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Volumn 34, Issue SUPPL. 2, 2008, Pages

GLP-1 receptor signaling: effects on pancreatic β-cell proliferation and survival

Author keywords

cell mass; Apoptosis; Dipeptidyl peptidase IV; Glucagon like peptide 1; Incretins

Indexed keywords

ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 3BETA; INSULIN; TRANSCRIPTION FACTOR PDX 1;

EID: 47149103321     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1262-3636(08)73398-6     Document Type: Article
Times cited : (129)

References (43)
  • 1
    • 33745918689 scopus 로고    scopus 로고
    • Introduction : Globalization and the noncommunicable disease epidemic
    • Zimmet P.Z., and Alberti kg. Introduction : Globalization and the noncommunicable disease epidemic. Obesity (Silver Spring) 14 (2006) 1-3
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 1-3
    • Zimmet, P.Z.1    Alberti, kg.2
  • 2
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet P., Alberti kg., and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414 (2001) 782-787
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, kg.2    Shaw, J.3
  • 3
    • 9444242665 scopus 로고    scopus 로고
    • Five stages of evolving Beta-cell dysfunction during progression to diabetes
    • Weir G.C., and Bonner-Weir S. Five stages of evolving Beta-cell dysfunction during progression to diabetes. Diabetes 53 Suppl 3 (2004) S16-S21
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Weir, G.C.1    Bonner-Weir, S.2
  • 4
    • 0041828484 scopus 로고    scopus 로고
    • Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes
    • Donath M.Y., Storling J., Mædler K., et al. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81 (2003) 455-470
    • (2003) J Mol Med , vol.81 , pp. 455-470
    • Donath, M.Y.1    Storling, J.2    Mædler, K.3
  • 5
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler A.E., Janson J., Bonner-Weir S., et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52 (2003) 102-110
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3
  • 6
    • 0035856952 scopus 로고    scopus 로고
    • beta-Cell death during progression to diabetes
    • Mathis D., Vence L., and Benoist C. beta-Cell death during progression to diabetes. Nature 414 (2001) 792-798
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 7
    • 0035857020 scopus 로고    scopus 로고
    • New drug targets for type 2 diabetes and the metabolic syndrome
    • Moller D.E. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414 (2001) 821-827
    • (2001) Nature , vol.414 , pp. 821-827
    • Moller, D.E.1
  • 8
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker D.J. The biology of incretin hormones. Cell Metab 3 (2006) 153-165
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 9
    • 0035106978 scopus 로고    scopus 로고
    • Minireview : the glucagon-like peptides
    • Drucker D.J. Minireview : the glucagon-like peptides. Endocrinology 142 (2001) 521-527
    • (2001) Endocrinology , vol.142 , pp. 521-527
    • Drucker, D.J.1
  • 10
    • 9444257639 scopus 로고    scopus 로고
    • The incretin approach for diabetes treatment : modulation of islet hormone release by GLP-1 agonism
    • Holst J.J., and Orskov C. The incretin approach for diabetes treatment : modulation of islet hormone release by GLP-1 agonism. Diabetes 53 Suppl 3 (2004) S197-S204
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Holst, J.J.1    Orskov, C.2
  • 11
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagons-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus
    • Gutniak M., Orskov C., Holst J.J., et al. Antidiabetogenic effect of glucagons-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus. N Engl J Med 326 (1992) 1316-1322
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Orskov, C.2    Holst, J.J.3
  • 12
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck M.A., Heimesaat mm., Orskov C., et al. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91 (1993) 301-307
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, mm.2    Orskov, C.3
  • 13
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: a physiological incretin in man
    • Kreymann B., Williams G., Ghatei M.A., et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2 (1987) 1300-1304
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3
  • 14
    • 14044264798 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus
    • Holst J.J., and Deacon C.F. Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus. Curr Opin Pharmacol 4 (2004) 589-596
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 589-596
    • Holst, J.J.1    Deacon, C.F.2
  • 15
    • 0026775150 scopus 로고
    • Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1
    • Thorens B. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89 (1992) 8641-8645
