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Volumn 3, Issue SEP, 2012, Pages

Human NKG2D-ligands: Cell biology strategies to ensure immune recognition

Author keywords

Exosomes; Immune evasion; Innate immunity; MICA B; NKG2D receptor; Shedding; ULBP

Indexed keywords


EID: 84874243786     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00299     Document Type: Review
Times cited : (78)

References (103)
  • 1
    • 65249106175 scopus 로고    scopus 로고
    • Brief residence at the plasma membrane of the MHC class I-related chain B is due to clathrin-mediated cholesteroldependentendocytosisandshedding
    • Aguera-Gonzalez, S., Boutet, P., Reyburn, H. T., and Vales-Gomez, M. (2009). Brief residence at the plasma membrane of the MHC class I-related chain B is due to clathrin-mediated cholesteroldependentendocytosisandshedding. J. Immunol. 182,4800-4808.
    • (2009) J. Immunol. , vol.182 , pp. 4800-4808
    • Aguera-Gonzalez, S.1    Boutet, P.2    Reyburn, H.T.3    Vales-Gomez, M.4
  • 4
    • 77952887985 scopus 로고    scopus 로고
    • Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6 extensive polymorphisms and evidence of diversity between human populations
    • Antoun, A., Jobson, S., Cook, M., O'Callaghan, C. A., Moss, P., and Briggs, D. C. (2010). Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: extensive polymorphisms and evidence of diversity between human populations. Hum. Immunol. 71, 610-620.
    • (2010) Hum. Immunol. , vol.71 , pp. 610-620
    • Antoun, A.1    Jobson, S.2    Cook, M.3    O'Callaghan, C.A.4    Moss, P.5    Briggs, D.C.6
  • 5
    • 70450195152 scopus 로고    scopus 로고
    • NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142
    • Ashiru, O., Bennett, N. J., Boyle, L. H., Thomas, M., Trowsdale, J., and Wills, M. R. (2009). NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142. J. Virol. 83,12345-12354.
    • (2009) J. Virol. , vol.83 , pp. 12345-12354
    • Ashiru, O.1    Bennett, N.J.2    Boyle, L.H.3    Thomas, M.4    Trowsdale, J.5    Wills, M.R.6
  • 6
    • 76549099879 scopus 로고    scopus 로고
    • Natural killercellcytotoxicityissuppressedby exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes
    • Ashiru, O., Boutet, P., Fernandez-Messina, L., Aguera-Gonzalez, S., Skepper, J. N., Vales-Gomez, M., and Reyburn, H. T. (2010). Natural killercellcytotoxicityissuppressedby exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res. 70, 481-489.
    • (2010) Cancer Res , vol.70 , pp. 481-489
    • Ashiru, O.1    Boutet, P.2    Fernandez-Messina, L.3    Aguera-Gonzalez, S.4    Skepper, J.N.5    Vales-Gomez, M.6    Reyburn, H.T.7
  • 7
    • 3142781416 scopus 로고    scopus 로고
    • Two humanULBP/RAET1moleculeswith transmembrane regions are ligands for NKG2D
    • Bacon, L., Eagle, R. A., Meyer, M., Easom, N., Young, N. T., and Trowsdale, J. (2004). Two humanULBP/RAET1moleculeswith transmembrane regions are ligands for NKG2D. J. Immunol. 173, 1078-1084.
    • (2004) J. Immunol. , vol.173 , pp. 1078-1084
    • Bacon, L.1    Eagle, R.A.2    Meyer, M.3    Easom, N.4    Young, N.T.5    Trowsdale, J.6
  • 8
    • 0028198760 scopus 로고
    • A second lineage of mammalian major histo-compatibility complex class I genes
    • Bahram, S., Bresnahan, M., Geraghty, D. E., and Spies, T. (1994). A second lineage of mammalian major histo-compatibility complex class I genes. Proc. Natl. Acad. Sci. U.S.A. 91, 6259-6263.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 6259-6263
    • Bahram, S.1    Bresnahan, M.2    Geraghty, D.E.3    Spies, T.4
  • 9
    • 0033618504 scopus 로고    scopus 로고
    • Activation of NK cells and T cells by NKG2D, a receptorforstress-inducibleMICA
    • Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L., and Spies, T. (1999). Activation of NK cells and T cells by NKG2D, a receptorforstress-inducibleMICA.Science 285,727-729.
