Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms

Atherosclerosis

Volumn 218, Issue 1, 2011, Pages 123-126

  Roberts, Rebecca L ^a,b   Van Rij, Andre M ^a   Phillips, L Vicky ^a   Young, Sarah ^a   McCormick, Sally P A ^a   Merriman, Tony R ^a   Jones, Gregory T ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

ASC; CIAS1; Cryopyrin; IL 1 ; NALP3; NOD2; TUCAN

Indexed keywords

C REACTIVE PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; LIPOPROTEIN A;

ABDOMINAL AORTA ANEURYSM; AGED; ALLELE; ARTICLE; CARD 8 GENE; CONTROLLED STUDY; FEMALE; GENE; GENE INTERACTION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; NLRP 3 GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGED, 80 AND OVER; ALLELES; AORTIC ANEURYSM, ABDOMINAL; C-REACTIVE PROTEIN; CARD SIGNALING ADAPTOR PROTEINS; CARRIER PROTEINS; CHOLESTEROL; FEMALE; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOTYPE; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPROTEIN(A); MALE; MIDDLE AGED; NEOPLASM PROTEINS; RISK;

EID: 80052262707     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.04.043     Document Type: Article

References (19)

1. Sakalihasan N., Limet R., Defawe O.D. Abdominal aortic aneurysm. Lancet 2005, 365:1577-1589.
2. Shah P.K. Inflammation, metalloproteinases, and increased proteolysis: an emerging pathophysiological paradigm in aortic aneurysm. Circulation 1997, 96:2115-2117.
3. Wahlgren C.M., Larsson E., Magnusson P.K., et al. Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population. J Vasc Surg 2010, 51:3-7.
4. Nordon I.M., Hinchliffe R.J., Loftus I.M., et al. Pathophysiology and epidemiology of abdominal aortic aneurysms. Nat Rev Cardiol 2011, 8:92-102.
5. Pawlikowski M., Pfitzner R., Skinner C. Mineral-cholesterol concentrations of the aortic aneurysmatic wall. Pol J Pathol 1996, 47:225-232.
6. Duewell P., Kono H., Rayner K.J., et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010, 464:1357-1361.
7. Martinon F., Mayor A., Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol 2009, 27:229-265.
8. Sidiropoulos P.I., Goulielmos G., Voloudakis G.K., et al. Inflammasomes and rheumatic diseases: evolving concepts. Ann Rheum Dis 2008, 67:1382-1389.
9. Gopal K., Kumar K., Nandini R., et al. High fat diet containing cholesterol induce aortic aneurysm through recruitment and proliferation of circulating agranulocytes in apoE knock out mice model. J Thromb Thrombolysis 2010, 30:154-163.
10. Roberts R.L., Topless R.K., Phipps-Green A.J., et al. Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease. Genes Immun 2010, 11:351-356.
11. Schoultz I., Verma D., Halfvarsson J., et al. Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men. Am J Gastroenterol 2009, 104:1180-1188.
12. Kastbom A., Verma D., Eriksson P., et al. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). Rheumatology (Oxford) 2008, 47:415-417.
13. Jones G.T., van Rij A.M., Cole J., et al. Plasma lipoprotein(a) indicates risk for 4 distinct forms of vascular disease. Clin Chem 2007, 53:679-685.
14. McGovern D.P., Butler H., Ahmad T., et al. TUCAN (CARD8) genetic variants and inflammatory bowel disease. Gastroenterology 2006, 131:1190-1196.
15. Fontalba A., Martinez-Taboada V., Gutierrez O., et al. Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. J Immunol 2007, 179:4867-4873.
16. Veldhuijzen van Zanten J.J., Kitas G.D. Inflammation, carotid intima-media thickness and atherosclerosis in rheumatoid arthritis. Arthritis Res Ther 2008, 10:102.
17. Villani A.C., Lemire M., Fortin G., et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 2009, 41:71-76.
18. Dehghan A., Dupuis J., Barbalic M., et al. Meta-analysis of genome-wide association studies in >80,000 subjects identifies multiple loci for C-reactive protein levels. Circulation 2011, 123:731-738.
19. Bonen D.K., Ogura Y., Nicolae D.L., et al. Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 2003, 124:140-146.