Physiological function as regulation of large transcriptional programs: The cellular response to genotoxic stress

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

Volumn 129, Issue 4, 2001, Pages 703-710

  Amundson, Sally A ^a   Bittner, Michael ^a   Meltzer, Paul ^a   Trent, Jeffrey ^a   Fornace, Albert J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Biomarkers; Cancer; cDNA microarray; Functional genomics; Gene expression; Ionizing radiation; p53; Stress

Indexed keywords

BIOLOGICAL MARKER; PROTEIN P53;

CANCER CELL CULTURE; CANCER THERAPY; CELL SPECIFICITY; DNA HYBRIDIZATION; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENETIC ANALYSIS; GENOTOXICITY; HUMAN; IONIZING RADIATION; PRIORITY JOURNAL; REVIEW; STRESS;

EID: 0034955680     PISSN: 10964959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-4959(01)00389-X     Document Type: Review

References (45)

1. Determining radiation exposure from nuclear accidents and atomic tests using dental enamel
2. Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress
3. cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses
4. Induction of stress genes by low doses of gamma rays
5. An informatics approach identifying markers of chemosensitivity in human cancer cell lines
6. Identification of potential mRNA markers in peripheral blood lymphocytes for human exposure to ionizing radiation
7. Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts
8. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
9. Establishing a human transcript map
10. Damage-sensing mechanisms in human cells after ionizing radiation
11. Ratio-based decisions and the quantitative analysis of cDNA microarray images
12. Use of a cDNA microarray to analyse gene expression patterns in human cancer
13. Cluster analysis and display of genome-wide expression patterns
14. DNA damage-inducible transcripts in mammalian cells
15. Mammalian genes induced by radiation; activation of genes associated with growth control
16. The National Cancer Institute: Cancer drug discovery and development program
17. DNA damage induced gene expression: Signal transduction and relation to growth factor signaling
18. Signaling events controlling the molecular response to genotoxic stress
19. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
20. p53: Puzzle and paradigm
21. Estimation of relative mRNA content by filter hybridization to a polyuridylic probe
22. Discrimination techniques applied to the NCI in vitro anti-tumour drug screen: Predicting biochemical mechanism of action
23. Three distinct signalling responses by murine fibroblasts to genotoxic stress
24. Mitotic misregulation and human aging
25. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
26. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
27. A protein expression database for the molecular pharmacology of cancer
28. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
29. Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data
30. Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines
31. Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents
32. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
33. A gene expression database for the molecular pharmacology of cancer
34. Genome maps 7. The human transcript map. Wall chart
35. Pieces of the puzzle: Expressed sequence tags and the catalog of human genes
36. Morphological and immunocytochemical characteristics of human tumor cell lines for use in a disease-oriented anticancer drug screen
37. p53 tagged sites from human genomic DNA
38. Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents
39. Serial analysis of gene expression
40. The sequence of the human genome
41. Neural computing in cancer drug development: Predicting mechanism of action
42. An information intensive approach to the molecular pharmacology of cancer
43. Radiation-induced responses in mammalian cells