MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells

Journal of Neuro-Oncology

Volumn 97, Issue 3, 2010, Pages 339-346

  Lim, Jung Yeon ^a   Oh, Ji Hyeon ^a   Jung, Ju Ri ^b   Kim, Seong Muk ^a   Ryu, Chung Hun ^a   Kim, Hong Tae ^c   Jeun, Sin Soo ^d  

^a The Catholic University of Korea   (South Korea)

^b Ellead Co Ltd   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

5 Lipoxygenase; Apoptosis; Growth inhibition; Malignant glioma; MK886

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; BETA ACTIN; CELL DNA; DOCEBENONE; LIPOXYGENASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL A172; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CELL U373; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; FLUORESCENCE ACTIVATED CELL SORTING; GENE ACTIVITY; GENE SILENCING; GLIOBLASTOMA; GLIOMA CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUCLEAR CONDENSATION ASSAY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; U 87MG CELL; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; INDOLES; LIPOXYGENASE INHIBITORS; MUTATION; RNA, SMALL INTERFERING; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953290988     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-009-0036-9     Document Type: Article

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