Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline

Neurology

Volumn 57, Issue 4, 2001, Pages 632-638

  O'Sullivan, Mike ^a   Jones, D K ^b   Summers, P E ^b   Morris, R G ^b   Williams, S C R ^b   Markus, H S ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; HUMAN; NEUROPATHOLOGY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SKILL; WHITE MATTER;

EID: 0035964210     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.57.4.632     Document Type: Article

References (27)

1. Life and death of neurons in the aging brain
2. Disconnection syndromes in animals and man
3. Large-scale neurocognitive networks and distributed processing for attention, language, and memory
4. Functional magnetic resonance image analysis of a large-scale neurocognitive network
5. Context-dependent, neural system-specific neurophysiological concomitants of ageing: Mapping PET correlates during cognitive activation
6. Age-induced white matter changes in the human brain: A stereological investigation
7. Morphometry of invivo human white matter association pathways with diffusion-weighted magnetic resonance imaging
8. Identification of "premyelination" by diffusion-weighted MRI
9. Characterisation of white matter damage in ischaemic leukoaraiosis with diffusion tensor magnetic resonance imaging
10. Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis
11. Diffusion tensor MRI assesses corticospinal tract damage in ALS
12. Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging
13. Microstructure of temporo-parietal white matter as a basis for reading ability: Evidence from diffusion tensor magnetic resonance imaging
14. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging
15. Microstructural and physiological features of tissue elucidated by quantitative-diffusion-tensor MRI
16. On the relation between brain images and brain neural networks
17. Myelination and organization of the frontal white matter in children: A diffusion tensor MRI study
18. Examination of the working memory components in normal aging and in dementia of the Alzheimer type
19. Working memory and the self-ordered pointing task: Further evidence of early prefrontal decline in normal aging
20. Age-related changes in oligodendrocytes in monkey cerebral cortex
21. Physiological activation of a cortical network during performance of the Wisconsin card sorting test: A positron emission tomography study
22. In vivo fiber tractography using DT-MRI data
23. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging
24. Toward a quantitative assessment of diffusion anisotropy
25. Enlarged and phagocytic, but not primed, interleukin-1 (IL-1) alpha-immunoreactive microglia increase with age in the normal human brain
26. Increased microglial activation and protein nitration in white matter of the aging monkey