Relationships between beta-amyloid and functional connectivity in different components of the default mode network in aging

Cerebral Cortex

Volumn 21, Issue 10, 2011, Pages 2399-2407

  Mormino, Elizabeth C ^a   Smiljic, Andre ^a   Hayenga, Amynta O ^a   H Onami, Susan ^a   Greicius, Michael D ^b   Rabinovici, Gil D ^a,c,d,e   Janabi, Mustafa ^c   Baker, Suzanne L ^c   V Yen, Irene ^c   Madison, Cindee M ^a   Miller, Bruce L ^d,e   Jagust, William J ^a,c,d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Beta amyloid; PIB PET; Resting state fMRI

Indexed keywords

AMYLOID BETA PROTEIN; PITTSBURGH COMPOUND B;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ANGULAR GYRUS; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DEFAULT MODE NETWORK; EPISODIC MEMORY; FEMALE; HUMAN; MALE; NERVE CELL NETWORK; PREFRONTAL CORTEX; PRIORITY JOURNAL; REST; TEMPORAL CORTEX;

ADULT; AGED; AGED, 80 AND OVER; AGING; AMYLOID BETA-PEPTIDES; BRAIN MAPPING; CEREBRAL CORTEX; COHORT STUDIES; FEMALE; HUMANS; MALE; MEMORY, EPISODIC; NERVE NET; POSITRON-EMISSION TOMOGRAPHY; YOUNG ADULT;

EID: 79960965577     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhr025     Document Type: Article

References (68)

1. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL. 2010. Functional-anatomic fractionation of the brain's default network. Neuron. 65:550-562.
2. Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW. 1991. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex. 1:103-116.
3. Beckmann CF, Smith SM. 2004. Probabilistic independent component analysis for functional magnetic resonance imaging. IEEE Trans Med Imaging. 23:137-152.
4. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS. 2006. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 66: 1837-1844. (Pubitemid 44049813)
5. Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE. 2004. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol. 61:378-384. (Pubitemid 38327357)
6. Bourgeat P, Chetelat G, Villemagne VL, Fripp J, Raniga P, Pike K, Acosta O, Szoeke C, Ourselin S, Ames D, et al. 2010. Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology. 74:121-127.
7. Buckner RL, Andrews-Hanna JR, Schacter DL. 2008. The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 1124:1-38. (Pubitemid 351506788)
8. Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, Andrews-Hanna JR, Sperling RA, Johnson KA. 2009. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 29:1860-1873.
9. Buckner RL, Snyder AZ, Shannon BJ, LaRossa G, Sachs R, Fotenos AF, Sheline YI, Klunk WE, Mathis CA, Morris JC, et al. 2005. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 25:7709-7717. (Pubitemid 41208641)
10. Buckner RL, Vincent JL. 2007. Unrest at rest: default activity and spontaneous network correlations. Neuroimage. 37:1091-1096; discussion 1097-1099. (Pubitemid 47385256)
11. Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM. 2005. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron. 48:913-922. (Pubitemid 41814696)
12. Dale AM, Fischl B, Sereno MI. 1999. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage. 9:179-194. (Pubitemid 29369874)
13. Damoiseaux JS, Beckmann CF, Arigita EJ, Barkhof F, Scheltens P, Stam CJ, Smith SM, Rombouts SA. 2008. Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex. 18:1856-1864. (Pubitemid 352019901)
14. Damoiseaux JS, Rombouts SA, Barkhof F, Scheltens P, Stam CJ, Smith SM, Beckmann CF. 2006. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A. 103:13848-13853. (Pubitemid 44413996)
15. Davis DG, Schmitt FA, Wekstein DR, Markesbery WR. 1999. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropathol Exp Neurol. 58:376-388. (Pubitemid 29187900)
16. de Leon MJ, Convit A, Wolf OT, Tarshish CY, DeSanti S, Rusinek H, Tsui W, Kandil E, Scherer AJ, Roche A, et al. 2001. Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2- deoxy-D-glucose/poitron-emission tomography (FDG/PET). Proc Natl Acad Sci U S A. 98:10966-10971. (Pubitemid 32878727)
17. Delis D, Kramer J, Kaplan E, Ober B. 2000. California verbal learning test. San Antonio (TX): The Psychological Corporation.
18. Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, et al. 2009. The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex. 19:497-510.
19. Engler H, Forsberg A, Almkvist O, Blomquist G, Larsson E, Savitcheva I, Wall A, Ringheim A, Langstrom B, Nordberg A. 2006. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain. 129:2856-2866. (Pubitemid 44684508)
20. Filippini N, MacIntosh BJ, Hough MG, Goodwin GM, Frisoni GB, Smith SM, Matthews PM, Beckmann CF, Mackay CE. 2009. Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci U S A. 106:7209-7214.
21. Fischl B, Liu A, Dale AM. 2001. Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging. 20:70-80. (Pubitemid 32293421)
22. Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, et al. 2002. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 33:341-355. (Pubitemid 34162530)
23. Fox MD, Raichle ME. 2007. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci. 8:700-711. (Pubitemid 47283145)
24. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME. 2005. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A. 102:9673-9678. (Pubitemid 40981739)
25. Greicius MD, Krasnow B, Reiss AL, Menon V. 2003. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A. 100:253-258. (Pubitemid 36078061)
26. Greicius MD, Srivastava G, Reiss AL, Menon V. 2004. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A. 101:4637-4642. (Pubitemid 38437463)
27. Greicius MD, Supekar K, Menon V, Dougherty RF. 2009. Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex. 19:72-78.
28. Hagmann P, Cammoun L, Gigandet X, Meuli R, Honey CJ, Wedeen VJ, Sporns O. 2008. Mapping the structural core of human cerebral cortex. PLoS Biol. 6:e159.
29. Hedden T, Van Dijk KR, Becker JA, Mehta A, Sperling RA, Johnson KA, Buckner RL. 2009. Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. J Neurosci. 29:12686-12694.
30. Hulette CM, Welsh-Bohmer KA, Murray MG, Saunders AM, Mash DC, McIntyre LM. 1998. Neuropathological and neuropsychological changes in "normal" aging: evidence for preclinical Alzheimer disease in cognitively normal individuals. J Neuropathol Exp Neurol. 57:1168-1174. (Pubitemid 28562746)
31. Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, Lopresti BJ, Ziolko S, Bi W, Paljug WR, et al. 2008. Postmortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain. 131:1630-1645. (Pubitemid 351806448)
32. Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ. 2010. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 9:119-128.
33. Jack CR, Jr, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, Knopman DS, Boeve BF, Klunk WE, Mathis CA, et al. 2008. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain. 131:665-680. (Pubitemid 351294719)
