A
, vol.1076
, pp. 193-197
-
-
Li, A.1
Sun, A.2
Liu, R.3
-
43
-
-
33746861111
-
PTP1B inhibitors from Saussrurea lappa
-
Li S, An TY, Li J, Shen Q, Lou FC, Hu LH. PTP1B inhibitors from Saussrurea lappa. J Asian Nat Prod Res. 2006; 8: 281-86.
-
(2006)
J Asian Nat Prod Res
, vol.8
, pp. 281-286
-
-
Li, S.1
An, T.Y.2
Li, J.3
Shen, Q.4
Lou, F.C.5
Hu, L.H.6
-
44
-
-
0035254648
-
Angiogenesis: Regulators and clinical applications
-
Liekens S, De Clercq E, Neyts J. Angiogenesis: regulators and clinical applications. Biochem Pharmacol. 2001; 61: 253-70.
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 253-270
-
-
Liekens, S.1
de Clercq, E.2
Neyts, J.3
-
45
-
-
79957571352
-
Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells
-
Liu CY, Chang HS, Chen IS, Chen CJ, Hsu ML, Fu SL, Chen YJ. Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells. Radiat Oncol. 2011a; 6: 56.
-
(2011)
Radiat Oncol
, vol.6
, pp. 56
-
-
Liu, C.Y.1
Chang, H.S.2
Chen, I.S.3
Chen, C.J.4
Hsu, M.L.5
Fu, S.L.6
Chen, Y.J.7
-
46
-
-
84863428454
-
Essential oil composition and larvicidal activity of Saussurea lappa roots against the mosquito Aedes albopictus (Diptera: Culicidae)
-
DOI: 10.1007/s00436-011-2738-0
-
Liu ZL, He Q, Chu SS, Wang CF, Du SS, Deng ZW. Essential oil composition and larvicidal activity of Saussurea lappa roots against the mosquito Aedes albopictus (Diptera: Culicidae). Parasitol Res. 2011b; DOI: 10.1007/s00436-011-2738-0.
-
(2011)
Parasitol Res
-
-
Liu, Z.L.1
He, Q.2
Chu, S.S.3
Wang, C.F.4
Du, S.S.5
Deng, Z.W.6
-
47
-
-
34248140692
-
Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp
-
Luna-Herrera J, Costa MC, Gonzalez HG, Rodrigues AI, Castilho PC. Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp. J Antimicrob Chemother. 2007; 59: 548-52.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 548-552
-
-
Luna-Herrera, J.1
Costa, M.C.2
Gonzalez, H.G.3
Rodrigues, A.I.4
Castilho, P.C.5
-
48
-
-
2542509273
-
Sesquiterpene lactones with potential use as natural herbicide models (I): Trans,trans-germacranolides
-
Macias FA, Galindo JC, Castellano D, Velasco RF. Sesquiterpene lactones with potential use as natural herbicide models (I): trans,trans-germacranolides. J Agric Food Chem. 1999; 47: 4407-14.
-
(1999)
J Agric Food Chem
, vol.47
, pp. 4407-4414
-
-
Macias, F.A.1
Galindo, J.C.2
Castellano, D.3
Velasco, R.F.4
-
49
-
-
0036329660
-
Sesquiterpene lactones and phenylpropanoids from Cosmos pringlei
-
Mata R, Rivero-Cruz I, Rivero-Cruz B, Bye R, Timmermann BN. Sesquiterpene lactones and phenylpropanoids from Cosmos pringlei. J Nat Prod. 2002; 65: 1030-32.
-
(2002)
J Nat Prod
, vol.65
, pp. 1030-1032
-
-
Mata, R.1
Rivero-Cruz, I.2
Rivero-Cruz, B.3
Bye, R.4
Timmermann, B.N.5
-
50
-
-
0034697312
-
Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide- activated macrophages: Structure requirement and role of heat shock protein induction
-
Matsuda H, Kagerura T, Toguchida I, Ueda H, Morikawa T, Yoshikawa M. Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide- activated macrophages: structure requirement and role of heat shock protein induction. Life Sci. 2000; 66: 2151-57.