    • (1999) Science , vol.285 , pp. 727-729
    • Bauer, S.1    Groh, V.2    Wu, J.3    Steinle, A.4    Phillips, J.H.5    Lanier, L.L.6    Spies, T.7
  • 12
    • 59849101423 scopus 로고    scopus 로고
    • Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein
    • Boutet, P., Aguera-Gonzalez, S., Atkinson, S., Pennington, C. J., Edwards, D. R., Murphy, G., Reyburn, H. T., and Vales-Gomez, M. (2009). Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein. J. Immunol. 182, 49-53.
    • (2009) J. Immunol. , vol.182 , pp. 49-53
    • Boutet, P.1    Aguera-Gonzalez, S.2    Atkinson, S.3    Pennington, C.J.4    Edwards, D.R.5    Murphy, G.6    Reyburn, H.T.7    Vales-Gomez, M.8
  • 14
  • 18
    • 33846141778 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptorNKG2Dandinhibitsnaturalkiller cell-mediated cytotoxicity
    • Cerboni, C., Neri, F., Casartelli, N., Zingoni, A., Cosman, D., Rossi, P., Santoni, A., and Doria, M. (2007). Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptorNKG2Dandinhibitsnaturalkiller cell-mediated cytotoxicity. J. Gen. Virol. 88,242-250.
    • (2007) J. Gen. Virol. , vol.88 , pp. 242-250
    • Cerboni, C.1    Neri, F.2    Casartelli, N.3    Zingoni, A.4    Cosman, D.5    Rossi, P.6    Santoni, A.7    Doria, M.8
  • 19
    • 3042689208 scopus 로고    scopus 로고
    • Human MHC class I chain related (MIC) genes: their biological function and relevance to disease and transplantation
    • Collins, R. W. (2004). Human MHC class I chain related (MIC) genes: their biological function and relevance to disease and transplantation. Eur. J. Immunogenet. 31, 105-114.
    • (2004) Eur. J. Immunogenet. , vol.31 , pp. 105-114
    • Collins, R.W.1
  • 20
    • 0035099068 scopus 로고    scopus 로고
    • ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    • Cosman, D., Mullberg, J., Sutherland, C. L., Chin, W., Armitage, R., Fanslow, W., Kubin, M., and Chalupny, N. J. (2001). ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14, 123-133.
    • (2001) Immunity , vol.14 , pp. 123-133
    • Cosman, D.1    Mullberg, J.2    Sutherland, C.L.3    Chin, W.4    Armitage, R.5    Fanslow, W.6    Kubin, M.7    Chalupny, N.J.8
  • 21
    • 23944519927 scopus 로고    scopus 로고
    • Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
    • Coudert, J. D., Zimmer, J., Tomasello, E., Cebecauer, M., Colonna, M., Vivier, E., and Held, W. (2005). Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood 106,1711-1717.
    • (2005) Blood , vol.106 , pp. 1711-1717
    • Coudert, J.D.1    Zimmer, J.2    Tomasello, E.3    Cebecauer, M.4    Colonna, M.5    Vivier, E.6    Held, W.7
  • 22
    • 33744990829 scopus 로고    scopus 로고
    • Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142
    • Chalupny, N. J., Rein-Weston, A., Dosch, S., and Cosman, D. (2006). Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. Biochem. Biophys. Res. Commun. 346,175-181.
    • (2006) Biochem. Biophys. Res. Commun. , vol.346 , pp. 175-181
    • Chalupny, N.J.1    Rein-Weston, A.2    Dosch, S.3    Cosman, D.4
  • 24
    • 77951683908 scopus 로고    scopus 로고
    • Effect of NKG2D ligand expression on host immune responses
    • Champsaur, M., and Lanier, L. L. (2010). Effect of NKG2D ligand expression on host immune responses. Immunol. Rev. 235, 267-285.
    • (2010) Immunol. Rev. , vol.235 , pp. 267-285
    • Champsaur, M.1    Lanier, L.L.2
  • 27
    • 0141989779 scopus 로고    scopus 로고
    • IL-2-activated CD8+CD44high cells express both adaptive and innate immune system receptors and demonstrate specificity for syngeneic tumor cells
    • Dhanji, S., and Teh, H. S. (2003). IL-2-activated CD8+CD44high cells express both adaptive and innate immune system receptors and demonstrate specificity for syngeneic tumor cells. J. Immunol. 171, 3442-3450.
