Susceptibility to the ototoxic properties of toluene is species specific

Hearing Research

Volumn 166, Issue 1-2, 2002, Pages 24-32

  Davis, Rickie R ^a,b   Murphy, William J ^a   Snawder, John E ^a   Striley, Cynthia A F ^a   Henderson, Donald ^c   Khan, Amir ^a   Krieg, Edward F ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Chinchilla; CYP2B; CYP2E1; Hepatic microsome; Ototoxicity; Toluene

Indexed keywords

BENZYL ALCOHOL; CYTOCHROME P450 2B; CYTOCHROME P450 2E1; TOLUENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1;

ANIMAL TISSUE; ARTICLE; AUDITORY STIMULATION; CHINCHILLA; CONTROLLED STUDY; DETOXIFICATION; DISEASE PREDISPOSITION; EVOKED AUDITORY RESPONSE; EXPOSURE; HEARING; HUMAN; HUMAN TISSUE; LIVER MICROSOME; NOISE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; ANIMAL; COCHLEA; COMPARATIVE STUDY; DRUG DETOXIFICATION; DRUG EFFECT; EVOKED BRAIN STEM AUDITORY RESPONSE; IN VITRO STUDY; INJURY; METABOLISM; MOUSE; NOISE INJURY; PHYSIOLOGY; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT;

ANIMAL; BENZYL ALCOHOL; CHINCHILLA; COCHLEA; COMPARATIVE STUDY; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP2E1; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HEARING LOSS, NOISE-INDUCED; HUMAN; IN VITRO; METABOLIC DETOXICATION, DRUG; MICE; MICROSOMES, LIVER; NOISE; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; TOLUENE; ANIMALS; HUMANS;

EID: 0035985748     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5955(02)00280-0     Document Type: Article

References (28)

1. Investigation of the impact of pharmacokinetic variability and uncertainty on risks predicted with a pharmacokinetic model for chloroform
2. Effects of noise and salicylate on auditory evoked-response thresholds in the chinchilla
3. No interaction between noise and toluene on cochlea in the guinea pig
4. Toluene and styrene intoxication route in the rat cochlea
5. Does liver control susceptibility to toluene ototoxicity?
6. Effects of toluene and noise on the chinchilla auditory system
7. Changes in microsomal activity in alcoholism and obesity
8. Ototoxic effects of chemicals alone or in concert with noise: A review of human studies
9. A comparison of chinchilla evoked response and behavioral response thresholds
10. Progressive hair cell loss induced by toluene exposure
11. Effect of interaction between noise and toluene on auditory function in the rat
12. Sequence of exposure to noise and toluene can determine loss of auditory sensitivity in the rat
13. Combined effects of a simultaneous exposure to noise and toluene on hearing function
14. Genetic influences on susceptibility of the auditory system to aging and environmental factors
15. Toluene disrupts outer hair cell morphology and intracellular calcium homeostasis in cochlear cells of guinea pigs
16. Study of the effects of simultaneous exposure to noise and carbon disulfide on workers' hearing
17. Toluene-induced hearing loss among rotogravure printing workers
18. Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomes
19. Ethnic and genetic differences in metabolism genes and risk of toxicity and cancer
20. Interindividual differences in 2H8-toluene toxicokinetics assessed by semiempirical physiologically based model
21. Toluene-induced hearing loss in rats evidenced by the brainstem auditory-evoked response
22. Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice
23. Interindividual variance of cytochrome P450 forms in human hepatic microsomes: Correlation of individual forms with xenobiotic metabolism and implications in risk assessment
24. A novel chinchilla restraint device
25. Ototoxicity of toluene in rats