MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Cai, Kun ^a   Qi, Dongfei ^a   Hou, Xinwei ^a   Wang, Oumei ^a   Chen, Juan ^a   Deng, Bo ^a   Qian, Lihua ^a   Liu, Xiaolong ^b   Le, Yingying ^a  

^a Chinese Academy of Sciences   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; CHEMOKINE RECEPTOR CCR2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; PROINSULIN; PROINSULIN 1; PROINSULIN 2; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; PROTEIN AP1; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CCL2 PROTEIN, MOUSE; CCR2 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; INSULIN RESISTANCE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PANCREAS ISLET; PHYSIOLOGY; UPREGULATION;

MURINAE; MUS;

ANIMALS; CHEMOKINE CCL2; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; ISLET AMYLOID POLYPEPTIDE; ISLETS OF LANGERHANS; MAP KINASE KINASE 4; MICE; MICE, INBRED C57BL; NF-KAPPA B; RECEPTORS, CCR2; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 79955895603     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019559     Document Type: Article

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