Applications of microneedle technology to transdermal drug delivery

Toxicology of the Skin

Volumn , Issue , 2010, Pages 301-316

  Gittard, Shaun D ^a   Narayan, Roger J ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84874601796     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (72)

1. Brown MB, Martin GP, Jone SA, et al. Dermal and transdermal drug delivery systems: current and future prospects. Drug Deliv 2006; 13(3):175-187.
2. Khafagy ES, Morishita M, Onuki Y, et al. Current challenges in noninvasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev 2007; 59(15):1521-1546.
3. Elias PM. The stratum corneum as an organ of protection old and new concepts. In: Fritsch PG, Hintner H, eds. Current Problems in Dermatology. Vol 18. Basel, Switzerland: S. Karger Ag, 1989:10-21.
4. Griss P, Stemme G. Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer. J Microelectromech Syst 2003; 12(3):296-301.
5. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 2004; 3(2):115-124.
6. Chabri F, Bouris K, Jones T, et al. Microfabricated silicon microneedles for nonviral cutaneous gene delivery. Br J Dermatol 2004; 150(5):869-877.
7. Mukerjee E, Collins SD, Isseroff RR, et al. Microneedle array for transdermal biological fluid extraction and in situ analysis. Sens Actuators A Phys 2004; 114(2-3): 267-275.
8. Lee Y, Hwang K. Skin thickness of Korean adults. Surg Radiol Anat 2002; 24(3-4): 183-189.
9. Nordquist L, Roxhed N, Griss P, et al. Novel microneedle patches for active insulin delivery are efficient in maintaining glycaemic control: an initial comparison with subcutaneous administration. Pharm Res 2007; 24(7):1381-1388.
10. Kaushik S, Hord AH, Denson DD, et al. Lack of pain associated with microfabricated microneedles. Anesth Analg 2001; 92(2):502-504.
11. Sivamani RK, Stoeber B, Wu GC, et al. Clinical microneedle injection of methyl nicotinate: stratum corneum penetration. Skin Res Technol 2005; 11(2):152-156.
12. Gill HS, Denson DD, Burris BA, et al. Effect of microneedle design on pain in human volunteers. Clin J Pain 2008; 24(7):585-594.
13. Roxhed N, Gasser TC, Griss P, et al. Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J Microelectromech Syst 2007; 16(6):1429-1440.
14. Davis SP, Landis BJ, Adams ZH, et al. Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. J Biomech 2004; 37(8):1155-1163.
15. Park JH, Yoon YK, Choi SO, et al. Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery. IEEE Trans Biomed Eng 2007; 54(5):903-913.
16. Yang M, Zahn JD. Microneedle insertion force reduction using vibratory actuation. Biomed Microdevices 2004; 6(3):177-182.
17. Gardeniers HJGE, Luttge R, Berenschot EJW, et al. Silicon micromachined hollow microneedles for transdermal liquid transport. J Microelectromech Syst 2003; 12(6): 855-862.
18. Teo MA, Shearwood C, Ng KC, et al. In vitro and in vivo characterization of MEMS microneedles. Biomed Microdevices 2005; 7(1):47-52.
19. Verbaan FJ, Bal SM, van den Berg DJ, et al. Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method. J Control Release 2008; 128(1):80-88.
20. Verbaan FJ, Bal SM, van den Berg DJ, et al. Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin. J Control Release 2007; 117(2):238-245.
21. Han M, Hyun DH, Park HH, et al. A novel fabrication process for out-of-plane microneedle sheets of biocompatible polymer. J Micromech Microeng 2007; 17(6): 1184-1191.
22. Ovsianikov A, Chichkov B, Mente P, et al. Two photon polymerization of polymerceramic hybrid materials for transdermal drug delivery. Int J Appl Ceram Technol 2007; 4(1):22-29.
23. Lee JW, Park JH, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials 2008; 29(13):2113-2124.
24. Perennes F, Marmiroli B, Matteucci M, et al. Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol. J Micromech Microeng 2006; 16(3):473-479.
25. Chandrasekaran S, Brazzle JD, Frazier AB. Surface micromachined metallic microneedles. J Microelectromech Syst 2003; 12(3):281-288.
