Resting-state functional connectivity in normal brain aging

Neuroscience and Biobehavioral Reviews

Volumn 37, Issue 3, 2013, Pages 384-400

  Ferreira, Luiz Kobuti ^a   Busatto, Geraldo F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aging; Attention; Cognition; Elderly; FMRI; Functional connectivity; Functional magnetic resonance imaging; Memory; Resting state

Indexed keywords

AMYLOID BETA PROTEIN;

AGE; AGING; AMYLOID PLAQUE; BOLD SIGNAL; BRAIN ATROPHY; BRAIN DISEASE; BRAIN FUNCTION; DOPAMINERGIC DEFICIT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; IMAGE ANALYSIS; MOTOR NETWORK; NERVE CELL NETWORK; NERVOUS SYSTEM PARAMETERS; NEUROIMAGING; NEUROPHYSIOLOGY; PRIORITY JOURNAL; REDUCED WHITE MATTER INTEGRITY; RESTING STATE FUNCTIONAL CONNECTIVITY; RESTING STATE FUNCTIONAL MAGNETIC RESONANCE IMAGING; REVIEW; TASK PERFORMANCE; VISUAL NETWORK;

AGING; ANIMALS; BRAIN; BRAIN MAPPING; COGNITION; HUMANS; MAGNETIC RESONANCE IMAGING; MEMORY;

EID: 84873742703     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2013.01.017     Document Type: Review

References (207)

1. Abrahamsom K., Clark D., Perkins A., Greg A. Does cognitive impairment influence quality of life among nursing home residents?. The Gerontologist 2012, 52:632-640.
2. Achard S., Bullmore E. Efficiency and cost of economical brain functional networks. PLoS Computation Biology 2007, 3:e17.
3. Addis D.R., Leclerc C.M., Muscatell K.A., Kensinger E.A. There are age-related changes in neural connectivity during the encoding of positive, but not negative, information. Cortex 2010, 46:425-433.
4. Aizenstein H.J., Nebes R.D., Saxton J.A., Price J.C., Mathis C.A., Tsopelas N.D., Ziolko S.K., James J.A., Snitz B.E., Houck P.R., Bi W., Cohen A.D., Lopresti B.J., DeKosky S.T., Halligan E.M., Klunk W.E. Frequent amyloid deposition without significant cognitive impairment among the elderly. Archives of Neurology 2008, 65:1509-1517.
5. Albert N.B., Robertson E.M., Miall R.C. The resting human brain and motor learning. Current Biology 2009, 19:1023-1027.
6. Allen E.A., Erhardt E.B., Damaraju E., Gruner W., Segall J.M., Silva R.F., Havlicek M., Rachakonda S., Fries J., Kalyanam R., Michael A.M., Caprihan A., Turner J.A., Eichele T., Adelsheim S., Bryan A.D., Bustillo J., Clark V.P., Feldstein Ewing S.W., Filbey F., Ford C.C., Hutchison K., Jung R.E., Kiehl K.A., Kodituwakku P., Komesu Y.M., Mayer A.R., Pearlson G.D., Phillips J.P., Sadek J.R., Stevens M., Teuscher U., Thoma R.J., Calhoun V.D. A baseline for the multivariate comparison of resting-state networks. Frontiers in Systematic Neuroscience 2011, 5:2.
7. Alves T.C.T.F., Ferreira L.K., Busatto G.F. Vascular diseases and old age mental disorders: an update of neuroimaging findings. Current Opinion in Psychology 2010, 23:491.
8. Andrews-Hanna J.R., Snyder A.Z., Vincent J.L., Lustig C., Head D., Raichle M.E., Buckner R.L. Disruption of large-scale brain systems in advanced aging. Neuron 2007, 56:924-935.
9. Antonenko D., Meinzer M., Lindenberg R., Witte A.V., Floel A. Grammar learning in older adults is linked to white matter microstructure and functional connectivity. NeuroImage 2012, 62:1667-1674.
10. Backman L., Lindenberger U., Li S.C., Nyberg L. Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues. Neuroscience and Biobehavioral Reviews 2010, 34:670-677.
11. Backman L., Nyberg L., Lindenberger U., Li S.C., Farde L. The correlative triad among aging, dopamine, and cognition: current status and future prospects. Neuroscience and Biobehavioral Reviews 2006, 30:791-807.
12. Bai F., Xie C., Watson D.R., Shi Y., Yuan Y., Wang Y., Yue C., Teng Y., Wu D., Zhang Z. Aberrant hippocampal subregion networks associated with the classifications of aMCI subjects: a longitudinal resting-state study. PLoS One 2011, 6:e29288.
13. Batouli A.H., Boroomand A., Fakhri M., Sikaroodi H., Oghabian M.A., Firouznia K. The effect of aging on resting-state brain function: an fMRI study. Iranian Journal of Radiology 2009, 6:153-158.
14. Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR in Biomedicine 2002, 15:435-455.
15. Becker J.A., Hedden T., Carmasin J., Maye J., Rentz D.M., Putcha D., Fischl B., Greve D.N., Marshall G.A., Salloway S., Marks D., Buckner R.L., Sperling R.A., Johnson K.A. Amyloid-beta associated cortical thinning in clinically normal elderly. Annals of Neurology 2011, 69:1032-1042.
16. Beckmann C.F., Smith S.M. Probabilistic independent component analysis for functional magnetic resonance imaging. IEEE Transactions on Medical Imaging 2004, 23:137-152.
17. Bero A.W., Bauer A.Q., Stewart F.R., White B.R., Cirrito J.R., Raichle M.E., Culver J.P., Holtzman D.M. Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2012, 32:4334-4340.
18. Bero A.W., Yan P., Roh J.H., Cirrito J.R., Stewart F.R., Raichle M.E., Lee J.M., Holtzman D.M. Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. Nature Neuroscience 2011, 14:750-756.
