Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: The Candidate Gene Association Resource (CARe)

Blood

Volumn 117, Issue 1, 2011, Pages 268-275

  Wassel, Christina L ^a   Lange, Leslie A ^b   Keating, Brendan J ^c   Taylor, Kira C ^b   Johnson, Andrew D ^d   Palmer, Cameron ^e   Ho, Lindsey A ^b   Smith, Nicholas L ^f,g   Lange, Ethan M ^b   Li, Yun ^b   Yang, Qiong ^h   Delaney, Joseph A ⁱ   Tang, Weihong ^j   Tofler, Geoffrey ^k   Redline, Susan ^l   Taylor Jr , Herman A ^m   Wilson, James G ^m   Tracy, Russell P ⁿ   Jacobs Jr , David R ^j   Folsom, Aaron R ^j   Green, David ^o   O'Donnell, Christopher J ^d   Reiner, Alexander P ^f   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

^g DEPARTMENT OF VETERANS AFFAIRS   (United States)

^h BOSTON UNIVERSITY   (United States)

ⁱ UNIVERSITY OF FLORIDA   (United States)

^j UNIVERSITY OF MINNESOTA   (United States)

^k HARVARD UNIVERSITY   (United States)

^l CASE WESTERN RESERVE UNIVERSITY   (United States)

^m UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

ⁿ UNIVERSITY OF VERMONT   (United States)

^o NORTHWESTERN UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; INTERFERON REGULATORY FACTOR 1; LEUCINE; PROLINE;

ADULT; AFRICAN AMERICAN; ARTICLE; DNA POLYMORPHISM; EUROPEAN AMERICAN; FEMALE; GENE; GENE LOCUS; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 78650965893     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-06-289546     Document Type: Article

References (53)