-
(2000)
Life Sci
, vol.66
, pp. 2151-2157
-
-
Matsuda, H.1
Kagerura, T.2
Toguchida, I.3
Ueda, H.4
Morikawa, T.5
Yoshikawa, M.6
-
51
-
-
0036131164
-
Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: Involvement of inhibition of gastric emptying and increase in gastric juice secretion
-
Matsuda H, Shimoda H, Ninomiya K, Yoshikawa M. Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: Involvement of inhibition of gastric emptying and increase in gastric juice secretion. Alcohol Alcohol 2002; 37: 121-27.
-
(2002)
Alcohol Alcohol
, vol.37
, pp. 121-127
-
-
Matsuda, H.1
Shimoda, H.2
Ninomiya, K.3
Yoshikawa, M.4
-
52
-
-
0025675581
-
Sesquiterpene lactones and other constituents from a cytotoxic extract of Michelia floribunda
-
Mondranondra IO, Che CT, Rimando AM, Vajrodaya S, Fong HH, Farnsworth NR. Sesquiterpene lactones and other constituents from a cytotoxic extract of Michelia floribunda. Pharm Res. 1990; 7: 1269-72.
-
(1990)
Pharm Res
, vol.7
, pp. 1269-1272
-
-
Mondranondra, I.O.1
Che, C.T.2
Rimando, A.M.3
Vajrodaya, S.4
Fong, H.H.5
Farnsworth, N.R.6
-
53
-
-
0028038184
-
Chemopreventive effect of costunolide, a constituent of oriental medicine, on azoxymethane-induced intestinal carcinogenesis in rats
-
Mori H, Kawamori T, Tanaka T, Ohnishi M, Yamahara J. Chemopreventive effect of costunolide, a constituent of oriental medicine, on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett. 1994; 83: 171-75.
-
(1994)
Cancer Lett
, vol.83
, pp. 171-175
-
-
Mori, H.1
Kawamori, T.2
Tanaka, T.3
Ohnishi, M.4
Yamahara, J.5
-
54
-
-
33746862576
-
Naturally occurring NF-kappaB inhibitors
-
Nam NH. Naturally occurring NF-kappaB inhibitors. Mini Rev Med Chem. 2006; 6: 945-51.
-
(2006)
Mini Rev Med Chem
, vol.6
, pp. 945-951
-
-
Nam, N.H.1
-
55
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007; 70: 461-77.
-
(2007)
J Nat Prod
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
56
-
-
38349165342
-
Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages
-
Pae HO, Jeong GS, Kim HS, Woo WH, Rhew HY, Sohn DH, Kim YC, Chung HT. Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages. Inflamm Res. 2007; 56: 520-26.
-
(2007)
Inflamm Res
, vol.56
, pp. 520-526
-
-
Pae, H.O.1
Jeong, G.S.2
Kim, H.S.3
Woo, W.H.4
Rhew, H.Y.5
Sohn, D.H.6
Kim, Y.C.7
Chung, H.T.8
-
57
-
-
33847724668
-
Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant
-
Pandey MM, Rastogi S, Rawat AK. Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant. J Ethnopharmacol. 2007; 110: 379-90.
-
(2007)
J Ethnopharmacol
, vol.110
, pp. 379-390
-
-
Pandey, M.M.1
Rastogi, S.2
Rawat, A.K.3
-
58
-
-
0030445832
-
Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldii
-
Park HJ, Jung WT, Basnet P, Kadota S, Namba T. Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldii. J Nat Prod. 1996; 59: 1128-30.
-
(1996)
J Nat Prod
, vol.59
, pp. 1128-1130
-
-
Park, H.J.1
Jung, W.T.2
Basnet, P.3
Kadota, S.4
Namba, T.5
-
59
-
-
0035433438
-
Apoptosis-Inducing costunolide and a novel acyclic monoterpene from the stem bark of Magnolia sieboldii
-
Park HJ, Kwon SH, Han YN, Choi JW, Miyamoto K, Lee SH, Lee KT. Apoptosis-Inducing costunolide and a novel acyclic monoterpene from the stem bark of Magnolia sieboldii. Arch Pharm Res. 2001a; 24: 342-48.