19. Birn R.M., Diamond J.B., Smith M.A., Bandettini P.A. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI. NeuroImage 2006, 31:1536-1548.
20. Biswal B., Yetkin F.Z., Haughton V.M., Hyde J.S. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine 1995, 34:537-541.
21. Biswal B.B. Resting state fMRI: a personal history. NeuroImage 2012, 62:938-944.
22. Biswal B.B., Mennes M., Zuo X.N., Gohel S., Kelly C., Smith S.M., Beckmann C.F., Adelstein J.S., Buckner R.L., Colcombe S., Dogonowski A.M., Ernst M., Fair D., Hampson M., Hoptman M.J., Hyde J.S., Kiviniemi V.J., Kotter R., Li S.J., Lin C.P., Lowe M.J., Mackay C., Madden D.J., Madsen K.H., Margulies D.S., Mayberg H.S., McMahon K., Monk C.S., Mostofsky S.H., Nagel B.J., Pekar J.J., Peltier S.J., Petersen S.E., Riedl V., Rombouts S.A., Rypma B., Schlaggar B.L., Schmidt S., Seidler R.D., Siegle G.J., Sorg C., Teng G.J., Veijola J., Villringer A., Walter M., Wang L., Weng X.C., Whitfield-Gabrieli S., Williamson P., Windischberger C., Zang Y.F., Zhang H.Y., Castellanos F.X., Milham M.P. Toward discovery science of human brain function. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:4734-4739.
23. Bluhm R.L., Osuch E.A., Lanius R.A., Boksman K., Neufeld R.W., Theberge J., Williamson P. Default mode network connectivity: effects of age, sex, and analytic approach. Neuroreport 2008, 19:887-891.
24. Bollinger J., Rubens M.T., Masangkay E., Kalkstein J., Gazzaley A. An expectation-based memory deficit in aging. Neuropsychologia 2011, 49:1466-1475.
25. Braak E., Griffing K., Arai K., Bohl J., Bratzke H., Braak H. Neuropathology of Alzheimer's disease: what is new since A. Alzheimer?. European Archives of Psychiatry and Clinical Neuroscience 1999, 249(Suppl. 3):14-22.
26. Braskie M.N., Wilcox C.E., Landau S.M., O'Neil J.P., Baker S.L., Madison C.M., Kluth J.T., Jagust W.J. Relationship of striatal dopamine synthesis capacity to age and cognition. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2008, 28:14320-14328.
27. Broyd S.J., Demanuele C., Debener S., Helps S.K., James C.J., Sonuga-Barke E.J. Default-mode brain dysfunction in mental disorders: a systematic review. Neuroscience and Biobehavioral Reviews 2009, 33:279-296.
28. Bu G. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nature Reviews. Neuroscience 2009, 10:333-344.
29. Buckner R.L. Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron 2004, 44:195-208.
30. Buckner R.L., Andrews-Hanna J.R., Schacter D.L. The brain's default network: anatomy, function, and relevance to disease. Annals of the New York Academy of Sciences 2008, 1124:1-38.
31. Buckner R.L., Sepulcre J., Talukdar T., Krienen F.M., Liu H., Hedden T., Andrews-Hanna J.R., Sperling R.A., Johnson K.A. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2009, 29:1860-1873.
32. Buckner R.L., Snyder A.Z., Shannon B.J., LaRossa G., Sachs R., Fotenos A.F., Sheline Y.I., Klunk W.E., Mathis C.A., Morris J.C., Mintun M.A. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2005, 25:7709-7717.
33. Cabeza R. Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychology and Aging 2002, 17:85-100.
34. Campbell K.L., Grady C.L., Ng C., Hasher L. Age differences in the frontoparietal cognitive control network: implications for distractibility. Neuropsychologia 2012, 50:2212-2223.
35. CDC The CDC Healthy Brain Initiative: Progress 2006-2011 2011, Centers for Disease Control and Prevention, Atlanta, GA.
36. Chang C., Glover G.H. Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. NeuroImage 2009, 47:1448-1459.
37. Chen N.K., Chou Y.H., Song A.W., Madden D.J. Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity. Brain Structure & Function 2009, 213:571-585.
38. Choi S.H., Lee H., Chung T.S., Park K.M., Jung Y.C., Kim S.I., Kim J.J. Neural network functional connectivity during and after an episode of delirium. The American Journal of Psychiatry 2012, 169:498-507.
39. Chou Y.H., Panych L.P., Dickey C.C., Petrella J.R., Chen N.K. Investigation of long-term reproducibility of intrinsic connectivity network mapping: a resting-state fMRI study. AJNR. American Journal of Neuroradiology 2012, 33:833-838.
40. Church J.A., Fair D.A., Dosenbach N.U., Cohen A.L., Miezin F.M., Petersen S.E., Schlaggar B.L. Control networks in paediatric Tourette syndrome show immature and anomalous patterns of functional connectivity. Brain 2009, 132:225-238.
41. Cirrito J.R., Deane R., Fagan A.M., Spinner M.L., Parsadanian M., Finn M.B., Jiang H., Prior J.L., Sagare A., Bales K.R., Paul S.M., Zlokovic B.V., Piwnica-Worms D., Holtzman D.M. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation 2005, 115:3285-3290.
42. Cole D.M., Smith S.M., Beckmann C.F. Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Frontiers in Systematic Neuroscience 2010, 4:8.
43. Cole M.W., Anticevic A., Repovs G., Barch D. Variable global dysconnectivity and individual differences in schizophrenia. Biological Psychiatry 2010, 70:43-50.
44. Craik F.I., Rose N.S. Memory encoding and aging: a neurocognitive perspective. Neuroscience and Biobehavioral Reviews 2012, 36:1729-1739.
45. Curiati P.K., Tamashiro-Duran J.H., Duran F.L., Buchpiguel C.A., Squarzoni P., Romano D.C., Vallada H., Menezes P.R., Scazufca M., Busatto G.F., Alves T.C. Age-related metabolic profiles in cognitively healthy elders: results from a voxel-based [18F]fluorodeoxyglucose-positron-emission tomography study with partial volume effects correction. AJNR. American Journal of Neuroradiology 2011, 32:560-565.