26. Gill HS, Prausnitz MR. Pocketed microneedles for drug delivery to the skin. J Phys Chem Solids 2008; 69(5-6):1537-1541.
27. McAllister DV, Wang PM, Davis SP, et al. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc Natl Acad Sci U S A 2003; 100(24):13755-13760.
28. Aoyagi S, Izumi H, Fukuda M. Biodegradable polymer needle with various tip angles and effect of vibration and surface tension on easy insertion. In: Proceedings MEMS, Kobe, Japan, IEEE, Jan 21-25, 2007:397-400.
29. Aoyagi S, Izumi H, Fukuda M. Biodegradable polymer needle with various tip angles and consideration on mechanism of mosquito’s proboscis. Sens Actuators A Phys 2008; 143(1):20-28.
30. Biomedical Optics and Medical Imaging. Two-photon polymerization enhances rapid prototyping of medical devices. Available at: http://spie.org/x13541.xml. Accessed September, 2007.
31. Owen WB. Morphology of the head skeleton and muscles of the mosquito, Culisetainornata (Williston) (Diptera: Culicidae). J Morphol 1985; 183(1):51-85.
32. Henry S, McAllister DV, Allen MP, et al. Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 1998; 87(8):922-925.
33. Shikida M, Ando M, Ishihara Y, et al. Non-photolithographic pattern transfer for fabricating pen-shaped microneedle structures. J Micromech Microeng 2004; 14(11): 1462-1467.
34. Wilke N, Mulcahy A, Ye SR, et al. Process optimization and characterization of silicon microneedles fabricated by wet etch technology. Microelectron J 2005; 36:650-656.
35. Reaume SE. The use of hydrofluoric acid in making glass microneedles. Science 1952; 116(3023):641.
36. Wang PM, Cornwell M, Hill J, et al. Precise microinjection into skin using hollow microneedles. J Invest Dermatol 2006; 126(5):1080-1087.
37. Dorf RC, ed. CRC Handbook of Engineering Tables. Boca Raton: CRC Press, 2004.
38. Howatson AM, Lund PG, Todd JD. Engineering Tables and Data. 1st ed. London: Chapman and Hall, 1972.
39. Yoshida S, Tanaka H, Hayashi T, et al. Scratch resistance of sodium borosilicate glass. J Ceram Soc Japan 2001; 109(1270):511-515.
40. Brady GS, Clauser HR, Vaccari JA. Materials Handbook. 14th ed. New York: McGraw Hill, 1997.
41. Lynch CT. Table 1.5-1.7. In: Lynch CT, ed. CRC Handbook of Materials Science. 1st ed. Vol 2. Cleveland: CRC Press, 1974.
42. Doraiswamy A, Jin C, Narayan RJ, et al. Two photon induced polymerization of organic-inorganic hybrid biomaterials for microstructured medical devices. Acta Biomater 2006; 2(3):267-275.
43. Lourdin D, Colonna P, Ring SG. Volumetric behaviour of maltose-water, maltoseglycerol and starch-sorbitol-water systems mixtures in relation to structural relaxation. Carbohydr Res 2004; 338:2883-2887.
44. Hopcroft M, Kramer T, Kim G, et al. Micromechanical testing of SU-8 cantilevers. Fatigue Fract Eng Mater Struct 2005; 28(8):735-742.
45. Kim K, Lee JB. High aspect ratio tapered hollow metallic microneedle arrays with microfluidic interconnector. Microsyst Technol 2007; 13:3-4; 231-235.
46. Shikida M, Hasada T, Sato K. Fabrication of a hollow needle structure by dicing, wet etching, and metal deposition. J Micromech Microeng 2006; 16(10):2230-2239.
47. Brazzle J, Papautsky I, Frazier AB. Micromachined needle arrays for drug delivery or fluid extraction—design and fabrication aspects of fluid coupled arrays of hollow metallic microneedles. IEEE Eng Med Biol Mag 1999; 18(6):53-58.
48. Kobayashi K, Suzuki H. A sampling mechanism employing the phase transition of a gel and its application to a micro analysis system imitating a mosquito. Sens Actuators B Chem 2001; 80(1):1-8.
49. Suzuki H, Tokuda T, Kobayashi K. A disposable “intelligent mosquito” with a reversible sampling mechanism using the volume-phase transition of a gel. Sens Actuators B Chem 2002; 83(1-3):53-59.
