Re-evaluation of the 2-year chloroform drinking water carcinogenicity bioassay in Osborne-Mendel rats supports chronic renal tubule injury as the mode of action underlying the renal tumor response

Toxicological Sciences

Volumn 53, Issue 2, 2000, Pages 237-244

  Hard, Gordon C ^a   Boorman, Gary A ^b   Wolf, Douglas C ^c  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Adenoma; Carcinoma; Cytotoxicity; Karyomegaly; Kidney; Rat; Regeneration; Risk assessment; Simple tubule hyperplasia

Indexed keywords

CHLOROFORM; CORN OIL; DRINKING WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CARCINOGEN TESTING; CARCINOGENESIS; CELL HYPERPLASIA; CELL REGENERATION; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE EPITHELIUM; KIDNEY TUMOR; LIVER TUMOR; MALE; NONHUMAN; RAT; TISSUE REACTION;

EID: 0033976659     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/53.2.237     Document Type: Article

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