메뉴 건너뛰기




Volumn 6, Issue 1, 2012, Pages 45-52

Cholesterol, Inflammasomes, and Atherogenesis

Author keywords

Atherogenesis; Cardiovascular diseases; Cholesterol; Inflammasome; Inflammation

Indexed keywords

AMYLIN; AMYLOID A PROTEIN; C REACTIVE PROTEIN; CD14 ANTIGEN; CD36 ANTIGEN; CHOLESTEROL; CRYOPYRIN; G PROTEIN COUPLED RECEPTOR 120; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN MD 2; PURINERGIC P2X RECEPTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOREDOXIN INTERACTING PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

EID: 84873813804     PISSN: 19329520     EISSN: 19329563     Source Type: Journal    
DOI: 10.1007/s12170-011-0212-2     Document Type: Review
Times cited : (19)

References (56)
  • 1
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature. 2002; 420: 868-74.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 2
    • 79951669207 scopus 로고    scopus 로고
    • The immune system in atherosclerosis
    • Hansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011; 12: 204-12.
    • (2011) Nat Immunol , vol.12 , pp. 204-212
    • Hansson, G.K.1    Hermansson, A.2
  • 3
    • 79955535643 scopus 로고    scopus 로고
    • Macrophages in the pathogenesis of atherosclerosis
    • Moore KJ, Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell. 2011; 145: 341-55.
    • (2011) Cell , vol.145 , pp. 341-355
    • Moore, K.J.1    Tabas, I.2
  • 4
    • 77249118801 scopus 로고    scopus 로고
    • The inflammasomes: mechanisms of activation and function
    • Latz E. The inflammasomes: mechanisms of activation and function. Curr Opin Immunol. 2010; 22: 28-33.
    • (2010) Curr Opin Immunol , vol.22 , pp. 28-33
    • Latz, E.1
  • 5
    • 77950362382 scopus 로고    scopus 로고
    • The Inflammasomes
    • Schroder K, Tschopp J. The Inflammasomes. Cell. 2010; 140: 821-32.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 6
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • This the seminal article linking NLRP3 to sensing damage induced by cholesterol crystals and playing a role in the progression of atherosclerosis
    • • Duewell P, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010; 464: 1357-61. This the seminal article linking NLRP3 to sensing damage induced by cholesterol crystals and playing a role in the progression of atherosclerosis.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1
  • 7
    • 68849085894 scopus 로고    scopus 로고
    • A cell biological view of Toll-like receptor function: regulation through compartmentalization
    • Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol. 2009; 9: 535-42.
    • (2009) Nat Rev Immunol , vol.9 , pp. 535-542
    • Barton, G.M.1    Kagan, J.C.2
  • 8
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: sensing and reacting to damage
    • Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010; 10: 826-37.
    • (2010) Nat Rev Immunol , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nuñez, G.2
  • 10
    • 71949107774 scopus 로고    scopus 로고
    • Innate immune signals in atherosclerosis
    • Lundberg AM, Hansson GK. Innate immune signals in atherosclerosis. Clin Immunol. 2010; 134: 5-24.
    • (2010) Clin Immunol , vol.134 , pp. 5-24
    • Lundberg, A.M.1    Hansson, G.K.2
  • 12
    • 0034678402 scopus 로고    scopus 로고
    • Infectious agents are not necessary for murine atherogenesis
    • Wright SD et al. Infectious agents are not necessary for murine atherogenesis. J Exp Med. 2000; 191: 1437-41.
    • (2000) J Exp Med , vol.191 , pp. 1437-1441
    • Wright, S.D.1
  • 13
    • 0037449723 scopus 로고    scopus 로고
    • Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells
    • Miller YI. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2002; 278: 1561-8.
    • (2002) J Biol Chem , vol.278 , pp. 1561-1568
    • Miller, Y.I.1
  • 14
    • 75649087741 scopus 로고    scopus 로고
    • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    • This is a description of a novel trimeric receptor for oxidized LDL, which has great relevance for understanding how endogenous ligands can provide proinflammatory signals
    • • Stewart CR, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2009; 11: 155-61. This is a description of a novel trimeric receptor for oxidized LDL, which has great relevance for understanding how endogenous ligands can provide proinflammatory signals.
    • (2009) Nat Immunol , vol.11 , pp. 155-161
    • Stewart, C.R.1
  • 15
    • 59849086158 scopus 로고    scopus 로고
    • Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2
    • Bae YS et al. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009; 104: 210-8.
    • (2009) Circ Res , vol.104 , pp. 210-218
    • Bae, Y.S.1
  • 16
    • 3242710174 scopus 로고    scopus 로고
    • Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
    • Michelsen KS et al. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. PNAS. 2004; 101: 10679-84.
    • (2004) Pnas , vol.101 , pp. 10679-10684
    • Michelsen, K.S.1
  • 17
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi H et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006; 116: 3015-25.
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1
  • 18
    • 34250169823 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    • Kim F et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res. 2007; 100: 1589-96.