1. Fibrinogen Studies Collaboration, Danesh J, Lewington S, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005;294(14):1799- 1809. (Pubitemid 41434626)
2. Kathiresan S, Yang Q, Larson MG, et al. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2006;26(6):1405- 1412. (Pubitemid 44305389)
3. Reiner AP, Carty CL, Carlson CS, et al. Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study. J Thromb Haemost. 2006;4(6):1279-1287. (Pubitemid 43756706)
4. Reiner AP, Gross MD, Carlson CS, et al. Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascular Health Study. Circ Cardiovasc Genet. 2009;2(3):244-254.
5. Danik JS, Pare G, Chasman DI, et al. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genomewide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. Circ Cardiovasc Genet. 2009;2(2):134-141.
6. Dehghan A, Yang Q, Peters A, et al. Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet. 2009;2(2):125-133.
7. Hamsten A, Iselius L, de Faire U, Blomback M. Genetic and cultural inheritance of plasma fibrinogen concentration. Lancet. 1987;2(8566):88-991. (Pubitemid 17150857)
8. Livshits G, Schettler G, Graff E, Blettner M, Wahrendorf J, Brunner D. Tel Aviv-Heidelberg three-generation offspring study: genetic determinants of plasma fibrinogen level. Am J Med Genet. 1996;63(4):509-517. (Pubitemid 126455507)
9. de Lange M, Snieder H, Ariens RA, Spector TD, Grant PJ. The genetics of haemostasis: a twin study. Lancet. 2001;357(9250):101-105.
10. Folsom AR, Wu KK, Conlan MG, et al. Distributions of hemostatic variables in blacks and whites: population reference values from the Atherosclerosis Risk in Communities (ARIC) Study. Ethn Dis. 1992;2(1):35-46.
11. Green D, Ruth KJ, Folsom AR, Liu K. Hemostatic factors in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Arterioscler Thromb. 1994;14(5):686-693. (Pubitemid 124004489)
12. Lutsey PL, Cushman M, Steffen LM, et al. Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study. J Thromb Haemost. 2006;4:2629-2635. (Pubitemid 44741559)
13. Tracy RP, Bovill EG, Fried LP, et al. The distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years. Results from the Cardiovascular Health study. Ann Epidemiol. 1992;2(4):509-519.
14. Fibrinogen Studies Collaboration, Kaptoge S, White IR, et al. Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration. Am J Epidemiol. 2007;166(8):867-879. (Pubitemid 47511690)
15. Chambless LE, Folsom AR, Sharrett AR, et al. Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study. J Clin Epidemiol. 2003;56(9):880-890. (Pubitemid 37162663)
16. Carty CL, Cushman M, Jones D, et al. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. Thromb Haemost. 2008;99(2):388-395. (Pubitemid 351230971)
17. Keating BJ, Tischfield S, Murray SS, et al. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS ONE. 2008;3(10):e3583.
18. Clauss A. [Rapid physiological coagulation method in determination of fibrinogen.] Gerin-nungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 1957;17(14):237-246.
19. Kannel WB, Wolf PA, Castelli WP, D'Agostino RB. Fibrinogen and risk of cardiovascular disease. The Framingham study. J Am Med Assoc. 1987;258(9):1183-1186.
20. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559-575. (Pubitemid 47330214)
21. Chen MH, Yang Q. GWAF: an R package for genome-wide association analyses with family data. Bioinformatics. 2010;26(4):580-581.
22. Humphries SE, Ye S, Talmud P, Bara L, Wilhelmsen L, Tiret L. European Atherosclerosis Research Study: genotype at the fibrinogen locus (G-455-A beta-gene) is associated with differences in plasma fibrinogen levels in young men and women from different regions in Europe. Evidence for gender-genotype-environment interaction. Arterioscler Thromb Vasc Biol. 1995;15(1):96-104.
23. Schadt EE, Molony C, Chudin E, et al. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 2008;6(5):e107. (Pubitemid 351824739)
24. Verschuur M, de Jong M, Felida L, de Maat MP, Vos HL. A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism. J Biol Chem. 2005;280(17):16763-16771. (Pubitemid 41389134)
25. van der Bom JG, de Maat MP, Bots ML, et al. Elevated plasma fibrinogen: cause or consequence of cardiovascular disease? Arterioscler Thromb Vasc Biol. 1998;18(4):621-625. (Pubitemid 28177903)
26. Smith GD, Harbord R, Milton J, Ebrahim S, Sterne JA. Does elevated plasma fibrinogen increase the risk of coronary heart disease? Evidence from a meta-analysis of genetic association studies. Arterioscler Thromb Vasc Biol. 2005;25(10):2228-2233. (Pubitemid 41416326)
