Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells

Archives of Toxicology

Volumn 86, Issue 6, 2012, Pages 947-959

  Xu, Yuan ^a,b   Li, Yuan ^a,b   Pang, Ying ^a,b   Ling, Min ^a,b   Shen, Lu ^a,b   Jiang, Rongrong ^a,b   Zhao, Yue ^a,b   Zhou, Jianwei ^b   Wang, Xinru ^b   Liu, Qizhan ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Nanjing Medical University   (China)

Author keywords

Arsenite; Hypoxia inducible factor 1 ; Hypoxia inducible factor 2 ; P53 function; Tumorigenesis

Indexed keywords

ARSENIC TRIOXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; PROTEASOME; PROTEIN P53; UBIQUITIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRONCHUS MUCOSA; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ARSENITES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRONCHI; CARCINOGENICITY TESTS; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, NUDE; TUMOR SUPPRESSOR PROTEIN P53;

MUS MUSCULUS;

EID: 84866012670     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0810-x     Document Type: Article

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