    • (2003) J. Immunol. , vol.171 , pp. 3442-3450
    • Dhanji, S.1    Teh, H.S.2
  • 28
    • 0037905745 scopus 로고    scopus 로고
    • Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands,protectingagainstnaturalkiller cell cytotoxicity
    • Dunn, C., Chalupny, N. J., Sutherland, C. L., Dosch, S., Sivakumar, P. V., Johnson, D. C., and Cosman, D. (2003). Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands,protectingagainstnaturalkiller cell cytotoxicity. J. Exp. Med. 197, 1427-1439.
    • (2003) J. Exp. Med. , vol.197 , pp. 1427-1439
    • Dunn, C.1    Chalupny, N.J.2    Sutherland, C.L.3    Dosch, S.4    Sivakumar, P.V.5    Johnson, D.C.6    Cosman, D.7
  • 30
    • 34548247599 scopus 로고    scopus 로고
    • Promiscuity and the single receptor: NKG2D
    • Eagle, R. A., and Trowsdale, J. (2007). Promiscuity and the single receptor: NKG2D. Nat. Rev. Immunol. 7, 737-744.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 737-744
    • Eagle, R.A.1    Trowsdale, J.2
  • 31
    • 17844388888 scopus 로고    scopus 로고
    • IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL-10, the latter promoting Fas ligand-mediated cytotoxicity
    • Ebert, E. C. (2005). IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL-10, the latter promoting Fas ligand-mediated cytotoxicity. Immunology 115, 118-126.
    • (2005) Immunology , vol.115 , pp. 118-126
    • Ebert, E.C.1
  • 32
    • 85043082363 scopus 로고    scopus 로고
    • Fernández-Messina, L. (2011). Studies on the biochemistry and cell biology of the glycosyl-phosphatidylinositol (GPI)-anchored NKG2D-ligands. PhD thesis,University of Cambridge, Cambridge.
    • (2011)
    • Fernández-Messina, L.1
  • 35
    • 0036910991 scopus 로고    scopus 로고
    • NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
    • Gilfillan, S., Ho, E. L., Cella, M., Yokoyama, W. M., and Colonna, M. (2002). NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3, 1150-1155.
    • (2002) Nat. Immunol. , vol.3 , pp. 1150-1155
    • Gilfillan, S.1    Ho, E.L.2    Cella, M.3    Yokoyama, W.M.4    Colonna, M.5
  • 37
    • 0029861713 scopus 로고    scopus 로고
    • Cell stressregulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
    • Groh, V., Bahram, S., Bauer, S., Herman, A., Beauchamp, M., and Spies, T. (1996). Cell stressregulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 93, 12445-12450.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 12445-12450
    • Groh, V.1    Bahram, S.2    Bauer, S.3    Herman, A.4    Beauchamp, M.5    Spies, T.6
  • 38
    • 0041422233 scopus 로고    scopus 로고
    • Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis
    • Groh, V., Bruhl, A., El-Gabalawy, H., Nelson, J. L., and Spies, T. (2003). Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A. 100, 9452-9457.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 9452-9457
    • Groh, V.1    Bruhl, A.2    El-Gabalawy, H.3    Nelson, J.L.4    Spies, T.5
  • 39
    • 0035286345 scopus 로고    scopus 로고
    • Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells
    • Groh, V., Rhinehart, R., Randolph- Habecker, J., Topp, M. S., Riddell, S. R., and Spies, T. (2001). Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2,255-260.
    • (2001) Nat. Immunol. , vol.2 , pp. 255-260
    • Groh, V.1    Rhinehart, R.2    Randolph-Habecker, J.3    Topp, M.S.4    Riddell, S.R.5    Spies, T.6
  • 40
    • 33745183385 scopus 로고    scopus 로고
    • Fas-ligand-mediated paracrine T cell regulation by the receptorNKG2Dintumorimmunity
    • Groh, V., Smythe, K., Dai, Z., and Spies,T. (2006). Fas-ligand-mediated paracrine T cell regulation by the receptorNKG2Dintumorimmunity. Nat. Immunol. 7,755-762.