50. Cormier M, Johnson B, Ameri M, et al. Transdermal delivery of desmopressin using a coated microneedle array patch system. J Control Release 2004; 97(3):503-511.
51. Parker ER, Rao MP, Turner KL, et al. Bulk micromachined titanium microneedles. J Microelectromech Syst 2007; 16(2):289-295.
52. Gill HS, Prausnitz MR. Coated microneedles for transdermal delivery. J Control Release 2007; 117(2):227-237.
53. Assad M, Lemieux N, Rivard CH, et al. Comparative in vitro biocompatibility of nickel-titanium, pure nickel, pure titanium, and stainless steel: genotoxicity and atomic absorption evaluation. Biomed Mater Eng 1999; 9(1):1-12.
54. Matteucci M, Casella M, Bedoni M, et al. A compact and disposable transdermal drug delivery system. Microelectron Eng 2008; 85(5-6):1066-1073.
55. Sullivan SP, Murthy N, Prausnitz MR. Minimally invasive protein delivery with rapidly dissolving polymer microneedles. Adv Mater 2008; 20:933-938.
56. Huang H, Fu C. Different fabrication methods of out-of-plane polymer hollow needle arrays and their variations. J Micromech Microeng 2007; 17(2):393-402.
57. Park JH, Allen MG, Prausnitz MR. Biodegradable polymer microneedles: fabrication, mechanics, and transdermal drug delivery. J Control Release 2005; 104(1):51-66.
58. Park JH, Allen MG, Prausnitz MR. Polymer microneedles for controlled-release drug delivery. Pharm Res 2006; 23(5):1008-1019.
59. Haas KH, Wolter H. Synthesis, properties, and applications of inorganic-organic copolymers (Ormocer1s). Curr Opin Solid State Mater Sci 1999; 4(6):571-580.
60. Schlie S, Ngezahayo A, Ovsianikov A, et al. Three-dimensional cell growth on structures fabricated from ORMOCER1 by two-photon polymerization technique. J Biomater Appl 2007; 22(3).
61. Miyano T, Tobinaga Y, Kanno T, et al. Sugar micro needles as transdermic drug delivery system. Biomed Microdevices 2005; 7(3):185-188.
62. Kolli CS, Banga AK. Characterization of solid maltose microneedles and their use for transdermal delivery. Pharm Res 2008; 25(1):104-113.
63. Ji J, Tay FEH, Miao JM, et al. Microfabricated microneedle with porous tip for drug delivery. J Micromech Microeng 2006; 16(5):958-964.
64. Stoeber B, Liepmann D. Arrays of hollow out-of-plane microneedles for drug delivery. J Microelectromech Syst 2005; 14(3):472-479.
65. Moon SJ, Lee SS, Lee HS, et al. Fabrication of microneedle array using LIGA and hot embossing process. Microsyst Technol 2005; 11(4-5):311-318.
66. Davis SP, Martano W, Allen MG, et al. Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans Biomed Eng 2005; 52(5):909-915.
67. Serbin J, Egbert A, Ostendorf A, et al. Femtosecond laser-induced two-photon polymerization of inorganic-organic hybrid materials for applications in photonics. Opt Lett 2003; 28(5):301-303.
68. Maruo S, Nakamura O, Kawata S. Three-dimensional microfabrication with twophoton-absorbed photopolymerization. Opt Lett 1997; 22(2):132-134.
69. Aoyagi S, Izumi H, Isono Y, et al. Laser fabrication of high aspect ratio thin holes on biodegradable polymer and its application to a microneedle. Sens Actuators A Phys 2007; 139(1-2):293-302.
70. Zahn JD, Deshmukh A, Pisano AP, et al. Continuous on-chip micropumping for microneedle enhanced drug delivery. Biomed Microdevices 2004; 6(3):183-190.
71. Lin WQ, Cormier M, Samiee A, et al. Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux1) technology. Pharm Res 2001; 18(12):1789-1793.
72. Matriano JA, Cormier M, Johnson J, et al. Macroflux1 microprojection array patch technology: a new and efficient approach for intracutaneous immunization. Pharm Res 2002; 19(1):63-70.