46. D'Esposito M., Deouell L.Y., Gazzaley A. Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging. Nature Reviews. Neuroscience 2003, 4:863-872.
47. Damoiseaux J.S. Resting-state fMRI as a biomarker for Alzheimer's disease?. Alzheimer's Research & Therapy 2012, 4:8.
48. Damoiseaux J.S., Beckmann C.F., Arigita E.J., Barkhof F., Scheltens P., Stam C.J., Smith S.M., Rombouts S.A. Reduced resting-state brain activity in the default network in normal aging. Cerebral Cortex (New York, N. Y.: 1991) 2008, 18:1856-1864.
49. Damoiseaux J.S., Greicius M.D. Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Structure & Function 2009, 213:525-533.
50. Damoiseaux J.S., Prater K.E., Miller B.L., Greicius M.D. Functional connectivity tracks clinical deterioration in Alzheimer's disease. Neurobiology of Aging 2012, 33(82):e819-e830.
51. Davis S.W., Kragel J.E., Madden D.J., Cabeza R. The architecture of cross-hemispheric communication in the aging brain: linking behavior to functional and structural connectivity. Cerebral Cortex (New York, N. Y.: 1991) 2012, 22:232-242.
52. De Luca M., Beckmann C.F., De Stefano N., Matthews P.M., Smith S.M. fMRI resting state networks define distinct modes of long-distance interactions in the human brain. NeuroImage 2006, 29:1359-1367.
53. DeCarli C., Massaro J., Harvey D., Hald J., Tullberg M., Au R., Beiser A., D'Agostino R., Wolf P.A. Measures of brain morphology and infarction in the framingham heart study: establishing what is normal. Neurobiology of Aging 2005, 26:491-510.
54. Diaconescu A.O., Menon M., Jensen J., Kapur S., McIntosh A.R. Dopamine-induced changes in neural network patterns supporting aversive conditioning. Brain Research 2010, 1313:143-161.
55. Doucet G., Naveau M., Petit L., Zago L., Crivello F., Jobard G., Delcroix N., Mellet E., Tzourio-Mazoyer N., Mazoyer B., Joliot M. Patterns of hemodynamic low-frequency oscillations in the brain are modulated by the nature of free thought during rest. NeuroImage 2012, 59:3194-3200.
56. Drzezga A., Becker J.A., Van Dijk K.R., Sreenivasan A., Talukdar T., Sullivan C., Schultz A.P., Sepulcre J., Putcha D., Greve D., Johnson K.A., Sperling R.A. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 2011, 134:1635-1646.
57. Eisele Y.S., Obermuller U., Heilbronner G., Baumann F., Kaeser S.A., Wolburg H., Walker L.C., Staufenbiel M., Heikenwalder M., Jucker M. Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 2010, 330:980-982.
58. Esposito F., Aragri A., Pesaresi I., Cirillo S., Tedeschi G., Marciano E., Goebel R., Di Salle F. Independent component model of the default-mode brain function: combining individual-level and population-level analyses in resting-state fMRI. Journal of Magnetic Resonance Imaging: JMRI 2008, 26:905-913.
59. Evers E.A., Klaassen E.B., Rombouts S.A., Backes W.H., Jolles J. The effects of sustained cognitive task performance on subsequent resting state functional connectivity in healthy young and middle-aged male schoolteachers. Brain Connectivity 2012, 2:102-112.
60. Evin G., Weidemann A. Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides. Peptides 2002, 23:1285-1297.
61. Fair D.A., Posner J., Nagel B.J., Bathula D., Dias T.G., Mills K.L., Blythe M.S., Giwa A., Schmitt C.F., Nigg J.T. Atypical default network connectivity in youth with attention-deficit/hyperactivity disorder. Biological Psychiatry 2010, 68:1084-1091.
62. Ferreira L.K., Busatto G.F. Neuroimaging in Alzheimer's disease: current role in clinical practice and potential future applications. Clinics (Sao Paulo) 2011, 66(Suppl. 1):19-24.
63. Filippini N., MacIntosh B.J., Hough M.G., Goodwin G.M., Frisoni G.B., Smith S.M., Matthews P.M., Beckmann C.F., Mackay C.E. Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:7209-7214.
64. Fingelkurts A.A., Fingelkurts A.A., Kahkonen S. Functional connectivity in the brain - is it an elusive concept?. Neuroscience and Biobehavioral Reviews 2005, 28:827-836.
65. Fitzgerald K.D., Welsh R.C., Stern E.R., Angstadt M., Hanna G.L., Abelson J.L., Taylor S.F. Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry 2011, 50:938-948. e933.
66. Fleisher A.S., Sherzai A., Taylor C., Langbaum J.B., Chen K., Buxton R.B. Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groups. NeuroImage 2009, 47:1678-1690.
67. Fox M.D., Raichle M.E. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nature Reviews. Neuroscience 2007, 8:700-711.
68. Fox M.D., Snyder A.Z., Vincent J.L., Corbetta M., Van Essen D.C., Raichle M.E. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:9673-9678.
69. Fox M.D., Snyder A.Z., Vincent J.L., Raichle M.E. Intrinsic fluctuations within cortical systems account for intertrial variability in human behavior. Neuron 2007, 56:171-184.
70. Friston K.J., Frith C.D., Liddle P.F., Frackowiak R.S.J. Functional connectivity: the principal-component analysis of large (PET) data sets. Journal of Cerebral Blood Flow and Metabolism 1993, 13:5-14.
71. Fukunaga M., Horovitz S.G., de Zwart J.A., van Gelderen P., Balkin T.J., Braun A.R., Duyn J.H. Metabolic origin of BOLD signal fluctuations in the absence of stimuli. Journal of Cerebral Blood Flow and Metabolism 2008, 28:1377-1387.