    • (2006) Nat. Immunol. , vol.7 , pp. 755-762
    • Groh, V.1    Smythe, K.2    Dai, Z.3    Spies, T.4
  • 41
    • 68949117871 scopus 로고    scopus 로고
    • Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function
    • Hedlund, M., Stenqvist,A. C., Nagaeva, O., Kjellberg, L., Wulff, M., Baranov, V., and Mincheva-Nilsson, L. (2009). Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function. J. Immunol. 183,340-351.
    • (2009) J. Immunol. , vol.183 , pp. 340-351
    • Hedlund, M.1    Stenqvist, A.C.2    Nagaeva, O.3    Kjellberg, L.4    Wulff, M.5    Baranov, V.6    Mincheva-Nilsson, L.7
  • 42
    • 84855906694 scopus 로고    scopus 로고
    • Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D
    • Heinemann, A., Zhao, F., Pechlivanis, S., Eberle, J., Steinle, A., Diederichs, S., Schadendorf, D., and Paschen, A. (2012). Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D. Cancer Res. 72, 460-471.
    • (2012) Cancer Res , vol.72 , pp. 460-471
    • Heinemann, A.1    Zhao, F.2    Pechlivanis, S.3    Eberle, J.4    Steinle, A.5    Diederichs, S.6    Schadendorf, D.7    Paschen, A.8
  • 43
    • 0025754310 scopus 로고
    • DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
    • Houchins, J. P., Yabe, T., Mcsherry, C., and Bach, F. H. (1991). DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173,1017-1020.
    • (1991) J. Exp. Med. , vol.173 , pp. 1017-1020
    • Houchins, J.P.1    Yabe, T.2    Mcsherry, C.3    Bach, F.H.4
  • 46
    • 0037310821 scopus 로고    scopus 로고
    • Critical role of MHC class I-relatedchainAandBexpressionon IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection
    • Jinushi, M., Takehara, T., Kanto, T., Tatsumi, T., Groh, V., Spies, T., Miyagi, T., Suzuki, T., Sasaki,Y., and Hayashi, N. (2003). Critical role of MHC class I-relatedchainAandBexpressionon IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection. J. Immunol. 170,1249-1256.
    • (2003) J. Immunol. , vol.170 , pp. 1249-1256
    • Jinushi, M.1    Takehara, T.2    Kanto, T.3    Tatsumi, T.4    Groh, V.5    Spies, T.6    Miyagi, T.7    Suzuki, T.8    Sasaki, Y.9    Hayashi, N.10
  • 49
    • 0035347169 scopus 로고    scopus 로고
    • Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA
    • Li, P., Morris, D. L., Willcox, B. E., Steinle, A., Spies, T., and Strong, R. K. (2001). Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat. Immunol. 2,443-451.
    • (2001) Nat. Immunol. , vol.2 , pp. 443-451
    • Li, P.1    Morris, D.L.2    Willcox, B.E.3    Steinle, A.4    Spies, T.5    Strong, R.K.6
  • 50
    • 0034677175 scopus 로고    scopus 로고
    • A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts duringthedevelopmentof cell-mediated killing
    • Lou,Z.,Jevremovic,D.,Billadeau,D.D., and Leibson, P. J. (2000). A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts duringthedevelopmentof cell-mediated killing. J. Exp. Med. 191,347-354.
    • (2000) J. Exp. Med. , vol.191 , pp. 347-354
    • Lou, Z.1    Jevremovic, D.2    Billadeau, D.D.3    Leibson, P.J.4
  • 52
    • 79961141890 scopus 로고    scopus 로고
    • Structural remodeling, trafficking and functions of glycosylphos- phatidylinositol-anchored proteins
    • Maeda, Y., and Kinoshita, T. (2011). Structural remodeling, trafficking and functions of glycosylphos- phatidylinositol-anchored proteins. Prog. Lipid Res. 50,411-424.
    • (2011) Prog. Lipid Res. , vol.50 , pp. 411-424
    • Maeda, Y.1    Kinoshita, T.2
  • 53
    • 79956195348 scopus 로고    scopus 로고
    • Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane
    • Martinez,E.,Brzostowski,J.A.,Long,E. O., and Gross, C. C. (2011). Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane. J. Immunol. 186,5538-5542.