27. Keavney B, Danesh J, Parish S, et al. Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'. Int J Epidemiol. 2006;35(4):935-943.
28. Siegerink B, Rosendaal FR, Algra A. Genetic variation in fibrinogen; its relationship to fibrinogen levels and the risk of myocardial infarction and ischemic stroke. J Thromb Haemost. 2009;7(3):385-390.
29. Jood K, Danielson J, Ladenvall C, Blomstrand C, Jern C. Fibrinogen gene variation and ischemic stroke. J Thromb Haemost. 2008;6(6):897-904. (Pubitemid 351689909)
30. Jayo A, Arnold E, Gonzalez-Manchon C, Green D, Lord ST. Hypodysfibrinogenemia causing mild bleeding and thrombotic complications in a compound heterozygote of AalphaIVS4+1G > T mutation and Aalpha4841delC truncation (Aalpha(Perth)). Thromb Haemost. 2009;101(4):770-772.
31. Stangou AJ, Banner NR, Hendry BM, et al. Hereditary fibrinogen A alpha chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation. Blood. 2010;115(15):2998-3007.
32. Cortes-Canteli M, Strickland S. Fibrinogen, a possible key player in Alzheimer's disease. J Thromb Haemost. 2009;7(suppl 1):146-150.
33. Zhang JZ, Redman C. Fibrinogen assembly and secretion. Role of intrachain disulfide loops. J Biol Chem. 1996;271(47):30083-30088. (Pubitemid 26389648)
34. Yuan HY, Chiou JJ, Tseng WH, et al. FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res. 2006;34(Web Server issue):W635-641.
35. Uitte de Willige SU, Standeven KF, Philippou H, Ariens RA. The pleiotropic role of the fibrinogen gamma' chain in hemostasis. Blood. 2009;114(19):3994-4001.
36. Uitte de Willige S, Rietveld IM, De Visser MC, Vos HL, Bertina RM. Polymorphism 10034C > T is located in a region regulating polyadenylation of FGG transcripts and influences the fibrinogen gamma'/gammaA mRNA ratio. J Thromb Haemost. 2007;5(6):1243-1249.
37. Rasmussen-Torvik LJ, Cushman M, Tsai MY, Zhang Y, Heckbert SR, Rosamond WD, Folsom AR. The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study. Thromb Res. 2007;121(1):1-7. (Pubitemid 350025992)
38. Carter AM, Catto AJ, Grant PJ. Association of the alpha-fibrinogen Thr312Ala polymorphism with poststroke mortality in subjects with atrial fibrillation. Circulation. 1999;99(18):2423-2426.
39. Lim BC, Ariëns RA, Carter AM, Weisel JW, Grant PJ. Genetic regulation of fibrin structure and function: complex gene-environment interactions may modulate vascular risk. Lancet. 2003;361(9367):1424-1431.
40. Lowe GD, Rumley A, Mackie IJ. Plasma fibrinogen. Ann Clin Biochem. 2004;41(Pt 6):430-440.
41. Magnani B, Fenton T, Lapp C, Brugnara C. Degree of agreement in plasma fibrinogen among two functional and one immunonephelometric assays. Am J Clin Pathol. 1997;107(5):527-533. (Pubitemid 27183984)
42. Rumley A, Woodward M, Hoffmeister A, Koenig W, Lowe GD. Comparison of plasma fibrinogen by Clauss, prothrombin time-derived, and immunonephelometric assays in a general population: implications for risk stratification by thirds of fibrinogen. Blood Coagul Fibrinolysis. 2003;14(2):197-201. (Pubitemid 36332484)
43. Fuller GM, Zhang Z. Transcriptional control mechanism of fibrinogen gene expression. Ann N Y Acad Sci. 2001;936:469-479. (Pubitemid 32613932)
44. Goring HH, Curran JE, Johnson MP, et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet. 2007;39(10):1208-1216.
45. Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science. 2010;327(5963):296-300.
46. Rioux JD, Daly MJ, Silverberg MS, et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet. 2001;29(2):223-228.
47. Summar ML, Gainer JV, Pretorius M, et al. Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function. Hypertension. 2004;43(2):186-191. (Pubitemid 38174172)
48. Pare G, Chasman DI, Parker AN, et al. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health study. Circ Cardiovasc Genet. 2009;2(2):142-150.
49. Chasman DI, Pare G, Mora S, et al. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genomewide analysis. PLoS Genet. 2009;5(11):e1000730.
50. Von Eyben FE, Mouritsen EA, Holm J, et al. Fibrinogen and other coronary risk factors. Metabolism. 2005;54(2):165-170. (Pubitemid 40174843)
51. Chiu DS, Oram JF, LeBoeuf RC, Alpers CE, O'Brien KD. High-density lipoprotein-binding protein (HBP)/vigilin is expressed in human atherosclerotic lesions and colocalizes with apolipoprotein E. Arterioscler Thromb Vasc Biol. 1997;17(11):2350-2358.
52. Ek J, Rose CS, Jensen DP, et al. The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta cell function among Danes. J Clin Endocrinol Metab. 2005;90(5):3054-3059. (Pubitemid 40686363)
53. Kathiresan S, Willer CJ, Peloso GM, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009;41(1):56-65.