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8641-8645
    • Thorens, B.1
  • 16
    • 0027425034 scopus 로고
    • Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin- (9-39) an antagonist of the receptor
    • Thorens B., Porret A., Buhler L., et al. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin- (9-39) an antagonist of the receptor. Diabetes 42 (1993) 1678-1682
    • (1993) Diabetes , vol.42 , pp. 1678-1682
    • Thorens, B.1    Porret, A.2    Buhler, L.3
  • 17
    • 0036378574 scopus 로고    scopus 로고
    • Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors
    • Brubaker P.L., and Drucker D.J. Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors. Receptors Channels 8 (2002) 179-188
    • (2002) Receptors Channels , vol.8 , pp. 179-188
    • Brubaker, P.L.1    Drucker, D.J.2
  • 18
    • 0028978243 scopus 로고
    • Activation of a cAMP-regulated Ca (2+) -signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1
    • Holz G.G., Leech C.A., and Habener J.F. Activation of a cAMP-regulated Ca (2+) -signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J Biol Chem 270 (1995) 17749-17757
    • (1995) J Biol Chem , vol.270 , pp. 17749-17757
    • Holz, G.G.1    Leech, C.A.2    Habener, J.F.3
  • 19
    • 0035886966 scopus 로고    scopus 로고
    • Holz GG. cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+ -induced Ca2+ release in INS-1 pancreatic beta-cells
    • Kang G., and Chepurny O.G. Holz GG. cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+ -induced Ca2+ release in INS-1 pancreatic beta-cells. J Physiol 536 (2001) 375-385
    • (2001) J Physiol , vol.536 , pp. 375-385
    • Kang, G.1    Chepurny, O.G.2
  • 20
    • 0031965604 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling
    • Gromada J., Bokvist K., Ding W.G., et al. Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling. Diabetes 47 (1998) 57-65
    • (1998) Diabetes , vol.47 , pp. 57-65
    • Gromada, J.1    Bokvist, K.2    Ding, W.G.3
  • 21
    • 0037221488 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor
    • Buteau J., Foisy S., Joly E., et al. Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 52 (2003) 124-132
    • (2003) Diabetes , vol.52 , pp. 124-132
    • Buteau, J.1    Foisy, S.2    Joly, E.3
  • 22
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1) -cells
    • Buteau J., Roduit R., Susini S., et al. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1) -cells. Diabetologia 42 (1999) 856-864
    • (1999) Diabetologia , vol.42 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3
  • 23
    • 0035489990 scopus 로고    scopus 로고
    • Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation
    • Buteau J., Foisy S., Rhodes C.J., et al. Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation. Diabetes 50 (2001) 2237-2243
    • (2001) Diabetes , vol.50 , pp. 2237-2243
    • Buteau, J.1    Foisy, S.2    Rhodes, C.J.3
  • 24
    • 2942568445 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
    • Buteau J., El-Assaad W., Rhodes C.J., et al. Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 47 (2004) 806-815
    • (2004) Diabetologia , vol.47 , pp. 806-815
    • Buteau, J.1    El-Assaad, W.2    Rhodes, C.J.3
  • 25
    • 0034505107 scopus 로고    scopus 로고
    • Integrative mitogenic role of protein kinase B/Akt in beta-cells
    • Trumper K., Trumper A., Trusheim H., et al. Integrative mitogenic role of protein kinase B/Akt in beta-cells. Ann N Y Acad Sci 921 (2000) 242-250
    • (2000) Ann N Y Acad Sci , vol.921 , pp. 242-250
    • Trumper, K.1    Trumper, A.2    Trusheim, H.3
  • 26
    • 0037386156 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3- kinase-dependent pathway
    • Hui H., Nourparvar A., Zhao X., et al. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3- kinase-dependent pathway. Endocrinology 144 (2003) 1444-1455
    • (2003) Endocrinology , vol.144 , pp. 1444-1455
    • Hui, H.1    Nourparvar, A.2    Zhao, X.3
  • 27
    • 1842855402 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
    • Wang Q., Li L., Xu E., et al. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia 47 (2004) 478-487
    • (2004) Diabetologia , vol.47 , pp. 478-487
    • Wang, Q.1    Li, L.2    Xu, E.3
  • 28
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagons-like peptide-I (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells
    • Fehmann H.C., and Habener J.F. Insulinotropic hormone glucagons-like peptide-I (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 130 (1992) 159-166
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H.C.1    Habener, J.F.2
  • 29
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers D.A., Kieffer T.J., Hussain M.A., et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49 (2000) 741-748