72. Galvin J.E., Price J.L., Yan Z., Morris J.C., Sheline Y.I. Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease. Neurology 2011, 76:1797-1803.
73. Goh J.O. Functional dedifferentiation and altered connectivity in older adults: neural accounts of cognitive aging. Aging Disease 2011, 2:30-48.
74. Gouw A.A., Seewann A., Vrenken H., van der Flier W.M., Rozemuller J.M., Barkhof F., Scheltens P., Geurts J.J. Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology. Brain 2008, 131:3286-3298.
75. Grady C. The cognitive neuroscience of ageing. Nature Reviews. Neuroscience 2012, 13:491-505.
76. Grady C.L. Cognitive neuroscience of aging. Annals of the New York Academy of Sciences 2008, 1124:127-144.
77. Grady C.L., Grigg O., Ng C. Age differences in default and reward networks during processing of personally relevant information. Neuropsychologia 2012, 50:1682-1697.
78. Grady C.L., Protzner A.B., Kovacevic N., Strother S.C., Afshin-Pour B., Wojtowicz M., Anderson J.A., Churchill N., McIntosh A.R. A multivariate analysis of age-related differences in default mode and task-positive networks across multiple cognitive domains. Cerebral Cortex (New York, N. Y.: 1991) 2010, 20:1432-1447.
79. Greicius M. Resting-state functional connectivity in neuropsychiatric disorders. Current Opinion in Neurobiology 2008, 21:424-430.
80. Greicius M.D., Supekar K., Menon V., Dougherty R.F. Resting-state functional connectivity reflects structural connectivity in the default mode network. Cerebral Cortex (New York, N. Y.: 1991) 2009, 19:72-78.
81. Grieve S.M., Clark C.R., Williams L.M., Peduto A.J., Gordon E. Preservation of limbic and paralimbic structures in aging. Human Brain Mapping 2005, 25:391-401.
82. Grigg O., Grady C.L. Task-related effects on the temporal and spatial dynamics of resting-state functional connectivity in the default network. PLoS One 2010, 5:e13311.
83. Guo C.C., Kurth F., Zhou J., Mayer E.A., Eickhoff S.B., Kramer J.H., Seeley W.W. One-year test-retest reliability of intrinsic connectivity network fMRI in older adults. NeuroImage 2012, 61:1471-1483.
84. Hafkemeijer A., van der Grond J., Rombouts S.A. Imaging the default mode network in aging and dementia. Biochimica et Biophysica Acta 2012, 1822:431-441.
85. Hampson M., Driesen N.R., Skudlarski P., Gore J.C., Constable R.T. Brain connectivity related to working memory performance. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2006, 26:13338-13343.
86. Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
87. Harrison B.J., Pujol J., Ortiz H., Fornito A., Pantelis C., Yucel M. Modulation of brain resting-state networks by sad mood induction. PLoS One 2008, 3:e1794.
88. Hawelleka D.J., Hippa J.F., Lewis C.M., Corbetta M., Engel A.K. Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis. Proceedings of the National Academy of Science 2011, 108:19066-19071.
89. He J., Carmichael O., Fletcher E., Singh B., Iosif A.M., Martinez O., Reed B., Yonelinas A., Decarli C. Influence of functional connectivity and structural MRI measures on episodic memory. Neurobiology of Aging 2012, 33:2612-2620.
90. He Y., Wang L., Zang Y., Tian L., Zhang X., Li K., Jiang T. Regional coherence changes in the early stages of Alzheimer's disease: a combined structural and resting-state functional MRI study. NeuroImage 2007, 35:488-500.
91. Hedden T., Gabrieli J.D. Insights into the ageing mind: a view from cognitive neuroscience. Nature Reviews. Neuroscience 2004, 5:87-96.
92. Hedden T., Van Dijk K.R., Becker J.A., Mehta A., Sperling R.A., Johnson K.A., Buckner R.L. Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2009, 29:12686-12694.
93. Honey G.D., Suckling J., Zelaya F., Long C., Routledge C., Jackson S., Ng V., Fletcher P.C., Williams S.C., Brown J., Bullmore E.T. Dopaminergic drug effects on physiological connectivity in a human cortico-striato-thalamic system. Brain 2003, 126:1767-1781.
94. Horovitz S.G., Fukunaga M., de Zwart J.A., van Gelderen P., Fulton S.C., Balkin T.J., Duyn J.H. Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study. Human Brain Mapping 2008, 29:671-682.
95. Huang Y., Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell 2012, 148:1204-1222.
96. Huettel S.A., Song A.W., McCarthy G. Functional Magnetic Resonance Imaging 2009, Sinauer Associates, Sunderland, MA. Second ed.
97. Inouye S.K. Delirium in older persons. The New England Journal of Medicine 2006, 354:1157-1165.
98. Jack C.R., Knopman D.S., Jagust W.J., Shaw L.M., Aisen P.S., Weiner M.W., Petersen R.C., Trojanowski J.Q. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurology 2010, 9:119-128.
99. Jack C.R., Lowe V.J., Weigand S.D., Wiste H.J., Senjem M.L., Knopman D.S., Shiung M.M., Gunter J.L., Boeve B.F., Kemp B.J., Weiner M., Petersen R.C. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009, 132:1355-1365.
100. Jagust W.J., Mormino E.C. Lifespan brain activity, beta-amyloid, and Alzheimer's disease. Trends in Cognitive Sciences 2011, 15:520-526.
101. Jones D.T., Machulda M.M., Vemuri P., McDade E.M., Zeng G., Senjem M.L., Gunter J.L., Przybelski S.A., Avula R.T., Knopman D.S., Boeve B.F., Petersen R.C., Jack C.R. Age-related changes in the default mode network are more advanced in Alzheimer disease. Neurology 2011, 77:1524-1531.
102. Kalkstein J., Checksfield K., Bollinger J., Gazzaley A. Diminished top-down control underlies a visual imagery deficit in normal aging. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2011, 31:15768-15774.
