Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cells

Food and Chemical Toxicology

Volumn 44, Issue 6, 2006, Pages 868-876

  McKean, C ^a   Tang, L ^a   Tang, M ^a   Billam, M ^a   Wang, Z ^a   Theodorakis, C W ^a   Kendall, R J ^a   Wang, J S ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

Acute; Aflatoxin B1; BEAS 2B; Combinative; Fumonisin B1; HepG2; Mosquitofish; Rats; Toxicity

Indexed keywords

AFLATOXIN B1; FUMONISIN B1;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS MUCOSA; CELL IMMORTALIZATION; CELL STRAIN HEPG2; COMPARATIVE TOXICOLOGY; CONTROLLED STUDY; DOSE RESPONSE; EPITHELIUM CELL; FISH; GAMBUSIA AFFINIS; HUMAN; HUMAN CELL; IC 50; LC 50; LD 50; MALE; NONHUMAN; PUBLIC HEALTH; RAT;

AFLATOXIN B1; ANIMALS; BRONCHI; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYPRINODONTIFORMES; DRUG INTERACTIONS; EPITHELIAL CELLS; FOOD CONTAMINATION; FUMONISINS; HUMANS; LIVER NEOPLASMS; MALE; MYCOTOXINS; RATS; RATS, INBRED F344;

ANIMALIA; GAMBUSIA AFFINIS;

EID: 33645917357     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.11.011     Document Type: Article

References (57)

