Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice

Toxicological Sciences

Volumn 131, Issue 2, 2013, Pages 360-374

  Sasso, Alan F ^a   Schlosser, Paul M ^b   Kedderis, Gregory L ^c   Genter, Mary Beth ^d   Snawder, John E ^e   Li, Zheng ^a   Rieth, Susan ^a   Lipscomb, John C ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c Independent Consultant   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^e NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Chloroform; Kidney; Model; PBPK; Renal toxicity

Indexed keywords

CHLOROFORM; CYTOCHROME P450 2E1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IN VITRO STUDY; KIDNEY METABOLISM; LIVER METABOLISM; MALE; METABOLITE; MOUSE; NEPHROTOXICITY; NONHUMAN; RAT;

EID: 84873882315     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs320     Document Type: Article

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