Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells

BMC Immunology

Volumn 4, Issue , 2003, Pages

  Valés Gómez, Mar ^a   Browne, Helena ^a   Reyburn, Hugh T ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS GLYCOPROTEIN UL16; GLYCOPROTEIN; IMMUNOGLOBULIN RECEPTOR; LIGAND; NATURAL KILLER CELL ACTIVATING RECEPTORS; VIRUS PROTEIN;

ARTICLE; CELL PROTECTION; CELL SURFACE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOLYSIS; CYTOMEGALOVIRUS INFECTION; DELETION MUTANT; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IN VITRO STUDY; MOLECULAR RECOGNITION; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SKIN FIBROBLAST; STRAIN DIFFERENCE; VIRUS MUTANT; WILD TYPE; CELL LINE; CYTOMEGALOVIRUS; CYTOTOXICITY; FIBROBLAST; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; NATURAL KILLER CELL; PATHOGENICITY; VIROLOGY;

CELL LINE; CYTOMEGALOVIRUS; CYTOTOXICITY, IMMUNOLOGIC; FIBROBLASTS; GENE EXPRESSION; GLYCOPROTEINS; HUMANS; KILLER CELLS, NATURAL; LIGANDS; RECEPTORS, IMMUNOLOGIC; VIRAL PROTEINS;

EID: 0347386420     PISSN: 14712172     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2172-4-4     Document Type: Article

References (37)

