In vivo CHCl3 bioactivation, toxicokinetics, toxicity, and induced compensatory cell proliferation in B6C3F1 male mice

Toxicology and Applied Pharmacology

Volumn 141, Issue 2, 1996, Pages 394-402

  Gemma, Simonetta ^a   Faccioli, Silvia ^b   Chieco, Pasquale ^b   Sbraccia, Maria ^a   Testai, Emanuela ^a   Vittozzi, Luciano ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROFORM; CARBON DIOXIDE; GLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HISTOLOGY; IN VIVO STUDY; KIDNEY NECROSIS; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; MOUSE; NEPHROTOXICITY; NONHUMAN; TOXICOKINETICS; XENOBIOTIC METABOLISM; ANIMAL; BIOTRANSFORMATION; CELL DIVISION; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; METABOLISM;

ANIMALS; BIOTRANSFORMATION; CARBON DIOXIDE; CELL DIVISION; CHLOROFORM; GLUTATHIONE; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; MALE; MICE;

EID: 0030340026     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0305     Document Type: Article

References (59)

1. Ade, P., Guastadisegni, C., Testai, E., and Vittozzi, L. (1994). Multiple activation of chloroform in kidney microsomes from male and female DBA/2J mice. J. Biochem. Toxicol. 9, 289-295.
2. Agar, N. S. (1979). The activity of sorbitol dehydrogenase in some mammalian erythrocytes. Experientia 35, 790-793.
3. Belfiore, F., and Zimmerman, H. J. (1970). Cytotoxicity of chlorinated hydrocarbons in vitro. Observations on chloroform-induced hemolysis. Proc. Soc. Exp. Biol. Med. 134, 61-66.
4. Branchflower, R. V., Nunn, D. S., Highet, R. J., Smith, J. H., Hook, J. B., and Pohl, L. R. (1984). Nephrotoxicity of chloroform: Metabolism to phosgene by the mouse kidney. Toxicol. Appl. Pharmacol. 72, 159-168.
5. 14C]chloroform by different species. Xenobiotica 4, 151-163.
6. Brown, B. R., Jr., Sipes, I. G., and Sagalyn, A. M. (1974). Mechanisms of acute hepatic toxicity: Chloroform, halothane and gluthatione. Anesthesiology 41, 554-561.
7. Bull, R. J., Brown, J. M., Meierhenry, E. A., Jorgenson, T. A., Robinson, M., and Stober, J. A. (1986). Enhancement of the hepatotoxicity of chloroform in B6C3F1 mice by corn oil: Implications for chloroform carcinogenesis. Environ. Health Perspect. 69, 49-58.
8. Chieco, P., Hrelia, P., Lisignoli, G., and Cantelli-Forti, G. (1988). Quantitative enzyme histochemistry of rat foetal brain and trigeminal ganglion. Histochem. J. 20, 455-463.
9. Chieco, P., Jonker, A., Melchiorri, C., Vanni, G., and Van Noorden, C. J. F. (1994). A user's guide for avoiding errors in absorbance image cytometry: A review with original experimental observations. Histochem. J. 26, 1-19.
10. Cohen, S. M., and Ellwein, L. B. (1990a). Cell proliferation in carcinogenesis. Science 249, 1007-1011.
11. Cohen, S. M., and Ellwein, L. B. (1990b). Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: Biological modeling of the ED01 study. Toxicol. Appl. Pharmacol. 104, 79-93.
12. Colacci, A., Bartoli, S., Bonora, B., Guidotti, L., Lattanzi, G., Mazzullo, M., Niero, A., Perocco, P., Silingardi, P., and Grilli, S. (1991). Chloroform bioactivation leading to nucleic acids binding. Tumori 77, 285-290.
13. 3 metabolites to microsomal phospholipids. Chem.-Biol. Interact. 85, 229-242.
14. De Curtis, V., Gemma, S., Sbraccia, M., Testai, E., and Vittozzi, L. (1994). The contribution of electrophilic and radicalic intermediates to phospholipid adducts formed by halomethanes in vivo. J. Biochem. Toxicol. 9, 305-310.
15. Docks, E. L., and Krishna, G. (1976). The role of gluthatione in chloroform-induced hepatotoxicity. Exp. Mol. Pathol. 24, 13-22.
16. Ekstrom, T., and Hogberg, J. (1980). Chloroform-induced glutathione depletion and toxicity in freshly isolated hepatocytes. Biochem. Pharmacol. 29, 3059-3065.