    • (2011) J. Immunol. , vol.186 , pp. 5538-5542
    • Martinez, E.1    Brzostowski, J.A.2    Long, E.O.3    Gross, C.C.4
  • 54
    • 0346160934 scopus 로고    scopus 로고
    • Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands
    • McFarland,B.J.,Kortemme,T.,Yu,S.F., Baker, D., and Strong, R. K. (2003). Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. Structure 11,411-422.
    • (2003) Structure , vol.11 , pp. 411-422
    • McFarland, B.J.1    Kortemme, T.2    Yu, S.F.3    Baker, D.4    Strong, R.K.5
  • 55
    • 77955619307 scopus 로고    scopus 로고
    • ULBP2 and RAET1E NKG2D ligands are independentpredictorsof poorprognosis in ovarian cancer patients
    • McGilvray, R. W., Eagle, R. A., Rolland, P., Jafferji, I., Trowsdale, J., and Durrant, L. G. (2010). ULBP2 and RAET1E NKG2D ligands are independentpredictorsof poorprognosis in ovarian cancer patients. Int. J. Cancer 127,1412-1420.
    • (2010) Int. J. Cancer , vol.127 , pp. 1412-1420
    • McGilvray, R.W.1    Eagle, R.A.2    Rolland, P.3    Jafferji, I.4    Trowsdale, J.5    Durrant, L.G.6
  • 58
    • 34447099969 scopus 로고    scopus 로고
    • Regulation of ligands for the activating receptor NKG2D
    • Mistry, A. R., and O'Callaghan, C. A. (2007). Regulation of ligands for the activating receptor NKG2D. Immunology 121, 439-447.
    • (2007) Immunology , vol.121 , pp. 439-447
    • Mistry, A.R.1    O'Callaghan, C.A.2
  • 59
    • 77649218586 scopus 로고    scopus 로고
    • Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands
    • doi:10.1371/journal.ppat.1000723
    • Muller, S., Zocher, G., Steinle, A., and Stehle, T. (2010). Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands. PLoS Pathog. 6, e1000723. doi: 10.1371/journal.ppat.1000723
    • (2010) PLoS Pathog , vol.6
    • Muller, S.1    Zocher, G.2    Steinle, A.3    Stehle, T.4
  • 60
    • 77954665674 scopus 로고    scopus 로고
    • Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection
    • Muntasell, A., Magri, G., Pende, D., Angulo, A., and Lopez-Botet, M. (2010). Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection. Blood 115,5170-5179.
    • (2010) Blood , vol.115 , pp. 5170-5179
    • Muntasell, A.1    Magri, G.2    Pende, D.3    Angulo, A.4    Lopez-Botet, M.5
  • 61
    • 64649083498 scopus 로고    scopus 로고
    • Diverse herpesvirus microR- NAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells
    • Nachmani, D., Stern-Ginossar, N., Sarid, R., and Mandelboim, O. (2009). Diverse herpesvirus microR- NAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells. Cell Host Microbe 5, 376-385.
    • (2009) Cell Host Microbe , vol.5 , pp. 376-385
    • Nachmani, D.1    Stern-Ginossar, N.2    Sarid, R.3    Mandelboim, O.4
  • 62
    • 53549124398 scopus 로고    scopus 로고
    • NKG2D ligands in tumor immunity
    • Nausch, N., and Cerwenka, A. (2008). NKG2D ligands in tumor immunity. Oncogene 27, 5944-5958.
    • (2008) Oncogene , vol.27 , pp. 5944-5958
    • Nausch, N.1    Cerwenka, A.2
  • 64
    • 0034866114 scopus 로고    scopus 로고
    • Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60
    • O'Callaghan, C. A., Cerwenka,A., Willcox, B. E., Lanier, L. L., and Bjorkman, P. J. (2001). Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60. Immunity 15, 201-211.
    • (2001) Immunity , vol.15 , pp. 201-211
    • O'Callaghan, C.A.1    Cerwenka, A.2    Willcox, B.E.3    Lanier, L.L.4    Bjorkman, P.J.5
  • 65
    • 77952784625 scopus 로고    scopus 로고
    • Post-translational modificationoftheNKG2DligandRAET1G leads to cell surface expression of a glycosylphosphatidylinositollinked isoform
    • Ohashi,M.,Eagle,R.A.,and Trowsdale, J. (2010). Post-translational modificationoftheNKG2DligandRAET1G leads to cell surface expression of a glycosylphosphatidylinositollinked isoform. J. Biol. Chem. 285, 16408-16415.