103. Kalpouzos G., Chetelat G., Baron J.C., Landeau B., Mevel K., Godeau C., Barre L., Constans J.M., Viader F., Eustache F., Desgranges B. Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiology of Aging 2009, 30:112-124.
104. Kalpouzos G., Persson J., Nyberg L. Local brain atrophy accounts for functional activity differences in normal aging. Neurobiology of Aging 2012, 33. 623.e1-623.e13.
105. Kenna H., Hoeft F., Kelley R., Wroolie T., Demuth B., Reiss A., Rasgon N. Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease. Neurobiology of Aging 2013, 34:641-649.
106. Klostermann E.C., Braskie M.N., Landau S.M., O'Neil J.P., Jagust W.J. Dopamine and frontostriatal networks in cognitive aging. Neurobiology of Aging 2012, 33:e15-e24.
107. Koch W., Teipel S., Mueller S., Benninghoff J., Wagner M., Bokde A.L., Hampel H., Coates U., Reiser M., Meindl T. Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease. Neurobiology of Aging 2012, 33:466-478.
108. Koch W., Teipel S., Mueller S., Buerger K., Bokde A.L., Hampel H., Coates U., Reiser M., Meindl T. Effects of aging on default mode network activity in resting state fMRI: does the method of analysis matter?. NeuroImage 2010, 51:280-287.
109. Koyama M.S., Di Martino A., Zuo X.N., Kelly C., Mennes M., Jutagir D.R., Castellanos F.X., Milham M.P. Resting-state functional connectivity indexes reading competence in children and adults. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2011, 31:8617-8624.
110. Krajcovicova L., Mikl M., Marecek R., Rektorova I. The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent. Journal of Neural Transmission 2012, 119:443-454.
111. Kwak Y., Peltier S., Bohnen N.I., Muller M.L., Dayalu P., Seidler R.D. Altered resting state cortico-striatal connectivity in mild to moderate stage Parkinson's disease. Frontiers in Systematic Neuroscience 2010, 4:143.
112. Langan J., Peltier S.J., Bo J., Fling B.W., Welsh R.C., Seidler R.D. Functional implications of age differences in motor system connectivity. Frontiers in Systematic Neuroscience 2010, 4:17.
113. Li Z., Moore A.B., Tyner C., Hu X. Asymmetric connectivity reduction and its relationship to HAROLD in aging brain. Brain Research 2009, 1295:149-158.
114. Luk G., Bialystok E., Craik F.I., Grady C.L. Lifelong bilingualism maintains white matter integrity in older adults. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2011, 31:16808-16813.
115. Luo C., Qiu C., Guo Z., Fang J., Li Q., Lei X., Xia Y., Lai Y., Gong Q., Zhou D., Yao D. Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study. PLoS One 2012, 7:e28196.
116. Madden D.J., Bennett I.J., Burzynska A., Potter G.G., Chen N.K., Song A.W. Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochimica et Biophysica Acta 2012, 1822:386-400.
117. Madden D.J., Bennett I.J., Song A.W. Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging. Neuropsychology Review 2009, 19:415-435.
118. Margulies D.S., Bottger J., Long X., Lv Y., Kelly C., Schafer A., Goldhahn D., Abbushi A., Milham M.P., Lohmann G., Villringer A. Resting developments: a review of fMRI post-processing methodologies for spontaneous brain activity. Magma 2010, 23:289-307.
119. Mayda A.B., Westphal A., Carter C.S., DeCarli C. Late life cognitive control deficits are accentuated by white matter disease burden. Brain 2011, 134:1673-1683.
120. Meier T.B., Desphande A.S., Vergun S., Nair V.A., Song J., Biswal B.B., Meyerand M.E., Birn R.M., Prabhakaran V. Support vector machine classification and characterization of age-related reorganization of functional brain networks. NeuroImage 2012, 60:601-613.
121. Meindl T., Teipel S., Elmouden R., Mueller S., Koch W., Dietrich O., Coates U., Reiser M., Glaser C. Test-retest reproducibility of the default-mode network in healthy individuals. Human Brain Mapping 2010, 31:237-246.
122. Meunier D., Achard S., Morcom A., Bullmore E. Age-related changes in modular organization of human brain functional networks. NeuroImage 2009, 44:715-723.
123. Mevel K., Chetelat G., Eustache F., Desgranges B. The default mode network in healthy aging and Alzheimer's disease. International Journal of Alzheimer's Disease 2011, 2011:535816.
124. Mevel K., Landeau B., Fouquet M., La Joie R., Villain N., Mézenge F., Perrotin A., Eustache F., Desgranges B., Chételat G. Age effect on the default mode network, inner thoughts, and cognitive abilities. Neurobiology of Aging 2013, 34:1292-1301.
125. Meyer-Lindenberg A., Straub R.E., Lipska B.K., Verchinski B.A., Goldberg T., Callicott J.H., Egan M.F., Huffaker S.S., Mattay V.S., Kolachana B., Kleinman J.E., Weinberger D.R. Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. The Journal of Clinical Investigation 2007, 117:672-682.
126. Morgenstern H. Ecologic studies in epidemiology: concepts, principles, and methods. Annual Review of Public Health 1995, 16:61-81.
127. Mormino E.C., Smiljic A., Hayenga A.O., Onami S.H., Greicius M.D., Rabinovici G.D., Janabi M., Baker S.L., Yen I.V., Madison C.M., Miller B.L., Jagust W.J. Relationships between beta-amyloid and functional connectivity in different components of the default mode network in aging. Cerebral Cortex (New York, N. Y.: 1991) 2011, 21:2399-2407.
128. Mowinckel A.M., Espeseth T., Westlye L.T. Network-specific effects of age and in-scanner subject motion: a resting-state fMRI study of 238 healthy adults. NeuroImage 2012, 63:1364-1373.