    • (2007) Circ Res , vol.100 , pp. 1589-1596
    • Kim, F.1
  • 19
    • 33845921575 scopus 로고    scopus 로고
    • Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages
    • Seimon TA et al. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. PNAS. 2006; 103: 19794-9.
    • (2006) Pnas , vol.103 , pp. 19794-19799
    • Seimon, T.A.1
  • 20
    • 77958532945 scopus 로고    scopus 로고
    • Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
    • Seimon TA et al. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metabol. 2010; 12: 467-82.
    • (2010) Cell Metabol , vol.12 , pp. 467-482
    • Seimon, T.A.1
  • 21
    • 0038143617 scopus 로고    scopus 로고
    • Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids
    • Lee JY. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res. 2002; 44: 479-86.
    • (2002) J Lipid Res , vol.44 , pp. 479-486
    • Lee, J.Y.1
  • 22
    • 17844391306 scopus 로고    scopus 로고
    • Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4
    • Weatherill AR et al. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. J Immunol. 2005; 174: 5390-7.
    • (2005) J Immunol , vol.174 , pp. 5390-5397
    • Weatherill, A.R.1
  • 23
    • 78249286865 scopus 로고    scopus 로고
    • Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    • Joosten LAB et al. Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. 2010; 62: 3237-48.
    • (2010) Arthritis Rheum , vol.62 , pp. 3237-3248
    • Joosten, L.A.B.1
  • 24
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • This article identifies a receptor that is expressed on macrophages that can mediate the inflammatory effects of omega-3 fatty acids
    • • Da Young Oh, et al. GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects. Cell. 2010; 142: 687-98. This article identifies a receptor that is expressed on macrophages that can mediate the inflammatory effects of omega-3 fatty acids.
    • (2010) Cell , vol.142 , pp. 687-698
    • Da Young, O.1
  • 25
    • 0037130195 scopus 로고    scopus 로고
    • Toll-like receptor 4 polymorphisms and atherogenesis
    • Kiechl S et al. Toll-like receptor 4 polymorphisms and atherogenesis. NEJM. 2002; 347: 185-92.
    • (2002) Nejm , vol.347 , pp. 185-192
    • Kiechl, S.1
  • 26
    • 77954314064 scopus 로고    scopus 로고
    • Variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults
    • Noel SE et al. Variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults. Atherosclerosis. 2010; 211: 210-5.
    • (2010) Atherosclerosis , vol.211 , pp. 210-215
    • Noel, S.E.1
  • 27
    • 0038578149 scopus 로고    scopus 로고
    • Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the Framingham study
    • Osgood D et al. Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the Framingham study. J Clin Endocrinol Metab. 2003; 88: 2869-79.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2869-2879
    • Osgood, D.1
  • 28
    • 48249134451 scopus 로고    scopus 로고
    • Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice
    • Yajima N et al. Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice. Circulation. 2008; 117: 3079-87.
    • (2008) Circulation , vol.117 , pp. 3079-3087
    • Yajima, N.1
  • 29
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006; 440: 237-41.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1
  • 30
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • Dostert C et al. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 2008; 320: 674-7.
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1
  • 31
    • 47849097202 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    • Hornung V et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008; 9: 847-56.
    • (2008) Nat Immunol , vol.9 , pp. 847-856
    • Hornung, V.1
  • 32
    • 33947512416 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in atherosclerosis
    • Madamanchi NR, Runge MS. Mitochondrial dysfunction in atherosclerosis. Circ Res. 2007; 100: 460-73.
    • (2007) Circ Res , vol.100 , pp. 460-473
    • Madamanchi, N.R.1    Runge, M.S.2
  • 33
    • 77955356552 scopus 로고    scopus 로고
    • Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
    • Rajamäki K et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One. 2010; 5: e11765.
    • (2010) PLoS One , vol.5
    • Rajamäki, K.1
  • 35
    • 77952532171 scopus 로고    scopus 로고
    • Macrophage plasticity in experimental atherosclerosis
    • Khallou-Laschet J et al. Macrophage plasticity in experimental atherosclerosis. PLoS One. 2010; 5: e8852.
    • (2010) PLoS One , vol.5
    • Khallou-Laschet, J.1
  • 36
    • 79955622218 scopus 로고    scopus 로고
    • Apolipoprotein E induces antiinflammatory phenotype in macrophages
    • Baitsch D et al. Apolipoprotein E induces antiinflammatory phenotype in macrophages. Arterioscler Thromb Vasc Biol. 2011; 31: 1160-8.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1160-1168
    • Baitsch, D.1
  • 37
    • 79955552375 scopus 로고    scopus 로고
    • HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells
    • Feig JE et al. HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells. PNAS. 2011; 108: 6166-7171.
    • (2011) Pnas , vol.108 , pp. 6166-7171
    • Feig, J.E.1
  • 38
    • 79959732295 scopus 로고    scopus 로고
    • Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
    • Freigang S et al. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol. 2011; 41: 2040-51.