17. Ellman, G. L. (1959). Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70-77.
18. Eschenbrenner, A. B., and Miller, E. (1945). Induction of hepatomas in mice by repeated oral administration of chloroform, with observations on sex differences. J. Natl. Cancer Inst. 5, 251-255.
19. 2+ on substrate utilization. Biochemistry 12, 1438-1445.
20. Folch, J., Lees, M., and Sloane-Stanley, G. M. (1957). A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509.
21. Gemma, S., Sbraccia, M., Testai, E., and Vittozzi, L. (1994). In vivo production of different chloroform metabolites: Effect of phenobarbital and buthionine sulfoximine pretreatment. Environ. Health Perspect. 102, 45-47.
22. Heywood, R., Sortwell, R. J., Noel, P. R. B., Street, A. E., Prentice, D. E., Roe, F. J. C., Wadsworth, P. F., Worden, A. N., and Van Abbé, N. J. (1979). Safety evalutation of toothpaste containing chloroform III. Long-term study in beagle dogs. J. Environ. Pathol. Toxicol. 2, 835-851.
23. Hill, R. N., Clemens, T. L., Liu, D. K., Vesell, E. S., and Johnson, W. D. (1975). Genetic control of chloroform toxicity in mice. Science 190, 159-161.
24. Ilett, K. F., Reid, W. D., Sipes, I. G., and Krishna, G. (1973). Chloroform toxicity in mice: Correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules. Exp. Mol. Pathol. 19, 215-229.
25. Jorgenson, T. A., Meierhenry, E. F., Rushbrook, C. J., Bull, R. J., and Robinson, M. (1985). Carcinogenicity of chloroform in drinking water to male Osborne Mendel rats and female B6C3F1 mice. Fundam. Appl. Toxicol. 5, 760-769.
26. Larson, J. L., Wolf, D. C., and Butterworth, B. E. (1993). Acute hepatotoxic and nephrotoxic effects of chloroform in male F-344 rats and female B6C3F1 mice. Fundam. Appl. Toxicol. 20, 302-315.
27. Larson, J. L., Wolf, D. C., and Butterworth, B. E. (1994). Induced cytolethality and regenerative cell proliferation in the livers and kidneys of male B6C3F1 mice given chloroform by gavage. Fundam. Appl. Toxicol. 23, 537-543.
28. Larson, J. L., Wolf, D. C., and Butterworth, B. E. (1995). Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water. Toxicology 95, 73-86.
29. Lojda, Z. (1979). Studies on dipeptidyl (amino)peptidase IV (glycyl-proline naphthylamidase). Histochemistry 59, 153-166.
30. Mansuy, D., Beaune, P., Cresteil, T. H., Lange, M., and Leroux, J. P. (1977). Evidence for phosgene formation during liver microsomal oxidation of chloroform. Biochem. Biophys. Res. Commun. 79, 513-517.
31. McGee and Russel, S. M. (1985). Histochemical methods for calcium. J. Histochem. Cytochem. 6, 22-27.
32. 14C-trihalomethanes in mice and rats. Bull. Environ. Contam. Toxicol. 37, 752-758.
33. Moore, D. H., Chasseaud, L. F., Majeed, S. K., Prentice, D. E., Roe, F. J. C., and Van Abbe, N. J. (1982). The effect of dose and vehicle on early tissue damage and regenerative activity after chloroform administration to mice. Food Chem. Toxicol. 20, 951-954.
34. NCI (1976). Report on Carcinogenesis Bioassay of Chloroform. Natl. Tech. Inf. Serv. PB-264018/AS.
35. Palmer, A. K., Street, A. E., Roe, F. J. C., Worden, A. N., and Van Abbe, N. J. (1979). Safety evalutation of toothpaste containing chloroform. III. Long term studies in rats. J. Environ. Pathol. Toxicol. 2, 821-833.
36. Pearse, A. G. E. (1991). Histochemistry. In Theoretical and Applied Enzyme Histochemistry (Edinburg, Ed.), pp. 607-618. Churchill Livingstone, London.
37. Pereira, M. A., Lin, L. C., Lippitt, J. M., and Herren, S. L. (1982). Trihalomethanes as initiators and promoters of carcinogenesis. Environ. Health Perspect. 46, 151-156.