-
(2001)
Arch Pharm Res
, vol.24
, pp. 342-348
-
-
Park, H.J.1
Kwon, S.H.2
Han, Y.N.3
Choi, J.W.4
Miyamoto, K.5
Lee, S.H.6
Lee, K.T.7
-
60
-
-
77949878023
-
Cytotoxic germacranolide sesquiterpenes from the bark of Magnolia kobus
-
Park HW, Lee JH, Choi SU, Baek NI, Kim SH, Yang JH, Kim DK. Cytotoxic germacranolide sesquiterpenes from the bark of Magnolia kobus. Arch Pharm Res. 2010; 33: 71-74.
-
(2010)
Arch Pharm Res
, vol.33
, pp. 71-74
-
-
Park, H.W.1
Lee, J.H.2
Choi, S.U.3
Baek, N.I.4
Kim, S.H.5
Yang, J.H.6
Kim, D.K.7
-
61
-
-
0034961142
-
Costunolide, a sesquiterpene from the stem bark of Magnolia sieboldii, inhibits the RAS-farnesyl-proteintransferase
-
Park SH, Choi SU, Lee CO, Yoo SE, Yoon SK, Kim YK, Ryu SY. Costunolide, a sesquiterpene from the stem bark of Magnolia sieboldii, inhibits the RAS-farnesyl-proteintransferase. Planta Med. 2001b; 67: 358-59.
-
(2001)
Planta Med
, vol.67
, pp. 358-359
-
-
Park, S.H.1
Choi, S.U.2
Lee, C.O.3
Yoo, S.E.4
Yoon, S.K.5
Kim, Y.K.6
Ryu, S.Y.7
-
62
-
-
84863808834
-
Costunolide, a sesquiterpene lactone, induces G2/M phase arrest and mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells
-
Rasul A, Yu B, Yang L, Arshad M, Khan M, Ma T, Yang H. Costunolide, a sesquiterpene lactone, induces G2/M phase arrest and mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. J Med Plants Res. 2011; 6: 1191-1200.
-
(2011)
J Med Plants Res
, vol.6
, pp. 1191-1200
-
-
Rasul, A.1
Yu, B.2
Yang, L.3
Arshad, M.4
Khan, M.5
Ma, T.6
Yang, H.7
-
63
-
-
0035218412
-
A new sesquiterpene lactone from Tsoongiodendron odorum Chun
-
Song XK, Tu PF, Wu LJ, Cai Y, Zhu H, Lu Y, Liu XY, Zheng QT. A new sesquiterpene lactone from Tsoongiodendron odorum Chun. J Asian Nat Prod Res. 2001; 3: 285-91.
-
(2001)
J Asian Nat Prod Res
, vol.3
, pp. 285-291
-
-
Song, X.K.1
Tu, P.F.2
Wu, L.J.3
Cai, Y.4
Zhu, H.5
Lu, Y.6
Liu, X.Y.7
Zheng, Q.T.8
-
64
-
-
33745817829
-
Synthesis of 13-amino costunolide derivatives as anticancer agents
-
Srivastava SK, Abraham A, Bhat B, Jaggi M, Singh AT, Sanna VK, Singh G, Agarwal SK, Mukherjee R, Burman AC. Synthesis of 13-amino costunolide derivatives as anticancer agents. Bioorg Med Chem Lett. 2006; 16: 4195-99.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 4195-4199
-
-
Srivastava, S.K.1
Abraham, A.2
Bhat, B.3
Jaggi, M.4
Singh, A.T.5
Sanna, V.K.6
Singh, G.7
Agarwal, S.K.8
Mukherjee, R.9
Burman, A.C.10
-
65
-
-
33750951048
-
Sesquiterpene lactones from Dimerostemma species (Asteraceae) and in vitro potential anti-inflammatory activities
-
Stefani R, Schorr K, Tureta JM, Vichnewski W, Merfort I, da Costa FB. Sesquiterpene lactones from Dimerostemma species (Asteraceae) and in vitro potential anti-inflammatory activities. Z Naturforsch C 2006; 61: 647-52.
-
(2006)
Z Naturforsch C
, vol.61
, pp. 647-652
-
-
Stefani, R.1
Schorr, K.2
Tureta, J.M.3
Vichnewski, W.4
Merfort, I.5
da Costa, F.B.6
-
66
-
-
0141677804
-
Cytotoxic sesquiterpene lactones from the root of Saussurea lappa
-
Sun CM, Syu WJ, Don MJ, Lu JJ, Lee GH. Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. J Nat Prod. 2003; 66: 1175-80.