    • (2011) Eur J Immunol , vol.41 , pp. 2040-2051
    • Freigang, S.1
  • 39
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2010; 469: 221-5.
    • (2010) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 40
    • 79960542894 scopus 로고    scopus 로고
    • Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome
    • Bauernfeind F et al. Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol. 2011; 187: 613-7.
    • (2011) J Immunol , vol.187 , pp. 613-617
    • Bauernfeind, F.1
  • 41
    • 84873883467 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • doi: 10. 1038/ni. 2022
    • Wen H, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nature Publishing Group 1-9 (2011). doi: 10. 1038/ni. 2022.
    • (2011) Nature Publishing Group , vol.1-9
    • Wen, H.1
  • 42
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • This article links the NLRP3 inflammasome both in humans and mice to diseases falling under the umbrella of metabolic syndrome
    • • Vandanmagsar B, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 2011; 17: 179-88. This article links the NLRP3 inflammasome both in humans and mice to diseases falling under the umbrella of metabolic syndrome.
    • (2011) Nature Medicine , vol.17 , pp. 179-188
    • Vandanmagsar, B.1
  • 43
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nature Publishing Group. 2009; 11: 136-40.
    • (2009) Nature Publishing Group , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 44
    • 77956958947 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    • Masters SL et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nature Publishing Group. 2010; 11: 897-904.
    • (2010) Nature Publishing Group , vol.11 , pp. 897-904
    • Masters, S.L.1
  • 46
    • 79958040762 scopus 로고    scopus 로고
    • Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway
    • Niemi K et al. Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway. J Immunol. 2011; 186: 6119-28.
    • (2011) J Immunol , vol.186 , pp. 6119-6128
    • Niemi, K.1
  • 47
    • 34547138176 scopus 로고    scopus 로고
    • The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing
    • Papin S et al. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing. Cell Death Differ. 2007; 14: 1457-66.
    • (2007) Cell Death Differ , vol.14 , pp. 1457-1466
    • Papin, S.1
  • 48
    • 79956299492 scopus 로고    scopus 로고
    • Gain-of-function pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice
    • Chae JJ et al. Gain-of-function pyrin mutations induce NLRP3 protein-independent interleukin-1& beta; activation and severe autoinflammation in mice. Immunity. 2011; 34: 755-68.
    • (2011) Immunity , vol.34 , pp. 755-768
    • Chae, J.J.1
  • 49
    • 80054952422 scopus 로고    scopus 로고
    • Vascular comorbidities in familial Mediterranean fever
    • Özçakar ZB, Yalçi{dotless}nkaya F. Vascular comorbidities in familial Mediterranean fever. Rheumatol Int. 2011; 31: 1275-81.
    • (2011) Rheumatol Int , vol.31 , pp. 1275-1281
    • Özçakar, Z.B.1    Yalçinkaya, F.2
  • 50
    • 79952069515 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple Loci for C-reactive protein levels
    • Dehghan A et al. Meta-analysis of genome-wide association studies in > 80 000 subjects identifies multiple Loci for C-reactive protein levels. Circulation. 2011; 123: 731-8.
    • (2011) Circulation , vol.123 , pp. 731-738
    • Dehghan, A.1
  • 51
    • 67849121952 scopus 로고    scopus 로고
    • Association of novel genetic loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts
    • Dehghan A et al. Association of novel genetic loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circulation: Cardiovascular Genetics. 2009; 2: 125-33.
    • (2009) Circulation: Cardiovascular Genetics , vol.2 , pp. 125-133
    • Dehghan, A.1
  • 52
    • 78650965893 scopus 로고    scopus 로고
    • Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe)
    • Wassel CL et al. Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). Blood. 2011; 117: 268-75.
    • (2011) Blood , vol.117 , pp. 268-275
    • Wassel, C.L.1
  • 53
    • 80052262707 scopus 로고    scopus 로고
    • Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms
    • Roberts RL et al. Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms. Atherosclerosis. 2011; 218: 123-6.
    • (2011) Atherosclerosis , vol.218 , pp. 123-126
    • Roberts, R.L.1
  • 54
    • 77955776526 scopus 로고    scopus 로고
    • Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1 secretion
    • Stokes L et al. Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1 secretion. FASEB J. 2010; 24: 2916-27.
    • (2010) FASEB J , vol.24 , pp. 2916-2927
    • Stokes, L.1
  • 55
    • 55949114397 scopus 로고    scopus 로고
    • Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes
    • Palomino-Doza J et al. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. Hypertension. 2008; 52: 980-5.
    • (2008) Hypertension , vol.52 , pp. 980-985
    • Palomino-Doza, J.1
  • 56
    • 77956335920 scopus 로고    scopus 로고
    • Exercise effects on methylation of ASC gene
    • Nakajima K et al. Exercise effects on methylation of ASC gene. Int J Sports Med. 2010; 31(9): 671-5.
    • (2010) Int J Sports Med , vol.31 , Issue.9 , pp. 671-675
    • Nakajima, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.