129. Nagano-Saito A., Leyton M., Monchi O., Goldberg Y.K., He Y., Dagher A. Dopamine depletion impairs frontostriatal functional connectivity during a set-shifting task. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2008, 28:3697-3706.
130. Noimark D. Predicting the onset of delirium in the post-operative patient. Age and Ageing 2009, 38:368-373.
131. O'Sullivan M., Jones D.K., Summers P.E., Morris R.G., Williams S.C., Markus H.S. Evidence for cortical disconnection as a mechanism of age-related cognitive decline. Neurology 2001, 57:632-638.
132. Oh H., Mormino E.C., Madison C., Hayenga A., Smiljic A., Jagust W.J. beta-Amyloid affects frontal and posterior brain networks in normal aging. NeuroImage 2011, 54:1887-1895.
133. Onoda K., Ishihara M., Yamaguchi S. Decreased functional connectivity by aging is associated with cognitive decline. Journal of Cognitive Neuroscience 2012, 24:2186-2198.
134. Orru G., Pettersson-Yeo W., Marquand A.F., Sartori G., Mechelli A. Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review. Neuroscience and Biobehavioral Reviews 2012, 36:1140-1152.
135. Palop J.J., Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nature Neuroscience 2010, 13:812-818.
136. Park C.H., Chang W.H., Ohn S.H., Kim S.T., Bang O.Y., Pascual-Leone A., Kim Y.H. Longitudinal changes of resting-state functional connectivity during motor recovery after stroke. Stroke 2011, 42:1357-1362.
137. Park D.C., Reuter-Lorenz P. The adaptive brain: aging and neurocognitive scaffolding. Annual Review of Psychology 2009, 60:173-196.
138. Pieramico V., Esposito R., Sensi F., Cilli F., Mantini D., Mattei P.A., Frazzini V., Ciavardelli D., Gatta V., Ferretti A., Romani G.L., Sensi S.L. Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes. PLoS One 2012, 7:e43901.
139. Prvulovic D., Bokde A.L., Faltraco F., Hampel H. Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease. Progress in Neurobiology 2011, 95:557-569.
140. Querfurth H.W., LaFerla F.M. Alzheimer's disease. The New England Journal of Medicine 2010, 362:329-344.
141. Rabinovici G.D., Jagust W.J. Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. Behavioural Neurology 2009, 21:117-128.
142. Raichle M.E., MacLeod A.M., Snyder A.Z., Powers W.J., Gusnard D.A., Shulman G.L. A default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:676-682.
143. Rentz D.M., Amariglio R.E., Becker J.A., Frey M., Olson L.E., Frishe K., Carmasin J., Maye J.E., Johnson K.A., Sperling R.A. Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia 2011, 49:2776-2783.
144. Rieckmann A., Karlsson S., Fischer H., Backman L. Caudate dopamine D1 receptor density is associated with individual differences in frontoparietal connectivity during working memory. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2011, 31:14284-14290.
145. Ritter P., Villringer A. Simultaneous EEG-fMRI. Neuroscience and Biobehavioral Reviews 2006, 30:823-838.
146. Rodrigue K.M., Kennedy K.M., Devous M.D., Rieck J.R., Hebrank A.C., Diaz-Arrastia R., Mathews D., Park D.C. beta-Amyloid burden in healthy aging: regional distribution and cognitive consequences. Neurology 2012, 78:387-395.
147. Rowe C.C., Ellis K.A., Rimajova M., Bourgeat P., Pike K.E., Jones G., Fripp J., Tochon-Danguy H., Morandeau L., O'Keefe G., Price R., Raniga P., Robins P., Acosta O., Lenzo N., Szoeke C., Salvado O., Head R., Martins R., Masters C.L., Ames D., Villemagne V.L. Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of Aging 2010, 31:1275-1283.
148. Sambataro F., Murty V.P., Callicott J.H., Tan H.Y., Das S., Weinberger D.R., Mattay V.S. Age-related alterations in default mode network: impact on working memory performance. Neurobiology of Aging 2010, 31:839-852.
149. Seeley W.W., Menon V., Schatzberg A.F., Keller J., Glover G.H., Kenna H., Reiss A.L., Greicius M.D. Dissociable intrinsic connectivity networks for salience processing and executive control. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2007, 27:2349-2356.
150. Selkoe D.J. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behavioural Brain Research 2008, 192:106-113.
151. Shehzad Z., Kelly A.M., Reiss P.T., Gee D.G., Gotimer K., Uddin L.Q., Lee S.H., Margulies D.S., Roy A.K., Biswal B.B., Petkova E., Castellanos F.X., Milham M.P. The resting brain: unconstrained yet reliable. Cerebral Cortex (New York, N. Y.: 1991) 2009, 19:2209-2229.
152. Sheline Y.I., Morris J.C., Snyder A.Z., Price J.L., Yan Z., D'Angelo G., Liu C., Dixit S., Benzinger T., Fagan A., Goate A., Mintun M.A. APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Abeta42. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2010, 30:17035-17040.
153. Sheline Y.I., Price J.L., Yan Z., Mintun M.A. Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:11020-11025.
154. Sheline Y.I., Raichle M.E., Snyder A.Z., Morris J.C., Head D., Wang S., Mintun M.A. Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biological Psychiatry 2010, 67:584-587.
155. Sheppard J.P., Wang J.P., Wong P.C. Large-scale cortical functional organization and speech perception across the lifespan. PLoS One 2011, 6:e16510.
156. Simon S.S., Yokomizo J.E., Bottino C.M. Cognitive intervention in amnestic mild cognitive impairment: a systematic review. Neuroscience and Biobehavioral Reviews 2012, 36:1163-1178.
157. Soderlund H., Nyberg L., Adolfsson R., Nilsson L.G., Launer L.J. High prevalence of white matter hyperintensities in normal aging: relation to blood pressure and cognition. Cortex 2003, 39:1093-1105.
158. Sperling R. Potential of functional MRI as a biomarker in early Alzheimer's disease. Neurobiology of Aging 2011, 32(Suppl. 1):S37-S43.
