A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Yamanaka, Kinrin ^a   Dorjsuren, Dorjbal ^b   Eoff, Robert L ^c   Egli, Martin ^d   Maloney, David J ^b   Jadhav, Ajit ^b   Simeonov, Anton ^b   Lloyd, R Stephen ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; CANDESARTAN HEXETIL; DNA POLYMERASE; DNA POLYMERASE KAPPA; MANOALIDE; TRANSLESION SYNTHESIS POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND; DOSE RESPONSE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PROTEIN DNA INTERACTION; QUANTITATIVE ANALYSIS; ULTRAVIOLET RADIATION;

ACROLEIN; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; CELL LINE, TRANSFORMED; CELL SURVIVAL; DEOXYGUANOSINE; DNA; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INDOLES; SMALL MOLECULE LIBRARIES; TERPENES; TETRAZOLES; ULTRAVIOLET RAYS;

EID: 84867304060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045032     Document Type: Article

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