1. Hengel H, Brune W and Koszinowski UH Immune evasion by cytomegalovirus-survival strategies of a highly adapted opportunist Trends Microbiol 1998, 6:190-197
2. Tortorella D, Gewurz BE, Furman MH, Schust DJ and Ploegh HL Viral subversion of the immune system Annu Rev Immunol 2000, 18:861-926
3. Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME and Greenberg PD Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones Science 1992, 257:238-241
4. Reddehase MJ, Weiland F, Munch K, Jonjic S, Luske A and Koszinowski UH Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs J Virol 1985, 55:264-273
5. Quinnan G. V., Jr., Kirmani N, Rook AH, Manischewitz JF, Jackson L, Moreschi G, Santos GW, Saral R and Burns WH Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients N Engl J Med 1982, 307:7-13
6. Ljunggren H-G and Karre K In search of the 'missing self': MHC molecules and NK recognition Immunology Today 1990, 11:237
7. Beck S and Barrell BG Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens Nature 1988, 331:269 -2272
8. Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L and Hsu ML A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules Immunity 1997, 7:273-282
9. Ulbrecht M, Martinozzi S, Grzeschik M, Hengel H, Ellwart JW, Pla M and Weiss EH Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis J Immunol 2000, 164:5019-5022
10. Tomasec P, Braud VM, Rickards C, Powell MB, McSharry BP, Gadola S, Cerundolo V, Borysiewicz LK, McMichael AJ and Wilkinson GW Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40 Science 2000, 287:1031
11. Cosman D, Mullberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M and Chalupny NJ ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor Immunity 2001, 14:123-133
12. Leong CC, Chapman TL, Bjorkman PJ, Formankova D, Mocarski ES, Phillips JH and Lanier LL Modulation of Natural killer cell cytotoxicity in Human cytomegalovirus infection: The role of endogenous Class I major histocompatbility complex and a viral Class I homologue J. Exp. Med. 1998, 187:1681-1687
13. Cerboni C, Mousavi-Jazi M, Linde A, Soderstrom K, Brytting M, Wahren B, Karre K and Carbone E Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts J Immunol 2000, 164:4775-4782
14. Cerboni C, Mousavi-Jazi M, Wakiguchi H, Carbone E, Karre K and Soderstrom K Synergistic effect of IFN-gamma and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity Eur J Immunol 2001, 31:2926-2935
15. Wang EC, McSharry B, Retiere C, Tomasec P, Williams S, Borysiewicz LK, Braud VM and Wilkinson GW UL40-mediated NK evasion during productive infection with human cytomegalovirus Proc Natl Acad Sci U S A 2002, 99:7570-7575
16. Falk CS, Mach M, Schendel DJ, Weiss EH, Hilgert I and Hahn G NK cell activity during human cytomegalovirus infection is dominated by US2-11-mediated HLA class I down-regulation J Immunol 2002, 169:3257-3266
17. Kaye J, Browne H, Stoffel M and Minson T The UL16 gene of human cytomegalovirus encodes a glycoprotein that is dispensable for growth in vitro J Virol 1992, 66:6609-6615
18. Yokoyama W Recognition structures on Natural Killer cells Curr. Opin. Immunol. 1993, 5:67-73
19. Lanier LL, Corliss B and Phillips JH Arousal and inhibition of human NK cells Immunol Rev 1997, 155:145-154
20. Reyburn HT, Mandelboim O, Vales-Gomez M, Davis DM, Pazmany L and Strominger JL The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells [see comments] Nature 1997, 386:514-517
21. Fletcher JM, Prentice HG and Grundy JE Natural killer cell lysis of cytomegalovirus (CMV)-infected cells correlates with virally induced changes in cell surface lymphocyte function-associated antigen-3 (LFA-3) expression and not with the CMV-induced down-regulation of cell surface class I HLA J Immunol 1998, 161:2365-2374
22. Zwirner NW, Dole K and Stastny P Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes Hum Immunol 1999, 60:323-330
23. Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR and Spies T Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells Nat Immunol 2001, 2:255-260
24. Chee MS, Bankier AT, Beck S, Bohni R, Brown CM, Cerny R, Horsnell T, Hutchison C. A., 3rd, Kouzarides T, Martignetti JA and et al. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169 Curr Top Microbiol Immunol 1990, 154:125-169
25. Brown JM, Kaneshima H and Mocarski ES Dramatic interstrain differences in the replication of human cytomegalovirus in SCID-hu mice J Infect Dis 1995, 171:1599-1603
26. Chee MS, Bankier AT, Beck S, Bohni R, Brown CM, Cerny R, Horsnell T, Hutchison C. A., 3rd, Kouzarides T, Martignetti JA and et al. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169 Curr Top Microbiol Immunol 1990, 154:125-169
27. Groh V, Bahram S, Bauer S, Herman A, Beauchamp M and Spies T Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium Proc Natl Acad Sci U S A 1996, 93:12445-12450
28. Krmpotic A, Busch DH, Bubic I, Gebhardt F, Hengel H, Hasan M, Scalzo AA, Koszinowski UH and Jonjic S MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo Nat Immunol 2002, 3:529-535
29. Mandelboim O, Reyburn HT, Vales-Gomez M, Pazmany L, Colonna M, Borsellino G and Strominger JL Protection from lysis by Natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules J. Exp. Med. 1996, 184:913-922
30. Moretta A, Pantaleo G, Moretta L, Cerottini JC and Mingari MC Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity J Exp Med 1983, 157:743-754
31. Bahram S and Spies T Nucleotide sequence of a human MHC class I MICB cDNA Immunogenetics 1996, 43:230-233
32. Lin AY, Devaux B, Green A, Sagerstrom C, Elliott JF and Davis MM Expression of T cell antigen receptor heterodimers in a lipid-linked form Science 1990, 249:677-679
33. Perez-Villar JJ, Melero I, Navarro F, Carretero M, Bellon T, Llano M, Colonna M, Geraghty DE and Lopez-Botet M The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1 J Immunol 1997, 158:5736-5743
34. Banks TA, Jenkins FJ, Kanangat S, Nair S, Dasgupta S, Foster CM and Rouse BT Vaccination with the immediate-early protein ICP47 of herpes simplex virus-type 1 (HSV-1) induces virus-specific lymphoproliferation, but fails to protect against lethal challenge Virology 1994, 200:236-245
35. Mackett M, Smith GL and Moss B Vaccinia virus: a selectable eukaryotic cloning and expression vector Proc Natl Acad Sci U S A 1982, 79:7415-7419
36. Routledge EG, Lloyd I, Gorman SD, Clark M and Waldmann H A humanized monovalent CD3 antibody which can activate homologous complement Eur J Immunol 1991, 21:2717-2725
37. Chapman TL and Bjorkman PJ Characterization of a murine cytomegalovirus class I major histocompatibility complex (MHC) homolog: comparison to MHC molecules and to the human cytomegalovirus MHC homolog J Virol 1998, 72:460-466