The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation

Toxicology Letters

Volumn 218, Issue 2, 2013, Pages 105-117

  Pang, Ying ^a,b   Xu, Yuan ^a,b   Li, Huiqiao ^c   Li, Yuan ^a,b   Zhao, Yue ^a,b   Jiang, Rongrong ^a,b   Shen, Lu ^a,b   Zhou, Jianwei ^b   Wang, Xinru ^b   Liu, Qizhan ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Nanjing Medical University   (China)

^c Qujing Center for Disease Control and Prevention   (China)

Author keywords

Arsenite; Benzo(a)pyrene; Genomic instability; Hypoxia inducible factor 2 ; Malignant transformation

Indexed keywords

ARSENIC TRIOXIDE; ATM PROTEIN; BENZO[A]PYRENE; CHECKPOINT KINASE 2; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OCTAMER TRANSCRIPTION FACTOR 4; VASCULOTROPIN;

APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CANCER GROWTH; CELL MIGRATION; CHROMOSOME ABERRATION; DNA DAMAGE; DNA REPAIR; ENZYME INHIBITION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; ARSENITES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BENZO(A)PYRENE; BRONCHI; CELL CYCLE PROTEINS; CELL LINE; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; EPITHELIAL CELLS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84874547862     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.01.004     Document Type: Article

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