Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity

Chemical Research in Toxicology

Volumn 26, Issue 2, 2013, Pages 221-232

  Ketkar, Amit ^a   Zafar, Maroof K ^a   Maddukuri, Leena ^a   Yamanaka, Kinrin ^b,f   Banerjee, Surajit ^e   Egli, Martin ^d   Choi, Jeong Yun ^c   Lloyd, R Stephen ^b   Eoff, Robert L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; DNA POLYMERASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; COMPUTER MODEL; CONTROLLED STUDY; DNA BINDING; DRUG BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; IC 50; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING;

BINDING SITES; DNA-DIRECTED DNA POLYMERASE; HUMANS; INDOLES; KINETICS; LEUKOTRIENES; LIPOXYGENASE INHIBITORS; MOLECULAR DOCKING SIMULATION;

EID: 84874090568     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300392m     Document Type: Article

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