    • (2010) J. Biol. Chem. , vol.285 , pp. 16408-16415
    • Ohashi, M.1    Eagle, R.A.2    Trowsdale, J.3
  • 66
    • 24944500112 scopus 로고    scopus 로고
    • Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immuno- surveillance
    • Oppenheim, D. E., Roberts, S. J., Clarke, S. L., Filler, R., Lewis, J. M., Tigelaar, R. E., Girardi, M., and Hayday, A. C. (2005). Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immuno- surveillance. Nat. Immunol. 6, 928-937.
    • (2005) Nat. Immunol. , vol.6 , pp. 928-937
    • Oppenheim, D.E.1    Roberts, S.J.2    Clarke, S.L.3    Filler, R.4    Lewis, J.M.5    Tigelaar, R.E.6    Girardi, M.7    Hayday, A.C.8
  • 69
    • 0035695983 scopus 로고    scopus 로고
    • Conformationalplasticityrevealedby thecocrystalstructureofNKG2Dand its class I MHC-like ligand ULBP3
    • Radaev, S., Rostro, B., Brooks, A. G., Colonna, M., and Sun, P. D. (2001). Conformationalplasticityrevealedby thecocrystalstructureofNKG2Dand its class I MHC-like ligand ULBP3. Immunity 15,1039-1049.
    • (2001) Immunity , vol.15 , pp. 1039-1049
    • Radaev, S.1    Rostro, B.2    Brooks, A.G.3    Colonna, M.4    Sun, P.D.5
  • 70
    • 0142197631 scopus 로고    scopus 로고
    • Roles of the NKG2D immunoreceptor and its ligands
    • Raulet, D. H. (2003). Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3, 781-790.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 781-790
    • Raulet, D.H.1
  • 71
    • 67650239847 scopus 로고    scopus 로고
    • The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation
    • Roda-Navarro, P., and Reyburn, H. T. (2009). The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation. J. Biol. Chem. 284, 16463- 16472.
    • (2009) J. Biol. Chem. , vol.284 , pp. 16463-16472
    • Roda-Navarro, P.1    Reyburn, H.T.2
  • 72
    • 0038106522 scopus 로고    scopus 로고
    • Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein
    • Rolle, A., Mousavi-Jazi, M., Eriksson, M., Odeberg, J., Soderberg- Naucler, C., Cosman, D., Karre, K., and Cerboni, C. (2003). Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein. J. Immunol. 171, 902-908.
    • (2003) J. Immunol. , vol.171 , pp. 902-908
    • Rolle, A.1    Mousavi-Jazi, M.2    Eriksson, M.3    Odeberg, J.4    Soderberg-Naucler, C.5    Cosman, D.6    Karre, K.7    Cerboni, C.8
  • 73
    • 1942439040 scopus 로고    scopus 로고
    • Folate receptor endocytosis and trafficking
    • Sabharanjak, S., and Mayor, S. (2004). Folate receptor endocytosis and trafficking. Adv. Drug Deliv. Rev. 56, 1099-1109.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 1099-1109
    • Sabharanjak, S.1    Mayor, S.2
  • 75
    • 42649119742 scopus 로고    scopus 로고
    • Soluble NKG2D ligands:prevalence,release,andfunctional impact
    • Salih, H. R., Holdenrieder, S., and Steinle, A. (2008). Soluble NKG2D ligands:prevalence,release,andfunctional impact. Front. Biosci. 13, 3448-3456.
    • (2008) Front. Biosci , vol.13 , pp. 3448-3456
    • Salih, H.R.1    Holdenrieder, S.2    Steinle, A.3
  • 76
    • 0037108517 scopus 로고    scopus 로고
    • Cutting edge: down-regulationof MICAonhuman tumors by proteolytic shedding
    • Salih, H. R., Rammensee, H. G., and Steinle, A. (2002). Cutting edge: down-regulationof MICAonhuman tumors by proteolytic shedding. J. Immunol. 169,4098-4102.