34. Jack CR, Jr, Lowe VJ, Weigand SD, Wiste HJ, Senjem ML, Knopman DS, Shiung MM, Gunter JL, Boeve BF, Kemp BJ, et al. 2009. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain. 132:1355-1365.
35. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS. 2002. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology. 58:1188-1196. (Pubitemid 34411862)
36. Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF, Estrada S, et al. 2004. Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B. Ann Neurol. 55:306-319. (Pubitemid 38269583)
37. Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, et al. 2003. Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol. 62:1087-1095. (Pubitemid 37413820)
38. Kramer JH, Jurik J, Sha SJ, Rankin KP, Rosen HJ, Johnson JK, Miller BL. 2003. Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease. Cogn Behav Neurol. 16:211-218. (Pubitemid 37517826)
39. Langbaum JB, Chen K, Lee W, Reschke C, Bandy D, Fleisher AS, Alexander GE, Foster NL, Weiner MW, Koeppe RA, et al. 2009. Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neuroimage. 45: 1107-1116.
40. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. 1996. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab. 16:834-840. (Pubitemid 26292051)
41. Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE. 2003. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem. 46:2740-2754. (Pubitemid 36702542)
42. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 34:939-944. (Pubitemid 14076461)
43. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. 1997. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol. 42:85-94. (Pubitemid 27304784)
44. Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC. 2006. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 67:446-452. (Pubitemid 44214969)
45. Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ. 2009. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain. 132:1310-1323.
46. Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA. 2009. Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Arch Neurol. 66:1469-1475.
47. Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, et al. 2007. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 55:697-711. (Pubitemid 47321079)
48. Pike KE, Savage G, Villemagne VL, Ng S, Moss SA, Maruff P, Mathis CA, Klunk WE, Masters CL, Rowe CC. 2007. Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain. 130:2837-2844. (Pubitemid 350033975)
49. Price JC, Klunk WE, Lopresti BJ, Lu X, Hoge JA, Ziolko SK, Holt DP, Meltzer CC, DeKosky ST, Mathis CA. 2005. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh compound-B. J Cereb Blood Flow Metab. 25:1528-1547. (Pubitemid 41541962)
50. Price JL, Morris JC. 1999. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol. 45:358-368. (Pubitemid 29120041)
51. Qi Z, Wu X, Wang Z, Zhang N, Dong H, Yao L, Li K. 2010. Impairment and compensation coexist in amnestic MCI default mode network. Neuroimage. 50:48-55.
52. Rabinovici GD, Jagust WJ. 2009. Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. Behav Neurol. 21:117-128.
53. Raichle ME, Snyder AZ. 2007. A default mode of brain function: a brief history of an evolving idea. Neuroimage. 37:1083-1090discussion 1097-1089. (Pubitemid 47385262)
54. Reitan RM. 1958. Validity of the Trailmaking Test as an indication of organic brain damage. Percept Mot Skills. 8:271-276.
55. Reuter-Lorenz P. 2002. New visions of the aging mind and brain. Trends Cogn Sci. 6:394.
56. Salthouse TA, Babcock RL, Shaw RJ. 1991. Effects of adult age on structural and operational capacities in working memory. Psychol Aging. 6:118-127.
57. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C. 2009. Age, neuropathology, and dementia. N Engl J Med. 360: 2302-2309.
58. Segonne F, Dale AM, Busa E, Glessner M, Salat D, Hahn HK, Fischl B. 2004. A hybrid approach to the skull stripping problem in MRI. Neuroimage. 22:1060-1075. (Pubitemid 38829195)
59. Sheline YI, Raichle ME, Snyder AZ, Morris JC, Head D, Wang S, Mintun MA. 2010. Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biol Psychiatry. 67:584-587.
60. Sorg C, Riedl V, Muhlau M, Calhoun VD, Eichele T, Laer L, Drzezga A, Forstl H, Kurz A, Zimmer C, et al. 2007. Selective changes of restingstate networks in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci U S A. 104:18760-18765. (Pubitemid 350210770)
61. Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, et al. 2009. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 63:178-188.
62. Storandt M, Mintun MA, Head D, Morris JC. 2009. Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition. Arch Neurol. 66:1476-1481.
63. Thompson PM, Hayashi KM, Dutton RA, Chiang MC, Leow AD, Sowell ER, De Zubicaray G, Becker JT, Lopez OL, Aizenstein HJ, et al. 2007. Tracking Alzheimer's disease. Ann N Y Acad Sci. 1097:183-214. (Pubitemid 47084892)
64. Tomlinson BE, Blessed G, Roth M. 1968. Observations on the brains of non-demented old people. J Neurol Sci. 7:331-356.
65. Walsh DM, Selkoe DJ. 2007. A beta oligomers-a decade of discovery. J Neurochem. 101:1172-1184.
66. Wechsler D. 1987a. Wechsler adult intelligence scale-revised. San Antonio (TX): The Psychological Corporation.
67. Wechsler D. 1987b. Wechsler memory scale-revised. San Antonio (TX): The Psychological Corporation.
68. Zec RF. 1986. The stroop color-word test: a paradigm for procedural learning. Arch Clin Neuropsychol. 1:274-275.