A new cytotoxic prenylated chalcone from Sophora flavescens

Archives of Pharmacal Research

Volumn 30, Issue 4, 2007, Pages 408-411

  Jae, Hyeok Lee ^a   Baek, Nam In ^b   Kim, Sung Hoon ^b   Park, Hee Wook ^c   Jae, Heon Yang ^c   Jeong, Joo Lee ^c   Seong, Jin Kim ^c   Seung, Il Jeong ^d   Oh, Chan Ho ^c   Lee, Kyu Hee ^c   Dae, Keun Kim ^c  

^a Nambu University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Woosuk University   (South Korea)

^d Jeonju Bio Materials Institute   (South Korea)

Author keywords

7,9,2 ,4 Tetrahydroxy 8 isopentenyl 5 methoxychalcone; Cytotoxicity; Leguminosae; Prenylated chalcone; Sophora flavescens

Indexed keywords

EID: 34248158903     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02980212     Document Type: Article

References (20)

1. Chung, M. Y., Rho, M. C., Ko, J. S., Ryu, S. Y., Jeune, K. H., Kim, K., Lee, H. S., and Kim, Y. K., In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med., 70, 258-260 (2004).
2. Ding, P. L., Hou, A. J., and Chen, D. F., Three new isoprenylated flavonoids from the roots of Sophora flavescens. J. Asian Nat. Prod. Res., 7, 237-243 (2005).
3. Ding, Y., Tian, R. H., Kinjo, J., Nohara, T., and Kitagawa, I., Three new oleanene glycosides from Sophora flavescens. Chem. Pharm. Bull., 40, 2990-2994 (1992).
4. Jung, B. S., and Shin, M. K., Encyclopedia of Illustrated Korean Natural drugs. Young Lim Sa, Seoul, pp.707-708 (1989).
5. Jung, H. J., Kang, S. S., Woo, J. J., and Choi, J. S., A new lavandulylated flavonoid with free radical and ONOOscavenging activities from Sophora flavescens. Arch. Pharm. Res., 28, 1333-1336 (2005).
6. Kang, S. S., Kim, J. S., Son, K. H., Chang, H. W., and Kim, H. P., A new prenylated flavanone from the roots of Sophora flavescens. Fitoterapia, 71, 511-515 (2000a).
7. Kang, T. H., Jeong, S. J., Ko, W. G., Kim, N. Y., Lee, B. H., Inagaki, M., Miyamoto, T., Higuchi, R., and Kim, Y. C., Cytotoxic lavandulyl flavanones from Sophora flavescens. J. Nat. Prod., 63, 680-681 (2000b).
8. Kim, J. H., Ryu, Y. B., Kang, N. S., Lee, B. W., Heo, J. S., Jeong, I. Y., and Park, K. H., Glycosidase inhibitory flavonoids from Sophora flavescens. Biol. Pharm. Bull., 29, 302-305 (2006).
9. Kim, S. J, Son, K. H., Chang, H. W., Kang, S. S., and Kim, H. P., Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens. Biol. Pharm. Bull., 26, 1348-1350 (2003).
10. Kuroyanagi, M., Arakawa, T., Hirayama, Y., and Hayashi, T., Antibacterial and antiandrogen flavonoids from Sophora flavescens. J. Nat. Prod., 62, 1595-1599 (1999).
11. Kyogoku, K., Hatayama, K., and Komatsu, M., Constituents of Chinese crude drug "Kushen" (the root of Sophora flavescens Ait.). Isolation of five new flavonoids and formononetin. Chem. Pharm. Bull., 21, 2733-2738 (1973).
12. Okuda, S., Murakoshi, I., Kamata, H., Kashida, Y., Haginiwa, J., and Tsuda, K., Studies on lupin alkaloids. I. The minor alkaloids of Japanese Sophora flavescens. Chem. Pharm. Bull., 13, 482-487 (1965).
13. Ryu S. Y., Lee H. S., Kim Y. K., and Kim S. H., Determination of isoprenyl and lavandulyl positions of flavonoids from Sophora flavescens by NMR experiment. Arch. Pharm. Res., 20, 491-495 (1997).
14. Shen, C. C., Lin, T. W., Huang, Y. L., Wan, S. T., Shien, B. J., and Chen, C. C., Phenolic constituents of the roots of Sophora flavescens. J. Nat. Prod., 69, 1237-1240 (2006).
15. Sohn, H. Y., Son, K. H., Kwon, C. S., Kwon, G. S., and Kang, S. S., Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine, 11, 666-672 (2004).
16. Son, J. K., Park, J. S., Kim, J. A., Kim, Y., Chung, S. R., and Lee, S. H., Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med., 69, 559-561 (2003).
17. Song, J. Z., Xu, H. X., Tian, S. J., and But, P. P., Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis. J. Chromatogr. A., 857, 303-311 (1999).
18. Sekine, T., Saito, K., Minami, R., Arai, N., Suzuki, H., Koike, Y., and Murakoshi, I., A new lupin alkaloid, (-)-leontalbinine N-oxide, in Sophora flavescens var. angustifolia seeds and its synthesis by biomimetic transformation from (+)-matrine N-oxide. Yakugaku Zasshi, 113, 53-62 (1993).
19. Woo, E. R., Kwak, J. H., Kim, H. J., and Park, H., A new prenylated flavonol from the roots of Sophora flavescens. J. Nat. Prod., 61, 1552-1554 (1998).
20. Zhu, Y.-P., Chinese Materia Medica, Harwood Academic Publishers, Amsterdam, pp. 149-155 (1998).