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 30
    • 0027473729 scopus 로고
    • Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37)
    • Holz G.Gt., Kuhtreiber W.M., and Habener J.F. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature 361 (1993) 362-365
    • (1993) Nature , vol.361 , pp. 362-365
    • Holz, G.Gt.1    Kuhtreiber, W.M.2    Habener, J.F.3
  • 31
    • 33644850386 scopus 로고    scopus 로고
    • Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function
    • Park S., Dong X., Fisher T.L., et al. Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem 281 (2006) 1159-1168
    • (2006) J Biol Chem , vol.281 , pp. 1159-1168
    • Park, S.1    Dong, X.2    Fisher, T.L.3
  • 32
    • 0038339191 scopus 로고    scopus 로고
    • cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2
    • Jhala U.S., Canettieri G., Screaton R.A., et al. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 17 (2003) 1575-1580
    • (2003) Genes Dev , vol.17 , pp. 1575-1580
    • Jhala, U.S.1    Canettieri, G.2    Screaton, R.A.3
  • 33
    • 33745315716 scopus 로고    scopus 로고
    • Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass
    • Buteau J., Spatz ml., and Accili D. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes 55 (2006) 1190-1196
    • (2006) Diabetes , vol.55 , pp. 1190-1196
    • Buteau, J.1    Spatz, ml.2    Accili, D.3
  • 34
    • 33846975788 scopus 로고    scopus 로고
    • Metabolic diapause in pancreatic betacells expressing a gain-of-function mutant of the forkhead protein Foxo1
    • Buteau J., Shlien A., Foisy S., et al. Metabolic diapause in pancreatic betacells expressing a gain-of-function mutant of the forkhead protein Foxo1. J Biol Chem 282 (2007) 287-293
    • (2007) J Biol Chem , vol.282 , pp. 287-293
    • Buteau, J.1    Shlien, A.2    Foisy, S.3
  • 35
    • 0036950665 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    • Kitamura T., Nakae J., Kitamura Y., et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110 (2002) 1839-1847
    • (2002) J Clin Invest , vol.110 , pp. 1839-1847
    • Kitamura, T.1    Nakae, J.2    Kitamura, Y.3
  • 36
    • 12744259876 scopus 로고    scopus 로고
    • beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1
    • Li Y., Cao X., Li L.X., et al. beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes 54 (2005) 482-491
    • (2005) Diabetes , vol.54 , pp. 482-491
    • Li, Y.1    Cao, X.2    Li, L.X.3
  • 37
    • 0036381989 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
    • Wang Q., and Brubaker P.L. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia 45 (2002) 1263-1273
    • (2002) Diabetologia , vol.45 , pp. 1263-1273
    • Wang, Q.1    Brubaker, P.L.2
  • 38
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • Farilla L., Hui H., Bertolotto C., et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 143 (2002) 4397-4408
    • (2002) Endocrinology , vol.143 , pp. 4397-4408
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3
  • 39
    • 0037414781 scopus 로고    scopus 로고
    • Glucagon-like Peptide-1 Receptor Signaling Modulates beta Cell Apoptosis
    • Li Y., Hansotia T., Yusta B., et al. Glucagon-like Peptide-1 Receptor Signaling Modulates beta Cell Apoptosis. J Biol Chem 278 (2003) 471-478
    • (2003) J Biol Chem , vol.278 , pp. 471-478
    • Li, Y.1    Hansotia, T.2    Yusta, B.3
  • 40
    • 33750448469 scopus 로고    scopus 로고
    • GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
    • Yusta B., Baggio L.L., Estall J.L., et al. GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab 4 (2006) 391-406
    • (2006) Cell Metab , vol.4 , pp. 391-406
    • Yusta, B.1    Baggio, L.L.2    Estall, J.L.3
  • 41
    • 34247340606 scopus 로고    scopus 로고
    • Protection of pancreatic{beta}-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies
    • Tsunekawa S., Yamamoto N., Tsukamoto K., et al. Protection of pancreatic{beta}-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies. J Endocrinol 193 (2007) 65-74
    • (2007) J Endocrinol , vol.193 , pp. 65-74
    • Tsunekawa, S.1    Yamamoto, N.2    Tsukamoto, K.3
  • 42
    • 0036107064 scopus 로고    scopus 로고
    • Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
    • Reimer M.K., Holst J.J., and Ahren B. Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur J Endocrinol 146 (2002) 717-727
    • (2002) Eur J Endocrinol , vol.146 , pp. 717-727
    • Reimer, M.K.1    Holst, J.J.2    Ahren, B.3
  • 43
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • Pospisilik J.A., Martin J., Doty T., et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes 52 (2003) 741-750
    • (2003) Diabetes , vol.52 , pp. 741-750
    • Pospisilik, J.A.1    Martin, J.2    Doty, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.