ULBP4 is a novel ligand for human NKG2D

Biochemical and Biophysical Research Communications

Volumn 305, Issue 1, 2003, Pages 129-135

  Chalupny, N Jan ^a   Sutherland, Claire L ^a   Lawrence, William A ^a   Rein Weston, Annie ^a   Cosman, David ^a  

^a AMGEN INC   (United States)

Author keywords

Cytotoxicity; MHC; NK cell; NKG2D; ULBP

Indexed keywords

BINDING PROTEIN; LIGAND; MEMBRANE PROTEIN; PROTEIN ULBP4; RECEPTOR PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CYTOPLASM; CYTOTOXICITY; HUMAN; HUMAN CELL; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN;

EID: 0038745605     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00714-9     Document Type: Article

References (33)

1. Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., Kubin M., Chalupny N.J. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity. 14:2001;123-133.
2. Groh V., Bahram L., Bauer S., Herman A., Beauchamp M., Spies T. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. USA. 93:1996;12445-12450.
3. Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285:1999;727-729.
4. Houchins J.P., Yabe T., McSherry C., Miyokawa N., Bach F.H. Isolation and characterization of NK cells or NK/T cell-specific cDNA clones. J. Mol. Cell. Immunol. 4:1990;295-304.
5. Wu J., Song Y., Bakker A.B., Bauer S., Spies T., Lanier L.L., Phillips J.H. An activating immunoreceptor complex formed by NKG2D and DAP10. Science. 285:1999;730-732.
6. Diefenbach A., Tomasello E., Lucas M., Jamieson A.M., Hsia J.K., Vivier E., Raulet D.H. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3:2002;1142-1149.
7. Gilfillan S., Ho E.L., Cella M., Yokoyama W.M., Colonna M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3:2002;1150-1155.
8. Diefenbach A., Jamieson A.M., Liu S.D., Shastri N., Raulet D.H. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1:2000;119-126.
9. Cerwenka A., Bakker A.B., McClanahan T., Wagner J., Wu J., Phillips J.H., Lanier L.L. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity. 12:2000;721-727.
10. Nomura M., Takihara Y., Shimada K. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells; one of the early inducible clones endoces a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 57:1994;39-50.
11. Nomura M., Zhou Z., Jon T., Takihara Y., Matsuda Y., Shimada K. Genomic structures and characterization of Rae 1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. J. Biochem. (Tokyo). 120:1996;987-995.
12. Malarkannan S., Shih P.P., Eden P.A., Horng T., Zuberi A.R., Christianson G., Roopenian D., Shastri N. The molecular and functional characterization of a dominant minor H antigen, H60. J. Immunol. 161:1998;3501-3509.
13. Carayannopoulos L.N., Naidenko O.V., Fremont D.H., Yokoyama W.M. Murine UL16 binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D. J. Immunol. 169:2002;4079-4083.
14. Trincheri G. Biology of natural killer cells. Adv. Immunol. 47:1989;137-187.
15. Long E.O. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17:1999;875-904.
16. Lanier L.L. NK cell receptors. Annu. Rev. Immunol. 16:1998;359-393.
17. Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Riddell S.R., Spies T. Costimulation of CD8 α-β T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2:2001;255-260.
18. Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., Bukowski J.F. MICA engagement by human V γ 2, V δ 2 T cells enhances their antigen-dependent effector function. Immunity. 15:2001;83-93.
19. Tieng V., Le Bouguenec C., du Merle L., Bertheau P., Desreumaux P., Janin A., Charron D., Toubert A. Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc. Natl. Acad. Sci. USA. 99:2002;2977-2982.
20. Biron C.A., Nguyen K.B., Pien G.C., Cousens L.P., Salazar-Mather T.P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:1999;189-220.
21. Kubin M., Cassiano L., Chalupny J., Chin W., Cosman D., Fanslow W., Mullberg J., Rousseau A.M., Ulrich D., Armitage R. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur. J. Immunol. 31:2001;1428-1437.
22. Robertson M.J., Cochran K.J., Cameron C., Le J.M., Tantravahi R., Ritz J. Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. Exp. Hematol. 24:1996;406-415.
23. C. Dunn, N.J. Chalupny, C.L. Sutherland, S. Dosch, P.V. Sivakumar, D.C. Johnson, D. Cosman, Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against NK cell cytotoxicity, J. Exp. Med. (2003), in press.
24. McMahan C.J., Slack J.L., Mosley B., Cosman D., Lupton S.D., Brunton L.L., Grubin C.E., Wignall J.M., Jenkins N.A., Brannan C.I. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed by many cell types. EMBO J. 10:1991;2821-2832.
25. Fanslow W.C., Anderson D.M., Grabstein K.H., Clark E.A., Cosman D., Armitage R.J. Soluble forms of CD40 inhibit biologic responses of human B cells. J. Immunol. 149:1992;655-660.
26. Kinsella T.M., Nolan G.P. Episomal vectors rapidly and stably produce high titre recombinant retrovirus. Hum. Gene Ther. 7:1996;1405-1413.
27. Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. J. Immunol. 168:2002;671-679.
28. Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., Gilfillan S., Beck S., Trowsdale J., Bahram S. A cluster of ten novel MCH class I-related genes on human chromosome 6q24.2-q25.3. Genomics. 79:2002;114-123.
29. Welte S.A., Sinzger C., Lutz S.Z., Singh-Jasuja H., Sampaio K.L., Eknigk U., Mammensee H.-G., Steinle A. Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein. Eur. J. Immunol. 33:2003;194-203.
30. Wu J., Chalupny N.J., Manley T.J., Riddell S.R., Cosman D., Spies T. Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein. J. Immunol. 170:2003;4196-4200.
31. Girardi M., Oppenheim D.E., Steele C.R., Lewis J.M., Glusac E., Filler R., Hobby P., Sutton B., Tigelaar R.E., Hayday A.C. Regulation of cutaneous malignancy by. γδ T cells Science. 294:2001;605-609.
32. Rabinovich B.A., Li J., Shannon J., Hurren R., Chalupny J., Cosman D., Miller R.G. Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells. J. Immunol. 170:2003;3572-3576.
33. Pende D., Rivera P., Marcenaro S., Chang C.C., Biassoni R., Conte R., Kubin M., Cosman D., Ferrone S., Moretta L., Moretta A. Major Histocompatibility Complex Class I-related chanin A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent Natural Killer cell cytotoxicity. Cancer Res. 62:2002;6178-6186.