1. Bezuidenhout S.C., Gelderblom W.C.A., and Gorstallman C.P. Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. J. Chem. Soc. Chem. Comm. 11 (1988) 743-745
2. Bhandari N., Enongene E.N., Riley R.T., Meredith F.I., and Sharma R.P. Temporal expression of fumonisin B1-induced tumor necrosis factor-α and interferon γ in mice. Comp. Biochem. Phys. C 131 2 (2002) 113-122
3. Busby W.F., and Wogan G.N. Aflatoxins. In: Searle C.E. (Ed). Chemical Carcinogenesis (1984), American Chemical Society, Washington, DC 945-1136
4. Carpenter D.O., Arcaro K.F., Bush B., Niemi W.D., Pang S., and Vakharia D.D. Human health and chemical mixtures: an overview. Environ. Health Perspect. 106 (1998) 1263-1270
5. Ciegler A., Burmaister H.R., Vesonder R.F., and Hesseltine C.W. Mycotoxins: occurrence in the environment. In: Shank R.C. (Ed). Mycotoxins and N-Nitro-Compounds: Environmental Risks (1981), CRC Press, Boca Raton, FL 1-50
6. Cole R.J., and Cox R.H. Handbook of Toxic Fungal Metabolites (1981), Academic Press, New York
7. Cornfield J. Measurement and composition of toxicities: the quantal response. In: Kempthorne O., Bancroft T.A., Gowen J.W., and Lush J.L. (Eds). Statistics and Mathematics in Biology (1964), Hofner, New York 327-344
8. Creppy E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett. 127 1-3 (2002) 19-28
9. Cullen J.M., and Newberne P.M. Acute hepatotoxicity of aflatoxins. In: Eaton D.L., and Groopman J.D. (Eds). The Toxicology of Aflatoxins (1994), Academic Press, San Diego 3-26
10. In: Eaton D.L., and Groopman J.D. (Eds). The Toxicology of Aflatoxins. Human Health, Veterinary and Agricultural Significance (1994), Academic Press, San Diego, CA
11. Ehrlich V., Darroudi F., and Uhl M. Fumonisin B1 is genotoxic in human derived hepatoma (HepG2) cells. Mutagenesis 17 3 (2002) 257-260
12. 1) in channel catfish liver. Toxicol. Appl. Pharmacol. 132 (1995) 82-90
13. Gelderblom W.C.A., Jaskiewicz K., Marasas W.F.O., Thiel P.G., Horak R.M., Vleggaar R., and Kriek N.P.J. Fumonisins; novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 54 (1988) 1806-1811
14. Gelderblom W.C.A., Marasas W.F.O., and Vleggaar R. Fumonisins-isolation, chemical characterization and biological effects. Mycopathologia 117 1-2 (1992) 11-16
15. Gelderblom W.C.A., Marasas W.F.O., and Lebepe-Mazur S. Interaction of fumonisin B1 and aflatoxin B1 in a short term carcinogenesis model in rat liver. Toxicology 171 2-3 (2002) 161-173
16. Goel S., Lenz S.D., and Lumlertsacha S. Sphingolipid levels in catfish consuming Fusarium moniliforme corn culture material containing fumonisins. Aquat. Toxicol. 30 4 (1994) 285-294
17. Gutleb A.C., Morrison E., and Murk A.J. Cytotoxicity assays for mycotoxins produced by Fusarium strains: a review. Environ. Toxicol. Phar. 11 3-4 (2002) 309-320
18. Harrison L.R., Colvin B.M., Greene J.T., Newman L.E., and Cole J.R. Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Invest. 2 (1990) 217-221
19. Harvey R.B., Edrington T.S., and Kubena L.F. Influence of aflatoxin and fumonisin B1 containing culture material on growing barrows. AM J. Vet. Res. 56 12 (1995) 1668-1672
20. Horn H.J. Simplified LD50 (or ED50) calculations. Biometrics 12 (1956) 311-322
21. Howard P.C., Eppley R.M., and Stack M.E. Fumonisin B1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F(1) mice. Environ. Health Persp. 109 Suppl. 2 (2001) 277-282
22. International Agency for Research on Cancer (IARC), 1993. Working Group on the Evaluation of Carcinogenic Risks to Humans. Some Naturally Occurring substances: Food Items and Constituents, Heterocyclic Aromatic Amine and Mycotoxins, vol. 56. IARC, Lyon, France.
23. International Agency for Research on Cancer (IARC), 1994. Working Group on the Evaluation of Carcinogenic Risks to Humans. Hepatitis viruses, vol. 59. IARC, Lyon, France.
24. International Agency for Research on Cancer (IARC), 2002. Working Group on the Evaluation of Carcinogenic Risks to Humans. Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene, vol. 82. IARC, Lyon, France.
25. Kubena L.F., Edrington T.S., and Kampsholtzapple C. Effects of feeding fumonisin B1 present in Fusarium moniliforme culture material and aflatoxin singly and in combination to Turkey poults. Poultry Sci. 74 8 (1995) 1295
26. Lewis C.W., Smith J.E., and Anderson J.G. Increased cytotoxicity of food-borne mycotoxins toward human cell lines in vitro via enhanced cytochrome p450 expression using the MTT bioassay. Mycopathologia 148 2 (1999) 97-102
27. Macé K., Gonzalez F.J., McConnell I.R., Garner R.C., Avanti O., Harris C.C., and Pfeifer A.M.A. Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2. Mol. Carcinogen. 11 (1994) 65-73
28. Marasas W.F.O., Kellerman T.S., and Gelderblom W.C.A. Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstrpoort. J. Vet. 55 4 (1988) 197-203
29. Marasas W.F.O. Risk assessment of Fumonisins produced by Fusarium moniliforme in corn. Cereal Res. Commun. 25 3 (1997) 399-406