-
(2003)
J Nat Prod
, vol.66
, pp. 1175-1180
-
-
Sun, C.M.1
Syu, W.J.2
Don, M.J.3
Lu, J.J.4
Lee, G.H.5
-
67
-
-
0035810054
-
Regulation of the G2/M transition by p53
-
Taylor WR, Stark GR. Regulation of the G2/M transition by p53. Oncogene 2001; 20: 1803-15.
-
(2001)
Oncogene
, vol.20
, pp. 1803-1815
-
-
Taylor, W.R.1
Stark, G.R.2
-
68
-
-
0034615908
-
Fungicidal activity of natural and synthetic sesquiterpene lactone analogs
-
Wedge DE, Galindo JC, Macias FA. Fungicidal activity of natural and synthetic sesquiterpene lactone analogs. Phytochemistry 2000; 53: 747-57.
-
(2000)
Phytochemistry
, vol.53
, pp. 747-757
-
-
Wedge, D.E.1
Galindo, J.C.2
Macias, F.A.3
-
69
-
-
0030718488
-
Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114)
-
Woynarowski JM, Napier C, Koester SK, Chen SF, Troyer D, Chapman W, MacDonald JR. Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114). Biochem Pharmacol. 1997; 54: 1181-93.
-
(1997)
Biochem Pharmacol
, vol.54
, pp. 1181-1193
-
-
Woynarowski, J.M.1
Napier, C.2
Koester, S.K.3
Chen, S.F.4
Troyer, D.5
Chapman, W.6
Macdonald, J.R.7
-
70
-
-
0035721220
-
Two new germacranolides from Magnolia grandiflora
-
Wu SH, Luo XD, Ma YB, Hao XJ, Zhou J, Wu DG. Two new germacranolides from Magnolia grandiflora. J Asian Nat Prod Res. 2001; 3: 95-102.
-
(2001)
J Asian Nat Prod Res
, vol.3
, pp. 95-102
-
-
Wu, S.H.1
Luo, X.D.2
Ma, Y.B.3
Hao, X.J.4
Zhou, J.5
Wu, D.G.6
-
71
-
-
77149152491
-
Analysis of sesquiterpene lactones in Eupatorium lindleyanum by HPLC-PDA-ESI-MS/MS
-
Yang NY, Duan JA, Shang EX, Tian LJ. Analysis of sesquiterpene lactones in Eupatorium lindleyanum by HPLC-PDA-ESI-MS/MS. Phytochem Anal. 2010; 21: 144-49.
-
(2010)
Phytochem Anal
, vol.21
, pp. 144-149
-
-
Yang, N.Y.1
Duan, J.A.2
Shang, E.X.3
Tian, L.J.4
-
72
-
-
81155123109
-
Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species
-
Yang YI, Kim JH, Lee KT, Choi JH. Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species. Gynecol Oncol. 2011; 123: 588-96.
-
(2011)
Gynecol Oncol
, vol.123
, pp. 588-596
-
-
Yang, Y.I.1
Kim, J.H.2
Lee, K.T.3
Choi, J.H.4
-
73
-
-
80052386051
-
Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B. Clarke
-
Zhang Q, Cai D, Liu J. Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B. Clarke. J Chromatogr B Analyt Technol Biomed Life Sci. 2011; 879: 2809-14.
-
(2011)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.879
, pp. 2809-2814
-
-
Zhang, Q.1
Cai, D.2
Liu, J.3
-
74
-
-
18444367100
-
Anti-cancer potential of sesquiterpene lactones: Bioactivity and molecular mechanisms
-
Zhang S, Won YK, Ong CN, Shen HM. Anti-cancer potential of sesquiterpene lactones: Bioactivity and molecular mechanisms. Curr Med Chem Anticancer Agents 2005; 5: 239-49.
-
(2005)
Curr Med Chem Anticancer Agents
, vol.5
, pp. 239-249
-
-
Zhang, S.1
Won, Y.K.2
Ong, C.N.3
Shen, H.M.4
|