Biologically motivated computational modeling of chloroform cytolethality and regenerative cellular proliferation

Toxicological Sciences

Volumn 75, Issue 1, 2003, Pages 192-200

  Tan, Yu Mei ^a   Butterworth, Byron E ^a,b   Gargas, Michael L ^a,c   Conolly, Rory B ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b Butterworth Consulting   (United States)

^c Sapphire Group   (United States)

Author keywords

Chloroform; Inhaled chloroform cytolethality; Labeling index (LI); Liver; Pharmacodynamic (PD); Physiologically based pharmacokinetic (PBPK) model; Regenerative cellular proliferation

Indexed keywords

CHLOROFORM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL DIVISION; CELL KILLING; CELL LABELING; CELL PROLIFERATION; CELL REGENERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; DESMOSOME; FEMALE; HYPOTHESIS; LABELING INDEX; LINEAR SYSTEM; LIVER CARCINOGENESIS; LIVER CELL; LIVER METABOLISM; MATHEMATICAL MODEL; MOUSE; MOUSE STRAIN; NONHUMAN; PREDICTION; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, INHALATION; ANIMALS; CARCINOGENS; CELL DEATH; CELL DIVISION; CHLOROFORM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MICE; MODELS, BIOLOGICAL;

ANIMALIA; RODENTIA;

EID: 0042883799     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg152     Document Type: Article

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