30. Massey T.E., Stewart R.K., Daniels J.M., and Liu L. Biochemical and molecular aspects of mammalian susceptibility to aflatoxin B1 carcinogenicity. Proc. Soc. Exp. Biol. Med. 208 (1995) 213-227
31. Meredith F.I., Riley R.T., and Bacon C.W. Extraction, quantification, and biological availability of fumonisin B1 incorporated into the oregon test diet and fed to rainbow trout. J. Food Protect 61 8 (1998) 1034-1038
32. Merrill A.H., Hannun Y.A., and Bell R.M. Sphingolipids and their metabolites in cell regulation. In: Bell R.M., Hannun Y.A., and Merrill A.H. (Eds). Advances in Lipid Research: Sphingolipids and their Metabolites vol. 25 (1993), Academic Press, Orlando, FL 1-24
33. Miller J.D., and Trenholm H.L. Mycotoxins in Grain: Compounds other than Aflatoxins (1994), Eagan Press, St Paul, MN
34. Norred W.P., Voss K.A., Bacon C.W., and Riley R.T. Effectiveness of ammonia treatment in detoxification of fumonisin contaminated corn. Food Chem. Toxicol. 29 (1991) 815-819
35. Pozzi C.R., Correa B., Xavier J.G., Direito G.M., Orsi R.B., and Matarazzo S.V. Effects of prolonged oral administration of fumonisin B1 and aflatoxin B1 in rats. Mycopathologia 151 (2001) 21-27
36. Reddel R.R., Ke Y., and Gerwin B.I. Transformation of human bronchial epithelial-cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 48 7 (1988) 1904-1909
37. Riley R.T., An N.H., Showker J.L., Yoo H.S., Norred W.P., Chamberlain W.J., Wang E., Merrill A.H., Motelin G., Beasley V., and Haschek W.M. Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. Toxicol. Appl. Pharmacol. 118 (1993) 105-112
38. Riley R.T. Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins. Nat. Toxins 4 (1996) 3-15
39. Sharma R.P., and Salunkhe D.K. Mycotoxins and Phytotoxins (1991), CRC Press, Boca Raton, FL
40. Shephard G.S., Thiel P.G., and Sydenham E.W. Biliary excretion of the mycotoxin fumonisin B1 in rats. Food Chem. Toxicol. 32 5 (1994) 489-491
41. Shier W.T., Abbas H.K., and Mirocha C.J. Toxicity of the mycotoxins fumonisins B1 and B2 and Alternaria alternata f.Sp. lycopersici toxin (AL) in cultured cammalian cells. Mycopathologia 116 (1991) 97-104
42. Tallarida R.J. Drug synergism: its detection and applications. J. Pharmacol. Exp. Ther. 298 3 (2001) 865-872
43. Terse P., Madhyastha M.S., Zurovac O., Stringfellow D., Marquardt R.R., and Kemppainen B.W. Comparison of in vitro and in vivo biological activity of mycotoxins. Toxicon 31 (1993) 1-7
44. Theumer M.G., Lopez A.G., Masih D.T., Chulze S.N., and Rubinstein H.R. Immunobiological effects of fumonisin B1 in experimental subchronic mycotoxicoses in rats. Clin. Diagn. Lab. Immunol. 9 (2002) 149-155
45. Thompson W.R. Use of moving averages and interpolation to estimate median effective dose. Bacteriol. Rev. 11 (1947) 115-145
46. Tolleson W.H., Melchior W.B., Morris S.M., McGarrity L.J., Domon O.E., Muskhelishvili L., James S.J., and Howard P.C. Apoptotic and antiproliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells. Carcinogenisis 17 (1996) 239-249
47. Turner P.C., Nikiema P., and Wild C.P. Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks. Mutat. Res-Gen. Tox. En. 443 1-2 (1999) 81-93
48. Ueno Y., Iijima K., Wang S.D., Sugiura Y., Sekijima M., Tanaka T., Chen C., and Yu S.Z. Fumonisins as a possible contributory risk factor for primary liver cancer: a 3-year study of corn harvested in Haimen, China by HPLC and ELISA. Food Chem. Toxicol. 35 (1997) 1143-1150
49. Van Vleet T.R., Klein P.J., and Coulombe R.A. Metabolism and cytotoxicity of aflatoxin B1 in cytochrome P-450 expressing human lung cells. J. Toxicol. Env. Heal. A 65 12 (2002) 853-867
50. Voss K.A., Riley R.T., and Norred W.P. An overview of rodent toxicities: liver and kidney effects of Fumonisins and Fusarium moniliforme. Environ. Health Persp. 109 Suppl. 2 (2001) 259-266
51. Wang J.-S., and Groopman J.D. DNA damage by mycotoxins. Mutation Res. 424 (1999) 167-181
52. Wang E., Norred W.P., Bacon C.W., Riley R.T., and Merrill A.H. Inhibition of sphingolipid biosynthesis by fumonisins: implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266 (1991) 14486-14490
53. Wang D.S., Liang Y.X., Chau N.T., Dien L.D., Tanaka T., and Ueno Y. Natural co-occurrence of Fusarium toxins and aflatoxin B1 in corn for feed in North Vietnam. Nat. Toxins 3 (1995) 445-449
54. Wang J.-S., Kensler T.W., and Groopman J.D. Toxicants in food: fungal contaminants. In: Ioannides C. (Ed). Current Toxicology Series: Nutrition and Chemical Toxicity (1998), Wiley, New York 29-57
55. Wong Z.A., and Hsieh D.P. The comparative metabolism and toxicokinetics of aflatoxin B1 in the monkey, rat, and mouse. Toxicol. Appl. Pharmacol. 55 (1980) 115-125
56. Yoo H.S., Norred W.P., Wang E., Merrill A.H., and Riley R.T. Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. Toxicol. Appl. Pharmacol. 114 (1992) 9-15
57. Yoo H.S., Norred W.P., Showker J.L., and Riley R.T. Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. Toxicol. Appl. Pharmacol. 138 (1996) 211-218