38. Plaa, G. L., and Hewitt, W. R. (1982). Detection and evaluation of chemically induced liver injury. In Principles and Methods of Toxicology (A. W. Hayes, Ed.), pp. 407-446. Raven Press, New York.
39. Pohl, L. R., Bhooshan, B., Whittaker, N. F., and Krishna, G. (1977). Phosgene: A metabolite of chloroform. Biochem. Biophys. Res. Commun. 79, 684-691.
40. Pohl, L. R., Martin, J. L., and George, J. W. (1980). Mechanism of metabolic activation of chloroform by rat liver microsomes. Biochem. Pharmacol. 29, 3271-3276.
41. Reitz, R. H., Gehring, P. J., and Park, C. N. (1978). Carcinogenic risk estimation for chloroform: An alternative to EPA's procedures. Food Cosmet. Toxicol. 16, 511-514.
42. Reitz, R. H., Fox, T. R., and Quast, J. F. (1982). Mechanistic considerations for carcinogenic risk estimation: Chloroform. Environ. Health Perspect. 46, 163-168.
43. Reitz, R. H., Mendrala, A. L., Corley, R. A., Quast, J. F., Gargas, M. L., Andersen, M. E., Staats, D. A., and Conolly, R. B. (1990). Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling. Toxicol. Appl. Pharmacol. 105, 443-459.
44. Reuber, M. D. (1979). Carcinogenigity of chloroform. Environ. Health Perspect. 31, 171-182.
45. Roe, F. J. C., Palmer, A. K., Worden, A. N., and Van Abbe, N. J. (1979). Safety evalutation of toothpaste containing chloroform. I. Long term studies in mice. J. Environ. Pathol. Toxicol. 2, 799-819.
46. Rose, C. I., and Henderson, A. R. (1975). Reaction-rate assay of serum sorbitol dehydrogenase activity at 37°C. Clin. Chem. 21, 1619-1626.
47. Rosenthal, S. L. (1987). A review of the mutagenicity of chloroform. Environ. Mol. Mut. 10, 211-226.
48. Schutte, B., Reynders, M. M. J., Bosman, F. T., and Blijham (1987). Effect of tissue fixation on anti-bromodeoxyuridine immunohistochemistry. J. Histochem. Cytochem. 35, 1343-1345.
49. Smith, J. H., Maita, K., Sleight, S. D., and Hook, J. B. (1983). Mechanism of chloroform nephrotoxicity. I. Time course of chloroform toxicity in male and female mice. Toxicol. Appl. Pharmacol. 70, 467-479.
50. Stevens, J. L., and Anders, M. W. (1981). Effect of cysteine, diethylmaleate, and phenobarbital treatments on the hepatotoxicity of (1H)-and (2H)-chloroform. Chem. Biol. Interact. 37, 207-217.
51. Testai, E., Di Marzio, S., di Domenico, A., Piccardi, A., and Vittozzi, L. (1995). An in vitro investigation of the reductive metabolism of chloroform. Arch. Toxicol. 70, 83-88.
52. Testai, E., Di Marzio, S., and Vittozzi, L. (1990). Multiple activation of chloroform in hepatic microsomes from uninduced B6C3F1 mice. Toxicol. Appl. Pharmacol. 104, 496-503.
53. 3 carcinogenicity. Toxicol. Appl. Pharmacol. 114, 197-203.
54. Testai, E., and Vittozzi, L. (1986). Biochemical alterations elicited in rat liver microsomes by oxidation and reduction products of chloroform metabolism. Chem. Biol. Interact. 59, 157-171.
55. Tomasi, A., Albano, E., Biasi, F., Slater, T. F., Vannini, V., and Dianzani, M. U. (1985). Activation of chloroform and related trihalomethanes to free radical intermediates in isolated hepatocytes and in the rat in vivo as detected by the ESR-spin trapping technique. Chem. Biol. Interact. 55, 303-316.
56. Uehleke, H., and Werner, T. (1975). A comparative study on the irreversible binding of labeled halotane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo. Arch. Toxicol. 34, 289-308.
57. USDHHS (1994). 7th Annual Report on Carcinogens, 1994, pp. 127-130. [Summary]
58. 2+ stimulation of rat liver mitochondrial glycerophospate dehydrogenase. J. Biol. Chem. 256, 12767-12777.
59. Zimmermann, H. J. (1978). Experimental hepatotoxicity. In Hepatotoxicity (H. J. Zimmermann, Ed.), pp. 167-197. Appleton-Century-Crofts, New York.