    • (2002) J. Immunol. , vol.169 , pp. 4098-4102
    • Salih, H.R.1    Rammensee, H.G.2    Steinle, A.3
  • 77
    • 81755166703 scopus 로고    scopus 로고
    • The human herpesvirus- 7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB
    • doi:10.1371/journal.ppat.1002362
    • Schneider, C. L., and Hudson, A. W. (2011). The human herpesvirus- 7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB. PLoS Pathog. 7, e1002362. doi: 10.1371/journal.ppat.1002362
    • (2011) PLoS Pathog , vol.7
    • Schneider, C.L.1    Hudson, A.W.2
  • 78
    • 36249023845 scopus 로고    scopus 로고
    • In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer
    • doi:10.1371/journal.pone.0000518
    • Schrambach, S., Ardizzone, M., Leymarie, V., Sibilia, J., and Bahram, S. (2007). In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer. PLoSONE 2,e518.doi:10.1371/journal.pone.0000518
    • (2007) PLoSONE , vol.2
    • Schrambach, S.1    Ardizzone, M.2    Leymarie, V.3    Sibilia, J.4    Bahram, S.5
  • 80
    • 67949097489 scopus 로고    scopus 로고
    • Exosomes - vesicular carriers for intercellular communication
    • Simons, M., and Raposo, G. (2009). Exosomes - vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 21,575-581.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 575-581
    • Simons, M.1    Raposo, G.2
  • 81
    • 0345772230 scopus 로고    scopus 로고
    • The double life of NK receptors: stimulation or co-stimulation?
    • Snyder, M. R., Weyand, C. M., and Goronzy, J. J. (2004). The double life of NK receptors: stimulation or co-stimulation? Trends Immunol. 25, 25-32.
    • (2004) Trends Immunol , vol.25 , pp. 25-32
    • Snyder, M.R.1    Weyand, C.M.2    Goronzy, J.J.3
  • 82
    • 0034924218 scopus 로고    scopus 로고
    • Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family
    • Steinle, A., Li, P., Morris, D. L., Groh, V., Lanier, L. L., Strong, R. K., and Spies, T. (2001). Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics 53, 279-287.
    • (2001) Immunogenetics , vol.53 , pp. 279-287
    • Steinle, A.1    Li, P.2    Morris, D.L.3    Groh, V.4    Lanier, L.L.5    Strong, R.K.6    Spies, T.7
  • 83
    • 0034923215 scopus 로고    scopus 로고
    • MICA and MICB genes: can the enigma of their polymorphism be resolved?
    • Stephens, H. A. (2001). MICA and MICB genes: can the enigma of their polymorphism be resolved? Trends Immunol. 22,378-385.
    • (2001) Trends Immunol , vol.22 , pp. 378-385
    • Stephens, H.A.1
  • 85
    • 16544365848 scopus 로고    scopus 로고
    • NKG2D and related immunoreceptors
    • Strong, R. K., and McFarland, B. J. (2004). NKG2D and related immunoreceptors. Adv. Protein Chem. 68, 281-312.
    • (2004) Adv. Protein Chem. , vol.68 , pp. 281-312
    • Strong, R.K.1    McFarland, B.J.2
  • 88
  • 89
    • 33645976783 scopus 로고    scopus 로고
    • NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3- kinase in human natural killer cells
    • Upshaw, J. L., Arneson, L. N., Schoon, R. A., Dick, C. J., Billadeau, D. D., and Leibson, P. J. (2006). NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3- kinase in human natural killer cells. Nat. Immunol. 7,524-532.
    • (2006) Nat. Immunol. , vol.7 , pp. 524-532
    • Upshaw, J.L.1    Arneson, L.N.2    Schoon, R.A.3    Dick, C.J.4    Billadeau, D.D.5    Leibson, P.J.6
  • 90
    • 0347386420 scopus 로고    scopus 로고
    • Expression of the UL16 glycoprotein of human cytomegalovirus protects the virus- infected cell from attack by natural killer cells
    • doi:10.1186/1471-2172-4-4
    • Vales-Gomez, M., Browne, H., and Reyburn, H. T. (2003). Expression of the UL16 glycoprotein of human cytomegalovirus protects the virus- infected cell from attack by natural killer cells. BMC Immunol. 4, 4. doi: 10.1186/1471-2172-4-4
    • (2003) BMC Immunol , vol.4 , pp. 4
    • Vales-Gomez, M.1    Browne, H.2    Reyburn, H.T.3
  • 91
    • 40449129958 scopus 로고    scopus 로고
    • Selective induction of expression of a ligand for the NKG2D receptor by proteasome inhibitors
    • Vales-Gomez, M., Chisholm, S. E., Cassady-Cain, R. L., Roda-Navarro, P., and Reyburn, H. T. (2008). Selective induction of expression of a ligand for the NKG2D receptor by proteasome inhibitors. Cancer Res. 68,1546-1554.