159. Sperling R.A., Aisen P.S., Beckett L.A., Bennett D.A., Craft S., Fagan A.M., Iwatsubo T., Jack C.R., Kaye J., Montine T.J., Park D.C., Reiman E.M., Rowe C.C., Siemers E., Stern Y., Yaffe K., Carrillo M.C., Thies B., Morrison-Bogorad M., Wagster M.V., Phelps C.H. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia 2011, 7:280-292.
160. Sperling R.A., Dickerson B.C., Pihlajamaki M., Vannini P., LaViolette P.S., Vitolo O.V., Hedden T., Becker J.A., Rentz D.M., Selkoe D.J., Johnson K.A. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Medicine 2010, 12:27-43.
161. Sperling R.A., Laviolette P.S., O'Keefe K., O'Brien J., Rentz D.M., Pihlajamaki M., Marshall G., Hyman B.T., Selkoe D.J., Hedden T., Buckner R.L., Becker J.A., Johnson K.A. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron 2009, 63:178-188.
162. Spreng R.N., Wojtowicz M., Grady C.L. Reliable differences in brain activity between young and old adults: a quantitative meta-analysis across multiple cognitive domains. Neuroscience and Biobehavioral Reviews 2010, 34:1178-1194.
163. St John P.D., Montgomery P.R. Cognitive impairment and life satisfaction in older adults. International Journal of Geriatric Psychiatry 2010, 25:814-821.
164. Strick P.L., Dum R.P., Fiez J.A. Cerebellum and nonmotor function. Annual Review of Neuroscience 2009, 32:413-434.
165. Sullivan E.V., Pfefferbaum A. Diffusion tensor imaging and aging. Neuroscience and Biobehavioral Reviews 2006, 30:749-761.
166. Sullivan E.V., Rohlfing T., Pfefferbaum A. Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: relations to timed performance. Neurobiology of Aging 2010, 31:464-481.
167. Tagliazucchi E., von Wegner F., Morzelewski A., Borisov S., Jahnke K., Laufs H. Automatic sleep staging using fMRI functional connectivity data. NeuroImage 2012, 63:63-72.
168. Takeuchi H., Taki Y., Hashizume H., Sassa Y., Nagase T., Nouchi R., Kawashima R. The association between resting functional connectivity and creativity. Cerebral Cortex 2012, 22:2921-2929.
169. Teipel S.J., Bokde A.L., Meindl T., Amaro E., Soldner J., Reiser M.F., Herpertz S.C., Moller H.J., Hampel H. White matter microstructure underlying default mode network connectivity in the human brain. NeuroImage 2010, 49:2021-2032.
170. Terribilli D., Schaufelberger M.S., Duran F.L., Zanetti M.V., Curiati P.K., Menezes P.R., Scazufca M., Amaro E., Leite C.C., Busatto G.F. Age-related gray matter volume changes in the brain during non-elderly adulthood. Neurobiology of Aging 2011, 32:354-368.
171. Tomasi D., Volkow N.D. Aging and functional brain networks. Molecular Psychiatry 2012, 17(471):549-558.
172. Toussaint P.J., Maiz S., Coynel D., Messé A., Perlbarg V., Habert M.O., Benali H. Characterization of the default mode functional connectivity in normal aging and Alzheimer's disease: an approach combining entropy-based and graph theoretical measurements. IEEE International Symposium on Biomedical Imaging: From Nano to Macro 2011, 853-856.
173. United Nations, P.D., DESA, 2002. World Population Ageing: 1950-2050. United Nations Publications, New York.
174. van Buuren M., Gladwin T.E., Zandbelt B.B., van den Heuvel M., Ramsey N.F., Kahn R.S., Vink M. Cardiorespiratory effects on default-mode network activity as measured with fMRI. Human Brain Mapping 2009, 30:3031-3042.
175. van den Heuvel M.P., Hulshoff Pol H.E. Exploring the brain network: a review on resting-state fMRI functional connectivity. European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology 2010, 20:519-534.
176. van den Heuvel M.P., Mandl R.C., Kahn R.S., Hulshoff Pol H.E. Functionally linked resting-state networks reflect the underlying structural connectivity architecture of the human brain. Human Brain Mapping 2009, 30:3127-3141.
177. Van Dijk K.R., Hedden T., Venkataraman A., Evans K.C., Lazar S.W., Buckner R.L. Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. Journal of Neurophysiology 2010, 103:297-321.
178. Van Dijk K.R., Sabuncu M.R., Buckner R.L. The influence of head motion on intrinsic functional connectivity MRI. NeuroImage 2012, 59:431-438.
179. Van Dijk K.R., Sperling R.A. Defaulting on the default network: increased risk for dementia. Neurology 2011, 76:498-500.
180. van Duinkerken E., Schoonheim M.M., Sanz-Arigita E.J., IJzerman R.G., Moll A.C., Snoek F.J., Ryan C.M., Klein M., Diamant M., Barkhof F. Resting-state brain networks in type 1 diabetic patients with and without microangiopathy and their relation to cognitive functions and disease variables. Diabetes 2012, 61:1814-1821.
181. Vannini P., Hedden T., Becker J.A., Sullivan C., Putcha D., Rentz D., Johnson K.A., Sperling R.A. Age and amyloid-related alterations in default network habituation to stimulus repetition. Neurobiology of Aging 2012, 33:1237-1252.
182. Vemuri P., Jones D.T., Jack C.R. Resting state functional MRI in Alzheimer's disease. Alzheimer's Research & Therapy 2012, 4:2.
183. Vernooij M.W., de Groot M., van der Lugt A., Ikram M.A., Krestin G.P., Hofman A., Niessen W.J., Breteler M.M. White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging. NeuroImage 2008, 43:470-477.
