Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats

Toxicology

Volumn 283, Issue 1, 2011, Pages 8-17

  Kuwata, Kazunori ^a   Shibutani, Makoto ^a   Hayashi, Hitomi ^a,b   Shimamoto, Keisuke ^a,b   Hayashi, Shim Mo ^c   Suzuki, Kazuhiko ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c SAN EI GEN F F I INC   (Japan)

Author keywords

Apoptosis; Oxidative stress; Rat hepatocarcinogenesis; Regeneration; Tumor necrosis factor (TNF) ; Tumor promotion

Indexed keywords

BETA NAPHTHOFLAVONE; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; ISOQUERCITRIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL REGENERATION; CELL STRESS; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; LIVER CARCINOGENESIS; LIVER CELL; LIVER LEVEL; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; TUMOR PROMOTION;

ANIMALS; APOPTOSIS; BETA-NAPHTHOFLAVONE; CARCINOGENS; GLUTATHIONE TRANSFERASE; HEME OXYGENASE (DECYCLIZING); IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OXIDATIVE STRESS; QUERCETIN; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 79953120050     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2011.01.020     Document Type: Article

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