    • (2008) Cancer Res , vol.68 , pp. 1546-1554
    • Vales-Gomez, M.1    Chisholm, S.E.2    Cassady-Cain, R.L.3    Roda-Navarro, P.4    Reyburn, H.T.5
  • 93
    • 70350400641 scopus 로고    scopus 로고
    • The role of the activating receptor NKG2D in autoimmunity
    • Van Belle, T. L., and von Herrath, M. G. (2009). The role of the activating receptor NKG2D in autoimmunity. Mol. Immunol. 47,8-11.
    • (2009) Mol. Immunol. , vol.47 , pp. 8-11
    • Van Belle, T.L.1    von Herrath, M.G.2
  • 94
    • 1842526956 scopus 로고    scopus 로고
    • Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells
    • Verneris, M. R., Karami, M., Baker, J., Jayaswal, A., and Negrin, R. S. (2004). Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells. Blood 103, 3065-3072.
    • (2004) Blood , vol.103 , pp. 3065-3072
    • Verneris, M.R.1    Karami, M.2    Baker, J.3    Jayaswal, A.4    Negrin, R.S.5
  • 96
    • 33645049837 scopus 로고    scopus 로고
    • Proteolytic release of soluble UL16- binding protein 2 from tumor cells
    • Waldhauer, I., and Steinle, A. (2006). Proteolytic release of soluble UL16- binding protein 2 from tumor cells. Cancer Res. 66,2520-2526.
    • (2006) Cancer Res , vol.66 , pp. 2520-2526
    • Waldhauer, I.1    Steinle, A.2
  • 101
    • 4344624611 scopus 로고    scopus 로고
    • Prevalent expression of the immunostimulatory MHC class I chain-related moleculeiscounteractedbyshedding in prostate cancer
    • Wu, J. D., Higgins, L. M., Steinle, A., Cosman, D., Haugk, K., and Plymate, S. R. (2004). Prevalent expression of the immunostimulatory MHC class I chain-related moleculeiscounteractedbyshedding in prostate cancer. J. Clin. Invest. 114, 560-568.
    • (2004) J. Clin. Invest. , vol.114 , pp. 560-568
    • Wu, J.D.1    Higgins, L.M.2    Steinle, A.3    Cosman, D.4    Haugk, K.5    Plymate, S.R.6
  • 102
    • 59849122968 scopus 로고    scopus 로고
    • Cutting edge: down-regulation of MHC class I-related chain A on tumor cells by IFN-gamma- induced microRNA
    • Yadav, D., Ngolab, J., Lim, R. S., Krishnamurthy, S., and Bui, J. D. (2009). Cutting edge: down-regulation of MHC class I-related chain A on tumor cells by IFN-gamma- induced microRNA. J. Immunol. 182, 39-43.
    • (2009) J. Immunol. , vol.182 , pp. 39-43
    • Yadav, D.1    Ngolab, J.2    Lim, R.S.3    Krishnamurthy, S.4    Bui, J.D.5
  • 103
    • 43549085090 scopus 로고    scopus 로고
    • Opposing effects of interferon- alpha and interferon-gamma on the expression of major histocompatibility complex class I chain-related A in tumors
    • Zhang, C., Niu, J., Zhang, J., Wang, Y., Zhou, Z., and Tian, Z. (2008). Opposing effects of interferon- alpha and interferon-gamma on the expression of major histocompatibility complex class I chain-related A in tumors. Cancer Sci. 99, 1279-1286.
    • (2008) Cancer Sci , vol.99 , pp. 1279-1286
    • Zhang, C.1    Niu, J.2    Zhang, J.3    Wang, Y.4    Zhou, Z.5    Tian, Z.6


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