Transforming growth factor-β/Smad3 signaling regulates insulin gene transcription and pancreatic islet β-cell function

Journal of Biological Chemistry

Volumn 284, Issue 18, 2009, Pages 12246-12257

  Lin, Huei Min ^a   Lee, Ji Hyeon ^a   Yadav, Hariom ^a   Kamaraju, Anil K ^a   Liu, Eric ^a   Zhigang, Duan ^a   Vieira, Anthony ^b   Kim, Seong Jin ^c   Collins, Heather ^d   Matschinsky, Franz ^d   Harlan, David M ^a   Roberts, Anita B ^b   Rane, Sushil G ^a,e  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Gachon University College of Medicine   (South Korea)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e CRC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DYSFUNCTION; CELL FUNCTIONS; EX-VIVO; GLUCOSE TOLERANCE; GLUCOSE-STIMULATED INSULIN SECRETIONS; IN-VIVO; INSULIN GENE PROMOTER; INSULIN GENE TRANSCRIPTION; INSULIN RELEASE; NON-HUMAN PRIMATE; PANCREATIC ISLET; RECEPTOR SIGNALING; SIGNALING PATHWAYS; SMALL INTERFERING RNA; TARGET GENES; TRANSCRIPTIONAL REPRESSION; TRANSFORMING GROWTH FACTORS; TYPE-2 DIABETES;

BIOACTIVITY; GLUCOSE; INSULIN; MEDICAL PROBLEMS; PEPTIDES; SIGNALING;

TRANSCRIPTION;

INSULIN; INSULIN RECEPTOR; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; GLUCOSE; SMAD3 PROTEIN, HUMAN; SMAD3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; GENE REPRESSION; GENE TARGETING; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; HYPERINSULINEMIA; HYPOGLYCEMIA; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; GENETICS; HYPERINSULINISM; METABOLISM; MOUSE; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIMATE;

MUS; PRIMATES;

ANIMALS; CELL LINE; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; PRIMATES; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 66449119468     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805379200     Document Type: Article

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