184. Villemagne V.L., Fodero-Tavoletti M.T., Pike K.E., Cappai R., Masters C.L., Rowe C.C. The ART of loss: abeta imaging in the evaluation of Alzheimer's disease and other dementias. Molecular Neurobiology 2008, 38:1-15.
185. Villemagne V.L., Pike K.E., Darby D., Maruff P., Savage G., Ng S., Ackermann U., Cowie T.F., Currie J., Chan S.G., Jones G., Tochon-Danguy H., O'Keefe G., Masters C.L., Rowe C.C. Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia 2008, 46:1688-1697.
186. Vlassenko A.G., Vaishnavi S.N., Couture L., Sacco D., Shannon B.J., Mach R.H., Morris J.C., Raichle M.E., Mintun M.A. Spatial correlation between brain aerobic glycolysis and amyloid-beta (Abeta) deposition. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:17763-17767.
187. Voineskos A.N., Rajji T.K., Lobaugh N.J., Miranda D., Shenton M.E., Kennedy J.L., Pollock B.G., Mulsant B.H. Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study. Neurobiology of Aging 2012, 33:21-34.
188. Voss M.W., Erickson K.I., Prakash R.S., Chaddock L., Malkowski E., Alves H., Kim J.S., Morris K.S., White S.M., Wojcicki T.R., Hu L., Szabo A., Klamm E., McAuley E., Kramer A.F. Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?. Neuropsychologia 2010, 48:1394-1406.
189. Voss M.W., Prakash R.S., Erickson K.I., Basak C., Chaddock L., Kim J.S., Alves H., Heo S., Szabo A.N., White S.M., Wojcicki T.R., Mailey E.L., Gothe N., Olson E.A., McAuley E., Kramer A.F. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Frontiers in Aging Neuroscience 2010, 2. 32.
190. Wallace D.L., Vytlacil J.J., Nomura E.M., Gibbs S.E., D'Esposito M. The dopamine agonist bromocriptine differentially affects fronto-striatal functional connectivity during working memory. Frontiers in Human Neuroscience 2011, 5:32.
191. Wang L., Laviolette P., O'Keefe K., Putcha D., Bakkour A., Van Dijk K.R., Pihlajamaki M., Dickerson B.C., Sperling R.A. Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. NeuroImage 2010, 51:910-917.
192. Wang Z., Yuan Y., Bai F., You J., Li L., Zhang Z. Abnormal default-mode network in angiotensin converting enzyme D allele carriers with remitted geriatric depression. Behavioural Brain Research 2012, 230:325-332.
193. Waring J.D., Addis D.R., Kensinger E.A. Effects of aging on neural connectivity underlying selective memory for emotional scenes. Neurobiology of Aging 2013, 34:451-467.
194. Westlye E.T., Lundervold A., Rootwelt H., Lundervold A.J., Westlye L.T. Increased hippocampal default mode synchronization during rest in middle-aged and elderly APOE epsilon4 carriers: relationships with memory performance. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2011, 31:7775-7783.
195. Whalley L.J., Deary I.J., Appleton C.L., Starr J.M. Cognitive reserve and the neurobiology of cognitive aging. Ageing Research Reviews 2004, 3:369-382.
196. Whitfield-Gabrieli S., Ford J.M. Default mode network activity and connectivity in psychopathology. Annual Review of Clinical Psychology 2012, 8:49-76.
197. Whitwell J.L., Josephs K.A., Avula R., Tosakulwong N., Weigand S.D., Senjem M.L., Vemuri P., Jones D.T., Gunter J.L., Baker M., Wszolek Z.K., Knopman D.S., Rademakers R., Petersen R.C., Boeve B.F., Jack C.R. Altered functional connectivity in asymptomatic MAPT subjects: a comparison to bvFTD. Neurology 2011, 77:866-874.
198. Williams K.N., Kemper S. Interventions to reduce cognitive decline in aging. Journal of Psychosocial Nursing and Mental Health Services 2010, 48:42-51.
199. Wu J.T., Wu H.Z., Yan C.G., Chen W.X., Zhang H.Y., He Y., Yang H.S. Aging-related changes in the default mode network and its anti-correlated networks: a resting-state fMRI study. Neuroscience Letters 2011, 504:62-67.
200. Wu T., Zang Y., Wang L., Long X., Hallett M., Chen Y., Li K., Chan P. Aging influence on functional connectivity of the motor network in the resting state. Neuroscience Letters 2007, 422:164-168.
201. Wu T., Zang Y., Wang L., Long X., Li K., Chan P. Normal aging decreases regional homogeneity of the motor areas in the resting state. Neuroscience Letters 2007, 423:189-193.
202. Yan L., Zhuo Y., Wang B., Wang D.J. Loss of coherence of low frequency fluctuations of BOLD FMRI in visual cortex of healthy aged subjects. The Open Neuroimaging Journal 2011, 5:105-111.
203. Ystad M., Eichele T., Lundervold A.J., Lundervold A. Subcortical functional connectivity and verbal episodic memory in healthy elderly - a resting state fMRI study. NeuroImage 2010, 52:379-388.
204. Ystad M., Hodneland E., Adolfsdottir S., Haasz J., Lundervold A.J., Eichele T., Lundervold A. Cortico-striatal connectivity and cognition in normal aging: a combined DTI and resting state fMRI study. NeuroImage 2011, 55:24-31.
205. Zahr N.M., Rohlfing T., Pfefferbaum A., Sullivan E.V. Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: a quantitative fiber tracking study. NeuroImage 2009, 44:1050-1062.
206. Zuo X.N., Di Martino A., Kelly C., Shehzad Z.E., Gee D.G., Klein D.F., Castellanos F.X., Biswal B.B., Milham M.P. The oscillating brain: complex and reliable. NeuroImage 2010, 49:1432-1445.
207. Zuo X.N., Kelly C., Di Martino A., Mennes M., Margulies D.S., Bangaru S., Grzadzinski R., Evans A.C., Zang Y.F., Castellanos F.X., Milham M.P. Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2010, 30:15034-15043.